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    Methods and systems for delivering liquid substances to tissues surrounding body lumens
    6.
    发明授权
    Methods and systems for delivering liquid substances to tissues surrounding body lumens 有权
    将液体物质输送到体腔内的组织的方法和系统

    公开(公告)号：US07465298B2

    公开(公告)日：2008-12-16

    申请号：US10610790

    申请日：2003-06-30

    申请人： Kirk Patrick Seward ,  Lynn Barr ,  Judith Carol Wilber

    发明人： Kirk Patrick Seward ,  Lynn Barr ,  Judith Carol Wilber

    IPC分类号： A61M31/00

    CPC分类号： A61F2/91 ,  A61F2/915 ,  A61F2002/91533 ,  A61F2250/0068

    摘要： Methods, systems, and apparatus for delivering drugs and other substances to extraluminal tissue surrounding a body lumen are described. Catheters are used to inject the drug or other substance intraluminally into tissue surrounding a stent or other luminal scaffold. The drug or other substance is injected in an amount sufficient to cause diffusion back through the tissue to the stent. An absorptive structure, reservoir, or the like, on the stent then absorbs excess drug as it passes from the luminal tissue. In this way, the stent is first loaded with drug. After time, as the stent becomes fully loaded and the tissue becomes depleted, drug will be begin to flow back from the stent into the surrounding luminal tissue.

    摘要翻译： 描述了用于将药物和其他物质递送到体腔周围的外部组织的方法，系统和装置。 导管用于将药物或其他物质内腔注射到支架或其他管腔支架周围的组织中。 药物或其他物质的注射量足以引起扩散通过组织到支架。 支架上的吸收结构，储存器等在从管腔组织通过时吸收过量的药物。 以这种方式，支架首先装载药物。 随着时间的推移，当支架变得完全负载并且组织耗尽时，药物将开始从支架流回到周围的管腔组织中。

    Dual modulus balloon for interventional procedures
    7.
    发明授权
    Dual modulus balloon for interventional procedures 有权
    双模气囊用于介入手术

    公开(公告)号：US08016786B2

    公开(公告)日：2011-09-13

    申请号：US12711141

    申请日：2010-02-23

    申请人： Kirk Patrick Seward ,  Isidro M. Gandionco ,  David Gandionco

    发明人： Kirk Patrick Seward ,  Isidro M. Gandionco ,  David Gandionco

    IPC分类号： A61M25/10

    CPC分类号： A61M25/0012 ,  A61M5/007 ,  A61M5/158 ,  A61M25/0045 ,  A61M25/1002 ,  A61M2025/0096 ,  A61M2025/018 ,  A61M2025/1004 ,  A61M2025/1084 ,  A61M2025/1086

    摘要： A device for interventional surgical or medical procedures is presented. The device is generally in the form of a balloon and is used to position itself or other working elements up against or through lumen walls in the body. The balloon is comprised of at least two materials of different elastic modulus, which allows for a flexible but relatively non-distensible, unfolding component of the balloon as well as an elastomeric, inflatable component of the balloon. The elastomeric component is fixedly attached to the flexible but relatively non-distensible component and together they form a pressure vessel that can be inflated within the lumens of the body.

    摘要翻译： 介绍了外科手术或医疗手术的装置。 该装置通常为气球的形式，并且用于将自身或其它工作元件向上或靠近身体中的腔壁定位。 气囊由至少两种不同弹性模量的材料组成，其允许气囊的柔性但相对不扩张的展开部件以及气囊的弹性的，可充气的部件。 弹性体部件固定地附接到柔性但相对不扩张的部件上，并且它们一起形成可以在体内的腔内膨胀的压力容器。

    Microfabricated surgical device for interventional procedures
    9.
    发明授权
    Microfabricated surgical device for interventional procedures 有权
    微型手术器械用于介入手术

    公开(公告)号：US07547294B2

    公开(公告)日：2009-06-16

    申请号：US10490129

    申请日：2002-09-20

    申请人： Kirk Patrick Seward ,  Albert P. Pisano

    发明人： Kirk Patrick Seward ,  Albert P. Pisano

    IPC分类号： A61M37/00 ,  A61B17/20 ,  A61M5/32 ,  A61B17/34 ,  A61M29/00

    CPC分类号： A61B17/3478 ,  A61B2017/00247 ,  A61B2017/00398 ,  A61B2017/22069 ,  A61B2017/22077 ,  A61B2018/00392 ,  A61M2025/0096 ,  A61M2025/105

    摘要： An actuator for an interventional surgical procedure is described. The actuator may include an actuator body having a distal end and a proximal end. A central expandable section is located between the distal end and the proximal end. The expandable section is operable between an unactuated condition in which the expandable section is in a furled state and an actuated condition in which the expandable section is in an unfurled state. A needle is located at the expandable section. The needle is moveable in an approximately perpendicular direction relative to a central longitudinal axis of the actuator body from a position within the actuator body to a position outside of the actuator body.

    摘要翻译： 描述了用于介入外科手术的致动器。 致动器可以包括具有远端和近端的致动器本体。 中心可扩张部分位于远端和近端之间。 可膨胀部分可在可膨胀部分处于卷起状态的未致动状态和可膨胀部分处于未折叠状态的致动状态之间操作。 针位于可扩张部位。 针可以相对于致动器主体的中心纵向轴线在大致垂直的方向上从致动器本体内的位置移动到致动器主体外侧的位置。

    Treatment of hypertension by renal vascular delivery of guanethidine
    10.
    发明授权
    Treatment of hypertension by renal vascular delivery of guanethidine 有权
    用胍乙啶肾血管分泌治疗高血压

    公开(公告)号：US08399443B2

    公开(公告)日：2013-03-19

    申请号：US12765708

    申请日：2010-04-22

    申请人： Kirk Patrick Seward

    发明人： Kirk Patrick Seward

    IPC分类号： A01N43/00 ,  A61K31/33

    CPC分类号： A61M25/1002 ,  A61K9/0019 ,  A61K31/155 ,  A61K31/395 ,  A61K45/06 ,  A61M5/00 ,  A61M5/007 ,  A61M5/44 ,  A61M25/00 ,  A61M25/0084 ,  A61M2025/009 ,  A61K2300/00

    摘要： Sympathetic nerves run through the adventitia surrounding renal arteries and are critical in the modulation of systemic hypertension. Hyperactivity of these nerves can cause renal hypertension, a disease prevalent in 30-40% of the adult population. Hypertension can be treated with neuromodulating agents (such as angiotensin converting enzyme inhibitors, angiotensin II inhibitors, or aldosterone receptor blockers), but requires adherence to strict regimens and often does not reach target blood pressure threshold to reduce risk of major cardiovascular events. A minimally invasive solution is presented here to reduce the activity of the sympathetic nerves surrounding the renal artery by locally delivering neurotoxic or sympathetic nerve-blocking agents into the adventitia. Extended elution of these agents may also be accomplished in order to tailor the therapy to the patient.

    摘要翻译： 交感神经穿过肾动脉周围的外膜，对调节系统性高血压至关重要。 这些神经的多动症可引起肾性高血压，一种普遍存在于成年人群中的30-40％的疾病。 高血压可以用神经调节剂（例如血管紧张素转换酶抑制剂，血管紧张素II抑制剂或醛固酮受体阻断剂）治疗，但需要遵守严格的方案，并且通常不达到目标血压阈值以降低主要心血管事件的风险。 这里介绍一种微创溶液，通过局部输送神经毒性或交感神经阻滞剂到外膜中来减少肾动脉周围交感神经的活动。 这些试剂的延长洗脱也可以完成，以便对患者进行定制。