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    PHASE TRANSITIONING HYDROGELS
    1.
    发明申请
    PHASE TRANSITIONING HYDROGELS 有权
    相转移水凝胶

    公开(公告)号：US20110270400A1

    公开(公告)日：2011-11-03

    申请号：US12994336

    申请日：2009-05-27

    申请人： Kristin B. Kita ,  Nigel G. Smith ,  Anthony M. Lowman ,  Garland W. Fussell ,  Michael Keane

    发明人： Kristin B. Kita ,  Nigel G. Smith ,  Anthony M. Lowman ,  Garland W. Fussell ,  Michael Keane

    IPC分类号： A61F2/44 ,  C08K3/30 ,  C08L29/04

    CPC分类号： C08L29/04 ,  A61L27/26 ,  A61L27/52 ,  A61L2400/06 ,  C08K3/30 ,  C08L39/06 ,  C08L71/02 ,  C08L2666/14 ,  C08L2666/02

    摘要： A method of forming and the resulting hydrogel composition comprising poly(vinyl alcohol) at a final concentration of about 20% (w/w) to about 65% (w/w) and polyethylene glycol at a final concentration of about 2% (w/w) to about 20% (w/w), wherein the hydrogel composition has a total polymer content, above about 30% (w/w), higher than the total polymer content of a precursor polymer solution formulated prior to the formulation of the hydrogel composition. The hydrogel composition may further comprise poly(vinyl pyrrolidone) at a fmal concentration of about 0.10% (w/w) to about 0.75% (w/w).

    摘要翻译： 一种形成方法，所得到的水凝胶组合物包含最终浓度为约20％（w / w）至约65％（w / w）的聚乙烯醇和最终浓度为约2％的聚乙二醇（w / w）至约20％（w / w），其中所述水凝胶组合物的总聚合物含量高于约30％（w / w），高于在配制之前配制的前体聚合物溶液的总聚合物含量 水凝胶组合物。 水凝胶组合物还可以包含约0.10％（w / w）至约0.75％（w / w）的最高浓度的聚（乙烯基吡咯烷酮）。

    Crosslinked hydrogels
    2.
    发明授权
    Crosslinked hydrogels 有权
    交联水凝胶

    公开(公告)号：US09078953B2

    公开(公告)日：2015-07-14

    申请号：US12747411

    申请日：2008-12-16

    申请人： Kristin B. Kita ,  Nigel G. Smith ,  Anthony M. Lowman ,  Garland W. Fussell ,  Michael F. Keane

    发明人： Kristin B. Kita ,  Nigel G. Smith ,  Anthony M. Lowman ,  Garland W. Fussell ,  Michael F. Keane

    IPC分类号： A61K31/79 ,  A61K31/785 ,  A61P43/00 ,  A61L27/16

    CPC分类号： A61L27/16

    摘要： The present invention preferably provides for a method of forming and the resulting solid polymer gel composition comprising polyethylene imine and at least one hydrogen bonding polymer. The composition has a greater viscosity than either of the polyethylene imine or the hydrogen bonding polymer alone and is injectable immediately after mixing of the polyethylene imine and the at least one hydrogen bonding polymer. A method of tissue repair may include mixing about 9.25% (w/w) to about 13.65% (w/w) polyethylene imine and about 18.02% (w/w) to about 26.62% (w/w) polyvinyl alcohol to form an injectable composition; injecting the injectable composition into a cavity within a human body; and allowing the composition to solidify in situ. A kit may include a multi-barrel syringe at least one barrel is loaded with polyethylene imine and at least another barrel is loaded with at least one hydrogen bonding polymer.

    摘要翻译： 本发明优选提供一种形成方法和所得到的固体聚合物凝胶组合物，其包含聚乙烯亚胺和至少一种氢键聚合物。 该组合物比单独的聚乙烯亚胺或氢键聚合物具有更大的粘度，并且在聚乙烯亚胺和至少一种氢键聚合物混合后立即进行注射。 组织修复的方法可包括混合约9.25％（w / w）至约13.65％（w / w）的聚乙烯亚胺和约18.02％（w / w）至约26.62％（w / w）的聚乙烯醇，以形成 可注射组合物 将可注射组合物注射到人体内的空腔中; 并使组合物原位固化。 套件可以包括多桶注射器，至少一个桶装有聚乙烯亚胺，并且至少另一个筒装有至少一个氢键聚合物。

    Bioadhesive hydrogels
    3.
    发明授权
    Bioadhesive hydrogels 有权
    生物粘合剂水凝胶

    公开(公告)号：US08366778B2

    公开(公告)日：2013-02-05

    申请号：US12812141

    申请日：2009-01-12

    申请人： Kristin B. Kita ,  Nigel G. Smith ,  Anthony M. Lowman ,  Garland W. Fussell

    发明人： Kristin B. Kita ,  Nigel G. Smith ,  Anthony M. Lowman ,  Garland W. Fussell

    IPC分类号： A61F2/44

    CPC分类号： A61L24/043 ,  A61L2430/38

    摘要： A method of forming and the resulting bioadhesive hydrogel composition for repairing or supplementing a nucleus pulposus of an intervertebral disc comprises at least a first component, a second component and a third component, wherein the first component, the second component and the third component are crosslinked. The first component comprises an amine-containing polymer component at a concentration from about 0.1% weight by weight to about 13.65% weight by weight. The second component comprises a hydrophilic polymer or pre-polymer component at a concentration from about 3% weight by weight to about 35% weight by weight. The third component comprises an aldehyde component at a concentration from about 0.1% weight by weight to about 30% weight by weight. A method of repairing or supplementing a nucleus pulposus of an intervertebral disc comprises implanting the bioadhesive hydrogel composition in a patient.

    摘要翻译： 一种形成方法和所得到的用于修复或补充椎间盘髓核的生物粘附性水凝胶组合物包括至少第一组分，第二组分和第三组分，其中第一组分，第二组分和第三组分是交联的 。 第一组分包含浓度为约0.1重量％至约13.65重量％的含胺聚合物组分。 第二组分包含浓度为约3重量％至约35重量％的亲水性聚合物或预聚物组分。 第三组分包含浓度为约0.1重量％至约30重量％的醛组分。 修复或补充椎间盘的髓核的方法包括将生物粘附性水凝胶组合物植入患者体内。

    BIOADHESIVE HYDROGELS
    4.
    发明申请
    BIOADHESIVE HYDROGELS 有权

    公开(公告)号：US20100286786A1

    公开(公告)日：2010-11-11

    申请号：US12812141

    申请日：2009-01-12

    申请人： Kristin B. Kita ,  Nigel G. Smith ,  Anthony M. Lowman ,  Garland W. Fussell

    发明人： Kristin B. Kita ,  Nigel G. Smith ,  Anthony M. Lowman ,  Garland W. Fussell

    IPC分类号： A61F2/44 ,  A61K31/785

    CPC分类号： A61L24/043 ,  A61L2430/38

    摘要： A method of forming and the resulting bioadhesive hydrogel composition for repairing or supplementing a nucleus pulposus of an intervertebral disc comprises at least a first component, a second component and a third component, wherein the first component, the second component and the third component are crosslinked. The first component comprises an amine-containing polymer component at a concentration from about 0.1% weight by weight to about 13.65% weight by weight. The second component comprises a hydrophilic polymer or pre-polymer component at a concentration from about 3% weight by weight to about 35% weight by weight. The third component comprises an aldehyde component at a concentration from about 0.1% weight by weight to about 30% weight by weight. A method of repairing or supplementing a nucleus pulposus of an intervertebral disc comprises implanting the bioadhesive hydrogel composition in a patient.

    摘要翻译： 一种形成方法和所得到的用于修复或补充椎间盘髓核的生物粘附性水凝胶组合物包括至少第一组分，第二组分和第三组分，其中第一组分，第二组分和第三组分是交联的 。 第一组分包含浓度为约0.1重量％至约13.65重量％的含胺聚合物组分。 第二组分包含浓度为约3重量％至约35重量％的亲水性聚合物或预聚物组分。 第三组分包含浓度为约0.1重量％至约30重量％的醛组分。 修复或补充椎间盘的髓核的方法包括将生物粘附性水凝胶组合物植入患者体内。

    Phase transitioning hydrogels
    5.
    发明授权
    Phase transitioning hydrogels 有权
    相转移水凝胶

    公开(公告)号：US08703157B2

    公开(公告)日：2014-04-22

    申请号：US12994336

    申请日：2009-05-27

    申请人： Kristin B. Kita ,  Nigel G. Smith ,  Anthony M. Lowman ,  Garland W. Fussell ,  Michael F. Keane

    发明人： Kristin B. Kita ,  Nigel G. Smith ,  Anthony M. Lowman ,  Garland W. Fussell ,  Michael F. Keane

    IPC分类号： A61K9/00

    CPC分类号： C08L29/04 ,  A61L27/26 ,  A61L27/52 ,  A61L2400/06 ,  C08K3/30 ,  C08L39/06 ,  C08L71/02 ,  C08L2666/14 ,  C08L2666/02

    摘要： A method of forming and the resulting hydrogel composition comprising poly(vinyl alcohol) at a final concentration of about 20% (w/w) to about 65% (w/w) and polyethylene glycol at a final concentration of about 2% (w/w) to about 20% (w/w), wherein the hydrogel composition has a total polymer content, above about 30% (w/w), higher than the total polymer content of a precursor polymer solution formulated prior to the formulation of the hydrogel composition. The hydrogel composition may further comprise poly(vinyl pyrrolidone) at a final concentration of about 0.10% (w/w) to about 0.75% (w/w).

    摘要翻译： 一种形成方法，所得到的水凝胶组合物包含最终浓度为约20％（w / w）至约65％（w / w）的聚乙烯醇和最终浓度为约2％的聚乙二醇（w / w）至约20％（w / w），其中所述水凝胶组合物的总聚合物含量高于约30％（w / w），高于在配制之前配制的前体聚合物溶液的总聚合物含量 水凝胶组合物。 水凝胶组合物还可以包含最终浓度为约0.10％（w / w）至约0.75％（w / w）的聚（乙烯基吡咯烷酮）。

    CROSSLINKED HYDROGELS
    6.
    发明申请
    CROSSLINKED HYDROGELS 有权
    交联水晶

    公开(公告)号：US20100272672A1

    公开(公告)日：2010-10-28

    申请号：US12747411

    申请日：2008-12-16

    申请人： Kristin B. Kita ,  Nigel G. Smith ,  Anthony M. Lowman ,  Garland W. Fussell ,  Michael F. Keane

    发明人： Kristin B. Kita ,  Nigel G. Smith ,  Anthony M. Lowman ,  Garland W. Fussell ,  Michael F. Keane

    IPC分类号： A61K31/79 ,  A61K31/785 ,  A61P43/00

    CPC分类号： A61L27/16

    摘要： The present invention preferably provides for a method of forming and the resulting solid polymer gel composition comprising polyethylene imine and at least one hydrogen bonding polymer. The composition has a greater viscosity than either of the polyethylene imine or the hydrogen bonding polymer alone and is injectable immediately after mixing of the polyethylene imine and the at least one hydrogen bonding polymer. A method of tissue repair may include mixing about 9.25% (w/w) to about 13.65% (w/w) polyethylene imine and about 18.02% (w/w) to about 26.62% (w/w) polyvinyl alcohol to form an injectable composition; injecting the injectable composition into a cavity within a human body; and allowing the composition to solidify in situ. A kit may include a multi-barrel syringe at least one barrel is loaded with polyethylene imine and at least another barrel is loaded with at least one hydrogen bonding polymer.

    摘要翻译： 本发明优选提供一种形成方法和所得到的固体聚合物凝胶组合物，其包含聚乙烯亚胺和至少一种氢键聚合物。 该组合物比单独的聚乙烯亚胺或氢键聚合物具有更大的粘度，并且在聚乙烯亚胺和至少一种氢键聚合物混合后立即进行注射。 组织修复的方法可包括混合约9.25％（w / w）至约13.65％（w / w）的聚乙烯亚胺和约18.02％（w / w）至约26.62％（w / w）的聚乙烯醇，以形成 可注射组合物 将可注射组合物注射到人体内的空腔中; 并使组合物原位固化。 套件可以包括多桶注射器，至少一个桶装有聚乙烯亚胺，并且至少另一个筒装有至少一个氢键聚合物。

    BALLOON-ASSISTED ANNULUS REPAIR
    9.
    发明申请
    BALLOON-ASSISTED ANNULUS REPAIR 审中-公开
    气球辅助神经修复

    公开(公告)号：US20110153022A1

    公开(公告)日：2011-06-23

    申请号：US12994340

    申请日：2009-05-29

    申请人： Wamis Singhatat ,  Nigel G. Smith ,  Garland W. Fussell ,  Michael F. Keane ,  Anthony M. Lowman

    发明人： Wamis Singhatat ,  Nigel G. Smith ,  Garland W. Fussell ,  Michael F. Keane ,  Anthony M. Lowman

    IPC分类号： A61F2/44

    CPC分类号： A61F2/441 ,  A61F2002/30014 ,  A61F2002/3008 ,  A61F2002/30179 ,  A61F2002/30461 ,  A61F2002/30576 ,  A61F2002/30583 ,  A61F2002/30878 ,  A61F2002/4435

    摘要： The present invention is directed to an inflatable annulus repair device (10) for sealing an annulus defect located in an annulus fibrosis of an intervertebral disc space. In use, the inflatable device is introduced, in a first non-expanded state, preferably via a cannula (100) into the annulus defect. After the inflatable device has been properly positioned, a filler material (11) is injected into the inflatable device to expand the device to a second expanded state. In the second expanded state, the inflatable annulus repair device seals the annulus defect, secures its position within the annulus defect to thereby limit or prevent migration, and applies a compression force to a captured portion of the annulus adjacent to the defect. The inflatable device is preferably filled with a liquid that solidifies into an elastic material within the device.

    摘要翻译： 本发明涉及一种用于密封位于椎间盘空间的环状纤维化中的环带缺损的可充气环带修复装置（10）。 在使用中，充气装置以第一未膨胀状态优选通过插管（100）引入到环空缺陷中。 在充气装置被适当地定位之后，将填充材料（11）注入到充气装置中以使装置膨胀到第二膨胀状态。 在第二膨胀状态下，可充气环带修复装置密封环空缺陷，确保其在环空缺陷内的位置，从而限制或防止迁移，并将压缩力施加到与缺陷相邻的环的捕获部分。 充气装置优选地填充有在装置内固化成弹性材料的液体。