公开(公告)号：US08475532B2

公开(公告)日：2013-07-02

申请号：US12942720

申请日：2010-11-09

Applicant: Edward Vresilovic ,  Michael Keane ,  Thomas Peter Schaer ,  Amy Arthur ,  Wamis Singhatat

Inventor： Edward Vresilovic ,  Michael Keane ,  Thomas Peter Schaer ,  Amy Arthur ,  Wamis Singhatat

IPC: A61F2/44

CPC classification number: A61F2/4657 ,  A61B2090/064 ,  A61F2/4611 ,  A61F2002/30075 ,  A61F2002/3009 ,  A61F2002/30235 ,  A61F2002/30581 ,  A61F2002/30617 ,  A61F2002/444 ,  A61F2002/4627 ,  A61F2002/4663 ,  A61F2002/4677 ,  A61F2002/4693 ,  A61F2002/4694 ,  A61F2210/0061 ,  A61F2230/0069 ,  A61F2250/0091 ,  A61F2250/0097

Abstract: An instrument for inserting an elongated hydrogel prosthesis into an intervertebral disc includes an insertion cannula that is inserted through the annulus fibrosus of an intervertebral disc to provide access to the nucleus region of the disc, an elongated hydrogel prosthesis packaged within a tubular container adapted to be coupled to a proximal end of the insertion cannula, and a source of fluid pressure adapted to be coupled to a proximal end of the tubular container. Auxiliary instruments for use in convenient insertion of the insertion cannula through the nucleus pulposus and providing for a complete and controlled passage of the hydrogel prosthesis through the insertion cannula are provided in a kit with the insertion cannula. A sizing apparatus for determining the volume of prosthesis to be inserted includes a catheter or cannula capable of being inserted through the insertion cannula into the nucleus region of the intervertebral disc and having at its distal end a balloon capable of being inflated within the intervertebral disc with a measurable volume of a fluid in order to determine the amount of hydrogel prosthesis to be injected.

Abstract translation: 用于将细长水凝胶假体插入椎间盘的器械包括插入插入穿过椎间盘纤维环的插入套管，以提供进入椎间盘的细胞核区域的细长水凝胶假体， 耦合到插入套管的近端，以及适于联接到管状容器的近端的流体源的源。 用于通过髓核方便地插入插入插管并且通过插入套管提供水凝胶假体的完整和受控通道的辅助仪器在具有插入套管的套件中提供。 用于确定要插入的假体的体积的定径装置包括导管或套管，其能够穿过插入插管插入到椎间盘的细胞核区域中，并且在其远端具有能够在椎间盘内膨胀的气囊， 可测量体积的流体，以确定待注射的水凝胶假体的量。

公开(公告)号：US20110270400A1

公开(公告)日：2011-11-03

申请号：US12994336

申请日：2009-05-27

Applicant: Kristin B. Kita ,  Nigel G. Smith ,  Anthony M. Lowman ,  Garland W. Fussell ,  Michael Keane

Inventor： Kristin B. Kita ,  Nigel G. Smith ,  Anthony M. Lowman ,  Garland W. Fussell ,  Michael Keane

IPC: A61F2/44 ,  C08K3/30 ,  C08L29/04

CPC classification number: C08L29/04 ,  A61L27/26 ,  A61L27/52 ,  A61L2400/06 ,  C08K3/30 ,  C08L39/06 ,  C08L71/02 ,  C08L2666/14 ,  C08L2666/02

Abstract: A method of forming and the resulting hydrogel composition comprising poly(vinyl alcohol) at a final concentration of about 20% (w/w) to about 65% (w/w) and polyethylene glycol at a final concentration of about 2% (w/w) to about 20% (w/w), wherein the hydrogel composition has a total polymer content, above about 30% (w/w), higher than the total polymer content of a precursor polymer solution formulated prior to the formulation of the hydrogel composition. The hydrogel composition may further comprise poly(vinyl pyrrolidone) at a fmal concentration of about 0.10% (w/w) to about 0.75% (w/w).

Abstract translation: 一种形成方法，所得到的水凝胶组合物包含最终浓度为约20％（w / w）至约65％（w / w）的聚乙烯醇和最终浓度为约2％的聚乙二醇（w / w）至约20％（w / w），其中所述水凝胶组合物的总聚合物含量高于约30％（w / w），高于在配制之前配制的前体聚合物溶液的总聚合物含量 水凝胶组合物。 水凝胶组合物还可以包含约0.10％（w / w）至约0.75％（w / w）的最高浓度的聚（乙烯基吡咯烷酮）。

公开(公告)号：US20060100304A1

公开(公告)日：2006-05-11

申请号：US11134309

申请日：2005-05-23

Applicant: Edward Vresilovic ,  Michael Keane ,  Alastair Clemow ,  Nigel Smith

Inventor： Edward Vresilovic ,  Michael Keane ,  Alastair Clemow ,  Nigel Smith

IPC: A61F2/44 ,  A61F2/46 ,  A61B17/90 ,  A61F2/00 ,  A61B17/00 ,  A61L27/00

CPC classification number: A61F2/442 ,  A61B17/3468 ,  A61B17/3472 ,  A61F2/4611 ,  A61F2002/3008 ,  A61F2002/30242 ,  A61F2002/444 ,  A61F2002/4495 ,  A61F2002/4627 ,  A61F2230/0071 ,  A61F2250/0098 ,  A61L27/00 ,  A61L27/52

Abstract: A nucleus pulposus of an intervertebral disc is supplemented or replaced by an elongated, physiologically fully hydrated hydrogel prosthesis inserted into the central region of an intervertebral disc, where it can fold upon itself to form a prosthesis body within the central region of the annulus fibrosus. The hydrogel prosthesis may have expanded portions that assist in preventing expulsion of the prosthesis through the insertion aperture. An instrument for inserting the prosthesis has a cutter for severing the elongated prosthesis within the central region of the intervertebral disc after a sufficient amount has been implanted.

Abstract translation: 椎间盘的髓核由插入到椎间盘的中心区域中的细长的，生理上完全水合的水凝胶假体补充或代替，其中它可以折叠在其上以在纤维环的中心区域内形成假体。 水凝胶假体可以具有有助于防止假体通过插入孔排出的扩张部分。 用于插入假体的器具具有切割器，用于在已经植入足够数量之后切断椎间盘中心区域内的细长假体。

公开(公告)号：US10022122B2

公开(公告)日：2018-07-17

申请号：US12995758

申请日：2009-06-08

Applicant: Wamis Singhatat ,  James Talbot ,  Michael Keane ,  Brian Schmidt ,  Mark Reichen

Inventor： Wamis Singhatat ,  James Talbot ,  Michael Keane ,  Brian Schmidt ,  Mark Reichen

IPC: A61B17/04 ,  A61B17/00 ,  A61B17/08

Abstract: The present invention provides an apparatus for suture-based tissue repair, preferably for the annulus of a spinal disc, that includes a suture loop preferably pre-tied with a sliding knot, a clasp-type component that captures the ends of the suture loop, and an optional plug member that fills the tissue defect. Also disclosed is a method that places the suture loop in a full-thickness stitch encircling the tissue defect, secures the ends of the suture loop to the clasp, and cinches the suture loop to approximate the tissue without the need to tie knots. Also disclosed is a suture passer that enables a suture strand or loop to be passed through the tissue wall, captured, and retrieved. The suture passer may optionally incorporate a clasp in such an arrangement that enables a suture loop passed through the tissue wall to be captured directly by the clasp.

公开(公告)号：US08224178B2

公开(公告)日：2012-07-17

申请号：US11715049

申请日：2007-03-06

Applicant: Michael Keane ,  Trygve Duryea ,  Alex Robert Woods

Inventor： Michael Keane ,  Trygve Duryea ,  Alex Robert Woods

IPC: G03B19/00 ,  H04N7/14 ,  H04N11/00

CPC classification number: H04N5/232 ,  H04N1/00204 ,  H04N1/00244 ,  H04N1/00307 ,  H04N1/2112 ,  H04N1/32128 ,  H04N2101/00 ,  H04N2201/0039 ,  H04N2201/0055 ,  H04N2201/0084 ,  H04N2201/3226 ,  H04N2201/3253 ,  H04N2201/3266

Abstract: In accordance with the present invention, a system and method for effectively performing a streamlined photo distribution procedure is disclosed. A source device initially captures a photographic image of a target or subject using known techniques. The term “photographic image” as used herein is not limited to single photographs but includes moving pictures, video images and any other known or future means of capturing an image of an event. The source device is likewise broadly defined and includes, but is not limited to, digital cameras, video cameras, cell phones with digital photo capture means, computers, including PDA's or other devices or combination of devices with communication and photo capture means, as well as other image capture means.

Abstract translation: 根据本发明，公开了一种有效执行流线型照片分发程序的系统和方法。 源设备使用已知技术最初捕获目标或对象的摄影图像。 本文所用的术语“摄影图像”不限于单张照片，而是包括运动图像，视频图像以及捕获事件图像的任何其它已知或未来的方法。 源设备同样被广泛地定义，并且包括但不限于数字照相机，摄像机，具有数字照片捕捉装置的手机，包括PDA或其他设备的计算机或者具有通信和照片捕捉装置的设备的组合，以及 作为其他图像捕获手段。

公开(公告)号：US07850730B2

公开(公告)日：2010-12-14

申请号：US11391245

申请日：2006-03-29

Applicant: Edward Vresilovic ,  Michael Keane ,  Thomas Peter Schaer ,  Amy Arthur ,  Wamis Singhatat

Inventor： Edward Vresilovic ,  Michael Keane ,  Thomas Peter Schaer ,  Amy Arthur ,  Wamis Singhatat

IPC: A61F2/44

CPC classification number: A61F2/4657 ,  A61B2090/064 ,  A61F2/4611 ,  A61F2002/30075 ,  A61F2002/3009 ,  A61F2002/30235 ,  A61F2002/30581 ,  A61F2002/30617 ,  A61F2002/444 ,  A61F2002/4627 ,  A61F2002/4663 ,  A61F2002/4677 ,  A61F2002/4693 ,  A61F2002/4694 ,  A61F2210/0061 ,  A61F2230/0069 ,  A61F2250/0091 ,  A61F2250/0097

Abstract: An instrument for inserting an elongated hydrogel prosthesis into an intervertebral disc includes an insertion cannula that is inserted through the annulus fibrosus of an intervertebral disc to provide access to the nucleus region of the disc, an elongated hydrogel prosthesis packaged within a tubular container adapted to be coupled to a proximal end of the insertion cannula, and a source of fluid pressure adapted to be coupled to a proximal end of the tubular container. Auxiliary instruments for use in convenient insertion of the insertion cannula through the nucleus pulposus and providing for a complete and controlled passage of the hydrogel prosthesis through the insertion cannula are provided in a kit with the insertion cannula. A sizing apparatus for determining the volume of prosthesis to be inserted includes a catheter or cannula capable of being inserted through the insertion cannula into the nucleus region of the intervertebral disc and having at its distal end a balloon capable of being inflated within the intervertebral disc with a measurable volume of a fluid in order to determine the amount of hydrogel prosthesis to be injected.

Abstract translation: 用于将细长水凝胶假体插入椎间盘的器械包括插入插入穿过椎间盘纤维环的插入套管，以提供进入椎间盘的细胞核区域的细长水凝胶假体， 耦合到插入套管的近端，以及适于联接到管状容器的近端的流体源的源。 用于通过髓核方便地插入插入插管并且通过插入套管提供水凝胶假体的完整和受控通道的辅助仪器在具有插入套管的套件中提供。 用于确定要插入的假体的体积的定径装置包括导管或套管，其能够穿过插入插管插入到椎间盘的细胞核区域中，并且在其远端具有能够在椎间盘内膨胀的气囊， 可测量体积的流体，以确定待注射的水凝胶假体的量。

公开(公告)号：US06274781B1

公开(公告)日：2001-08-14

申请号：US08146334

申请日：1993-11-01

Applicant: Paul S. Furmanek ,  David A. Glasscock ,  Michael Keane, Jr. ,  Barry A. Mahler ,  V. N. Mallikarjuna Rao

Inventor： Paul S. Furmanek ,  David A. Glasscock ,  Michael Keane, Jr. ,  Barry A. Mahler ,  V. N. Mallikarjuna Rao

IPC: C07C1708

CPC classification number: C07C19/10 ,  C07C17/206 ,  C07C19/12 ,  C07C19/08

Abstract: A process for producing difluoromethane is disclosed which includes the step of contacting a gaseous mixture containing CH2Cl2 and hydrogen fluoride with a catalyst containing a catalytically effective amount of trivalent chromium supported on a carbon having an ash content of less than 0.5 percent by weight, at a temperature of from about 180 ° C. to about 375° C. The catalyst and temperature conditions of this process allow the concurrent reaction CCl3CF3 with HF to form CCl2FCF3. CH2ClF and unreacted CH2Cl2, each of which may be recovered as an azeotrope with HF, may be recycled.

Abstract translation: 公开了一种制备二氟甲烷的方法，其包括使含有CH 2 Cl 2和氟化氢的气体混合物与含有催化有效量的三价铬的催化剂接触的步骤，所述催化有效量的三价铬负载在灰分含量小于0.5重量％的碳上， 温度为约180℃至约375℃。该方法的催化剂和温度条件允许同时使CCl 3 CF 3与HF反应形成CCl 2 FCF 3。 CH 2 ClF和未反应的CH 2 Cl 2，其各自可以与HF共沸回收，可以循环使用。

公开(公告)号：US08323293B2

公开(公告)日：2012-12-04

申请号：US12810986

申请日：2008-12-29

Applicant: Mickey Morgan ,  John Peloza ,  Randall Lee ,  Michael Keane ,  William Miller ,  James Talbot ,  Daniel Vennard ,  Josef Gabelberger

Inventor： Mickey Morgan ,  John Peloza ,  Randall Lee ,  Michael Keane ,  William Miller ,  James Talbot ,  Daniel Vennard ,  Josef Gabelberger

IPC: A61B17/56

CPC classification number: A61B17/0401 ,  A61B17/0642 ,  A61B17/70 ,  A61B17/846 ,  A61B17/863 ,  A61B17/8685 ,  A61B17/8695 ,  A61B17/8872 ,  A61B17/92 ,  A61B2017/0414 ,  A61B2017/044 ,  A61B2017/0448 ,  A61B2017/0647 ,  A61B2017/0648 ,  A61B2090/08021 ,  A61B2090/3983

Abstract: The present invention relates to a surgical method or procedure for securing a prosthesis to bone. More particularly, the present invention relates to (i) a surgical method or procedure for securing a low load bearing prosthesis such as, for example, an adhesion barrier, to a patient's bone, (ii) a tack or drive screw for securing the low load bearing prosthesis and (iii) associated instrumentation for driving the tack or drive screw into the patient's bone.

Abstract translation: 本发明涉及一种将假体固定在骨上的手术方法或程序。 更具体地，本发明涉及（i）用于将低负荷假体（例如粘合屏障）固定到患者骨骼的外科方法或程序，（ii）用于固定低位的固定或驱动螺钉 承载假体和（iii）用于将钉头或驱动螺钉驱动到患者骨骼中的相关仪器。

公开(公告)号：US20080279452A1

公开(公告)日：2008-11-13

申请号：US12058436

申请日：2008-03-28

Applicant: Michael Keane ,  James J. Saccacio

Inventor： Michael Keane ,  James J. Saccacio

IPC: G06K9/34

CPC classification number: G06F16/50 ,  G06F16/29

Abstract: A system for isolating an image of a target property provides a user interface apparatus for receiving a property identifier. A virtual tile retriever is provided for retrieving a set of virtual tiles from a source of virtual tile images using the property identifier. An image isolator provides for generating an isolated image of the target property from the set of virtual tiles. An output device provides for displaying said isolated image of the target property.

Abstract translation: 用于隔离目标属性的图像的系统提供用于接收属性标识符的用户界面装置。 虚拟瓦片检索器被提供用于使用属性标识符从虚拟瓦片图像的源中检索一组虚拟瓦片。 图像隔离器提供从该组虚拟瓦片生成目标属性的隔离图像。 输出设备提供用于显示目标属性的所述孤立图像。

公开(公告)号：US20060122704A1

公开(公告)日：2006-06-08

申请号：US11189753

申请日：2005-07-27

Applicant: Edward Vresilovic ,  Michael Keane ,  Thomas Schaer

Inventor： Edward Vresilovic ,  Michael Keane ,  Thomas Schaer

IPC: A61F2/44

CPC classification number: A61F2/442 ,  A61B17/86 ,  A61F2/28 ,  A61F2/4611 ,  A61F2002/2839 ,  A61F2002/30224 ,  A61F2002/30242 ,  A61F2002/444 ,  A61F2002/4445 ,  A61F2002/4627 ,  A61F2002/4631 ,  A61F2230/0069 ,  A61F2230/0071

Abstract: A degenerated nucleus pulposus located in a central core region of an intervertebral disc within the annulus fibrosus is supplemented or replaced by a method wherein an amount of a biocompatible material is introduced into the central core region by a process including the steps of 1) forming a channel through a vertebral body adjacent to said intervertebral disc, extending from an exterior surface of the vertebral body to the central core region of the annulus fibrosus; 2) introducing an amount of a biocompatible material through the channel into the central core region of the annulus fibrosus; 3) pressurizing the biocompatible material through the channel to a postsurgical pressure sufficient to alleviate symptoms caused by the degenerated nucleus pulposus; and 4) sealing the channel while maintaining the sufficient postsurgical pressure. After sealing the channel, a vertebroplasty may optionally be performed in the vertebra.

Abstract translation: 位于纤维环内的椎间盘的中心核心区域的退化的髓核被补充或替换，其中通过包括以下步骤的方法将生物相容性材料的量引入中心核心区域的方法包括以下步骤：1） 通过与所述椎间盘相邻的椎体从椎体的外表面延伸到纤维环的中心纤芯区域; 2）通过通道将一定量的生物相容性物质引入到纤维环的中心纤芯区域; 3）通过通道将生物相容性材料加压至足以减轻由退化的髓核引起的症状的术后压力; 和4）密封通道同时保持足够的术后压力。 在密封通道之后，椎骨成形术可以可选地在椎骨中进行。