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    System for Monitoring Neural Shunt Function and Associated Methods
    5.
    发明申请
    System for Monitoring Neural Shunt Function and Associated Methods 失效
    监测神经分流功能及相关方法的系统

    公开(公告)号：US20080319340A1

    公开(公告)日：2008-12-25

    申请号：US12064002

    申请日：2006-08-15

    申请人： Kim Manwaring ,  Preston Manwaring ,  Mark Manwaring

    发明人： Kim Manwaring ,  Preston Manwaring ,  Mark Manwaring

    IPC分类号： A61B5/03

    CPC分类号： A61B5/031 ,  A61B5/4064

    摘要： A system and method for evaluating neural shunt functionality is provided. Accordingly, in one aspect a method for monitoring neural shunt functionality may include measuring a first intracranial pressure pulse inside the shunt, measuring a second intracranial pressure pulse outside the shunt, and comparing pulsatile characteristics from the first measurement to the second measurement in order to determine shunt functionality.

    摘要翻译： 提供了一种用于评估神经分流功能的系统和方法。 因此，一方面，用于监测神经分流功能的方法可以包括测量分路内的第一颅内压脉冲，测量分流外的第二颅内压脉冲，并将来自第一测量的脉动特征与第二测量值进行比较，以便确定 分流功能。

    SYSTEM FOR DETERMINATION OF BRAIN COMPLIANCE AND ASSOCIATED METHODS
    6.
    发明申请
    SYSTEM FOR DETERMINATION OF BRAIN COMPLIANCE AND ASSOCIATED METHODS 审中-公开
    用于确定脑的合规性和相关方法的系统

    公开(公告)号：US20090143656A1

    公开(公告)日：2009-06-04

    申请号：US12064000

    申请日：2006-08-15

    申请人： Preston Manwaring ,  Kim Manwaring ,  Mark Manwaring ,  Jotham Manwaring

    发明人： Preston Manwaring ,  Kim Manwaring ,  Mark Manwaring ,  Jotham Manwaring

    IPC分类号： A61B5/02 ,  A61B5/1455 ,  A61B5/053

    CPC分类号： A61B5/031 ,  A61B5/026 ,  A61B5/4076

    摘要： Systems and methods for measuring intracranial pressure and brain compliance are provided. In one aspect, for example, a method for noninvasive measurement of brain compliance in a subject may include calculating a phase shift between an intracranial pulsatile perfusion flow measured from the subject and an extracranial pulsatile perfusion flow measured from the subject, and determining brain compliance of the subject from the phase shift between the intracranial pulsatile perfusion flow and an extracranial pulsatile perfusion flow. Though various methods of calculating phase shift are contemplated, in one aspect such a calculation may include calculating an intracranial frequency waveform corresponding to the intracranial pulsatile perfusion flow, calculating an extracranial frequency waveform corresponding to the extracranial pulsatile perfusion flow, and calculating a phase difference between the intracranial frequency waveform and the extracranial frequency waveform.

    摘要翻译： 提供了测量颅内压和脑依从性的系统和方法。 在一个方面，例如，用于无创测量受试者脑顺应性的方法可包括计算从受试者测量的颅内搏动灌注流量与从受试者测量的颅外搏动灌注流量之间的相位偏移，以及确定 颅内搏动灌注流量与颅外搏动灌注流量之间相移的主题。 虽然考虑了计算相移的各种方法，但是在一个方面，这样的计算可以包括计算对应于颅内脉动灌注流的颅内频率波形，计算对应于颅外脉动灌注流的颅外频率波形，以及计算颅内脉搏灌注流之间的相位差 颅内频率波形和颅外频率波形。

    System for monitoring neural shunt function and associated methods
    7.
    发明授权
    System for monitoring neural shunt function and associated methods 失效
    监测神经分流功能及相关方法的系统

    公开(公告)号：US07833165B2

    公开(公告)日：2010-11-16

    申请号：US12064002

    申请日：2006-08-15

    申请人： Kim Manwaring ,  Preston Manwaring ,  Mark Manwaring

    发明人： Kim Manwaring ,  Preston Manwaring ,  Mark Manwaring

    IPC分类号： A61B5/00 ,  A61B5/02

    CPC分类号： A61B5/031 ,  A61B5/4064

    摘要： A system and method for evaluating neural shunt functionality is provided. Accordingly, in one aspect a method for monitoring neural shunt functionality may include measuring a first intracranial pressure pulse inside the shunt, measuring a second intracranial pressure pulse outside the shunt, and comparing pulsatile characteristics from the first measurement to the second measurement in order to determine shunt functionality.

    摘要翻译： 提供了一种用于评估神经分流功能的系统和方法。 因此，一方面，用于监测神经分流功能的方法可以包括测量分路内的第一颅内压脉冲，测量分流外的第二颅内压脉冲，并将来自第一测量的脉动特征与第二测量值进行比较，以便确定 分流功能。

    Water content probe
    8.
    发明申请
    Water content probe 审中-公开
    含水量探头

    公开(公告)号：US20050203438A1

    公开(公告)日：2005-09-15

    申请号：US11109370

    申请日：2005-04-19

    申请人： Kim Manwaring ,  Mark Manwaring

    发明人： Kim Manwaring ,  Mark Manwaring

    IPC分类号： A61B5/00 ,  A61B5/03 ,  A61B5/05 ,  A61B5/053 ,  A61B8/00

    CPC分类号： A61B5/0537 ,  A61B5/0031 ,  A61B5/031 ,  A61B5/0538 ,  A61B5/4869 ,  A61B5/6864

    摘要： A method and system to determine brain stiffness is disclosed. A probe to measure tissue water content is inserted through an aperture (burr hole) in the cranium into brain tissue. The probe has two electrically separated plate conductors with a dielectric which forms a capacitor plane. One conductor has a surface mount resistor to allow exact impedance matching to the core of a coaxial cable. The other conductor attaches electrically to the shield of the coaxial cable. The probe is stabilized in the brain tissue through a plastic ventriculostomy bolt which has been secured by screw tapping into the cranium. The coaxial cable connects to a spectrum analyzer. Brain water content and blood congestion alter the resonant frequency of the probe, allowing a realtime readout of apparent tissue water content. By monitoring the momentary shift in center resonant frequency or, alternatively, the standing wave ratio slightly off resonant frequency, a beat-to-beat pulsatile waveform is derived relating to the perfusion of the brain. A strain gauge intracranial pressure sensor (ICP) is separately affixed through the bolt and adjacent to the water content probe. By comparing the phase angle or lag time difference between the pressure tracing and the perfusion tracing, a realtime measurement of organ stiffness or compliance is derived.

    摘要翻译： 公开了一种确定脑僵硬度的方法和系统。 测量组织含水量的探针通过颅骨中的孔（钻孔）插入脑组织。 探头具有两个电隔离的板状导体，其中形成电容器平面的电介质。 一个导体具有表面贴装电阻器，以允许与同轴电缆芯的精确阻抗匹配。 另一导体电连接到同轴电缆的屏蔽。 探针通过塑料心室造口术螺栓稳定在脑组织中，该螺栓已经通过螺钉攻丝入颅骨而被固定。 同轴电缆连接到频谱分析仪。 脑水含量和血液充血会改变探头的共振频率，从而实时显示组织含水量。 通过监测中心谐振频率的瞬时偏移，或者替代地，驻波比稍微偏离谐振频率，导出与脑的灌注相关的搏动搏动波形。 应变计颅内压传感器（ICP）通过螺栓分别固定在水分探头附近。 通过比较压力跟踪和灌注跟踪之间的相位角或滞后时间差，得出器官刚度或依从性的实时测量。