公开(公告)号：US5291886A

公开(公告)日：1994-03-08

申请号：US795848

申请日：1991-11-21

申请人： Koji Katayama ,  Ayafumi Taniji ,  Muneharu Ishikawa

发明人： Koji Katayama ,  Ayafumi Taniji ,  Muneharu Ishikawa

IPC分类号： A61B5/0285 ,  A61B3/12 ,  A61B5/026 ,  A61B5/00

CPC分类号： A61B3/1233 ,  A61B5/0261

摘要： An apparatus for measuring blood flow repeatedly segmentally scans a region of in vivo tissue with a coherent light beam. Each scanning segment comprises a scanning period during which the light beam is scanned and a rest period during which the light beam is not scanned. During the rest period, the light beam is directed at a measuring point of the in vivo tissue. Measurement data is obtained dependent on the intensity of scattered light from the measurement point. The measurement data is time series data of chronological changes in the intensity of scattered light caused by blood in the in vivo tissue. The blood flow rate is calculated from frequency-analysis of the time series data.

摘要翻译： 用于测量血液流量的装置用相干光束重复地分段扫描体内组织的区域。 每个扫描段包括其中扫描光束的扫描周期和不扫描光束的休息期间。 在休息期间，光束被引导到体内组织的测量点。 取决于来自测量点的散射光的强度获得测量数据。 测量数据是由体内组织中的血液引起的散射光强度的时间顺序变化的时间序列数据。 通过时间序列数据的频率分析计算出血流量。

公开(公告)号：US5090808A

公开(公告)日：1992-02-25

申请号：US435717

申请日：1989-11-13

申请人： Muneharu Ishikawa ,  Ayafumi Taniji

发明人： Muneharu Ishikawa ,  Ayafumi Taniji

IPC分类号： G01B11/08 ,  G01N15/02 ,  G01N15/14

CPC分类号： G01N15/0205 ,  G01N2015/0238 ,  G01N2021/4711

摘要： A particle measurement apparatus is disclosed in which a laser beam is projected at a sample containing particles to be measured in a measurement zone and light scattered by particles in the sample is evaluated to thereby determine properties of particles in the sample. The apparatus includes a plurality of light receiving systems for receiving scattered light arranged at different angles relative to the axis of the laser beam. The amplitude of scattered light signals from the light receiving systems are compared with predetermined values. The arrangement is such that particles are counted by size only when the scattered light signals from the light receiving systems exceed a predetermined value, enabling false signals caused by noise and the like to be eliminated and assuring more accurate measurements.

公开(公告)号：US5291885A

公开(公告)日：1994-03-08

申请号：US795814

申请日：1991-11-21

申请人： Ayafumi Taniji ,  Muneharu Ishikawa

发明人： Ayafumi Taniji ,  Muneharu Ishikawa

IPC分类号： A61B5/0285 ,  A61B3/12 ,  A61B5/145 ,  A61B5/00

CPC分类号： A61B3/1233

摘要： An apparatus for measuring blood flow in which an optical system guides a coherent light beam to impinge on a stationary measurement spot of a measurement plane of an in vivo tissue. A light-receiving optical system focuses a light image of the measurement plane in the vicinity of an image point conjugate with the stationary measurement spot. The light-receiving optical system shares at least part of the optical components of the guiding optical system. Photodetectors are disposed at prescribed positions perpendicular to the optical axis of the light-receiving optical system, and in the vicinity of the image point, for measuring light scattered from the in vivo tissue to provide blood flow information. The blood flow information is related to blood flowing at a depth within the in vivo tissue. A visible image of the measurement plane is converted into a video image. The blood flow information corresponding to the position of the stationary measurement spot is superimposed on the video image and displayed to obtain a composite visible image.

摘要翻译： 一种用于测量血液流动的装置，其中光学系统引导相干光束撞击体内组织的测量平面的固定测量点。 光接收光学系统将测量平面的光图像聚焦在与固定测量点共轭的图像点附近。 光接收光学系统共享引导光学系统的光学部件的至少一部分。 光检测器设置在垂直于光接收光学系统的光轴的规定位置处，并且在像点附近，用于测量从体内组织散射的光，以提供血流信息。 血流信息与在体内组织内的深度流动的血液有关。 将测量平面的可视图像转换为视频图像。 将与静止测量点的位置对应的血流信息叠加在视频图像上并显示，以获得复合可视图像。

公开(公告)号：US5054913A

公开(公告)日：1991-10-08

申请号：US510292

申请日：1990-04-16

申请人： Muneharu Ishikawa ,  Ayafumi Taniji

发明人： Muneharu Ishikawa ,  Ayafumi Taniji

IPC分类号： G01P5/00 ,  G01P5/26

CPC分类号： G01P5/26 ,  G01P5/001

摘要： A method and apparatus for measuring the velocity of a fluid in which a double-exposure image of the speckle pattern or particle images of tracer particle in a fluid is irradiated with a collimated beam of coherent light, and is subjected to Fourier transformation to produce Young's fringes at its focal plane. A slit is rotated relatively with respect to the double-exposure image to produce changes in the amount of light transmitted by the slit and determine the direction of the fringes. To determine the spacing of the fringes, a variable-spacing grating filter is used which is complementary to the image of the fringes and has a transmission distribution function of sin.sup.2 or cos.sup.2. The thus obtained direction and spacing of the fringes are used to determine the velocity of the fluid.

公开(公告)号：US5522388A

公开(公告)日：1996-06-04

申请号：US306412

申请日：1994-09-15

申请人： Muneharu Ishikawa ,  Koji Katayama

发明人： Muneharu Ishikawa ,  Koji Katayama

IPC分类号： G01N21/35 ,  A61B5/00 ,  A61B5/0225 ,  A61B5/0245 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/3577 ,  G01N21/359

CPC分类号： A61B5/6826 ,  A61B5/02255 ,  A61B5/14551 ,  A61B5/14552 ,  A61B5/6816 ,  A61B5/6838 ,  A61B5/6843

摘要： A pulse spectrometer for noninvasively determining the concentration of blood constituents in in vivo tissue comprises a pressure application device for applying pressure to a measurement region of the in vivo tissue and a light source for irradiating the measurement region of the in vivo tissue with light. A spectroscope separates light transmitted from the measuring region into its spectral components, and a first light-receiving element receives the spectral components. A second light-receiving element receives scattered light from a vicinity of the measurement region. A control device controls the pressure which is applied on the measurement region by the pressure application device based on a signal obtained from the second light-receiving element. A signal separator separates a blood flow variation component from the spectral components received by the first light-receiving element based on the signal from the second light-receiving element.

摘要翻译： 用于非侵入性地确定体内组织中血液成分浓度的脉冲光谱仪包括用于向体内组织的测量区域施加压力的压力施加装置和用于用光照射体内组织的测量区域的光源。 分光器将从测量区域发射的光分离成其光谱分量，并且第一光接收元件接收光谱分量。 第二光接收元件从测量区域附近接收散射光。 控制装置基于从第二光接收元件获得的信号，控制由压力​​施加装置施加在测量区域上的压力。 信号分离器基于来自第二光接收元件的信号将血流变化分量与由第一光接收元件接收的光谱分量分离。

公开(公告)号：US5575285A

公开(公告)日：1996-11-19

申请号：US355516

申请日：1994-12-14

申请人： Satohiko Takanashi ,  Tetsuya Yamamoto ,  Tsuyoshi Watanabe ,  Muneharu Ishikawa

发明人： Satohiko Takanashi ,  Tetsuya Yamamoto ,  Tsuyoshi Watanabe ,  Muneharu Ishikawa

IPC分类号： G01N21/31 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455

CPC分类号： A61B5/14551 ,  A61B5/7253 ,  A61B5/7257

摘要： An apparatus for non-invasively measuring the oxygen saturation in the blood of a subject comprises light sources for irradiating a sample of blood in tissue with at least a first light beam and a second light beam having different wavelengths. A switching device drives the light sources and sequentially switches the irradiation of the sample of blood between the first and second laser beams. A photoelectric detector detects light transmitted through or reflected from the sample of blood and provides an electrical output signal indicative of the intensity of the detected light. A converter converts the electrical output signal of the photoelectric detecting device to a power spectrum, and a processor processes the power spectrum and calculates the oxygen saturation of the sample of blood. The blood oxygen saturation in the blood can be measured with high accuracy based on the detection of the light intensity transmitted through or reflected from the blood, regardless of the presence or absence of a pulsed blood flow. Additionally, by irradiating the subject by switching between laser beams of two wavelengths, the subject receives less irradiation than when two lasers are used at the same time. Thus even if the amount of irradiation at each wavelength is slightly increased, the accuracy measurement can be improved without adversely affecting the subject.

摘要翻译： 用于非侵入性地测量受试者的血液中的氧饱和度的装置包括用至少第一光束和具有不同波长的第二光束照射组织中的血液样本的光源。 切换装置驱动光源并顺序地切换第一和第二激光束之间的血液样本的照射。 光电检测器检测透过血液样本或从血液样本反射的光，并提供指示检测到的光的强度的电输出信号。 A转换器将光电检测装置的电输出信号转换为功率谱，并且处理器处理功率谱并计算血液样本的氧饱和度。 可以基于通过血液透过或反射的光强度的检测，以高精度测量血液中的血氧饱和度，而不管脉搏血流的存在与否。 此外，通过在两个波长的激光束之间切换来照射被摄体，与同时使用两个激光时相比，受检者的照射少。 因此，即使各波长的照射量稍微增加，也可以提高精度测量，而不会对被摄体造成不利影响。

公开(公告)号：US06715444B1

公开(公告)日：2004-04-06

申请号：US10129272

申请日：2002-05-03

申请人： Katsumi Yabusaki ,  Hiroshi Nakao ,  Muneharu Ishikawa

发明人： Katsumi Yabusaki ,  Hiroshi Nakao ,  Muneharu Ishikawa

IPC分类号： A01K103

CPC分类号： A01K1/031 ,  A01K29/005 ,  G01H1/12

摘要： A method of measuring the number of times of a specific behavior of an animal in a breeding cage comprising a step in which a common pattern of the specific behavior is determined by receiving a signal of vibration of the cage caused by the specific behavior of the animal and extracting the feature of a frequency component of the signal, a step in which a measurement objective pattern is determined in the same way, and a step in which the common patterns in the measurement objective patterns is counted; a device for the measurement including means for detecting the vibration of the breeding cage, means for extracting the feature of the frequency component, and means for counting the common patterns in the measurement objective patterns; and a method for measuring the specific behavior such as a scratching of a small animal, e.g., a mouse in a breeding cage noninvasively, and an automatic measuring instrument.

摘要翻译： 一种测量育种笼中动物的特定行为次数的方法，包括通过接收由动物的特定行为引起的笼的振动信号来确定特定行为的共同模式的步骤 并提取信号的频率分量的特征，以相同的方式确定测量对象图案的步骤，以及对测量对象图案中的共同图案进行计数的步骤; 用于测量的装置包括用于检测育种笼的振动的装置，用于提取频率分量的特征的装置，以及用于对测量目标图案中的共同图案进行计数的装置; 以及用于非侵入性地测量育种笼中的小动物例如小鼠的特定行为的方法和自动测量仪器。

公开(公告)号：US4830494A

公开(公告)日：1989-05-16

申请号：US72228

申请日：1987-07-09

申请人： Muneharu Ishikawa ,  Kouichi Akiyama ,  Eiichi Ito ,  Masunori Kawamura ,  Akihiro Fujita

发明人： Muneharu Ishikawa ,  Kouichi Akiyama ,  Eiichi Ito ,  Masunori Kawamura ,  Akihiro Fujita

IPC分类号： G01N15/02 ,  G01N15/14 ,  G01N21/53

CPC分类号： G01N15/1459 ,  G01N2015/0222 ,  G01N2015/0244 ,  G01N2015/1447 ,  G01N2021/4707 ,  G01N21/53

摘要： Disclosed is a method and apparatus for measuring particles in a fluid by irradiating the fluid containing the particle with a laser beam and analyzing the laser light scattered by the particle to determine the characteristics of the particle. An elliptical laser beam is projected into a particle detection area in which the particles to be measured are caused to flow. The laser light scattered by the particle is received for photoelectric conversion into a time-series photoelectric signal in a direction along which the particle flows. The photoelectric signal is subjected to a moving average process to determine a time width during which the signal exceeds a predetermined level to cause the change in intensity of the scattered light. This change is recognized as a change in intensity caused by the passage of the particle through the particle detection area when the time width falls within a certain range.

摘要翻译： 公开了一种用于通过用激光束照射含有颗粒的流体并分析由颗粒散射的激光以确定颗粒的特性来测量流体中的颗粒的方法和装置。 将椭圆激光束投影到使被测量的粒子流动的粒子检测区域中。 由粒子散射的激光被接收用于光电转换成沿粒子流动的方向的时间序列光电信号。 对光电信号进行移动平均处理，以确定信号超过预定水平的时间宽度，以引起散射光强度的变化。 当时间宽度落在一定范围内时，该变化被认为是由粒子通过粒子检测区域引起的强度变化。

公开(公告)号：US5135306A

公开(公告)日：1992-08-04

申请号：US413538

申请日：1989-09-27

申请人： Makoto Kanebako ,  Muneharu Ishikawa

发明人： Makoto Kanebako ,  Muneharu Ishikawa

IPC分类号： G01N15/02 ,  G01N21/21

CPC分类号： G01N15/0205 ,  G01N15/0211 ,  G01N2015/0222 ,  G01N2021/4792 ,  G01N21/21

摘要： Disclosed is a particle measurement method and apparatus for measuring particle properties in which a laser beam is projected into a detection region in a medium containing particles to be measured, and a photoelectric detector having a predetermined dynamic range is used to detect the laser light scattered by the particles in the medium to produce signals which are evaluated to measure the particle properties. The polarization of the laser beam and the intensity of the scattered light are regulated in accordance with the range of particle sizes measured so that the intensity of the scattered light is within the dynamic range of the photoelectric detector. This arrangement makes it possible to expand the range of particle sizes with an improved resolving power in particle measurement without multi-valued ranges.

公开(公告)号：US06719203B2

公开(公告)日：2004-04-13

申请号：US09901288

申请日：2001-07-09

申请人： Taisuke Hirono ,  Muneharu Ishikawa

发明人： Taisuke Hirono ,  Muneharu Ishikawa

IPC分类号： G06K710

CPC分类号： B01L3/5453 ,  B01L3/545 ,  G01N2035/00752 ,  Y10T436/11

摘要： Cuvettes in boxes for blood testing and the like, are to be distinguished by bar code cuvette identification codes on each cuvette, together with a box identification code. The cuvettes have very limited space for bar code characters. The cuvette bar code reader is responsive to at least two different kinds of control codes, i.e., two distinct start code values and/or stop code values. The distinct control codes operate the bar code reader, but also contribute to the information that is encoded. A cuvette identification code is developed that combines an information code value with distinctions among the control codes found, to increase the number of values that can be encoded. In one embodiment, four start codes, four stop codes and a single decimal information digit, provide 160 different values.

摘要翻译： 用于血液检测的盒子中的比色皿等将通过每个比色杯上的条形码比色皿识别代码以及盒子识别码进行区分。 比色杯的条形码字符空间非常有限。 比色皿条形码读取器响应于至少两种不同类型的控制代码，即两个不同的起始码值和/或停止码值。 不同的控制代码操作条形码读取器，但也有助于编码的信息。 开发了比色皿识别码，其将信息码值与找到的控制码之间的区别相结合，以增加可编码的值的数量。 在一个实施例中，四个起始码，四个停止码和一个十进制小数信息数字提供160个不同的值。