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公开(公告)号：US06699974B2
公开(公告)日：2004-03-02
申请号：US09269921
申请日：1999-04-01
申请人： Koichiro Ono , Toshihiko Ohtomo , Masayuki Tsuchiya , Yasushi Yoshimura , Yasuo Koishihara , Masaaki Kosaka
发明人： Koichiro Ono , Toshihiko Ohtomo , Masayuki Tsuchiya , Yasushi Yoshimura , Yasuo Koishihara , Masaaki Kosaka
IPC分类号： C07K1680
CPC分类号： C07K16/2896 , A61K38/00 , C07K16/3061 , C07K2317/24 , C07K2317/732 , C07K2317/734 , C07K2319/00
摘要： A reshaped human anti-HM 1.24 antibody comprising: (A) an L chain comprising (1) the C region of a human L chain, and (2) the V region of an L chain comprising the FR of a human L chain and the CDR of the L chain of a mouse anti-HM 1.24 monoclonal antibody; and (B) an H chain comprising (1) the C region of a human H chain, and (2) the V region of an H chain comprising the FR of a human H chain and the CDR of the H chain of a mouse anti-HM 1.24 monoclonal antibody. Since most of this reshaped human antibody is derived from human antibody and the CDR has a low antigenicity, the reshaped human antibody of the present invention has a low antigenicity and, therefore, is expected to be-used for medical treatment.
摘要翻译： 重构人抗HM 1.24抗体，其包含：（A）包含（1）人L链的C区的L链，和（2）包含人L链的FR的L链的V区和 小鼠抗HM 1.24单克隆抗体的L链的CDR; 和（B）包含（1）人H链的C区的H链，和（2）包含人H链的FR的H链的V区和小鼠抗体的H链的CDR -HM 1.24单克隆抗体。由于大部分重整人抗体衍生自人抗体，CDR具有低抗原性，本发明的重构人抗体具有低抗原性，因此预期用于医学 治疗。
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公开(公告)号：US07892543B2
公开(公告)日：2011-02-22
申请号：US10218253
申请日：2002-08-13
申请人： Koichiro Ono , Toshihiko Ohtomo , Masayuki Tsuchiya , Yasushi Yoshimura , Yasuo Koishihara , Masaaki Kosaka
发明人： Koichiro Ono , Toshihiko Ohtomo , Masayuki Tsuchiya , Yasushi Yoshimura , Yasuo Koishihara , Masaaki Kosaka
CPC分类号： C07K16/2896 , A61K38/00 , C07K16/3061 , C07K2317/24 , C07K2317/732 , C07K2317/734 , C07K2319/00
摘要： The invention provides a reshaped human anti-HM 1.24 antibody having: (A) an L chain having (1) the C region of a human L chain, and (2) the V region of an L chain having the FR of a human L chain and the CDR of the L chain of a mouse anti-HM 1.24 monoclonal antibody; and (B) an H chain having (1) the C region of a human H chain, and (2) the V region of an H chain having the FR of a human H chain and the CDR of the H chain of a mouse anti-HM 1.24 monoclonal antibody. This reshaped human antibody is derived from human antibody and the CDR has a low antigenicity, and the reshaped human antibody of the present invention has a low antigenicity and can be used for medical treatment.
摘要翻译： 本发明提供了重构人抗HM 1.24抗体，其具有：（A）具有（1）人L链的C区的L链，和（2）具有人L的FR的L链的V区 链和小鼠抗HM 1.24单克隆抗体的L链的CDR; 和（B）具有（1）人H链的C区的H链，和（2）具有人H链的FR和小鼠抗体的H链的CDR的H链的V区 -HM 1.24单克隆抗体。 该重构人抗体衍生自人抗体，CDR具有低抗原性，本发明的重构人抗体具有低抗原性，可用于治疗。
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公开(公告)号：US06908750B2
公开(公告)日：2005-06-21
申请号：US10423007
申请日：2003-04-25
IPC分类号： A61K38/00 , C07K14/47 , C07K14/705 , C07K16/30 , C12N15/12 , C12N15/00 , C07H21/04 , C12N15/63 , C12N15/85
CPC分类号： C07K14/4748 , A01K2217/05 , A61K38/00 , C07K14/705 , C07K16/3061
摘要： There are provided a genomic DNA comprising 4 exons encoding the amino acid sequence as set forth in SEQ ID NO: 2 and 3 introns ligating them, and a splicing variant of said genomic DNA; as well as a DNA having the base sequence as set forth in SEQ ID NO: 4 and a promoter activity and the fragment thereof, and uses thereof.
摘要翻译： 提供了包含编码SEQ ID NO：2所示的氨基酸序列的4个外显子和3个与其连接的内含子的基因组DNA和所述基因组DNA的剪接变体; 以及具有SEQ ID NO：4所示的碱基序列和启动子活性及其片段的DNA及其用途。
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公开(公告)号：US06613546B1
公开(公告)日：2003-09-02
申请号：US09622166
申请日：2000-08-14
IPC分类号： C12P2300
CPC分类号： C07K14/4748 , A01K2217/05 , A61K38/00 , C07K14/705 , C07K16/3061
摘要： There are provided a genomic DNA comprising 4 exons encoding the amino acid sequence as set forth in SEQ ID NO: 2 and 3 introns ligating them, and a splicing variant of said genomic DNA; as well as a DNA having the base sequence as set forth in SEQ ID NO: 4 and a promoter activity and the fragment thereof, and uses thereof.
摘要翻译： 提供了包含编码SEQ ID NO：2所示的氨基酸序列的4个外显子和3个与其连接的内含子的基因组DNA和所述基因组DNA的剪接变体; 以及具有SEQ ID NO：4所示的碱基序列和启动子活性及其片段的DNA及其用途。
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公开(公告)号：US08652839B2
公开(公告)日：2014-02-18
申请号：US10533104
申请日：2003-10-30
申请人： Yong Kwee , Masaaki Kosaka , Yasuo Koishihara
发明人： Yong Kwee , Masaaki Kosaka , Yasuo Koishihara
CPC分类号： A61K39/0011 , A61K2039/5154
摘要： A cancer vaccine containing as an active ingredient an antigen-specific dendritic cell pulsed by an HM1.24 protein, HM1.24 peptide or transduced with an HM1.24-encoding gene, or HM1.24 protein-encoding DNA or RNA.
摘要翻译： 含有由HM1.24蛋白质HM1.24肽或HM1.24编码基因或编码HM1.24蛋白的DNA编码的DNA转导的抗原特异性树突状细胞作为活性成分的癌症疫苗。
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公开(公告)号：US07790152B2
公开(公告)日：2010-09-07
申请号：US10428085
申请日：2003-05-02
申请人： Masaaki Kosaka , Yasuo Koishihara
发明人： Masaaki Kosaka , Yasuo Koishihara
IPC分类号： A61K45/00 , A61K39/395
CPC分类号： C07K16/3061 , A61K39/395 , A61K2039/505 , C07K2317/24 , C07K2317/732 , C07K2319/00 , A61K2300/00
摘要： An enhancer, for treatment of lymphocytic tumors, of an antibody that specifically binds to protein having the amino acid sequence as set forth in SEQ ID NO: 1 and that has a cytotoxic activity, said enhancer comprising a biological response modifier as an active ingredient.
摘要翻译： 用于治疗淋巴细胞肿瘤的增强剂，特异性结合具有如SEQ ID NO：1所示的氨基酸序列并具有细胞毒活性的蛋白质的抗体，所述增强子包含生物反应调节剂作为活性成分。
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公开(公告)号：US20060153883A1
公开(公告)日：2006-07-13
申请号：US10533104
申请日：2003-10-30
申请人： Yong Kwee , Masaaki Kosaka , Yasuo Koishihara
发明人： Yong Kwee , Masaaki Kosaka , Yasuo Koishihara
CPC分类号： A61K39/0011 , A61K2039/5154
摘要： A cancer vaccine containing as an active ingredient an antigen-specific dendritic cell pulsed by an HM1.24 protein, HM1.24 peptide or transduced with an HM1.24-encoding gene, or HM1.24 protein-encoding DNA or RNA.
摘要翻译： 含有由HM1.24蛋白质HM1.24肽或HM1.24编码基因或编码HM1.24蛋白的DNA编码的DNA转导的抗原特异性树突状细胞作为活性成分的癌症疫苗。
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公开(公告)号：US06503510B2
公开(公告)日：2003-01-07
申请号：US09355925
申请日：1999-08-11
IPC分类号： A61K39395
CPC分类号： C07K14/47 , A61K38/00 , A61K2039/505 , C07K16/3061 , C07K2317/24 , C07K2317/734
摘要： A therapeutic agent for lymphatic tumors (excluding myeloma) comprising as an active ingredient an antibody that specifically binds to a protein having the amino acid sequence as set forth in SEQ ID NO:1 and SEQ ID NO:5 and that has a cytotoxic activity.
摘要翻译： 一种淋巴瘤（不含骨髓瘤）治疗剂，其特征在于，具有与具有SEQ ID NO：1和SEQ ID NO：5所示的氨基酸序列的蛋白质特异性结合并具有细胞毒活性的抗体作为活性成分。
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公开(公告)号：US20070110753A1
公开(公告)日：2007-05-17
申请号：US10574860
申请日：2004-10-07
申请人： Shigeto Kawai , Masahiko Mihara , Yasuo Koishihara
发明人： Shigeto Kawai , Masahiko Mihara , Yasuo Koishihara
IPC分类号： A61K39/395
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/3061 , C07K2317/41 , C07K2317/732
摘要： A therapeutic agent for solid tumors, said agent comprising as an active ingredient, an antibody that specifically binds to a protein having the amino acid sequence as set forth in SEQ ID NO: 2 or an antibody fragment that maintains the antibody activity.
摘要翻译： 一种固体肿瘤治疗剂，所述药物含有作为活性成分的特异性结合于具有SEQ ID NO：2所示的氨基酸序列的蛋白质的抗体或保持抗体活性的抗体片段。
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公开(公告)号：US06900052B1
公开(公告)日：2005-05-31
申请号：US09959348
申请日：2000-05-10
申请人： Yasuko Ozaki , Yasuo Koishihara , Shin-ichi Kaiho
发明人： Yasuko Ozaki , Yasuo Koishihara , Shin-ichi Kaiho
CPC分类号： C07K16/00 , C12N2502/00 , C12N2510/02
摘要： A method of culturing a protein-producing cell, said method comprising co-culturing one transformed cell that can constitutively produce said protein with the parent cell of said transformed cell.
摘要翻译： 一种培养蛋白质生成细胞的方法，所述方法包括共培养可以与所述转化细胞的亲本细胞组成型产生所述蛋白质的一个转化细胞。
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