公开(公告)号：US11021586B2

公开(公告)日：2021-06-01

申请号：US15438215

申请日：2017-02-21

Applicant: Korea Institute of Science and Technology

Inventor： Nakwon Choi ,  Sohyun Kim ,  Sohyeon Jeong ,  Eui Sung Yoon ,  Changjoon Justin Lee ,  Il-Joo Cho

IPC: B29C43/18 ,  C08J7/043 ,  C08J7/04 ,  C12M3/00 ,  C12M1/12 ,  C12N5/00 ,  C12N5/09

Abstract: The present disclosure relates to an apparatus and a method for manufacturing a channel-coupled scaffold. The present disclosure provides a method for manufacturing a channel-coupled scaffold, which includes: (1) a step of compressing a first elastic substrate which includes a groove on the surface of the substrate to close the groove; (2) a step of loading a scaffold composition onto the closed groove; and (3) a step of restoring the elastic substrate. The present disclosure also provides an apparatus for manufacturing a channel-coupled scaffold, which includes: a first elastic substrate which includes a groove on the surface of the substrate and onto which a scaffold composition is loaded: and a compression module which compresses the width of the groove of the elastic substrate to close it. The apparatus or method may accumulate a microchannel controlling local mass transfer, and align a collagen fiber in the scaffold at the same time.

公开(公告)号：US12247910B2

公开(公告)日：2025-03-11

申请号：US17962066

申请日：2022-10-07

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Il-Joo Cho ,  Nakwon Choi ,  Hyogeun Shin

IPC: G01N15/1434 ,  F21V8/00 ,  G01N15/14 ,  G02B1/04

Abstract: A high resolution fluorescence imaging device includes a light guide plate having a fluid channel which allows a solution containing a fluorescent sample to pass; a light source disposed on a side of the light guide plate to irradiate light inward the light guide plate; an image sensor disposed under the light guide plate; and a thin film interposed between the light guide plate and the image sensor, wherein the thin film has a first surface having a plurality of pillars and a second surface, the pillars separate the light guide plate and the image sensor apart from each other, and the second surface is bonded to the light guide plate. According to an embodiment, since the light guide plate acts in place of a filter element, it is possible to manufacture in ultrasmall size and achieve multiple fluorescence imaging without replacing a filter.

公开(公告)号：US11439838B2

公开(公告)日：2022-09-13

申请号：US16894887

申请日：2020-06-08

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Il-Joo Cho ,  Namsun Chou

IPC: A61N5/06

Abstract: A neural probe structure includes a probe that is inserted into a subject, a body to support a rear end of the probe, at least one light source included in the body, a photo diode formed in the probe, and an optical waveguide extending from the at least one light source in the body to the photo diode of the probe, wherein the photo diode is formed at a smaller height than the optical waveguide.

公开(公告)号：US10004453B2

公开(公告)日：2018-06-26

申请号：US15250469

申请日：2016-08-29

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Il-Joo Cho ,  Eui Sung Yoon ,  Hyogeun Shin ,  Uikyu Chae ,  Hyunjoo Jenny Lee

IPC: A61M5/32 ,  A61B5/00 ,  A61B5/04 ,  A61M5/158 ,  A61M39/10

CPC classification number: A61B5/4848 ,  A61B5/04001 ,  A61B5/6848 ,  A61B2562/028 ,  A61M5/158 ,  A61M39/105 ,  A61M2210/0693

Abstract: A neural probe structure has a probe having a microfluidic channel. The probe is inserted into an inside of a subject. A body to which the probe is fixed has a fluid entrance communicating with the microfluidic channel. A cover element is fixed to the body to cover the fluid entrance. The cover element has a connecting opening to which an external conduit is connected, and a fluid delivery channel extending such that the connecting opening and the fluid entrance are in fluid communication. A fluid fed from the external conduit flows along the fluid delivery channel, goes into the fluid entrance, and is delivered to the subject through the microfluidic channel.