公开(公告)号：US12049610B2

公开(公告)日：2024-07-30

申请号：US17040134

申请日：2019-03-20

申请人： SEKISUI CHEMICAL CO., LTD.

发明人： Kokoro Hamachi ,  Kanetomo Sato

IPC分类号： C12M1/107 ,  C12N1/20 ,  C12P7/06 ,  C12R1/145

CPC分类号： C12M21/04 ,  C12P7/065 ,  C12N1/205 ,  C12R2001/145

摘要： Provided is a device for continuously manufacturing an organic substance with high productivity, in which a means is installed whereby a synthesis gas having a specific nutrient source concentration for microbes in a continuous fermenter is stored with good efficiency and the gas composition thereof is made uniform in a stage prior to supplying the synthesis gas to the fermenter including microbes, so that uniformity of the synthesis gas composition is ensured. A device for manufacturing an organic substance, provided with a gas generating unit for gasifying a carbon source and generating a starting material gas, a gas supply unit for supplying a synthesis gas including the starting material gas to a fermenter, and a fermenter for microbial fermentation of the synthesis gas in the fermenter, a gas circulation unit for making the gas composition uniform being further provided between the gas generating unit and the gas supply unit or to the gas supply unit.

公开(公告)号：US20240034983A1

公开(公告)日：2024-02-01

申请号：US18026128

申请日：2021-08-12

申请人： SUPERBREWED FOOD, INC.

发明人： Shawn Jones ,  Carissa A. Wiedel ,  Bryan P. Tracy

IPC分类号： C12N1/20 ,  C12N3/00 ,  C07K14/33 ,  A23K10/18 ,  C12N15/01 ,  C12N1/36

CPC分类号： C12N1/20 ,  C12N3/00 ,  C07K14/33 ,  A23K10/18 ,  C12N15/01 ,  C12N1/36 ,  C12R2001/145

摘要： Provided is an isolated asporogenous strain of Clostridium tyrobutyricum bacterium comprising a single base pair mutation in a gene involved in the control of a sporulation process and methods of production thereof. Also provided is a feed ingredient comprising an isolated asporogenous strain of Clostridium tyrobutyricum bacterium, such as an asporogenous strain comprising a mutation in a gene involved in the control of a sporulation process.

公开(公告)号：US20230340400A1

公开(公告)日：2023-10-26

申请号：US17787330

申请日：2021-01-21

申请人： AUBURN UNIVERSITY

发明人： Yi WANG ,  Jun FENG ,  Yuechao MA

IPC分类号： C12N9/10 ,  C12N1/20 ,  C12N15/52 ,  C12P7/62 ,  C12N15/74

CPC分类号： C12N1/20 ,  C12N9/1029 ,  C12N15/52 ,  C12N15/74 ,  C12P7/62 ,  C12Y203/01084 ,  C12R2001/145

摘要： Microorganisms and microbial production methods for the biosynthesis of ester compounds are provided. Useful examples employ microorganisms that have been genetically modified to express alcohol acyltransferases, either from other species or that have been modified to increase their activity in catalyzing the esterification of alcohols. Additional useful examples employ microorganisms that have been genetically modified to express lipases, either from other species or that have been modified to increase their activity in catalyzing the esterification of organic acids. Additional modifications are presented that significantly increase ester production.

公开(公告)号：US20240287448A1

公开(公告)日：2024-08-29

申请号：US18574028

申请日：2022-06-21

申请人： SUPERBREWED FOOD INC.

发明人： Alon Karpol ,  Aharon Eyal ,  Bryan P. Tracy

IPC分类号： C12N1/20 ,  C12N1/02 ,  C12R1/145

CPC分类号： C12N1/205 ,  C12N1/02 ,  C12N2500/32 ,  C12N2500/34 ,  C12N2500/38 ,  C12N2500/42 ,  C12N2500/72 ,  C12R2001/145

摘要： Provided is a composition comprising a total dry weight of proteins and amino acids in of at least 80%; and wherein at least 95 wt % of said proteins have a mass of from about 70 to about 5,000 Daltons. Further provided is a growth medium comprising the composition, methods for the manufacture of the composition and uses thereof.

公开(公告)号：US20240247245A1

公开(公告)日：2024-07-25

申请号：US18291001

申请日：2022-07-22

申请人： INIBIO CO., LTD.

发明人： Chung Sei Kim ,  Young Jun Song

IPC分类号： C12N9/52 ,  C07K1/18 ,  C07K14/33 ,  C12N1/20 ,  C12R1/145

CPC分类号： C12N9/52 ,  C07K1/18 ,  C07K14/33 ,  C12N1/20 ,  C12R2001/145 ,  C12Y304/24069

摘要： The present invention relates to a method for purification of botulinum toxin with improved purification purity and yield. When the method for purification of botulinum toxin of the present invention is used, botulinum toxin can be purified with a very high yield.

公开(公告)号：US20240002835A1

公开(公告)日：2024-01-04

申请号：US18457402

申请日：2023-08-29

申请人： IFP ENERGIES NOUVELLES ,  STICHTING WAGENINGEN RESEARCH

发明人： FRANÇOIS WASELS ,  NICOLAS LOPES FERREIRA ,  FLORENT COLLAS ,  ANA LOPEZ CONTRERAS

IPC分类号： C12N15/10 ,  C12N9/22 ,  C12N15/74 ,  C12N15/90 ,  C12P7/06 ,  C12P7/28 ,  C12P7/04 ,  C12N15/63 ,  C12N1/20

CPC分类号： C12N15/102 ,  C12N9/22 ,  C12N15/74 ,  C12N15/902 ,  C12P7/065 ,  C12P7/28 ,  C12P7/04 ,  C12N15/63 ,  C12N1/205 ,  Y02E50/10 ,  C12R2001/145

摘要： The present invention relates to a genetic tool comprising at least two different nucleic acids allowing the transformation, by homologous recombination, of a bacterium of the genus Clostridium, typically of a solventogenic bacterium.

公开(公告)号：US11660320B2

公开(公告)日：2023-05-30

申请号：US17490734

申请日：2021-09-30

申请人： Shanghai University

发明人： Junjie Xiao ,  Qiulian Zhou ,  Xue Pan ,  Danni Meng

IPC分类号： A61K35/74 ,  A61P9/10 ,  A61K47/10 ,  C12R1/145

CPC分类号： A61K35/74 ,  A61K47/10 ,  A61P9/10 ,  C12R2001/145

摘要： The present disclosure belongs to the technical field of biomedicine, and provides use of Faecalibacterium prausnitzii in preparation of a medicine for treating pathological ventricular remodeling and/or heart failure following myocardial infarction. The Faecalibacterium prausnitzii can improve pathological ventricular remodeling and/or heart failure caused by myocardial infarction in experimental animals, resume the systolic function, reduce the cardiac fibrosis, and inhibit the pathological myocardial hypertrophy of mice with myocardial infarction. Furthermore, the inactivated Faecalibacterium prausnitzii has no such improvement effect.

公开(公告)号：US11655486B2

公开(公告)日：2023-05-23

申请号：US16636237

申请日：2018-08-03

申请人： METABOLIC EXPLORER

发明人： Céline Raynaud ,  Olivier Tourrasse ,  Nadège Dumoulin

IPC分类号： C12P7/18 ,  C12N1/20 ,  C12R1/22 ,  C12R1/145

CPC分类号： C12P7/18 ,  C12N1/205 ,  C12R2001/145 ,  C12R2001/22

摘要： The present invention concerns a new method for the production of 1,3-propanediol comprising culturing a recombinant microorganism converting glycerol into 1,3-propanediol and overexpressing the hcpR and/or frdX gene on a medium comprising glycerine. A recombinant microorganism for the production of 1,3 propanediol from glycerol, wherein said microorganism converts glycerol into 1,3-propanediol and 10 overexpresses the hcpR and/or the frdX gene.

公开(公告)号：US20240327879A1

公开(公告)日：2024-10-03

申请号：US18741273

申请日：2024-06-12

申请人： S&P Ingredient Development, LLC

发明人： Paul Blum ,  Sambasiva Rao Chigurupati ,  Derrick Jermaine White

IPC分类号： C12P7/52 ,  C12N1/20 ,  C12R1/02 ,  C12R1/145 ,  C12R1/225

CPC分类号： C12P7/52 ,  C12N1/205 ,  C12R2001/02 ,  C12R2001/145 ,  C12R2001/225

摘要： Microbial cell lines suitable for industrial-scale production of organic acids and methods of making and isolating such cell lines, and using the cell lines for production of organic acids.

公开(公告)号：US20240254434A1

公开(公告)日：2024-08-01

申请号：US17787381

申请日：2020-12-18

申请人： EXOMNIS BIOTECH B.V.

发明人： ALEKSANDRA MARIA KUBIAK

IPC分类号： C12N1/20 ,  A61K35/74 ,  C12N1/36 ,  C12R1/145

CPC分类号： C12N1/205 ,  A61K35/74 ,  C12N1/36 ,  C12R2001/145

摘要： The present invention relates to genetically modified Clostridium strains that provide an improved combination of replication and physiological characteristics useful for a variety of clinical and industrial applications. In particular, clinical grade spores generated from the Clostridium strains described herein can be efficiently stored, formulated, and advantageously used in the prevention and/or treatment of medical conditions, such as cancer.