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公开(公告)号:US06245790B1
公开(公告)日:2001-06-12
申请号:US09424253
申请日:2000-03-08
申请人: Kouji Hattori , Osamu Okitsu , Naoaki Fujii , Akira Tanaka , Kiyoshi Taniguchi , Satoshi Koyama , Mie Nishio
发明人: Kouji Hattori , Osamu Okitsu , Naoaki Fujii , Akira Tanaka , Kiyoshi Taniguchi , Satoshi Koyama , Mie Nishio
IPC分类号: A61K31426
CPC分类号: C07D413/10 , C07D263/32
摘要: Azole compounds of the formula: wherein R1 is lower alkyl substituted with carboxy, etc., R2 is hydrogen or lower alkyl, R3 is aryl, etc. R4 is aryl, etc. Q is etc., and X is O, NH or S, and its salt, which are useful as medicament.
摘要翻译: 下式的唑类化合物:其中R1是被羧基取代的低级烷基等,R2是氢或低级烷基,R3是芳基等.R4是芳基等,Q是等等,X是O,NH或S, 及其盐,可用作药物。
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公开(公告)号:US5863918A
公开(公告)日:1999-01-26
申请号:US28861
申请日:1998-02-23
申请人: Kiyoshi Taniguchi , Masanobu Nagano , Kouji Hattori , Kazunori Tsubaki , Osamu Okitsu , Seiichiro Tabuchi
发明人: Kiyoshi Taniguchi , Masanobu Nagano , Kouji Hattori , Kazunori Tsubaki , Osamu Okitsu , Seiichiro Tabuchi
IPC分类号: A61K31/16 , A61K31/335 , A61K31/336 , A61K31/44 , A61K31/4418 , A61K31/4425 , A61K31/50 , A61P7/02 , A61P9/10 , A61P9/12 , A61P43/00 , C07C69/145 , C07C235/40 , C07C271/10 , C07C271/12 , C07C271/24 , C07C271/28 , C07C271/32 , C07C281/02 , C07D213/64 , C07D237/14 , C07D303/12 , C07D303/16 , A01N43/58 , C07D237/00
CPC分类号: C07D213/64 , C07C271/12 , C07C271/28 , C07C281/02 , C07D237/14 , C07D303/16 , C07C2102/10
摘要: A compound or the formula: ##STR1## wherein R.sup.1 is carboxy or protected carboxy, R.sup.2 is hydrogen, hydroxy or protected hydroxy,R.sup.3 is hydrogen, hydroxy, protected hydroxy, etc.,R.sup.4 is hydrogen or halogen,A.sup.1 is lower alkylene,A.sup.2 is bond or lower alkylene,--R.sup.5 is ##STR2## (in which R.sup.6 is mono(or di or tri)aryl(lower)alkyl and Z is N or CH), etc., and ##STR3## etc., and a pharmaceutically acceptable salt thereof which are useful as medicaments.
摘要翻译: 化合物或式:其中R 1是羧基或保护的羧基,R 2是氢,羟基或被保护的羟基,R 3是氢,羟基,保护的羟基等,R 4是氢或卤素,A 1是低级亚烷基,A 2 (其中R 6是单(或二或三)芳基(低级)烷基,Z是N或CH)等,和
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公开(公告)号:US06300344B1
公开(公告)日:2001-10-09
申请号:US09357664
申请日:1999-07-20
IPC分类号: A61K3142
CPC分类号: C07D263/32 , C07D413/04
摘要: Heterocyclic compounds of the formula: wherein R1 is carboxy or protected carboxy, R2 is aryl which may have suitable substituent(s), R3 is aryl which may have suitable substituent(s), R4 is hydrogen, lower alkyl, hydroxy or aryl, A1 is lower alkylene, etc., etc. and n is 0 or 1, and pharmaceutically acceptable salts thereof which are useful as a medicament.
摘要翻译: 下式的杂环化合物:其中R 1是羧基或保护的羧基,R 2是可以具有合适取代基的芳基,R 3是可具有合适取代基的芳基,R 4是氢,低级烷基,羟基或芳基,A 1是 低级亚烷基等。 和n为0或1,以及其药学上可接受的盐,其可用作药物。
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公开(公告)号:US5972965A
公开(公告)日:1999-10-26
申请号:US983139
申请日:1998-01-21
IPC分类号: A61K31/00 , A61K31/42 , A61K31/421 , A61K31/422 , A61P1/16 , A61P9/00 , A61P9/10 , A61P43/00 , C07D263/32 , C07D413/04 , A61K31/445 , C07D263/30
CPC分类号: C07D263/32 , C07D413/04
摘要: This invention relates to new heterocyclic compounds, compositions, process of making and method of use thereof for inhibition of platelet aggregation, vasodilation, antihypertensive activity and prostaglandin I.sub.2 agonist.
摘要翻译: PCT No.PCT / JP96 / 01996 Sec。 371日期1998年1月21日 102(e)1998年1月21日PCT PCT 1996年7月18日PCT公布。 出版物WO97 / 03973 日期1997年2月6日本发明涉及新的杂环化合物,组合物,制备方法及其用于抑制血小板聚集,血管舒张,抗高血压活性和前列腺素I2激动剂的方法。
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公开(公告)号:US6025375A
公开(公告)日:2000-02-15
申请号:US92027
申请日:1998-06-05
申请人: Kiyoshi Taniguchi , Masanobu Nagano , Kouji Hattori , Kazunori Tsubaki , Osamu Okitsu , Seiichiro Tabuchi
发明人: Kiyoshi Taniguchi , Masanobu Nagano , Kouji Hattori , Kazunori Tsubaki , Osamu Okitsu , Seiichiro Tabuchi
IPC分类号: A61K31/42 , A61K31/421 , A61P9/00 , A61P9/08 , A61P9/10 , C07D263/32 , C07D263/34
CPC分类号: C07D263/32
摘要: Heterocyclic compounds of the formula: ##STR1## whereinR.sup.1 is carboxy or protected carboxy,R.sup.2 is aryl which may have suitable substituent(s),R.sup.3 is aryl which may have suitable substituent(s),A.sup.1 is lower alkylene,A.sup.2 is bond or lower alkylene and-Q- is ##STR2## etc., and pharmaceutically acceptable salts thereof which are useful as a medicament.
摘要翻译: 下式的杂环化合物:其中R 1是羧基或保护的羧基,R 2是可以具有合适取代基的芳基,R 3是可以具有合适取代基的芳基,A 1是低级亚烷基,A 2是键或低级亚烷基, Q-等,及其药学上可接受的盐,其可用作药物。
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公开(公告)号:US5763489A
公开(公告)日:1998-06-09
申请号:US702546
申请日:1996-10-10
申请人: Kiyoshi Taniguchi , Masanobu Nagano , Kouji Hattori , Kazunori Tsubaki , Osamu Okitsu , Seiichiro Tabuchi
发明人: Kiyoshi Taniguchi , Masanobu Nagano , Kouji Hattori , Kazunori Tsubaki , Osamu Okitsu , Seiichiro Tabuchi
IPC分类号: A61K31/16 , A61K31/335 , A61K31/336 , A61K31/44 , A61K31/4418 , A61K31/4425 , A61K31/50 , A61P7/02 , A61P9/10 , A61P9/12 , A61P43/00 , C07C69/145 , C07C235/40 , C07C271/10 , C07C271/12 , C07C271/24 , C07C271/28 , C07C271/32 , C07C281/02 , C07D213/64 , C07D237/14 , C07D303/12 , C07D303/16 , A01N37/12 , A01N37/02 , C07C333/00
CPC分类号: C07D213/64 , C07C271/12 , C07C271/28 , C07C281/02 , C07D237/14 , C07D303/16 , C07C2102/10
摘要: A compound of the formula ##STR1## wherein R.sup.1 is carboxy or protected carboxy, R.sup.2 is hydrogen, hydroxy or protected hydroxy, R.sup.3 is hydrogen, hydroxy, protected hydroxy, etc., R.sup.4 is hydrogen or halogen, A.sup.1 is lower alkylene, A.sup.2 is bond or lower alkylene, --R.sup.5 is ##STR2## (in which R.sup.6 is mono(or di or tri)aryl(lower)alkyl and Z is N or CH), etc., and ##STR3## and a pharmaceutically acceptable salt thereof which are useful as medicaments.
摘要翻译: PCT No.PCT / JP95 / 00373 Sec。 371日期:1996年10月10日 102(e)日期1996年10月10日PCT 1995年3月8日PCT PCT。 第WO95 / 24393号公报 日期1995年9月14日具有下式的化合物其中R 1为羧基或被保护的羧基,R 2为氢,羟基或保护的羟基,R 3为氢,羟基,保护的羟基等,R 4为氢或卤素, 低级亚烷基,A2是键或低级亚烷基,-R5是(其中R6是单(或二或三)芳基(低级)烷基,Z是N或CH)等),和< IMAGE>和 其药学上可接受的盐可用作药物。
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公开(公告)号:US20130225387A1
公开(公告)日:2013-08-29
申请号:US13882654
申请日:2011-11-09
申请人: Satoshi Hirai , Noriko Takeda , Osamu Okitsu
发明人: Satoshi Hirai , Noriko Takeda , Osamu Okitsu
CPC分类号: B04B7/08 , B01D21/262 , B01L3/5021 , B01L2200/025 , B01L2300/0854
摘要: The present invention provides a separation container capable of preventing contamination with unnecessary components and efficiently separating a separation subject. The separation container is a separation container for separating a separation subject from a sample, including: an outer container; an inner container; and a lid, wherein the outer container has a bottomed tubular shape with upper end thereof open and a lower end thereof closed, the inner container is tubular with an upper and lower ends thereof open, the inner container can be disposed inside the outer container with the up and down orientation of the inner container and the outer container aligned, and with the inner container disposed inside the outer container, a region below the disposed inner container inside the outer container is a storage portion for a precipitate in the sample, the lid is attachable over and detachable from an opening at the upper end of the inner container, and the inner container is made liquid-tight by attaching the lid over the opening of the inner container.
摘要翻译: 本发明提供一种分离容器,其能够防止不必要的成分的污染,有效地分离分离对象物。 分离容器是用于将分离对象与样品分离的分离容器,包括:外容器; 内容器 和一个盖子,其中外容器具有一个有底的管状,其上端打开并且其下端封闭,该内容器是管状的,上端和下端打开,内容器可以设置在外容器的内部, 内部容器和外部容器的上下取向对齐,并且与设置在外部容器内部的内部容器相比,在外部容器内的设置的内部容器的下方的区域是用于样品中的沉淀物的存储部分,盖子 可以从内容器的上端的开口部上拆下,通过将盖子安装在内侧容器的开口部上而使内部容器成为液密的状态。
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公开(公告)号:US20100222196A1
公开(公告)日:2010-09-02
申请号:US12739096
申请日:2008-10-23
申请人: Keiko Ito , Satoshi Hirai , Osamu Okitsu , Yasunori Okamoto
发明人: Keiko Ito , Satoshi Hirai , Osamu Okitsu , Yasunori Okamoto
CPC分类号: B01L3/5021 , B01L2200/026 , B01L2300/041 , B01L2300/047 , B01L2300/0618 , B01L2300/0681 , G01N2035/00495
摘要: A separation container that can prevent the contamination with unnecessary components is provided. A separation container 1 for separating a separation subject from a sample by causing the separation subject to gather on the bottom thereof by centrifugation includes a container main body 11 and a dividing portion. The container main body 11 is a tubular container elongated in the axial direction with an upper end thereof being open and a lower end thereof being the bottom. The dividing portion has a partition 12 formed along the axial direction of the container main body, and an inner space of the container main body 11 is divided into a sample supply chamber 14 and a separation subject discharge chamber 15 by the partition 12. The sample supply chamber 14 and the separation subject discharge chamber 15 communicate with each other via a through hole 13 formed in a lower portion of the partition 12. A collection tube can be inserted into a lower portion of the separation subject discharge chamber 15 from the opening, and the separation subject located in the lower portion of the separation subject discharge chamber 15 can be collected with the collection tube and recovered to the outside of the container main body 11.
摘要翻译: 提供了可以防止不必要的部件污染的分离容器。 用于通过使分离对象通过离心而聚集在其底部的分离对象与样品分离的分离容器1包括容器主体11和分隔部。 容器主体11是沿轴向延伸的管状容器,其上端开口,下端为底部。 分隔部具有沿着容器主体的轴向形成的隔壁12,容器主体11的内部空间被分隔件12分割成样品供给室14和分离对象排出室15.样品 供给室14和分离对象物排出室15通过形成在分隔部12的下部的通孔13相互连通。收集管可以从开口插入分离对象排出室15的下部, 并且分离对象物排出室15的下部的分离对象能够与收集管一起收集并回收到容器主体11的外部。
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