摘要:
An object of the present invention is to provide a drug and a method for effectively inducing donor-specific immune tolerance in a recipient in transplantation therapy. A complex of an siRNA for a costimulatory factor and schizophyllan is delivered to a Dectin-1 expressing cell which specifically recognizes schizophyllan to regulate the function of the Dectin-1 expressing cell, and therefore can induce immunosuppression effect as well as induce immune tolerance effectively.
摘要:
An object of the present invention is to provide a highly stable nucleic acid-polysaccharide complex of an siRNA and schizophyllan. A nucleic acid-polysaccharide complex is formed by adding polydeoxyadenine in which at least part of the phosphodiester link portion is phosphorothioated to an siRNA and allowing the siRNA and schizophyllan to form a complex.
摘要:
An object of the present invention is to provide a drug and a method for effectively inducing donor-specific immune tolerance in a recipient in transplantation therapy. A complex of an siRNA for a costimulatory factor and schizophyllan is delivered to a Dectin-1 expressing cell which specifically recognizes schizophyllan to regulate the function of the Dectin-1 expressing cell, and therefore can induce immunosuppression effect as well as induce immune tolerance effectively.
摘要:
A highly stable nucleic acid-polysaccharide complex of an siRNA and schizophyllan is formed by adding polydeoxyadenine in which at least part of the phosphodiester link portion is phosphorothioated to an siRNA and allowing the siRNA and schizophyllan to form a complex.
摘要:
An object of the present invention is to provide a highly stable nucleic acid-polysaccharide complex of an siRNA and schizophyllan. A nucleic acid-polysaccharide complex is formed by adding polydeoxyadenine in which at least part of the phosphodiester link portion is phosphorothioated to an siRNA and allowing the siRNA and schizophyllan to form a complex.
摘要:
A spindle motor includes a base portion, a rotor hub, a stator, and a circuit board. The base portion preferably includes a through hole and is arranged to spread out radially around a central axis. The rotor hub is arranged above the base portion to rotate about the central axis. The stator is arranged above the base portion, and includes coils each including at least one lead wire. The circuit board is arranged radially outward of the through hole, and arranged on a lower surface of the base portion. The base portion includes a communicating groove arranged to join the through hole and the circuit board to each other. The at least one lead wire of the coils is arranged to pass inside the through hole and the communicating groove to be electrically connected to the circuit board. The through hole is sealed with a sealant.
摘要:
A fluid dynamic bearing mechanism includes a stationary shaft, a sleeve portion arranged to rotate with respect to the shaft, and a thrust portion including an upper end surface arranged oppose to a lower end surface of the sleeve portion. An inside surface of the thrust portion includes an inside surface contact portion arranged in contact with an outside surface of the shaft, and an inside surface lower non-contact portion spaced away from the outside surface of the shaft, and arranged to extend downward from a lower end of the inside surface contact portion. An outside surface of the thrust portion includes an outside surface inclined portion arranged in contact with an interface of a lubricating oil. The lower end of the inside surface contact portion is arranged at a level axially higher than that of a lower end of the outside surface inclined portion.
摘要:
A method and a device for automatically calibrating a light intensity measurement device is disclosed. The device includes an optical switch for switching a route of output from an optical intensity modulator, an optical attenuator arranged on a first waveguide, a second waveguide, a light intensity measurement device, a control device for receiving light intensity information measured by the light intensity measurement device and controlling the signal to be applied to the optical intensity modulator, and a signal source for receiving a control signal of the control device and adjusting the signal to be applied to the optical intensity modulator.
摘要:
Fluid-dynamic-pressure bearing manufacturing method for more efficient and fail-safe degassing of bearing oil. Method makes it possible to prevent the generation of air bubbles in the course of an oil-charging operation that amounts to a step following degassing, and to single out the causative source of air bubbles when their generation has been detected. At the same time oil that is under a reduced-pressure environment within an oil-storing vacuum chamber is vacuum-degassed, immersed within the oil a stirrer for agitating and degassing the oil is rotated by indirect drive means, and the oil after having been degassed is supplied to a vacuum chamber where a fluid-dynamic-pressure bearing unit is retained—which has been pumped down to a pressure below the pressure within the oil-storing vacuum chamber—and is charged into the bearing clearances by raising the internal pressure of the bearing-retaining vacuum chamber.
摘要:
In a wider flow path 4a surrounded with a shaft 3, a thrust plate 6 and an inner circumferential corner portion 1c of a bearing sleeve 1 in a small clearance 4 between a lower side radial bearing section 13 and an upper surface thrust bearing section 14, chamfering is performed at the inner circumferential corner portion 1c of the bearing sleeve 1, wherein a width of the wider flow path 4a in the radial direction in rotation is formed so as to be wider than a width of a communication hole 16 located below the wider flow path 4a in the radial direction in rotation to thereby render a flow of a lubricating fluid 5 flowing into the wider flow path 4a from the communication hole 16 smooth.