公开(公告)号：US20050261190A1

公开(公告)日：2005-11-24

申请号：US11119249

申请日：2005-04-29

申请人： Kong-Joo Lee ,  Hee-Jung Kim ,  Jeong Cho ,  Eunhee Kim ,  Eun Song ,  Cheol Maeng

发明人： Kong-Joo Lee ,  Hee-Jung Kim ,  Jeong Cho ,  Eunhee Kim ,  Eun Song ,  Cheol Maeng

IPC分类号： A61K38/00 ,  A61K38/18 ,  C07K14/47 ,  C07K14/475

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/4747

摘要： The present application describes a Fas associated Factor 1 protein and fragment thereof that bind Hsc70/Hsp70, ubiquitinated protein and valosin containing protein.

摘要翻译： 本申请描述了结合Hsc70 / Hsp70，泛素化蛋白质和含有valosin的蛋白质的Fas相关因子1蛋白及其片段。

公开(公告)号：US20060200330A1

公开(公告)日：2006-09-07

申请号：US11290793

申请日：2005-12-01

申请人： Babu Suresh ,  Eun Song ,  Young Yoo

发明人： Babu Suresh ,  Eun Song ,  Young Yoo

IPC分类号： G06G7/48 ,  G06G7/58

CPC分类号： G16B5/00

摘要： The present invention relates to a method for modeling and simulating a biochemical pathway and a system for the same, more particularly to a method for modeling and simulating a biochemical pathway which comprises: developing a mathematical dynamics model that applies biological data of a signal transduction pathway within a biological system such as protein concentration as a parameter; and simulating by using the same. The present invention enables protein functions, activation, interactions between proteins, signal transduction pathways and the like to be determined under overall environment, and a network of signal transduction to be understood in both quantitative and qualitative level. The simulation model of the present invention can be utilized to develop novel substances for a specified use such as medicine design even in a minimal trial. Further, it may promote to easily predict their application to improve the quality of target substance.

摘要翻译： 本发明涉及一种用于建模和模拟生物化学途径的方法及其系统，更具体地涉及一种用于建模和模拟生物化学途径的方法，该方法包括：开发应用信号转导途径生物学数据的数学动力学模型 在生物系统内，如蛋白质浓度作为参数; 并使用相同的模拟。 本发明能够在总体环境下确定蛋白质功能，蛋白质之间的相互作用，信号转导途径等，并且在定量和定性水平上都能理解信号转导网络。 本发明的模拟模型即使在最小的试验中也可用于开发用于特定用途的新型物质，例如药物设计。 此外，它可以促进容易地预测其应用以提高目标物质的质量。

公开(公告)号：US20070128194A1

公开(公告)日：2007-06-07

申请号：US11393897

申请日：2006-03-31

申请人： Eun Song ,  Jae Kim ,  Hee Lee ,  Jong Lim ,  Seung Choi ,  Mi Cho ,  Kyoung Baek ,  Jin Kim ,  Jong Kim ,  Do Yoon ,  Dur Kwon ,  Mi-Young Park ,  Young Yeom ,  Yong-Kyung Choe ,  Young-Jun Kim

发明人： Eun Song ,  Jae Kim ,  Hee Lee ,  Jong Lim ,  Seung Choi ,  Mi Cho ,  Kyoung Baek ,  Jin Kim ,  Jong Kim ,  Do Yoon ,  Dur Kwon ,  Mi-Young Park ,  Young Yeom ,  Yong-Kyung Choe ,  Young-Jun Kim

IPC分类号： A61K39/395 ,  G01N33/567 ,  C12N5/06 ,  C07K16/40

CPC分类号： C07K16/18 ,  G01N33/574 ,  G01N33/6842 ,  G01N2500/00

摘要： The present invention relates to a monoclonal antibody specific for N-myc downstream regulated gene 2 (NDRG 2) protein, a cell line producing the monoclonal antibody, a method for measuring a quantity and quality of NDRG 2 protein, and a protein chip using the same. In the present invention, NDRG 2, a cancer-related factor is specifically expressed in dendritic cells differentiated from a monocyte of human peripheral blood. Accordingly, the monoclonal antibody specific for the NDRG 2 protein, the protein chip comprising the same and the method for measuring a quantity and quality of the NDRG 2 protein by using the same can be applied to elucidate characteristics of the dendritic cell and perform a research on the NDRG 2. Therefore, the present invention may help clinically to investigate and treat intractable diseases and cancers using the dendritic cell.

摘要翻译： 本发明涉及对N-myc下游调控基因2（NDRG 2）蛋白特异性的单克隆抗体，产生单克隆抗体的细胞系，测定NDRG2蛋白质的量和质量的方法，以及使用 相同。 在本发明中，癌细胞因子NDRG2特异性地表达于与人外周血单核细胞分化的树突状细胞中。 因此，可以应用对NDRG2蛋白质特异性的单克隆抗体，包含该NDRG2蛋白质的蛋白质芯片以及使用该方法来测定NDRG2蛋白质的量和质量的方法，以阐明树突状细胞的特征并进行研究 因此，本发明可以帮助临床上使用树突状细胞调查和治疗难治性疾病和癌症。