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12 条记录 (耗时 0.025 秒)

    Novel Curcumin-Antibody Conjugates as Anti-Cancer Agents
    9.
    发明申请
    Novel Curcumin-Antibody Conjugates as Anti-Cancer Agents 有权
    新型姜黄素抗体偶联物作为抗癌剂

    公开(公告)号：US20130224229A1

    公开(公告)日：2013-08-29

    申请号：US13513348

    申请日：2010-12-01

    申请人： Probal Banerjee ,  Raja Krishnaswami

    发明人： Probal Banerjee ,  Raja Krishnaswami

    IPC分类号： A61K47/48

    CPC分类号： A61K47/48384 ,  A61K47/50 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6865

    摘要： The invention relates to curcumin derivatives having the formula I: wherein: Z represents: H3CO A represents —CH2—CH2— or —CH═CH—; L represents —C(O)—(NH)n1—R—(NH)n2—C(O)—; R represents a saturated or unsaturated, branched or unbranched hydrocarbyl chain having a minimum of 3 carbon atoms in the chain; wherein the maximum number of carbon atoms in the chain is 24; and wherein the carbon atoms of the chain can be replaced by at least one heteroatom, wherein the heteroatoms are independently —O— or —NH2—, with the proviso that each heteroatom is separated from each other heteroatom by at least two carbon atoms; n1 and n2 independently represent 0 or 1; and Y represents an antibody that binds specifically to a target antigen of a tumor cell. The invention further relates to methods of method of inhibiting the growth of tumors in a human by administering an effective amount of the curcumin derivative, and to methods of producing the curcumin derivative.

    摘要翻译： 本发明涉及具有式I的姜黄素衍生物：其中：Z表示：H3COA表示-CH2-CH2-或-CH = CH-; L表示-C（O） - （NH）n1-R-（NH）n2-C（O） - ; R表示链中具有最少3个碳原子的饱和或不饱和的支链或非支链烃基链; 其中链中最大碳原子数为24; 并且其中链的碳原子可以被至少一个杂原子替代，其中杂原子独立地是-O-或-NH2-，条件是每个杂原子彼此分开至少两个碳原子; n1和n2独立地表示0或1; Y表示与肿瘤细胞的靶抗原特异性结合的抗体。 本发明还涉及通过施用有效量的姜黄素衍生物抑制人类肿瘤生长的方法，以及生产姜黄素衍生物的方法。

    Novel cell lines, and methods of preparation and use thereof
    10.
    发明申请
    Novel cell lines, and methods of preparation and use thereof 审中-公开
    新型细胞系及其制备方法和用途

    公开(公告)号：US20070190039A1

    公开(公告)日：2007-08-16

    申请号：US10941478

    申请日：2004-09-14

    申请人： Probal Banerjee

    发明人： Probal Banerjee

    IPC分类号： A61K48/00 ,  C12N5/06 ,  C12N5/08 ,  C12N15/09

    CPC分类号： C12N5/0619 ,  C12N2501/01 ,  C12N2510/00

    摘要： The present invention provides, in some embodiments, hippocampal neuron-derived cell lines that display voltage-gated calcium channels of various types, including the N-type channels. Such mixed calcium channel activity is similar to that observed in the hippocampal neurons from which they were originally derived. The cells also can be differentiated into neurons and contain many of the important hippocampal neuron proteins. The invention further provides methods for using the cells.

    摘要翻译： 在一些实施方案中，本发明提供了显示各种类型的电压门控钙通道（包括N型通道）的来自海马神经元的细胞系。 这种混合的钙通道活性与其最初来源于海马神经元的观察相似。 细胞也可以分化为神经元，并含有许多重要的海马神经元蛋白。 本发明还提供了使用这些电池的方法。