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公开(公告)号：US20050266555A1
公开(公告)日：2005-12-01
申请号：US11172144
申请日：2005-06-30
申请人： Kuanghui Lu , Kevin Pang , Lee Rubin
发明人： Kuanghui Lu , Kevin Pang , Lee Rubin
CPC分类号： C12N5/0678 , C12N2501/01 , C12N2501/11 , C12N2501/115 , C12N2501/39 , C12N2501/70
摘要： The present invention relates to a substantially pure population of viable pancreatic progenitor cells, and methods for isolating such cells. The present invention further concerns certain therapeutic uses for such progenitor cells, and their progeny.
摘要翻译： 本发明涉及基本上纯的存活胰腺祖细胞群，以及分离这些细胞的方法。 本发明还涉及这些祖细胞及其后代的某些治疗用途。
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公开(公告)号：US07745216B2
公开(公告)日：2010-06-29
申请号：US10855676
申请日：2004-05-27
申请人： Kevin Pang , Kuanghui Lu
发明人： Kevin Pang , Kuanghui Lu
CPC分类号： A61K38/22 , A61K38/26 , A61K38/28 , G01N33/74 , G01N2333/645 , G01N2500/10 , A61K2300/00
摘要： The invention relates to methods for potentiating, enhancing or restoring glucose responsivity in pancreatic islets or cells. The methods can be used as therapies for diseases caused by, or coincident with, aberrant glucose metabolism, such as Type II Diabetes Mellitus.
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公开(公告)号：US07396809B1
公开(公告)日：2008-07-08
申请号：US09499526
申请日：2000-02-10
申请人： Kuanghui Lu , Kevin Pang
发明人： Kuanghui Lu , Kevin Pang
IPC分类号： C12N5/06 , A61K38/22 , C07K14/575
CPC分类号： A61K38/22 , A01K67/0275 , A01K2217/054 , A61K38/26 , A61K38/28 , G01N33/507 , A61K2300/00
摘要： The invention relates to methods for potentiating, enhancing or restoring glucose responsivity in pancreatic islets or cells. The methods can be used as therapies for diseases caused by, or coincident with, aberrant glucose metabolism, such as Type II Diabetes Mellitus.
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公开(公告)号：US06610535B1
公开(公告)日：2003-08-26
申请号：US09724632
申请日：2000-11-28
申请人： Kuanghui Lu , Kevin Pang , Lee Rubin
发明人： Kuanghui Lu , Kevin Pang , Lee Rubin
IPC分类号： C12N500
CPC分类号： C12N5/0676 , A61K35/12 , A61K48/00 , C12N5/0647 , C12N5/0678 , C12N2500/02 , C12N2500/34 , C12N2500/36 , C12N2501/01 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/12 , C12N2501/125 , C12N2501/148 , C12N2501/23 , C12N2501/26 , C12N2501/35 , C12N2501/39 , C12N2501/835 , C12N2510/02
摘要： The present invention relates to a substantially pure population of viable pancreatic progenitor cells, and methods for isolating such cells. The present invention further concerns certain therapeutic uses for such progenitor cells, and their progeny.
摘要翻译： 本发明涉及基本上纯的存活胰腺祖细胞群，以及分离这些细胞的方法。 本发明还涉及这些祖细胞及其后代的某些治疗用途。
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公开(公告)号：US07807641B2
公开(公告)日：2010-10-05
申请号：US11702776
申请日：2007-02-06
申请人： Kevin Pang , Kuanghui Lu
发明人： Kevin Pang , Kuanghui Lu
IPC分类号： A61K38/22 , C07K14/575
CPC分类号： A61K38/22 , A61K38/26 , A61K38/28 , G01N33/74 , G01N2333/645 , G01N2500/10 , A61K2300/00
摘要： The invention relates to methods for potentiating, enhancing or restoring glucose responsivity in pancreatic islets or cells. The methods can be used as therapies for diseases caused by, or coincident with, aberrant glucose metabolism, such as Type II Diabetes Mellitus.
摘要翻译： 本发明涉及在胰岛或细胞中增强，增强或恢复葡萄糖反应性的方法。 该方法可用作由异常葡萄糖代谢引起的疾病或与糖代谢异常相一致的疾病，如II型糖尿病。
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公开(公告)号：US20080188406A1
公开(公告)日：2008-08-07
申请号：US11702776
申请日：2007-02-06
申请人： Kevin Pang , Kuanghui Lu
发明人： Kevin Pang , Kuanghui Lu
CPC分类号： A61K38/22 , A61K38/26 , A61K38/28 , G01N33/74 , G01N2333/645 , G01N2500/10 , A61K2300/00
摘要： The invention relates to methods for potentiating, enhancing or restoring glucose responsivity in pancreatic islets or cells. The methods can be used as therapies for diseases caused by, or coincident with, aberrant glucose metabolism, such as Type II Diabetes Mellitus.
摘要翻译： 本发明涉及在胰岛或细胞中增强，增强或恢复葡萄糖反应性的方法。 该方法可用作由异常葡萄糖代谢引起的疾病或与糖代谢异常相一致的疾病，如II型糖尿病。
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公开(公告)号：US06946293B1
公开(公告)日：2005-09-20
申请号：US09635370
申请日：2000-08-09
申请人： Kuanghui Lu , Kevin Pang , Lee Rubin
发明人： Kuanghui Lu , Kevin Pang , Lee Rubin
CPC分类号： C12N5/0678 , C12N2501/01 , C12N2501/11 , C12N2501/115 , C12N2501/39 , C12N2501/70
摘要： The present invention relates to a substantially pure population of viable pancreatic progenitor cells, and methods for isolating such cells. The present invention further concerns certain therapeutic uses for such progenitor cells, and their progeny.
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公开(公告)号：US06326201B1
公开(公告)日：2001-12-04
申请号：US09499362
申请日：2000-02-10
申请人： Brenda Fung , Kevin Pang , David Kagan
发明人： Brenda Fung , Kevin Pang , David Kagan
IPC分类号： C12N502
CPC分类号： C12N5/0678 , A61K35/12 , C12N2500/36 , C12N2501/01 , C12N2501/11 , C12N2501/39 , Y02A50/471
摘要： The present invention relates to a substantially pure population of viable pancreatic progenitor cells, and methods for isolating such cells. The present invention further concerns certain therapeutic uses for such progenitor cells, and their progeny.
摘要翻译： 本发明涉及基本上纯的存活胰腺祖细胞群，以及分离这些细胞的方法。 本发明还涉及这些祖细胞及其后代的某些治疗用途。
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公开(公告)号：US07138492B2
公开(公告)日：2006-11-21
申请号：US09451939
申请日：1999-12-01
申请人： Ningning Miao , Monica Wang , Nagesh K. Mahanthappa , Ping Jin , Kevin Pang
发明人： Ningning Miao , Monica Wang , Nagesh K. Mahanthappa , Ping Jin , Kevin Pang
CPC分类号： A61K31/7076 , A61K31/00 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/553 , A61K38/1709 , A61K48/00 , C07K14/47
摘要： It is shown here that hedgehog proteins possess novel activities beyond phenotype specification. Using cultures derived from the embryonic day 14.5 (E14.5) rat ventral mesencephalon, we show that hedgehog is also trophic for dopaminergic neurons. Interestingly, hedgehog not only promotes dopaminergic neuron survival, but also promotes the survival of midbrain GABA-immunoreactive (GABA-ir) neurons.
摘要翻译： 这里显示，刺猬蛋白具有超出表型规范的新型活性。 使用来自胚胎第14.5（E14.5）大鼠腹侧中脑的培养物，我们显示刺猬也是营养多巴胺能神经元。 有趣的是，刺猬不仅促进多巴胺能神经元的存活，而且促进中脑GABA免疫反应（GABA-ir）神经元的存活。
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公开(公告)号：US20070048286A1
公开(公告)日：2007-03-01
申请号：US11586768
申请日：2006-10-25
申请人： Ningning Miao , Monica Wang , Nagesh Mahanthappa , Ping Jin , Kevin Pang
发明人： Ningning Miao , Monica Wang , Nagesh Mahanthappa , Ping Jin , Kevin Pang
CPC分类号： A61K31/7076 , A61K31/00 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/553 , A61K38/1709 , A61K48/00 , C07K14/47
摘要： It is shown here that hedgehog proteins possess novel activities beyond phenotype specification. Using cultures derived from the embryonic day 14.5 (E14.5) rat ventral mesencephalon, we show that hedgehog is also trophic for dopaminergic neurons. Interestingly, hedgehog not only promotes dopaminergic neuron survival, but also promotes the survival of midbrain GABA-immunoreactive (GABA-ir) neurons.
摘要翻译： 这里显示，刺猬蛋白具有超出表型规范的新型活性。 使用来自胚胎第14.5（E14.5）大鼠腹侧中脑的培养物，我们显示刺猬也是营养多巴胺能神经元。 有趣的是，刺猬不仅促进多巴胺能神经元的存活，而且促进中脑GABA免疫反应（GABA-ir）神经元的存活。
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