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    MEDICAL APPARATUS AND METHOD FOR COLLECTING BIOLOGICAL SAMPLES
    5.
    发明申请
    MEDICAL APPARATUS AND METHOD FOR COLLECTING BIOLOGICAL SAMPLES 有权
    用于收集生物样品的医疗装置和方法

    公开(公告)号：US20140227732A1

    公开(公告)日：2014-08-14

    申请号：US14256138

    申请日：2014-04-18

    申请人： The Trustees of Columbia University in the City of New York

    发明人： Anjali Saqi ,  Keith Yeager

    IPC分类号： G01N1/31

    CPC分类号： G01N1/31 ,  A61B10/0283 ,  B01L3/5021 ,  B01L2300/0618 ,  B01L2300/0681 ,  C12M47/02 ,  G01N1/36 ,  G01N1/4077 ,  G01N2001/2873 ,  G01N2001/4088

    摘要： A medical apparatus and method of preparing one or more cell blocks. The medical apparatus comprises at least one elongate tubular body having a proximal end and a distal end and a filter membrane disposed between the proximal end and a distal end of the elongate tubular body. The filter membrane, which can include alignment features and structural features to engage the tubular body, and/or cover, is sectionable. Additionally, in some embodiments a second elongate tubular body is provided which telescopingly receives at least a portion of the first elongate tubular body. In other embodiments, a support member is provided for engaging the filter membrane and positioning the filter membrane at a midpoint of the elongate tubular body during centrifuging.

    摘要翻译： 一种制备一个或多个细胞块的医疗装置和方法。 医疗设备包括至少一个细长的管状体，其具有近端和远端以及设置在细长管状体的近端和远端之间的过滤膜。 可以包括对准特征和与管状体接合的结构特征和/或覆盖物的过滤膜是可切割的。 另外，在一些实施例中，提供了第二细长管状体，其可伸缩地容纳第一细长管状体的至少一部分。 在其它实施例中，提供支撑构件用于接合过滤膜并且在离心过程中将过滤膜定位在细长管状体的中点处。

    All-In-One Sample Preparation Device And Method
    6.
    发明申请
    All-In-One Sample Preparation Device And Method 有权
    一体式样品制备装置及方法

    公开(公告)号：US20140017151A1

    公开(公告)日：2014-01-16

    申请号：US14031458

    申请日：2013-09-19

    申请人： EMD Millipore Corporation

    发明人： Christopher A. Scott ,  Timothy K. Nadler ,  Kurt Greenizen ,  Louis Bonhomme ,  Sara D. Gutierrez ,  Masaharu Mabuchi ,  David Briggs ,  Phillip Clark ,  Ralph T. Scaduto

    IPC分类号： G01N1/34

    CPC分类号： G01N1/34 ,  B01D61/18 ,  B01D63/06 ,  B01D63/16 ,  B01D2315/02 ,  B01L3/5021 ,  B01L3/5085 ,  B01L2300/0618 ,  B01L2300/0681 ,  C07K1/16 ,  C07K1/22 ,  G01N1/405 ,  G01N1/4077 ,  G01N2001/4088 ,  Y10T436/25375

    摘要： Sample preparation device that allows for a complete bind, wash, elute, buffer-exchange and concentration process to be carried out without sample transfer between multiple devices. The device includes a reservoir, a column for holding chromatography media, a holder region for holding a filtration device, and an outlet. The filtration device plugs into the holder region of the centrifugal device, and the assembly can be placed in an optional holder. The assembly, with or without the optional holder, can be placed in a conventional centrifuge tube for centrifugation. The entire bind, wash, elute, buffer exchange and concentration steps can be carried out with the apparatus without any pipette transfers (and the associated sample losses. The sample preparation device also can be used for binding and washing steps, in which case the filtration device is not needed, and for buffer exchange and concentration steps, in which case the media is not needed.

    摘要翻译： 允许完全结合，洗涤，洗脱，缓冲交换和浓缩过程的样品制备装置，在多个装置之间没有样品转移的情况下进行。 该装置包括储存器，用于保持色谱介质的柱，用于保持过滤装置的保持器区域和出口。 过滤装置插入到离心装置的保持器区域中，并且组件可以放置在可选的保持器中。 具有或不具有任选的保持器的组件可以放置在用于离心的常规离心管中。 整个结合，洗涤，洗脱，缓冲液交换和浓缩步骤可以在没有任何移液管转移（和相关样品损失）的情况下进行，样品制备装置也可用于结合和洗涤步骤，在这种情况下，过滤 设备不需要，并且用于缓冲区交换和集中步骤，在这种情况下不需要介质。

    Apparatus and methods for evaluating the barrier properties of a membrane
    7.
    发明授权
    Apparatus and methods for evaluating the barrier properties of a membrane 失效
    用于评估膜的阻隔性能的装置和方法

    公开(公告)号：US08277762B2

    公开(公告)日：2012-10-02

    申请号：US10566648

    申请日：2004-07-30

    申请人： John M. Newsam ,  Ilya Feygin ,  Samir Mitragotri ,  Robert Dominic King-Smith

    发明人： John M. Newsam ,  Ilya Feygin ,  Samir Mitragotri ,  Robert Dominic King-Smith

    IPC分类号： B01L3/00

    CPC分类号： G01N21/253 ,  B01L3/5025 ,  B01L3/50853 ,  B01L2300/045 ,  B01L2300/0609 ,  B01L2300/0618 ,  B01L2300/0829 ,  B01L2400/0611 ,  B01L2400/0633 ,  B01L2400/065 ,  G01N13/00 ,  G01N21/03 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/78 ,  G01N33/5082 ,  Y10T436/255

    摘要： The present invention teaches apparatus (511) and methods for screening the effect of test formulations on the barrier properties of a membrane (212), that are especially beneficial when skin is used as the test membrane (212). The apparatus (511) and methods enable more efficient measurements of skin permeabilization, of the permeation of molecular or particulate entities through skin, and of the absorption and adsorption by skin of ingredients in fluid formulations, together with screening of exfoliation of material from the exterior of the stratum corneum. The apparatus (511) provide for fluid contact to the skin from both donor and receptor sides, for measurements of skin electrical response in the presence of test formulations, of permeation and permeation enhancement, for the depth profiling of test formulation constituents through the skin, of stratum corneum component disruption, and of loss of material from the stratum corneum.

    摘要翻译： 本发明教导了用于筛选试验制剂对膜（212）的阻隔性能的影响的装置（511），当皮肤用作测试膜时（212）是特别有利的。 装置（511）和方法能够更有效地测量皮肤透化，分子或颗粒物质通过皮肤的渗透，以及流体配方中成分的皮肤吸收和吸附以及从外部筛选材料的剥离 的角质层。 设备（511）提供从供体和受体侧的流体接触皮肤，用于在测试制剂存在下测量皮肤电响应，渗透和渗透增强，用于通过皮肤测试制剂成分的深度分布， 的角质层组分破坏，以及角质层材料的损失。

    Method for the detection and characterization of microorganisms on a filter
    8.
    发明申请
    Method for the detection and characterization of microorganisms on a filter 审中-公开
    在过滤器上检测和表征微生物的方法

    公开(公告)号：US20110059433A1

    公开(公告)日：2011-03-10

    申请号：US11919474

    申请日：2006-04-26

    申请人： Frederic Marc ,  Serge Ohresser

    发明人： Frederic Marc ,  Serge Ohresser

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12M1/00

    CPC分类号： C12Q1/6888 ,  B01D61/18 ,  B01L3/502 ,  B01L2300/0618 ,  B01L2300/0681 ,  C12Q1/04 ,  C12Q2600/16

    摘要： The present invention relates to a method for the specific detection on a filter of one or more microorganisms present in a fluid, characterized in that it comprises the following steps: a) contacting the microorganisms present in the fluid or on the surface with the filter; b) amplifying specifically the nucleic acids from the microorganism or microorganisms present on the filter, in an isothermal manner, in order to obtain amplification products, c) detecting the amplification products. The invention also relates to a device, a kit and oligonucleotides suitable for the implementation of this method.

    摘要翻译： 本发明涉及用于特定检测存在于流体中的一种或多种微生物的过滤器的方法，其特征在于其包括以下步骤：a）使流体或表面上存在的微生物与过滤器接触; b）以等温方式特异性扩增存在于过滤器上的微生物或微生物的核酸，以获得扩增产物，c）检测扩增产物。 本发明还涉及适用于实施该方法的装置，试剂盒和寡核苷酸。

    Substrates, devices, and methods for cellular assays
    9.
    发明申请
    Substrates, devices, and methods for cellular assays 有权
    用于细胞测定的底物，装置和方法

    公开(公告)号：US20080160539A1

    公开(公告)日：2008-07-03

    申请号：US11890740

    申请日：2007-08-07

    申请人： Christopher Murphy ,  Barbara Israel ,  Nicholas Abbott

    发明人： Christopher Murphy ,  Barbara Israel ,  Nicholas Abbott

    IPC分类号： G01N33/53 ,  C12N5/00 ,  C12M1/34

    CPC分类号： C12M33/06 ,  B01L3/0289 ,  B01L3/5085 ,  B01L2300/0618 ,  C12M23/12 ,  C12M23/26

    摘要： The present invention relates to the field of molecular diagnostics. In particular, the present invention provided improved substrates and methods of using liquid crystals and other biophotonically based assays for quantitating the amount of an analyte in a sample. The present invention also provides materials and methods for detecting non-specific binding of an analyte to a substrate by using a liquid crystal or other biophotonically based assay formats.

    摘要翻译： 本发明涉及分子诊断领域。 特别地，本发明提供改进的底物和使用液晶的方法以及用于定量样品中分析物的量的其他基于生物光子学的测定法。 本发明还提供了通过使用液晶或其它基于生物光子学的测定形式来检测分析物与底物的非特异性结合的材料和方法。