Manufacture of improved support matrices
    3.
    发明授权
    Manufacture of improved support matrices 失效
    改进的支撑矩阵的制造

    公开(公告)号:US07208532B2

    公开(公告)日:2007-04-24

    申请号:US10168709

    申请日:2000-12-11

    摘要: A method for the production of a cross-linked support matrix that in form of a bed will permit liquid flow velocities above 5 cm/h, preferably above 50 cm/h, to pass through the bed. The method is characterized in that it comprises the steps: (a) providing a starting support matrix that has pendent unsaturated groups, and (b) subjecting said starting support matrix to electron beam or gamma-ray irradiation. The use of a cross-linked support matrix produced by a method comprising the steps of: (a) providing a starting support matrix that has pendent unsaturated groups, and (b) subjecting said starting support matrix to electron beam or gamma-ray irradiation as a support matrix in liquid chromatography, cell culturing, step-wise solid phase synthesis of organic compounds, running catalytic reactions by the use of a solid phase bound catalyst.

    摘要翻译: 用于生产以床形式的交联载体基质的方法将允许高于5cm / h,优选地高于50cm / h的液体流速通过床。 该方法的特征在于其包括以下步骤:(a)提供具有侧链不饱和基团的起始载体基质,和(b)使所述起始载体基质经受电子束或γ射线照射。 使用通过包括以下步骤的方法产生的交联载体基质:(a)提供具有侧链不饱和基团的起始载体基质,和(b)使所述起始载体基质进行电子束或γ射线照射, 液相色谱法中的支持基质,细胞培养,有机化合物的逐步固相合成,通过使用固相结合的催化剂进行催化反应。