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公开(公告)号：US08487139B2
公开(公告)日：2013-07-16
申请号：US12445356
申请日：2007-10-12
IPC分类号： C07C49/00
CPC分类号： C07C229/12 , A61K8/37 , A61K8/39 , A61K8/496 , A61K8/8147 , A61K2800/522 , A61K2800/56 , A61Q19/02 , C07C49/248 , C07C49/255 , C07C69/52 , C07C69/602 , C07C247/04 , C07D249/04
摘要： The invention relates to novel curcumin and tetrahydrocurcumin derivatives, which have been modified at one phenolic group to incorporate more-reactive groups. The curcumin and tetrahydrocurcumin derivatives are in the form of monomers, dimmers, and polymers.
摘要翻译： 本发明涉及新的姜黄素和四氢姜黄素衍生物，它们已经在一个酚基团被修饰以引入更多的反应性基团。 姜黄素和四氢姜黄素衍生物是单体，二聚体和聚合物的形式。
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公开(公告)号：US20100240905A1
公开(公告)日：2010-09-23
申请号：US12445356
申请日：2007-10-12
IPC分类号： C07D249/04 , C07C69/52 , C07C229/02 , C07C49/213
CPC分类号： C07C229/12 , A61K8/37 , A61K8/39 , A61K8/496 , A61K8/8147 , A61K2800/522 , A61K2800/56 , A61Q19/02 , C07C49/248 , C07C49/255 , C07C69/52 , C07C69/602 , C07C247/04 , C07D249/04
摘要： The invention relates to novel curcumin and tetrahydrocurcumin derivatives, which have been modified at one phenolic group to incorporate more-reactive groups. The curcumin and tetrahydrocurcumin derivatives are in the form of monomers, dimmers, and polymers.
摘要翻译： 本发明涉及新的姜黄素和四氢姜黄素衍生物，它们已经在一个酚基团被修饰以引入更多的反应性基团。 姜黄素和四氢姜黄素衍生物是单体，二聚体和聚合物的形式。
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公开(公告)号：US09447023B2
公开(公告)日：2016-09-20
申请号：US13942606
申请日：2013-07-15
IPC分类号： A61K8/37 , A61K8/39 , A61Q19/02 , C07C229/12 , C07C247/04 , C07C49/248 , C07C49/255 , C07C69/52 , C07C69/02 , A61K8/49 , A61K8/81 , C07D249/04 , C07C69/602
CPC分类号： C07C229/12 , A61K8/37 , A61K8/39 , A61K8/496 , A61K8/8147 , A61K2800/522 , A61K2800/56 , A61Q19/02 , C07C49/248 , C07C49/255 , C07C69/52 , C07C69/602 , C07C247/04 , C07D249/04
摘要： The invention relates to novel curcumin and tetrahydrocurcumin derivatives, which have been modified at one phenolic group to incorporate more-reactive groups. The curcumin and tetrahydrocurcumin derivatives are in the form of monomers, dimmers, and polymers. Z-Ln-Y (I) wherein: Z is represented by:
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公开(公告)号：US20130296527A1
公开(公告)日：2013-11-07
申请号：US13942606
申请日：2013-07-15
IPC分类号： C07C229/12 , C07C69/602 , C07C69/52 , C07C49/248
CPC分类号： C07C229/12 , A61K8/37 , A61K8/39 , A61K8/496 , A61K8/8147 , A61K2800/522 , A61K2800/56 , A61Q19/02 , C07C49/248 , C07C49/255 , C07C69/52 , C07C69/602 , C07C247/04 , C07D249/04
摘要： The invention relates to novel curcumin and tetrahydrocurcumin derivatives, which have been modified at one phenolic group to incorporate more-reactive groups. The curcumin and tetrahydrocurcumin derivatives are in the form of monomers, dimmers, and polymers.
摘要翻译： 本发明涉及新的姜黄素和四氢姜黄素衍生物，它们已经在一个酚基团被修饰以引入更多的反应性基团。 姜黄素和四氢姜黄素衍生物是单体，二聚体和聚合物的形式。
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5.发明申请公开(公告)号：US20110262991A1
公开(公告)日：2011-10-27
申请号：US12992854
申请日：2009-05-18
申请人： Krishnaswami Raja , Wei Shi , Sukanta Dolai , Saadyah Averick , William L'Amoreaux , Probal Banerjee
发明人： Krishnaswami Raja , Wei Shi , Sukanta Dolai , Saadyah Averick , William L'Amoreaux , Probal Banerjee
IPC分类号： C12N9/96 , C12N7/00 , C08F120/06
CPC分类号： A61K47/4823 , A61K47/4813 , A61K47/48215 , A61K47/48246 , A61K47/555 , A61K47/60 , A61K47/61 , A61K47/64 , A61K49/0032 , A61K49/0054 , A61K49/0056 , A61K49/085 , A61K49/12
摘要： Water soluble polymers having formula I: Y-(L1)ni-(C(O))n2—(R1)n3—R2 are claimed. The polymers may contain multiple water soluble, immunogenicity reducing moieties and multiple active moieties. The polymers may be linked to a protein, or a peptide having up to twelve amino acids.
摘要翻译： 具有式I：Y-（L1）ni-（C（O））n2-（R1）n3-R2的水溶性聚合物。 聚合物可以含有多个水溶性，免疫原性降低部分和多个活性部分。 聚合物可以连接到蛋白质或具有至多12个氨基酸的肽。
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6.发明授权公开(公告)号：US09242010B2
公开(公告)日：2016-01-26
申请号：US12992854
申请日：2009-05-18
申请人： Krishnaswami Raja , Wei Shi , Sukanta Dolai , Saadyah Averick , William L'Amoreaux , Probal Banerjee
发明人： Krishnaswami Raja , Wei Shi , Sukanta Dolai , Saadyah Averick , William L'Amoreaux , Probal Banerjee
CPC分类号： A61K47/4823 , A61K47/4813 , A61K47/48215 , A61K47/48246 , A61K47/555 , A61K47/60 , A61K47/61 , A61K47/64 , A61K49/0032 , A61K49/0054 , A61K49/0056 , A61K49/085 , A61K49/12
摘要： Water soluble polymers having formula I: Y-(L1)n1-(C(O))n2—(R1)n3—R2 are claimed. The polymers may contain multiple water soluble, immunogenicity reducing moieties and multiple active moieties. The polymers may be linked to a protein, or a peptide having up to twelve amino acids.
摘要翻译： 具有式I的水溶性聚合物：Y-（L1）n1-（C（O））n2-（R1）n3-R2。 聚合物可以含有多个水溶性，免疫原性降低部分和多个活性部分。 聚合物可以连接到蛋白质或具有至多12个氨基酸的肽。
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