公开(公告)号：US07537561B2

公开(公告)日：2009-05-26

申请号：US10721518

申请日：2003-11-25

申请人： Koji Yamaya ,  Haruhiko Ueno ,  Koji Nakamoto ,  Hisao Yabe

发明人： Koji Yamaya ,  Haruhiko Ueno ,  Koji Nakamoto ,  Hisao Yabe

IPC分类号： A61B1/00

CPC分类号： A61B1/00045 ,  A61B1/00098 ,  A61B1/0052 ,  A61B1/018

摘要： An edge portion of an endoscope inserting portion includes an observation optical system, a first treatment-tool oscillating base which guides, in a first direction, a first treatment tool guided via a first channel for inserting the treatment tool, and a second treatment-tool oscillating base which guides, in a second direction, a second treatment tool guided via a second channel for inserting the treatment tool. Upon endoscope treatment for the lesion portion using the first and second treatment tools which are projected from the edge openings of two first and second channels for inserting the treatment tool and which are guided by the two first and second treatment-tool oscillating bases, one of the first and second treatment tools is moved to the outside of a field of view of an endoscope image as needed.

摘要翻译： 内窥镜插入部的边缘部包括观察光学系统，第一处理工具摆动基座，其在第一方向上引导经由用于插入处理工具的第一通道引导的第一处理工具，以及第二处理工具 摆动基座，其在第二方向上引导经由用于插入治疗工具的第二通道引导的第二治疗工具。 利用从两个第一和第二通道的边缘开口突出的用于插入处理工具并由两个第一和第二处理工具摆动基座引导的第一和第二处理工具进行内窥镜处理时， 根据需要，将第一和第二处理工具移动到内窥镜图像的视野外部。

公开(公告)号：US06824509B2

公开(公告)日：2004-11-30

申请号：US10200631

申请日：2002-07-22

申请人： Koji Yamaya ,  Koji Nakamoto ,  Hisao Yabe

发明人： Koji Yamaya ,  Koji Nakamoto ,  Hisao Yabe

IPC分类号： A61B100

CPC分类号： A61B1/00147 ,  A61B1/00039 ,  A61B1/00098 ,  A61B1/0014 ,  A61B1/0052 ,  A61B1/018 ,  A61B17/29 ,  A61B18/1477 ,  A61B90/30 ,  A61B90/361 ,  A61B2017/003 ,  A61B2018/00166 ,  A61B2018/1425 ,  A61B2090/035

摘要： A treatment instrument passage channel through which a treatment instrument can be passed lies through an elongated insertion unit that is inserted into a body cavity or the like. The distal opening of the treatment instrument passage channel opens onto the distal part of the insertion unit. A treatment instrument swing stand having a hole, through which the distal part of a treatment instrument led out of the distal opening is passed, bored therein is disposed near the distal opening so that the treatment instrument swing stand can swing freely. The treatment instrument swing stand is manipulated by proximally pulling angling wires. Thus, the distal part of the treatment instrument is swung from a position near the center of a field of view in both the rightward and leftward directions of an endoscope. Thus, the mucosa of a lesion can be resected easily while being caught in the field of view.

摘要翻译： 处理器械通道通过治疗器具可以通过插入到体腔等中的细长插入单元。 处理器具通道通道的远端开口通向插入单元的远端部分。 具有孔的治疗器具摆动架设置在远端开口附近，使得从远端开口引出的处理器具的远端通过的孔设置在远端开口处，使得处理器具摆动架能够自由摆动。 治疗仪器摆动架由近端牵引钓鱼线操纵。 因此，治疗器具的远端部从内窥镜的左右两方向的中心附近摆动。 因此，可以容易地切除病变的粘膜，同时在视野中被捕获。

公开(公告)号：US5569157A

公开(公告)日：1996-10-29

申请号：US237000

申请日：1994-05-02

申请人： Masaaki Nakazawa ,  Hideo Ito ,  Koji Nakamoto ,  Yasuhito Kura ,  Seiji Kitano ,  Hisao Yabe ,  Tatsuya Furukawa

发明人： Masaaki Nakazawa ,  Hideo Ito ,  Koji Nakamoto ,  Yasuhito Kura ,  Seiji Kitano ,  Hisao Yabe ,  Tatsuya Furukawa

IPC分类号： A61B1/00 ,  A61B1/005 ,  A61B1/018 ,  A61B17/22

CPC分类号： A61B1/00066 ,  A61B1/0008 ,  A61B1/00091 ,  A61B1/00098 ,  A61B1/00165 ,  A61B1/00177 ,  A61B1/0051 ,  A61B1/018 ,  A61B2017/22072

摘要： An endoscope includes an operating portion placed outside a living body, an insertion portion having a proximal end portion coupled to the operating portion, a distal end portion inserted in the living body, and an instrument insertion channel extending through the insertion portion, a raising mechanism having an operation wire and designed to direct the distal end portion of an instrument, caused to extend through the channel, to a predetermined position, and an operation means for operating the operation wire. The endoscope includes a distal end body portion arranged at the distal end portion of the insertion portion and incorporating an observation means for observing the interior of the living body, a support member for forming at least a portion of the outer surface of the distal end portion. The support member is detachable from the distal end body portion. The endoscope further includes a raising base which is supported on the support member such that the angle at which the raising base is arranged can be adjusted. The angle of the raising base is adjusted by the operation wire. The operation wire is detachable from the operation means.

摘要翻译： 内窥镜包括设置在生物体外部的操作部，具有与操作部连结的基端部的插入部，插入生物体的前端部，以及穿过插入部延伸的器械插入通道， 具有操作线，其被设计成将仪器的远端部分引导通过通道延伸到预定位置;以及操作装置，用于操作操作线。 所述内窥镜包括设置在所述插入部的前端部的前端主体部，并且具有用于观察所述生物体的内部的观察装置，用于形成所述前端部的外表面的至少一部分的支撑部件 。 支撑构件可从远端主体部分拆卸。 内窥镜还包括支撑在支撑构件上的升高基座，使得可以调节设置升高基座的角度。 升高基座的角度由操作线调节。 操作线可从操作装置拆卸。

公开(公告)号：US5507717A

公开(公告)日：1996-04-16

申请号：US248422

申请日：1994-05-24

申请人： Yasuhito Kura ,  Takayuki Yokota ,  Koji Nakamoto ,  Masaaki Nakazawa ,  Hisao Yabe ,  Hideo Ito

发明人： Yasuhito Kura ,  Takayuki Yokota ,  Koji Nakamoto ,  Masaaki Nakazawa ,  Hisao Yabe ,  Hideo Ito

IPC分类号： A61B1/005 ,  A61M25/01 ,  A61B1/00

CPC分类号： A61B1/0052 ,  A61M25/0136

摘要： A device to be incorporated in the housing of the operation section of an endoscope, for operating a bending mechanism incorporated in the insertion section of the endoscope, comprises an operation shaft and a holder. The operation shaft has a distal end connected to the bending mechanism and a proximal end portion projecting from an operation section of the endoscope. The holder is mounted on a distal end portion of the operation shaft and comprises an upper and lower cover which are joined together and which define an outside surface and a hollow cylindrical space around the operation shaft. The upper and lower covers abut each other to form an interface on the outside surface.

摘要翻译： 一种装在内窥镜的操作部的壳体中的装置，其用于操作内置于内窥镜的插入部的弯曲机构，具有操作轴和保持件。 操作轴具有连接到弯曲机构的远端和从内窥镜的操作部突出的近端部。 保持器安装在操作轴的远端部分上，并且包括连接在一起并且围绕操作轴限定外表面和中空圆柱形空间的上盖和下盖。 上盖和下盖彼此邻接以在外表面上形成界面。

公开(公告)号：US5707344A

公开(公告)日：1998-01-13

申请号：US638984

申请日：1996-04-25

申请人： Masaaki Nakazawa ,  Hideo Ito ,  Koji Nakamoto ,  Yasuhito Kura ,  Seiji Kitano ,  Hisao Yabe ,  Tatsuya Furukawa

发明人： Masaaki Nakazawa ,  Hideo Ito ,  Koji Nakamoto ,  Yasuhito Kura ,  Seiji Kitano ,  Hisao Yabe ,  Tatsuya Furukawa

IPC分类号： A61B1/00 ,  A61B1/005 ,  A61B1/018 ,  A61B17/22 ,  A61B1/04

CPC分类号： A61B1/00066 ,  A61B1/0008 ,  A61B1/00091 ,  A61B1/00098 ,  A61B1/00165 ,  A61B1/00177 ,  A61B1/0051 ,  A61B1/018 ,  A61B2017/22072

摘要： An endoscope includes an operating portion placed outside a living body, an insertion portion having a proximal end portion coupled to the operating portion, a distal end portion inserted in the living body, and an instrument insertion channel extending through the insertion portion, a raising mechanism having an operation wire and designed to direct the distal end portion of an instrument, caused to extend through the channel, to a predetermined position, and an operation means for operating the operation wire. The endoscope includes a distal end body portion arranged at the distal end portion of the insertion portion and incorporating an observation means for observing the interior of the living body, a support member for forming at least a portion of the outer surface of the distal end portion. The support member is detachable from the distal end body portion. The endoscope further includes a raising base which is supported on the support member such that the angle at which the raising base is arranged can be adjusted. The angle of the raising base is adjusted by the operation wire. The operation wire is detachable from the operation means.

公开(公告)号：US07049441B2

公开(公告)日：2006-05-23

申请号：US10939293

申请日：2004-09-10

申请人： Shokyo Miki ,  Mitsuhiro Takeda ,  Koji Nakamoto

发明人： Shokyo Miki ,  Mitsuhiro Takeda ,  Koji Nakamoto

IPC分类号： C07D211/70

CPC分类号： C07D401/12 ,  C07D211/34 ,  C07D211/62 ,  C07D211/70 ,  C07D211/96 ,  C07F9/094 ,  C07F9/4056 ,  Y02P20/55

摘要： According to the process as shown in the following scheme having a step for reacting Compound (I) with Compound (II) to produce Compound (III), benzylpiperidine compounds useful as synthesis starting materials of pharmaceutical agents, agricultural chemicals and the like can be produced conveniently by a short step: wherein R1 is a hydrogen atom or an amino-protecting group, R2 is a hydrogen atom, a hydrocarbon group optionally having substituents, an alkoxy group optionally having substituents or a heterocyclic group optionally having substituents, and R3 is a lower alkyl group.

摘要翻译： 根据具有使化合物（I）与化合物（II）反应生成化合物（III）的步骤的方法所示的方法，可以制备用作药剂，农药等的合成原料的苄基哌啶化合物 方便地通过短步骤：其中R 1是氢原子或氨基保护基，R 2是氢原子，任选具有取代基的烃基，烷氧基 任选具有取代基的基团或任选具有取代基的杂环基，R 3是低级烷基。

公开(公告)号：US20050038257A1

公开(公告)日：2005-02-17

申请号：US10939293

申请日：2004-09-10

申请人： Shokyo Miki ,  Mitsuhiro Takeda ,  Koji Nakamoto

发明人： Shokyo Miki ,  Mitsuhiro Takeda ,  Koji Nakamoto

IPC分类号： C07D211/34 ,  C07D211/62 ,  C07D211/70 ,  C07D211/96 ,  C07F9/40 ,  C07D41/02 ,  C07D211/82

CPC分类号： C07D401/12 ,  C07D211/34 ,  C07D211/62 ,  C07D211/70 ,  C07D211/96 ,  C07F9/094 ,  C07F9/4056 ,  Y02P20/55

摘要： According to the process as shown in the following scheme having a step for reacting Compound (I) with Compound (II) to produce Compound (III), benzylpiperidine compounds useful as synthesis starting materials of pharmaceutical agents, agricultural chemicals and the like can be produced conveniently by a short step: wherein R1 is a hydrogen atom or an amino-protecting group, R2 is a hydrogen atom, a hydrocarbon group optionally having substituents, an alkoxy group optionally having substituents or a heterocyclic group optionally having substituents, and R3 is a lower alkyl group.

摘要翻译： 根据具有使化合物（I）与化合物（II）反应生成化合物（III）的步骤的方法所示的方法，可以制备用作药剂，农药等的合成原料的苄基哌啶化合物 方便地通过短步骤：其中R 1是氢原子或氨基保护基，R 2是氢原子，任选具有取代基的烃基，任选具有取代基的烷氧基或任选具有取代基的杂环基 取代基，R 3为低级烷基。

公开(公告)号：US06833457B1

公开(公告)日：2004-12-21

申请号：US10466494

申请日：2003-07-17

申请人： Shokyo Miki ,  Mitsuhiro Takeda ,  Koji Nakamoto

发明人： Shokyo Miki ,  Mitsuhiro Takeda ,  Koji Nakamoto

IPC分类号： C07D21160

CPC分类号： C07D401/12 ,  C07D211/34 ,  C07D211/62 ,  C07D211/70 ,  C07D211/96 ,  C07F9/094 ,  C07F9/4056 ,  Y02P20/55

摘要： According to the process as shown in the following scheme having a step for reacting Compound (I) with Compound (II) to produce Compound (III), benzylpiperidine compounds useful as synthesis starting materials of pharmaceutical agents, agricultural chemicals and the like can be produced conveniently by a short step: wherein R1 is a hydrogen atom or an amino-protecting group, R2 is a hydrogen atom, a hydrocarbon group optionally having substituents, an alkoxy group optionally having substituents or a heterocyclic group optionally having substituents, and R3 is a lower alkyl group.

摘要翻译： 根据具有使化合物（I）与化合物（II）反应生成化合物（III）的步骤的方法所示的方法，可以制备用作药剂，农药等的合成原料的苄基哌啶化合物 方便地通过短步骤：其中R 1是氢原子或氨基保护基，R 2是氢原子，任选具有取代基的烃基，任选具有取代基的烷氧基或任选具有取代基的杂环基 取代基，R 3为低级烷基。

公开(公告)号：US20100105922A1

公开(公告)日：2010-04-29

申请号：US12648022

申请日：2009-12-28

申请人： Jun-Ichi Kawakami ,  Koji Nakamoto ,  Shigeru Nuwa ,  Syoji Handa ,  Shokyo Miki

发明人： Jun-Ichi Kawakami ,  Koji Nakamoto ,  Shigeru Nuwa ,  Syoji Handa ,  Shokyo Miki

IPC分类号： C07D233/64 ,  C07C27/04

CPC分类号： C07D233/64 ,  C07D487/04 ,  C07F3/06

摘要： The present invention provides an industrially advantageous process for producing a steroid C17,20 lyase inhibitor represented by the general formula (I); and a Reformatsky reagent in a stable form suitable for the process.In the present invention, a compound represented by the general formula (I) is produced by reducing a specific β-hydroxy ester compound derivative or a salt thereof obtained from a specific carbonyl compound in a Reformatsky reaction in the presence of a metal hydride complex and a metal halide, and then subjecting it to a ring-closing reaction. In the above Reformatsky reaction, it is useful to use a stable solution of a compound represented by the general formula BrZnCH2COOC2H5 or a crystal of the compound which is represented by the formula (BrZnCH2COOC2H5.THF)2.

摘要翻译： 本发明提供了用于生产由通式（I）表示的类固醇C17,20裂解酶抑制剂的工业上有利的方法; 和一种适用于该方法的稳定形式的Reformatsky试剂。 在本发明中，通式（I）表示的化合物是通过在金属氢化物络合物的存在下，通过在Reformatsky反应中还原由特定的羰基化合物得到的特定的β-羟基酯化合物衍生物或其盐 和金属卤化物，然后使其进行闭环反应。 在上述Reformatsky反应中，使用由通式BrZnCH 2 COOC 2 H 5表示的化合物或由式（BrZnCH2COOC2H5.THF）2表示的化合物的晶体的稳定溶液是有用的。

公开(公告)号：US07662974B2

公开(公告)日：2010-02-16

申请号：US10500999

申请日：2003-01-09

申请人： Jun-ichi Kawakami ,  Koji Nakamoto ,  Shigeru Nuwa ,  Syoji Handa ,  Shokyo Miki

发明人： Jun-ichi Kawakami ,  Koji Nakamoto ,  Shigeru Nuwa ,  Syoji Handa ,  Shokyo Miki

IPC分类号： C07F3/06

CPC分类号： C07D233/64 ,  C07D487/04 ,  C07F3/06

摘要： The present invention provides an industrially advantageous process for producing a steroid C17,20 lyase inhibitor represented by the general formula (I): and a Reformatsky reagent in a stable form suitable for the process. In the present invention, a compound represented by the general formula (I) is produced by reducing a specific β-hydroxy ester compound derivative or a salt thereof obtained from a specific carbonyl compound in a Reformatsky reaction in the presence of a metal hydride complex and a metal halide, and then subjecting it to a ring-closing reaction. In the above Reformatsky reaction, it is useful to use a stable solution of a compound represented by the general formula BrZnCH2COOC2H5 or a crystal of the compound which is represented by the formula (BrZnCH2COOC2H5.THF)2.

摘要翻译： 本发明提供了用于生产由通式（I）表示的类固醇C17,20裂解酶抑制剂的工业上有利的方法：和适于该方法的稳定形式的Reformatsky试剂。 在本发明中，通式（I）表示的化合物是通过在金属氢化物络合物的存在下，通过在Reformatsky反应中还原由特定的羰基化合物得到的特定的β-羟基酯化合物衍生物或其盐， 金属卤化物，然后使其进行闭环反应。 在上述Reformatsky反应中，使用由通式BrZnCH 2 COOC 2 H 5表示的化合物或由式（BrZnCH2COOC2H5.THF）2表示的化合物的晶体的稳定溶液是有用的。