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    Medium composition comprising neuropeptide Y for the generation, maintenance, prolonged undifferentiated growth of pluripotent stem cells and method of culturing pluripotent stem cell using the same
    2.
    发明授权
    Medium composition comprising neuropeptide Y for the generation, maintenance, prolonged undifferentiated growth of pluripotent stem cells and method of culturing pluripotent stem cell using the same 有权
    包含用于产生，维持，多能干细胞的长期未分化生长的神经肽Y的培养基组合物和使用其培养多能干细胞的方法

    公开(公告)号：US08628963B2

    公开(公告)日：2014-01-14

    申请号：US13378912

    申请日：2010-06-16

    申请人： Yee Sook Cho ,  Mi-Young Son

    发明人： Yee Sook Cho ,  Mi-Young Son

    IPC分类号： C12N5/00 ,  C12N5/02 ,  C12N5/071

    CPC分类号： C12N5/0606 ,  C12N5/0696 ,  C12N2501/15 ,  C12N2501/835

    摘要： The present invention relates to a medium composition comprising neuropeptide Y, effective for proliferation and maintenance of undifferentiated pluripotent stem cells, and a method for culturing undifferentiated pluripotent stem cells using the same. The present invention improves the culture conditions for undifferentiated pluripotent stem cells, and ultimately, the present invention can be effectively used for the development of large-scale culture systems, thereby acquiring clinically applicable pluripotent stem cells. Further, the present invention relates to a dedifferentiation medium composition comprising neuropeptide Y (NPY), and a method for inducing dedifferentiation (or reprogramming) using the same. The present invention improves the culture conditions for dedifferentiation and contributes to develop technology of producing clinically applicable induced pluripotent stem cells, thereby being used for the development of stem cell therapy.

    摘要翻译： 本发明涉及包含对未分化多能干细胞的增殖和维持有效的神经肽Y的培养基组合物，以及使用该组合物培养未分化多能干细胞的方法。 本发明改善了未分化多能干细胞的培养条件，最终本发明可有效地用于大规模培养系统的开发，从而获得临床适用的多能干细胞。 此外，本发明涉及包含神经肽Y（NPY）的去分化培养基组合物和使用其的诱导去分化（或重编程）的方法。 本发明改善去分化的培养条件，有助于开发临床应用的诱导多能干细胞的生产技术，从而用于干细胞治疗的发展。

    MEDIUM COMPOSITION COMPRISING NEUROPEPTIDE Y FOR THE GENERATION, MAINTENANCE, PROLONGED UNDIFFERENTIATED GROWTH OF PLURIPOTENT STEM CELLS AND METHOD OF CULTURING PLURIPOTENT STEM CELL USING THE SAME
    3.
    发明申请
    MEDIUM COMPOSITION COMPRISING NEUROPEPTIDE Y FOR THE GENERATION, MAINTENANCE, PROLONGED UNDIFFERENTIATED GROWTH OF PLURIPOTENT STEM CELLS AND METHOD OF CULTURING PLURIPOTENT STEM CELL USING THE SAME 有权
    包含神经元Y的中成组合物用于产生，维持，扩大的PLUIPOTETE STEM细胞的不成熟生长以及使用该培养基的培养细胞干细胞的方法

    公开(公告)号：US20120171766A1

    公开(公告)日：2012-07-05

    申请号：US13378912

    申请日：2010-06-16

    申请人： Yee Sook Cho ,  Mi-Young Son

    发明人： Yee Sook Cho ,  Mi-Young Son

    IPC分类号： C12N5/071 ,  C12N5/0735 ,  C12N5/02

    CPC分类号： C12N5/0606 ,  C12N5/0696 ,  C12N2501/15 ,  C12N2501/835

    摘要： The present invention relates to a medium composition comprising neuropeptide Y, effective for proliferation and maintenance of undifferentiated pluripotent stem cells, and a method for culturing undifferentiated pluripotent stem cells using the same. The present invention improves the culture conditions for undifferentiated pluripotent stem cells, and ultimately, the present invention can be effectively used for the development of large-scale culture systems, thereby acquiring clinically applicable pluripotent stem cells. Further, the present invention relates to a dedifferentiation medium composition comprising neuropeptide Y (NPY), and a method for inducing dedifferentiation (or reprogramming) using the same. The present invention improves the culture conditions for dedifferentiation and contributes to develop technology of producing clinically applicable induced pluripotent stem cells, thereby being used for the development of stem cell therapy.

    摘要翻译： 本发明涉及包含对未分化多能干细胞的增殖和维持有效的神经肽Y的培养基组合物，以及使用该组合物培养未分化多能干细胞的方法。 本发明改善了未分化多能干细胞的培养条件，最终本发明可有效地用于大规模培养系统的开发，从而获得临床适用的多能干细胞。 此外，本发明涉及包含神经肽Y（NPY）的去分化培养基组合物和使用其的诱导去分化（或重编程）的方法。 本发明改善去分化的培养条件，有助于开发临床应用的诱导多能干细胞的生产技术，从而用于干细胞治疗的发展。