公开(公告)号：US20140088186A1

公开(公告)日：2014-03-27

申请号：US14036810

申请日：2013-09-25

Applicant: The Council for Scientific and Industrial Research ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyun Ok Yang ,  Sung-Kwon Chung ,  Hak Cheol Kwon ,  Jin Wook Cha ,  Young-Joo Kim ,  Gerda Fouche ,  Rudzani Nthambeleni ,  Dashnie Naidoo ,  Jeremiah Senabe ,  Vinesh Jaichand Maharaj ,  Eric Khorombi ,  Jungyeob Ham ,  Joon Ki Kim

IPC: A61K31/365 ,  A23L2/52 ,  A23L1/30

CPC classification number: A61K31/365 ,  A23L2/52 ,  A23L33/105 ,  A61K36/185

Abstract: A composition for preventing and/or treating dementia and ameliorating memory impairment and/or improving memory, comprising one or more arylnaphthalene lignan derivatives, such as Justicidin A, 5-methoxyjusticidin A, Chinensinaphthol, and a pharmaceutically-acceptable salt thereof, as active ingredient.

Abstract translation: 包含一种或多种芳基萘木酚素衍生物，例如贾斯汀素A，5-甲氧基调节蛋白A，钦嗪萘酚及其药学上可接受的盐作为活性成分的用于预防和/或治疗痴呆并改善记忆障碍和/或改善记忆的组合物 。

公开(公告)号：US09265806B2

公开(公告)日：2016-02-23

申请号：US14038378

申请日：2013-09-26

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  COUNCIL FOR SCIENTIFIC AND INDUSTRIAL RESEARCH (CSIR)

Inventor： Hyun Ok Yang ,  Sung-Kwon Chung ,  Hak Cheol Kwon ,  Jin Wook Cha ,  Vinesh Jaichand Maharaj ,  Rudzani Nthambeleni ,  Dashnie Naidoo ,  Young-Joo Kim ,  Jungyeob Ham ,  Jeremiah Senabe ,  Gerda Fouche ,  Eric Khorombi ,  Joon Ki Kim

IPC: A01N65/00 ,  A61K36/185 ,  A23L1/30 ,  A23L2/52

CPC classification number: A61K36/185 ,  A23L2/52 ,  A23L33/105 ,  A61K2236/39

Abstract: A pharmaceutical composition and a food composition including extracts of Monsonia sp. for treating dementia, which compositions inhibit the formation of β-amyloid, and a method of preparing the extracts.

Abstract translation: 一种药物组合物和包含Monsonia sp。 用于治疗痴呆，所述组合物抑制β-淀粉样蛋白的形成，以及制备提取物的方法。

公开(公告)号：US20240216462A1

公开(公告)日：2024-07-04

申请号：US18530106

申请日：2023-12-05

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jaeyoung KWON ,  Hak Cheol Kwon ,  Won Kyu Kim ,  Choong-Gu Lee ,  InWha Park ,  Hyeon-Seong Lee ,  Sungmin Song ,  Hoseong Hwang ,  Soon Kwang Lee ,  Jong Gwon Baek ,  Dong Hoon Kim ,  Yujin Kwon ,  Su-Yeon Cho ,  Dae Sik Jang

IPC: A61K36/68 ,  A61K31/7034 ,  A61K31/7048

CPC classification number: A61K36/68 ,  A61K31/7034 ,  A61K31/7048 ,  A61K2236/333 ,  A61K2236/39

Abstract: The present disclosure is completed by confirming the differentiation into Th17 and its activity-increasing function and the differentiation into Treg and its activity-suppressing function in compounds isolated from Pseudolysimachion nakaianum (Ohwi) T. Yamaz. The composition of the present disclosure increases the immune response by simultaneously regulating Th17 and Treg cell groups and their activities, and thus may be applied for the prevention and treatment of cancer and infectious diseases. According to the present disclosure, there is an advantage of having very few or no side effects by using Pseudolysimachion nakaianum (Ohwi) T. Yamaz, a natural product with safety that has been verified for a long time. Therefore, the present disclosure is expected to be used in various fields such as drugs, quasi-drugs, cosmetic materials, functional biomaterials, and functional food materials for immunity reinforcement and improvement, prevention, or treatment of infectious diseases and tumors.

公开(公告)号：US09132160B2

公开(公告)日：2015-09-15

申请号：US13661205

申请日：2012-10-26

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyun Ok Yang ,  Hak Cheol Kwon ,  Joon Ki Kim ,  Jin Wook Cha ,  Young-Joo Kim ,  Jungyeob Ham

IPC: A61K36/00 ,  A61K36/489

CPC classification number: A61K36/489 ,  A23L33/105 ,  A23V2002/00 ,  A61K2236/30 ,  A23V2200/334 ,  A23V2250/21

Abstract: A method of preventing or alleviating alcohol hangover, which comprises administering one or more selected from the group consisting of Sophora flavescens extracts, dried products of the extracts, and concentrates of the extracts to a subject in need of preventing or alleviating alcohol hangover is provided.

Abstract translation: 提供了一种预防或减轻酒精宿醉的方法，其包括将需要预防或缓解酒精宿醉的受试者中的一种或多种选自由苦参提取物，提取物的干燥产物和提取物的浓缩物组成的组。

公开(公告)号：US12234257B2

公开(公告)日：2025-02-25

申请号：US17199651

申请日：2021-03-12

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyun Ok Yang ,  Hak Cheol Kwon ,  Li Jun Zhang ,  Jaeyoung Kwon ,  Kee Beom Ko

IPC: C07H15/24 ,  A23L33/00 ,  A23L33/105 ,  A61K9/00 ,  A61P25/28

Abstract: Provided are astersaponin I, which is a novel triterpene saponin derivative isolated and identified from a Aster koraiensis Nakai (Korean starwort) extract, and a use thereof for preventing or treating a neurodegenerative disorder.

公开(公告)号：US11285186B2

公开(公告)日：2022-03-29

申请号：US16555950

申请日：2019-08-29

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Chu Won Nho ,  Hak Cheol Kwon ,  Ji-Hye Yoo ,  Jaeyoung Kwon ,  Jin Soo Park ,  Hyuk-Jai Jang ,  Seong-Su Kim ,  Cheon Soo Park ,  Hwa-Mi Lee ,  Hee Ju Lee

IPC: A61K36/28 ,  A61P9/10 ,  A23L33/00 ,  A23L33/105

Abstract: Provided are a pharmaceutical composition including a Crepidiastrum denticulatum extract as an active ingredient; and a method for preventing or treating ischemia-reperfusion injury in a subject by using a food composition or the pharmaceutical composition.

公开(公告)号：US09211278B2

公开(公告)日：2015-12-15

申请号：US14036810

申请日：2013-09-25

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  The Council for Scientific and Industrial Research

Inventor： Hyun Ok Yang ,  Sung-Kwon Chung ,  Hak Cheol Kwon ,  Jin Wook Cha ,  Young-Joo Kim ,  Gerda Fouche ,  Rudzani Nthambeleni ,  Dashnie Naidoo ,  Jeremiah Senabe ,  Vinesh Jaichand Maharaj ,  Eric Khorombi ,  Jungyeob Ham ,  Joon Ki Kim

IPC: A01N43/30 ,  A61K31/36 ,  A61K31/365 ,  A23L1/30 ,  A23L2/52 ,  A61K36/185

CPC classification number: A61K31/365 ,  A23L2/52 ,  A23L33/105 ,  A61K36/185

Abstract: Composition and method for preventing and/or treating dementia and ameliorating memory impairment and/or improving memory, comprising one or more arylnaphthalene lignan derivatives, namely Justicidin A, 5-methoxyjusticidin A, Chinensinaphthol, and a pharmaceutically-acceptable salt thereof, as active ingredient.

Abstract translation: 包含一种或多种芳基萘木酚素衍生物的组合物和方法，其中包括一种或多种芳基萘木酚素衍生物，即Justicidin A，5-甲氧基调节蛋白A，Chinininaphthol及其药学上可接受的盐作为活性成分 。

公开(公告)号：US12201664B2

公开(公告)日：2025-01-21

申请号：US17059595

申请日：2019-05-28

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyun Ok Yang ,  Keon Wook Kang ,  Sung Won Kwon ,  Jeong Hill Park ,  Hocheol Kim ,  Myung Sook Oh ,  Dae Sik Jang ,  Doheon Lee ,  Hak Cheol Kwon ,  Byung Hwa Jung

IPC: A61K36/54 ,  A61K36/268 ,  A61K36/346 ,  A23K10/30 ,  A23L33/105

Abstract: The present invention relates to a pharmaceutical composition for prevention or treatment of an allergic disease comprising a mixed extract of two or more selected from the group consisting of Asiasarum root, Platycodon root, and Cinnamomi ramulus as an active ingredient; a method for prevention or treatment of an allergic disease using the pharmaceutical composition; and a health functional food and a feed composition for improvement of an allergic disease. The composition and method of the invention can specifically inhibit the differentiation of Th2 cells and thus can be effectively used as a composition for prevention or treatment of an allergic disease.

公开(公告)号：US09650355B2

公开(公告)日：2017-05-16

申请号：US14760400

申请日：2014-01-28

Applicant: Korea Institute of Science and Technology

Inventor： Jungyeob Ham ,  Tae Jung Kim ,  Hak Cheol Kwon ,  Kyu Hyuk Jeong ,  Jungho Song ,  Bong Chul Chung

IPC: C07D407/04 ,  C07D409/04 ,  C07D307/88 ,  C07D405/04 ,  C07D493/04

CPC classification number: C07D307/88 ,  C07D405/04 ,  C07D407/04 ,  C07D409/04 ,  C07D493/04

Abstract: The present disclosure relates to a novel method for preparing an arylnaphthalene lignan compound. In synthesis of arylnaphthalene lignan compounds and derivatives according to the present disclosure, a naphthalene backbone may be constructed first and an aryl group may be introduced at the final stage. Through this, various kinds of derivatives that could not be prepared from the existing methods can be synthesized effectively. Further, the synthesis method according to the present disclosure is appropriate for large-scale production.

公开(公告)号：US09650325B2

公开(公告)日：2017-05-16

申请号：US14243488

申请日：2014-04-02

Applicant: SNU R&DB FOUNDATION ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

Inventor： Dong-Chan Oh ,  Seong-Hwan Kim ,  Jongheon Shin ,  Hak Cheol Kwon ,  So Hee Kwon

IPC: C12R1/465 ,  A61K31/122 ,  C07C49/747 ,  C12P7/26

CPC classification number: C07C49/747 ,  A61K31/122 ,  C12P7/26 ,  C12R1/465 ,  C12Y114/11 ,  C12Y114/11027

Abstract: Provided are a novel compound, preparing method thereof, and use thereof as inhibitor of histone demethylase. The compound represented by Chemical Formula 1 has activity which inhibits histone demethylase and thus is capable of specifically and effectively inhibit activity of histone demethylase.