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公开(公告)号：US20130012913A1
公开(公告)日：2013-01-10
申请号：US13177613
申请日：2011-07-07
申请人： Valerie R. Binetti , Kristin B. Kita , Garland W. Fussell , Anthony M. Lowman , Michele S. Marcolongo
发明人： Valerie R. Binetti , Kristin B. Kita , Garland W. Fussell , Anthony M. Lowman , Michele S. Marcolongo
CPC分类号： A61L27/26 , A61F2/441 , A61F2002/30075 , A61L27/50 , A61L27/52 , A61L27/54 , A61L2300/44 , A61L2400/06 , A61L2430/38 , C08L29/04 , C08L71/02
摘要： An injectable hydrogel composition comprising: water; and poly(vinyl alcohol) chemically cross-linked with a second polymer to form a cross-linked resin, wherein the second polymer is selected from the group consisting of: a polyhydric alcohol compound, a polyvalent epoxy compound, a polyvalent amine compound, a dialdehyde compound, a diisocyanate compound, and mixtures thereof, wherein the cross-linked resin has a degree of cross-linking of from about 0.0001 mol/mL to about 0.002 mol/mL, and wherein the hydrogel is flowable when heated above its melting point.
摘要翻译： 一种可注射的水凝胶组合物，其包含：水; 和与第二聚合物化学交联以形成交联树脂的聚（乙烯醇），其中第二聚合物选自：多元醇化合物，多价环氧化合物，多价胺化合物， 二醛化合物，二异氰酸酯化合物及其混合物，其中所述交联树脂具有约0.0001mol / mL至约0.002mol / mL的交联度，并且其中当加热到高于其熔点时，所述水凝胶可流动 。
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公开(公告)号：US08617519B2
公开(公告)日：2013-12-31
申请号：US13177613
申请日：2011-07-07
申请人： Valerie R. Binetti , Kristin B. Kita , Garland W. Fussell , Anthony M. Lowman , Michele S. Marcolongo
发明人： Valerie R. Binetti , Kristin B. Kita , Garland W. Fussell , Anthony M. Lowman , Michele S. Marcolongo
CPC分类号： A61L27/26 , A61F2/441 , A61F2002/30075 , A61L27/50 , A61L27/52 , A61L27/54 , A61L2300/44 , A61L2400/06 , A61L2430/38 , C08L29/04 , C08L71/02
摘要： An injectable hydrogel composition comprising: water; and poly(vinyl alcohol) chemically cross-linked with a second polymer to form a cross-linked resin, wherein the second polymer is selected from the group consisting of: a polyhydric alcohol compound, a polyvalent epoxy compound, a polyvalent amine compound, a dialdehyde compound, a diisocyanate compound, and mixtures thereof, wherein the cross-linked resin has a degree of cross-linking of from about 0.0001 mol/mL to about 0.002 mol/mL, and wherein the hydrogel is flowable when heated above its melting point.
摘要翻译： 一种可注射的水凝胶组合物，其包含：水; 和与第二聚合物化学交联以形成交联树脂的聚（乙烯醇），其中第二聚合物选自：多元醇化合物，多价环氧化合物，多价胺化合物， 二醛化合物，二异氰酸酯化合物及其混合物，其中所述交联树脂具有约0.0001mol / mL至约0.002mol / mL的交联度，并且其中当加热到高于其熔点时，所述水凝胶可流动 。
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公开(公告)号：US09078953B2
公开(公告)日：2015-07-14
申请号：US12747411
申请日：2008-12-16
IPC分类号： A61K31/79 , A61K31/785 , A61P43/00 , A61L27/16
CPC分类号： A61L27/16
摘要： The present invention preferably provides for a method of forming and the resulting solid polymer gel composition comprising polyethylene imine and at least one hydrogen bonding polymer. The composition has a greater viscosity than either of the polyethylene imine or the hydrogen bonding polymer alone and is injectable immediately after mixing of the polyethylene imine and the at least one hydrogen bonding polymer. A method of tissue repair may include mixing about 9.25% (w/w) to about 13.65% (w/w) polyethylene imine and about 18.02% (w/w) to about 26.62% (w/w) polyvinyl alcohol to form an injectable composition; injecting the injectable composition into a cavity within a human body; and allowing the composition to solidify in situ. A kit may include a multi-barrel syringe at least one barrel is loaded with polyethylene imine and at least another barrel is loaded with at least one hydrogen bonding polymer.
摘要翻译： 本发明优选提供一种形成方法和所得到的固体聚合物凝胶组合物，其包含聚乙烯亚胺和至少一种氢键聚合物。 该组合物比单独的聚乙烯亚胺或氢键聚合物具有更大的粘度，并且在聚乙烯亚胺和至少一种氢键聚合物混合后立即进行注射。 组织修复的方法可包括混合约9.25％（w / w）至约13.65％（w / w）的聚乙烯亚胺和约18.02％（w / w）至约26.62％（w / w）的聚乙烯醇，以形成 可注射组合物 将可注射组合物注射到人体内的空腔中; 并使组合物原位固化。 套件可以包括多桶注射器，至少一个桶装有聚乙烯亚胺，并且至少另一个筒装有至少一个氢键聚合物。
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公开(公告)号：US20100286786A1
公开(公告)日：2010-11-11
申请号：US12812141
申请日：2009-01-12
IPC分类号： A61F2/44 , A61K31/785
CPC分类号： A61L24/043 , A61L2430/38
摘要： A method of forming and the resulting bioadhesive hydrogel composition for repairing or supplementing a nucleus pulposus of an intervertebral disc comprises at least a first component, a second component and a third component, wherein the first component, the second component and the third component are crosslinked. The first component comprises an amine-containing polymer component at a concentration from about 0.1% weight by weight to about 13.65% weight by weight. The second component comprises a hydrophilic polymer or pre-polymer component at a concentration from about 3% weight by weight to about 35% weight by weight. The third component comprises an aldehyde component at a concentration from about 0.1% weight by weight to about 30% weight by weight. A method of repairing or supplementing a nucleus pulposus of an intervertebral disc comprises implanting the bioadhesive hydrogel composition in a patient.
摘要翻译： 一种形成方法和所得到的用于修复或补充椎间盘髓核的生物粘附性水凝胶组合物包括至少第一组分，第二组分和第三组分，其中第一组分，第二组分和第三组分是交联的 。 第一组分包含浓度为约0.1重量％至约13.65重量％的含胺聚合物组分。 第二组分包含浓度为约3重量％至约35重量％的亲水性聚合物或预聚物组分。 第三组分包含浓度为约0.1重量％至约30重量％的醛组分。 修复或补充椎间盘的髓核的方法包括将生物粘附性水凝胶组合物植入患者体内。
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公开(公告)号：US08366778B2
公开(公告)日：2013-02-05
申请号：US12812141
申请日：2009-01-12
IPC分类号： A61F2/44
CPC分类号： A61L24/043 , A61L2430/38
摘要： A method of forming and the resulting bioadhesive hydrogel composition for repairing or supplementing a nucleus pulposus of an intervertebral disc comprises at least a first component, a second component and a third component, wherein the first component, the second component and the third component are crosslinked. The first component comprises an amine-containing polymer component at a concentration from about 0.1% weight by weight to about 13.65% weight by weight. The second component comprises a hydrophilic polymer or pre-polymer component at a concentration from about 3% weight by weight to about 35% weight by weight. The third component comprises an aldehyde component at a concentration from about 0.1% weight by weight to about 30% weight by weight. A method of repairing or supplementing a nucleus pulposus of an intervertebral disc comprises implanting the bioadhesive hydrogel composition in a patient.
摘要翻译： 一种形成方法和所得到的用于修复或补充椎间盘髓核的生物粘附性水凝胶组合物包括至少第一组分，第二组分和第三组分，其中第一组分，第二组分和第三组分是交联的 。 第一组分包含浓度为约0.1重量％至约13.65重量％的含胺聚合物组分。 第二组分包含浓度为约3重量％至约35重量％的亲水性聚合物或预聚物组分。 第三组分包含浓度为约0.1重量％至约30重量％的醛组分。 修复或补充椎间盘的髓核的方法包括将生物粘附性水凝胶组合物植入患者体内。
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公开(公告)号：US08703157B2
公开(公告)日：2014-04-22
申请号：US12994336
申请日：2009-05-27
IPC分类号： A61K9/00
CPC分类号： C08L29/04 , A61L27/26 , A61L27/52 , A61L2400/06 , C08K3/30 , C08L39/06 , C08L71/02 , C08L2666/14 , C08L2666/02
摘要： A method of forming and the resulting hydrogel composition comprising poly(vinyl alcohol) at a final concentration of about 20% (w/w) to about 65% (w/w) and polyethylene glycol at a final concentration of about 2% (w/w) to about 20% (w/w), wherein the hydrogel composition has a total polymer content, above about 30% (w/w), higher than the total polymer content of a precursor polymer solution formulated prior to the formulation of the hydrogel composition. The hydrogel composition may further comprise poly(vinyl pyrrolidone) at a final concentration of about 0.10% (w/w) to about 0.75% (w/w).
摘要翻译： 一种形成方法，所得到的水凝胶组合物包含最终浓度为约20％（w / w）至约65％（w / w）的聚乙烯醇和最终浓度为约2％的聚乙二醇（w / w）至约20％（w / w），其中所述水凝胶组合物的总聚合物含量高于约30％（w / w），高于在配制之前配制的前体聚合物溶液的总聚合物含量 水凝胶组合物。 水凝胶组合物还可以包含最终浓度为约0.10％（w / w）至约0.75％（w / w）的聚（乙烯基吡咯烷酮）。
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公开(公告)号：US20110270400A1
公开(公告)日：2011-11-03
申请号：US12994336
申请日：2009-05-27
CPC分类号： C08L29/04 , A61L27/26 , A61L27/52 , A61L2400/06 , C08K3/30 , C08L39/06 , C08L71/02 , C08L2666/14 , C08L2666/02
摘要： A method of forming and the resulting hydrogel composition comprising poly(vinyl alcohol) at a final concentration of about 20% (w/w) to about 65% (w/w) and polyethylene glycol at a final concentration of about 2% (w/w) to about 20% (w/w), wherein the hydrogel composition has a total polymer content, above about 30% (w/w), higher than the total polymer content of a precursor polymer solution formulated prior to the formulation of the hydrogel composition. The hydrogel composition may further comprise poly(vinyl pyrrolidone) at a fmal concentration of about 0.10% (w/w) to about 0.75% (w/w).
摘要翻译： 一种形成方法，所得到的水凝胶组合物包含最终浓度为约20％（w / w）至约65％（w / w）的聚乙烯醇和最终浓度为约2％的聚乙二醇（w / w）至约20％（w / w），其中所述水凝胶组合物的总聚合物含量高于约30％（w / w），高于在配制之前配制的前体聚合物溶液的总聚合物含量 水凝胶组合物。 水凝胶组合物还可以包含约0.10％（w / w）至约0.75％（w / w）的最高浓度的聚（乙烯基吡咯烷酮）。
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公开(公告)号：US20100272672A1
公开(公告)日：2010-10-28
申请号：US12747411
申请日：2008-12-16
IPC分类号： A61K31/79 , A61K31/785 , A61P43/00
CPC分类号： A61L27/16
摘要： The present invention preferably provides for a method of forming and the resulting solid polymer gel composition comprising polyethylene imine and at least one hydrogen bonding polymer. The composition has a greater viscosity than either of the polyethylene imine or the hydrogen bonding polymer alone and is injectable immediately after mixing of the polyethylene imine and the at least one hydrogen bonding polymer. A method of tissue repair may include mixing about 9.25% (w/w) to about 13.65% (w/w) polyethylene imine and about 18.02% (w/w) to about 26.62% (w/w) polyvinyl alcohol to form an injectable composition; injecting the injectable composition into a cavity within a human body; and allowing the composition to solidify in situ. A kit may include a multi-barrel syringe at least one barrel is loaded with polyethylene imine and at least another barrel is loaded with at least one hydrogen bonding polymer.
摘要翻译： 本发明优选提供一种形成方法和所得到的固体聚合物凝胶组合物，其包含聚乙烯亚胺和至少一种氢键聚合物。 该组合物比单独的聚乙烯亚胺或氢键聚合物具有更大的粘度，并且在聚乙烯亚胺和至少一种氢键聚合物混合后立即进行注射。 组织修复的方法可包括混合约9.25％（w / w）至约13.65％（w / w）的聚乙烯亚胺和约18.02％（w / w）至约26.62％（w / w）的聚乙烯醇，以形成 可注射组合物 将可注射组合物注射到人体内的空腔中; 并使组合物原位固化。 套件可以包括多桶注射器，至少一个桶装有聚乙烯亚胺，并且至少另一个筒装有至少一个氢键聚合物。
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公开(公告)号：US20110153022A1
公开(公告)日：2011-06-23
申请号：US12994340
申请日：2009-05-29
IPC分类号： A61F2/44
CPC分类号： A61F2/441 , A61F2002/30014 , A61F2002/3008 , A61F2002/30179 , A61F2002/30461 , A61F2002/30576 , A61F2002/30583 , A61F2002/30878 , A61F2002/4435
摘要： The present invention is directed to an inflatable annulus repair device (10) for sealing an annulus defect located in an annulus fibrosis of an intervertebral disc space. In use, the inflatable device is introduced, in a first non-expanded state, preferably via a cannula (100) into the annulus defect. After the inflatable device has been properly positioned, a filler material (11) is injected into the inflatable device to expand the device to a second expanded state. In the second expanded state, the inflatable annulus repair device seals the annulus defect, secures its position within the annulus defect to thereby limit or prevent migration, and applies a compression force to a captured portion of the annulus adjacent to the defect. The inflatable device is preferably filled with a liquid that solidifies into an elastic material within the device.
摘要翻译： 本发明涉及一种用于密封位于椎间盘空间的环状纤维化中的环带缺损的可充气环带修复装置（10）。 在使用中，充气装置以第一未膨胀状态优选通过插管（100）引入到环空缺陷中。 在充气装置被适当地定位之后，将填充材料（11）注入到充气装置中以使装置膨胀到第二膨胀状态。 在第二膨胀状态下，可充气环带修复装置密封环空缺陷，确保其在环空缺陷内的位置，从而限制或防止迁移，并将压缩力施加到与缺陷相邻的环的捕获部分。 充气装置优选地填充有在装置内固化成弹性材料的液体。
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公开(公告)号：US20100047437A1
公开(公告)日：2010-02-25
申请号：US12608565
申请日：2009-10-29
申请人： Edward Vresilovic , Michele S. Marcolongo , Anthony M. Lowman , Alastair J. T. Clemow , Michael F. Keane
发明人： Edward Vresilovic , Michele S. Marcolongo , Anthony M. Lowman , Alastair J. T. Clemow , Michael F. Keane
IPC分类号： A61L33/04
CPC分类号： A61L27/52 , A61F2/30767 , A61F2/441 , A61F2002/444
摘要： A prosthesis for replacing or supplementing a nucleus pulposus of an intervertebral disk is an expandable container having flexible walls, the container being adapted to be inserted into a central cavity of an intervertebral disk through a narrow cannula, and the flexible walls are made from a biocompatible hydrogel. A preferred hydrogel is a cryogel formed from an aqueous solution of poly(vinyl alcohol) and poly(vinyl pyrrolidone). The prosthesis may be prepared by dip-coating a mandrel with an aqueous solution of a hydrogel-forming polymer or mixture of such polymers, gelling the coated solution by chilling, and subjecting the gelled coating to a series of repeated freeze-thaw treatments. In use, the prosthesis is inserted into a central cavity of an intervertebral disk and filled with biocompatible material, e.g., a biocompatible liquid, a biocompatible polymer, and a biocompatible hydrogel, particularly a thermogelling hydrogel.
摘要翻译： 用于替换或补充椎间盘髓核的假体是具有柔性壁的可扩张容器，该容器适于通过狭窄的插管插入到椎间盘的中心空腔中，并且柔性壁由生物相容性 水凝胶。 优选的水凝胶是由聚（乙烯醇）和聚（乙烯基吡咯烷酮）的水溶液形成的冷冻凝胶。 假体可以通过用形成水凝胶的聚合物或这种聚合物的混合物的水溶液浸渍心轴来制备，通过冷却使涂覆的溶液凝胶化，并使凝胶涂层进行一系列重复的冻融处理。 在使用中，将假体插入到椎间盘的中心空腔中，并填充有生物相容性材料，例如生物相容性液体，生物相容性聚合物和生物相容性水凝胶，特别是热胶凝水凝胶。
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