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1.发明授权Process for preparing an antibiotic complex by culturing actinomyces strain ATCC 39417 失效通过培养放线菌菌株ATCC 39417制备抗生素复合物的方法
公开(公告)号：US4572895A
公开(公告)日：1986-02-25
申请号：US690283
申请日：1985-02-19
CPC分类号： C07H17/04 , C12P19/60 , C12R1/465 , Y10S435/822 , Y10S435/826
摘要： A novel antibiotic complex designated BBM-2478 is produced by fermentation of an actinomycete strain J907-21 (ATCC 39417). The complex may be separated chromatographically into two bioactive components designated BBM-2478A and BBM-2478B. The BBM-2478A component displays both antibacterial and antitumor activity while the BBM-2478B component has antibacterial activity.
摘要翻译： 通过放线菌菌株J907-21（ATCC 39417）的发酵产生了称为BBM-2478的新型抗生素复合物。 该复合物可以色谱分离成两种生物活性成分，称为BBM-2478A和BBM-2478B。 BBM-2478A组分显示抗菌和抗肿瘤活性，而BBM-2478B组分具有抗菌活性。
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公开(公告)号：US4518589A
公开(公告)日：1985-05-21
申请号：US538453
申请日：1983-10-03
IPC分类号： C12P19/46 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/04 , A61P35/00 , C07H17/04 , C12P19/60 , C12R1/01 , C12R1/04 , C12R1/465 , C12R1/52 , A61K31/71 , C07H15/24
摘要： A novel antibiotic complex designated BBM-2478 is produced by fermentation of an actinomycete strain J907-21 (ATCC 39417). The complex may be separated chromatographically into two bioactive components designated BBM-2478A and BBM-2478B. The BBM-2478A component displays both antibacterial and antitumor activity while the BBM-2478B component has antibacterial activity.
摘要翻译： 通过放线菌菌株J907-21（ATCC 39417）的发酵产生了称为BBM-2478的新型抗生素复合物。 该复合物可以色谱分离成两种生物活性成分，称为BBM-2478A和BBM-2478B。 BBM-2478A组分显示抗菌和抗肿瘤活性，而BBM-2478B组分具有抗菌活性。
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公开(公告)号：US5037836A
公开(公告)日：1991-08-06
申请号：US555887
申请日：1990-07-23
IPC分类号： C07D405/06
CPC分类号： C07D405/06 , Y10S435/886
摘要： A novel antibiotic designated BU-4146T is produced by fermentation of Streptomyces amphibiosporus strain R310-104 (ATCC-53964). The antibiotic possesses both antifungal and antitumor activity.
摘要翻译： 命名为BU-4146T的新型抗生素通过发酵链霉菌（Streptomyces amphibiosporus）菌株R310-104（ATCC-53964）产生。 抗生素具有抗真菌和抗肿瘤活性。
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公开(公告)号：US5002959A
公开(公告)日：1991-03-26
申请号：US448441
申请日：1989-12-11
IPC分类号： C12P17/16 , A61K31/443 , A61K31/445 , A61P31/04 , A61P35/00 , C07D405/06 , C12N1/20 , C12R1/465
CPC分类号： C07D405/06
摘要： A novel antibiotic designated BU-4146T is produced by fermentation of Streptomyces amphibiosporus strain R310-104 (ATCC-53964). The antibiotic possesses both antifungal and antitumor activity.
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公开(公告)号：US4409210A
公开(公告)日：1983-10-11
申请号：US339355
申请日：1982-01-15
IPC分类号： C12N1/20 , A23K20/195 , A61K35/74 , A61K38/00 , A61P17/00 , A61P31/04 , C07K5/117 , C07K7/06 , C07K11/02 , C07K14/195 , C07K14/41 , C12P21/02 , C12P21/04 , C12R1/01 , A61K37/00 , C07C103/52
CPC分类号： C12R1/01 , C07K5/1024 , C07K7/06 , A61K38/00 , Y10S930/19 , Y10S930/27
摘要： A novel water-soluble peptide designated herein as Bu-2517 is produced by fermentation of Empedobacter sp. strain G393-B445 (ATCC 31962). The antibiotic exists in a cyclic depsipeptide structure and contains the amino acids D-serine, D-proline, L-proline, D-threo-.beta.-hydroxyaspartic acid, L-threo-.beta.-hydroxyaspartic acid, L-arginine and trans-L-3-hydroxyproline and the residue of the C.sub.14 fatty acid, 3-hydroxytetradecanoic acid. The Bu-2517 antibiotic inhibits the growth of a variety of aerobic and anaerobic gram-positive bacteria.
摘要翻译： 本文命名为Bu-2517的新型水溶性肽是通过Empedobacter sp。 菌株G393-B445（ATCC 31962）。 抗生素存在于环状肽末端结构中，含有D-丝氨酸，D-脯氨酸，L-脯氨酸，D-苏氨酸-β-羟基天冬氨酸，L-苏氨酸-β-羟基天冬氨酸，L-精氨酸和反式-L-氨基酸 3-羟基脯氨酸和C14脂肪酸的残基，3-羟基十四烷酸。 Bu-2517抗生素抑制各种需氧和厌氧革兰氏阳性菌的生长。
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公开(公告)号：US4533631A
公开(公告)日：1985-08-06
申请号：US478751
申请日：1983-03-25
CPC分类号： C12R1/01 , C07K7/06 , A61K38/00 , Y10S435/822 , Y10S930/19 , Y10S930/27
摘要： Disclosed is a process for preparation of the water-soluble peptide antibiotic designated Bu-2517 by fermentation of Empedobacter sp. strain G393-B445 (ATCC 31962).
摘要翻译： 本发明公开了通过Empedobacter sp的发酵制备名为Bu-2517的水溶性肽抗生素的方法。 菌株G393-B445（ATCC 31962）。
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公开(公告)号：US4314028A
公开(公告)日：1982-02-02
申请号：US109427
申请日：1980-01-03
CPC分类号： C07H15/26 , Y10S435/822
摘要： Addition of certain amine precursor compounds to the culture medium during fermentation of a tallysomycin-producing strain of Streptoalloteichus hindustanus results in production of new tallysomycin derivatives having advantageous antimicrobial and antitumor properties.
摘要翻译： 在培养的产丝菌霉素生产菌株Streptoalloteichus hindustanus的发酵期间向培养基中加入某些胺前体化合物导致产生具有有利的抗微生物和抗肿瘤性质的新的菌丝霉素衍生物。
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公开(公告)号：US4360593A
公开(公告)日：1982-11-23
申请号：US346451
申请日：1982-02-08
CPC分类号： C12R1/09 , C07K7/62 , A61K38/00 , Y10S435/835
摘要： A novel peptide antibiotic complex designated herein as Bu-2470 is produced by fermentation of Bacillus circulans strain G493-B6 (ATCC 31,805). Complex Bu-2470 may be separated into four bioactive peptide antibiotics designated as Bu-2470A, B.sub.1, B.sub.2a, and B.sub.2b. The complex and individual bioactive factors possess significant antimicrobial activity.
摘要翻译： 本文命名为Bu-2470的新型肽抗生素复合物是通过环状芽孢杆菌菌株G493-B6（ATCC 31,805）的发酵产生的。 复合物Bu-2470可以分成四种被称为Bu-2470A，B1，B2a和B2b的生物活性肽抗生素。 复杂和个体的生物活性因子具有显着的抗菌活性。
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公开(公告)号：US4508647A
公开(公告)日：1985-04-02
申请号：US608736
申请日：1984-05-10
IPC分类号： C07D487/04 , C12P17/18 , C12N1/20 , C12R1/465
CPC分类号： C07D487/04 , C12P17/182 , C12R1/465 , Y10S435/886
摘要： A novel antitumor antibiotic designated herein as BBM-2040 is produced by fermentation of Streptomyces sp. strain J576-99 (ATCC 39143). BBM-2040, which may be recovered from the fermentation broth in either a desmethanol (BBM-2040B) or methanol-adduct (BBM-2040A) form, inhibits gram positive and acid-fast bacteria and inhibits the growth of tumors such as P388 leukemia in mice.
摘要翻译： 本文命名为BBM-2040的新型抗肿瘤抗生素通过Streptomyces sp。 菌株J576-99（ATCC 39143）。 可从脱甲醇（BBM-2040B）或甲醇 - 加合物（BBM-2040A）形式的发酵液中回收的BBM-2040抑制革兰氏阳性和耐酸细菌，并抑制肿瘤如P388白血病 在小鼠中
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公开(公告)号：US4246400A
公开(公告)日：1981-01-20
申请号：US57528
申请日：1979-07-13
IPC分类号： C07H15/26 , A61K31/70 , A61K31/7028 , A61P31/04 , A61P35/00 , C07K9/00 , C12P19/58 , C12R1/01 , A61K31/71 , C07H15/22
CPC分类号： C07K9/003 , Y10S514/883
摘要： Addition of certain amine precursor compounds to the culture medium during fermentation of a tallysomycin-producing strain of Streptoalloteichus hindustanus results in production of new tallysomycin derivatives having advantageous antimicrobial and antitumor properties.
摘要翻译： 在培养的产丝菌霉素生产菌株Streptoalloteichus hindustanus的发酵期间向培养基中加入某些胺前体化合物导致产生具有有利的抗微生物和抗肿瘤性质的新的菌丝霉素衍生物。
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