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    Bead-based radioimmunoassay
    1.
    发明申请
    Bead-based radioimmunoassay 审中-公开
    基于珠的放射免疫测定

    公开(公告)号：US20080124813A1

    公开(公告)日：2008-05-29

    申请号：US11985835

    申请日：2007-11-17

    申请人： Jaw-Kang Chang ,  Rong Ming Lyu

    发明人： Jaw-Kang Chang ,  Rong Ming Lyu

    IPC分类号： G01N33/543

    CPC分类号： G01N33/5432 ,  G01N33/54326 ,  G01N2333/645 ,  G01N2333/95

    摘要： A method of small volume bead-based radioimmunoassay which includes utilization of an immunoassay particle having a solid phase substrate linked to a target particle capture moiety which dissociably captures target particles in an immunoassay sample. Specifically, a bead linked to antibody which competitively dissociably captures target particles and labeled particles of an immunoassay sample in a small volume bead-based radioimmunoassay to allow determination of the concentration of target particles, the level of protease activity, or the level of protease inhibitor activity in such immunoassay samples.

    摘要翻译： 一种小体积珠基放射免疫测定方法，其包括使用具有与靶细胞捕获部分连接的固相底物的免疫测定颗粒，其在免疫测定样品中解离地捕获靶颗粒。 具体地，与抗体竞争性地分离捕获目标颗粒的珠粒和在小体积珠基放射免疫测定中的免疫测定样品的标记颗粒以允许测定靶颗粒的浓度，蛋白酶活性的水平或蛋白酶抑制剂的水平 在这种免疫测定样品中的活性。

    G protein coupled receptor protein, production and use thereof
    2.
    发明申请
    G protein coupled receptor protein, production and use thereof 审中-公开
    G蛋白偶联受体蛋白，其生产和使用

    公开(公告)号：US20030118586A1

    公开(公告)日：2003-06-26

    申请号：US10184426

    申请日：2002-06-28

    发明人： Shuji Hinuma ,  Ryo Fujii ,  Yuji Kawamata

    IPC分类号： A61K039/395 ,  G01N033/53 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06

    CPC分类号： C07K14/705 ,  A01K2217/05 ,  A01K2217/075 ,  G01N2333/5757 ,  G01N2333/595 ,  G01N2333/63 ,  G01N2333/645 ,  G01N2333/655 ,  G01N2333/726 ,  G01N2500/02 ,  G01N2500/04

    摘要： Rabbit gastropyrolic part smooth muscle-derived G protein coupled receptor proteins, partial peptides thereof; and DNAs containing said protein or partial peptide-encoding DNA are provided. The receptor protein and the DNA coding for said protein can be used for {circle over (1)} determination of ligands; {circle over (2)} acquisition of antibody and antiserum; {circle over (3)} construction of expression system for of a recombinant type receptor protein; {circle over (4)} development of the receptor binding assay system using said expression system and screening of the candidate compounds for pharmaceuticals; {circle over (5)} conducting a drug design based upon a comparison with structurally analogous ligands and receptors; {circle over (6)} preparation of probes and PCR primers for a gene diagnosis; {circle over (7)} preparation of transgenic animals; and {circle over (8)} preparation of model patient animals deficient in the receptor protein DNA. Elucidation of the structure and property of the G protein coupled receptor is particularly related to the development of unique pharmaceuticals which act on such a system.

    摘要翻译： 兔子胃部分平滑肌衍生的G蛋白偶联受体蛋白，其部分肽; 并提供含有所述蛋白质或部分肽编码DNA的DNA。 受体蛋白和编码所述蛋白质的DNA可以用于（循环（1个配体的测定; {循环（2次获得抗体和抗血清; {circle over（3构建重组型受体蛋白质的表达系统 ;（循环（使用所述表达系统的受体结合测定系统的4个开发和用于药物的候选化合物的筛选）;循环（5个基于与结构上类似的配体和受体的比较进行药物设计; 6制备用于基因诊断的探针和PCR引物;（循环（7个转基因动物的制备）和{循环（8个缺陷受体蛋白DNA的模型患者动物的制备），阐明G蛋白的结构和性质 偶联受体与作用于这种系统的独特药物的开发特别相关。

    IDENTIFYING DUCT CANCERS
    5.
    发明申请
    IDENTIFYING DUCT CANCERS 审中-公开
    识别死亡癌

    公开(公告)号：US20100093005A1

    公开(公告)日：2010-04-15

    申请号：US12514491

    申请日：2007-11-12

    申请人： Laurence J. Miller ,  Gregory M. Hayes

    发明人： Laurence J. Miller ,  Gregory M. Hayes

    IPC分类号： G01N33/574 ,  C07K16/18

    CPC分类号： G01N33/57438 ,  C07K16/303 ,  C07K2317/34 ,  G01N2333/645 ,  G01N2333/72

    摘要： This document relates to methods and materials involved in identifying mammals that are likely to have duct cancer. For example, this document provides methods and materials related to using the presence of a variant form of the secretin receptor in a mammal's blood to identify the mammal (e.g., human) as being likely to have duct cancer.

    摘要翻译： 本文件涉及识别可能患有导管癌的哺乳动物的方法和材料。 例如，该文献提供了与哺乳动物血液中使用分泌型胰岛素受体的变体形式的存在相关的方法和材料，以将哺乳动物（例如人）鉴定为可能具有导管癌。