公开(公告)号：US11052141B1

公开(公告)日：2021-07-06

申请号：US16185122

申请日：2018-11-09

申请人： KODE BIOTECH LIMITED

发明人： Stephen Micheal Henry ,  Caroline Ann Oliver

IPC分类号： A61K39/00 ,  A61K47/54

摘要： Methods of mitigating the risk of rejection of an allograft or xenograft in an incompatible recipient by neutralizing one or more populations of circulating antibody cross-reactive with a carbohydrate antigen expressed by the allograft or xenograft. The method includes administering to the recipient by intravenous infusion a concentration of a synthetic antigen lipid construct sufficient to neutralize the one or more populations of circulating antibody in the recipient.

公开(公告)号：US10082515B2

公开(公告)日：2018-09-25

申请号：US13765314

申请日：2013-02-12

申请人： Kode Biotech Limited

发明人： Cristina-Simona Weinberg ,  Nicolai Bovin ,  Stephen Micheal Henry

IPC分类号： G01N33/92 ,  C07F9/09 ,  C07F9/572 ,  C07K5/103 ,  C07K14/47 ,  C07K17/08 ,  C12N5/00 ,  C12N5/078 ,  G01N33/555 ,  G01N33/68 ,  G01N33/53 ,  G01N33/554 ,  G01N33/80 ,  A61K47/54

CPC分类号： G01N33/92 ,  A61K47/543 ,  A61K47/544 ,  C07F9/091 ,  C07F9/572 ,  C07K5/1008 ,  C07K14/47 ,  C07K17/08 ,  C12N5/0006 ,  C12N5/0641 ,  C12N2503/00 ,  G01N33/5304 ,  G01N33/554 ,  G01N33/555 ,  G01N33/6854 ,  G01N33/80 ,  G01N2405/00

摘要： Method of incorporating a water soluble construct of the structure L-S-F into the lipid bi-layer of cells by contacting a suspension of the cells with a solution of the construct at a concentration and for a time and temperature sufficient to allow the construct to insert into the lipid bi-layer. In the structure L-S-F, F is a peptide, S is a spacer containing an oligomer of ethylene glycol covalently linking F to L and the number of ethylene oxide repeats in the oligomer of ethylene glycol is 6 to 14, and L is a phosphatidylethanolamine.

公开(公告)号：US20170218027A1

公开(公告)日：2017-08-03

申请号：US15350792

申请日：2016-11-14

申请人： KODE BIOTECH LIMITED

发明人： Nicolai Vladimirovich Bovin ,  Stephen Micheal Henry ,  Igor Leonidovich Rodionov ,  Critsina-Simona Weinberg ,  Alexander Borisovich Tuzikov

IPC分类号： C07K9/00

CPC分类号： C07K9/001 ,  A61K47/544 ,  A61K47/65 ,  C07F9/106 ,  C07F9/572 ,  C07F9/6561 ,  C07K7/06 ,  C07K7/08 ,  G01N33/80

摘要： The invention relates to functional lipid constructs and their use in diagnostic and therapeutic applications, including serodiagnosis, where the functional moiety is carbohydrate, peptide, chemically reactive group, conjugator or fluorophore.

公开(公告)号：US11073451B2

公开(公告)日：2021-07-27

申请号：US16284093

申请日：2019-02-25

申请人： KODE BIOTECH LIMITED

发明人： Stephen Micheal Henry ,  Stephen Robert Parker ,  Nicolai Vladimirovich Bovin ,  Igor Leonidovich Rodionov

IPC分类号： G01N1/40 ,  C08G64/42 ,  G01N33/543 ,  C12Q1/02 ,  C12Q1/24 ,  B01D65/08 ,  B01L3/00 ,  B01D69/14 ,  B01D67/00 ,  B01D63/08

摘要： Methods of treating an inert surface of a substrate to improve the adherence to the treated surface of micro-dimensioned particles including the steps of: contacting the inert surface with in an aqueous dispersion of a construct of the structure F-S-L; and then washing the surface with an aqueous vehicle to provide the treated surface, where F is a polyamine; S is —CO(CH2)2CO—, —CO(CH2)3CO—, —CO(CH2)4CO— or —CO(CH2)5CO—; and L is a diacyl- or dialkyl-glycerophospholipid.

公开(公告)号：US20140350217A1

公开(公告)日：2014-11-27

申请号：US14172346

申请日：2014-02-04

申请人： KODE Biotech Limited

发明人： Nicolai Vladimirovich Bovin ,  Stephen Micheal Henry ,  Igor Leonidovich Rodionov ,  Cristina-Simona Weinberg ,  Alexander Borisovich Tuzikov

IPC分类号： C07K7/02 ,  C07K5/02

CPC分类号： C07K7/02 ,  A61K47/544 ,  A61K47/65 ,  C07F9/106 ,  C07F9/572 ,  C07F9/6561 ,  C07K5/02 ,  C07K7/06 ,  C07K7/08 ,  G01N33/80

摘要： The invention relates to methods for effecting qualitative and quantitative changes in the functional moieties expressed at the surface of cells and multi-cellular structures, and functional lipid constructs for use in such methods. In particular, the invention relates to functional lipid constructs and their use in diagnostic and therapeutic applications, including serodiagnosis, where the functional moiety is a carbohydrate, peptide, chemically reactive group, conjugator or fluorophore.

摘要翻译： 本发明涉及用于实现在细胞和多细胞结构表面表达的功能部分的定性和定量变化的方法，以及用于这些方法的功能性脂质构建体。 特别地，本发明涉及功能性脂质构建体及其在诊断和治疗应用中的应用，包括血清诊断，其中功能部分是碳水化合物，肽，化学反应性基团，共轭体或荧光团。

公开(公告)号：US10215672B2

公开(公告)日：2019-02-26

申请号：US15363250

申请日：2016-11-29

申请人： KODE BIOTECH LIMITED

发明人： Stephen Micheal Henry ,  Stephen Robert Parker

IPC分类号： G01N1/40 ,  C08G64/42 ,  C12Q1/02 ,  G01N33/543 ,  B01D65/08 ,  C12Q1/24

摘要： Biocompatible methods of functionalizing inert surfaces for use in biological applications are described. The methods employ the use of synthetic constructs of the generic structure F-S-L (where F is a functional moiety, S is a spacer selected to provide a construct that is dispersible in water, and L is a diacyl- or dialkyl-glycerophospholipid). An object of the invention is to localize or immobilize functional moieties to the inert surface of a substrate wherein the surface is comprised of glass, silver, polyamide, polycarbonate, polypropylene, polyethersulfone, polytetrafluoroethylene or polyvinylidene fluoride, and the substrate is comprised of a fiber, membrane, microsphere or nanosphere.

公开(公告)号：US09802981B2

公开(公告)日：2017-10-31

申请号：US14172346

申请日：2014-02-04

申请人： KODE Biotech Limited

发明人： Nicolai Vladimirovich Bovin ,  Stephen Micheal Henry ,  Igor Leonidovich Rodionov ,  Cristina-Simona Weinberg ,  Alexander Borisovich Tuzikov

IPC分类号： C07K7/02 ,  C07K5/02 ,  A61K47/48 ,  C07F9/10 ,  C07F9/572 ,  C07F9/6561 ,  C07K7/06 ,  C07K7/08 ,  G01N33/80

CPC分类号： C07K7/02 ,  A61K47/544 ,  A61K47/65 ,  C07F9/106 ,  C07F9/572 ,  C07F9/6561 ,  C07K5/02 ,  C07K7/06 ,  C07K7/08 ,  G01N33/80

摘要： The invention relates to methods for effecting qualitative and quantitative changes in the functional moieties expressed at the surface of cells and multi-cellular structures, and functional lipid constructs for use in such methods. In particular, the invention relates to functional lipid constructs and their use in diagnostic and therapeutic applications, including serodiagnosis, where the functional moiety is a carbohydrate, peptide, chemically reactive group, conjugator or fluorophore.

公开(公告)号：US10124047B2

公开(公告)日：2018-11-13

申请号：US14794850

申请日：2015-07-09

申请人： KODE BIOTECH LIMITED

发明人： Stephen Micheal Henry ,  Caroline Ann Oliver

IPC分类号： A61K39/00 ,  A61K39/38 ,  A61K47/48

摘要： Methods of neutralizing circulating antibody and mitigating the risk of clinically significant adverse responses to incompatible transfusions and transplantations are described. The methods comprise the administration to the subject of dispersible antigen-lipid constructs.

公开(公告)号：US20150064690A1

公开(公告)日：2015-03-05

申请号：US14241578

申请日：2012-08-31

申请人： Kode Biotech Limited

发明人： Nikolai Vladimirovich Bovin ,  Stephen Micheal Henry

IPC分类号： G01N33/555 ,  G01N33/571 ,  G01N33/92

CPC分类号： G01N33/555 ,  G01N33/554 ,  G01N33/571 ,  G01N33/6815 ,  G01N33/92 ,  G01N2333/005 ,  G01N2333/20

摘要： A facile method of localising sulfhydryl (—SH) group containing biomolecules, in particular peptides, to the membranes of living cells and enveloped viruses and a kit for use in a biological laboratory in accordance with the method.

摘要翻译： 将含巯基（-SH）基团的生物分子，特别是肽，定向到活细胞膜和包膜病毒膜的简便方法，以及根据该方法用于生物实验室的试剂盒。

公开(公告)号：US10919941B2

公开(公告)日：2021-02-16

申请号：US15350792

申请日：2016-11-14

申请人： KODE BIOTECH LIMITED

发明人： Nicolai Vladimirovich Bovin ,  Stephen Micheal Henry ,  Igor Leonidovich Rodionov ,  Cristina-Simona Weinberg ,  Alexander Borisovich Tuzikov

IPC分类号： C07K9/00 ,  C07F9/10 ,  C07K7/08 ,  C07K7/06 ,  A61K47/54 ,  C07F9/6561 ,  A61K47/65 ,  G01N33/80 ,  C07F9/572

摘要： The invention relates to functional lipid constructs and their use in diagnostic and therapeutic applications, including serodiagnosis, where the functional moiety is carbohydrate, peptide, chemically reactive group, conjugator or fluorophore.