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    METHOD FOR DETECTING ARTERIOSCLEROTIC DISEASES ON THE BASIS OF SINGLE NUCLEOTIDE POLYMORPHISM AT HUMAN CHROMOSOME 5P15.3
    2.
    发明申请
    METHOD FOR DETECTING ARTERIOSCLEROTIC DISEASES ON THE BASIS OF SINGLE NUCLEOTIDE POLYMORPHISM AT HUMAN CHROMOSOME 5P15.3 审中-公开
    在人类色素5P15.3单核细胞多态性基础上检测异常性疾病的方法

    公开(公告)号：US20130022975A1

    公开(公告)日：2013-01-24

    申请号：US13579463

    申请日：2011-02-18

    申请人： Kouichi Ozaki ,  Toshihiro Tanaka ,  Yusuke Nakamura

    发明人： Kouichi Ozaki ,  Toshihiro Tanaka ,  Yusuke Nakamura

    IPC分类号： C12Q1/68 ,  C07H21/04

    CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/172

    摘要： An atherosclerotic disease such as myocardial infarction or angina pectoris is detected by analyzing a single nucleotide polymorphism on human chromosome 5p15.3, and by associating results of the analysis with the risk of the onset thereof. Examples of the single nucleotide polymorphism on human chromosome 5p15.3 include a nucleotide corresponding to the nucleotide at position 61 in the nucleotide sequence of SEQ ID NO: 1, SEQ ID NO: 2, or SEQ ID NO: 3, and a polymorphism at a nucleotide which is in linkage disequilibrium with the above nucleotide.

    摘要翻译： 通过分析人染色体5p15.3上的单核苷酸多态性，并通过将分析结果与其发病风险相关联来检测动脉粥样硬化性疾病如心肌梗塞或心绞痛。 人染色体5p15.3上的单核苷酸多态性的实例包括对应于SEQ ID NO：1，SEQ ID NO：2或SEQ ID NO：3的核苷酸序列中第61位的核苷酸的核苷酸， 与上述核苷酸连接不平衡的核苷酸。

    Method of judging inflammatory disease
    7.
    发明授权
    Method of judging inflammatory disease 失效
    炎症性疾病的诊断方法

    公开(公告)号：US07754422B2

    公开(公告)日：2010-07-13

    申请号：US10523723

    申请日：2003-08-08

    申请人： Toshihiro Tanaka ,  Yozo Ohnishi ,  Koichi Ozaki ,  Aritoshi Iida ,  Yusuke Nakamura ,  Masatsugu Hori

    发明人： Toshihiro Tanaka ,  Yozo Ohnishi ,  Koichi Ozaki ,  Aritoshi Iida ,  Yusuke Nakamura ,  Masatsugu Hori

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

    摘要： The object of the present invention is to determine inflammatory diseases such as myocardial infarction by identifying single nucleotide polymorphisms (SNPs) associated with myocardial infarction and utilizing these SNPs. The present invention provides a method for determining an inflammatory disease, which comprises detecting at least one gene polymorphism existing in at least one gene selected from the group consisting of a lymphotoxin-α (LT-α) gene, an I Kappa B-like (IKBL) gene, and a BAT1 gene; an oligonucleotide used in said method; a kit for diagnosing an inflammatory disease which comprises said oligonucleotide; and use thereof. The present invention further provides a method for treating an inflammatory disease; and a method for screening for a therapeutic agent for an inflammatory disease.

    摘要翻译： 本发明的目的是通过鉴定与心肌梗塞相关的单核苷酸多态性（SNP）和利用这些SNP来确定诸如心肌梗死的炎性疾病。 本发明提供了一种测定炎性疾病的方法，该方法包括检测至少一种存在于选自淋巴毒素-α（LT-α）基因，IκB样（LT-α） IKBL）基因和BAT1基因; 所述方法中使用的寡核苷酸; 用于诊断包含所述寡核苷酸的炎性疾病的试剂盒; 及其用途。 本发明还提供一种治疗炎性疾病的方法; 以及筛选炎性疾病治疗剂的方法。

    Physiologically active protein originating in mammals
    8.
    发明授权
    Physiologically active protein originating in mammals 失效
    源自哺乳动物的生理活性蛋白质

    公开(公告)号：US06710171B1

    公开(公告)日：2004-03-23

    申请号：US09380287

    申请日：1999-11-16

    申请人： Yusuke Nakamura ,  Toshihiro Tanaka ,  Shuichi Tsukuda

    发明人： Yusuke Nakamura ,  Toshihiro Tanaka ,  Shuichi Tsukuda

    IPC分类号： C07H2104

    CPC分类号： C07K14/4703 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  C07K14/705 ,  C07K14/82 ,  C07K2319/00

    摘要： The present invention provides novel physiologically active protein molecules originating in mammals, which are specifically expressed in arteriosclerosis and/or coronary restenosis, and are predicted to relate closely to the onset and progress of these diseases; DNAs encoding the protein molecules; antibodies reactive with the molecules; and pharmaceutical compositions comprising the above protein molecule or the antibody. The protein molecules, DNAs, and antibodies are useful for treating and preventing arteriosclerosis.

    摘要翻译： 本发明提供了起源于哺乳动物的新型生理活性蛋白质分子，其在动脉硬化和/或冠状动脉再狭窄中特异性表达，并被预测与这些疾病的发病和进展密切相关; 编码蛋白质分子的DNA; 与分子反应的抗体; 和包含上述蛋白质分子或抗体的药物组合物。 蛋白质分子，DNAs和抗体可用于治疗和预防动脉硬化。

    Method of judging inflammatory disease
    9.
    发明申请
    Method of judging inflammatory disease 失效
    炎症性疾病的诊断方法

    公开(公告)号：US20060147920A1

    公开(公告)日：2006-07-06

    申请号：US10523723

    申请日：2003-08-08

    申请人： Toshihiro Tanaka ,  Yozo Ohnishi ,  Koichi Ozaki ,  Aritoshi Iida ,  Yusuke Nakamura ,  Masatsugu Hori

    发明人： Toshihiro Tanaka ,  Yozo Ohnishi ,  Koichi Ozaki ,  Aritoshi Iida ,  Yusuke Nakamura ,  Masatsugu Hori

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

    摘要： The object of the present invention is to determine inflammatory diseases such as myocardial infarction by identifying single nucleotide polymorphisms (SNPs) associated with myocardial infarction and utilizing these SNPs. The present invention provides a method for determining an inflammatory disease, which comprises detecting at least one gene polymorphism existing in at least one gene selected from the group consisting of a lymphotoxin-α (LT-α) gene, an I Kappa B-like (IKBL) gene, and a BAT1 gene; an oligonucleotide used in said method; a kit for diagnosing an inflammatory disease which comprises said oligonucleotide; and use thereof. The present invention further provides a method for treating an inflammatory disease; and a method for screening for a therapeutic agent for an inflammatory disease.

    摘要翻译： 本发明的目的是通过鉴定与心肌梗塞相关的单核苷酸多态性（SNPs）和利用这些SNP来确定诸如心肌梗死的炎性疾病。 本发明提供了一种测定炎症性疾病的方法，该方法包括检测存在于选自淋巴毒素-α（LT-α）基因，IκB样（LT-α） IKBL）基因和BAT1基因; 所述方法中使用的寡核苷酸; 用于诊断包含所述寡核苷酸的炎性疾病的试剂盒; 及其用途。 本发明还提供一种治疗炎性疾病的方法; 以及筛选炎性疾病治疗剂的方法。