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公开(公告)号:US12127993B1
公开(公告)日:2024-10-29
申请号:US18591244
申请日:2024-02-29
申请人: Kun Peng , Yong Liang , Liquan Shen
发明人: Kun Peng , Yong Liang , Liquan Shen
CPC分类号: A61H19/44 , A61H23/0254 , A61H2201/0153 , A61H2201/169 , A61H2201/5007 , A61H2201/5025
摘要: A massager includes a massager main body, a driving source, a vibrating piece, and a vibrating assembly. The massager main body includes an installing portion and a massage portion connected to each other. The installing portion defines an installing cavity. The massage portion defines an accommodating cavity. The driving source is installed in the installing cavity. A first end of the vibrating piece is connected to the driving source and is driven to vibrate. A second end of the vibrating piece extends out of the installing cavity and is located on one side of the massage portion. The vibrating assembly is installed in the accommodating cavity and enables the massage portion to vibrate. The massage portion and the vibrating piece extend into a human body cavity and massage the human body cavity. A length of the vibrating piece is less than a length of the massage portion.
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公开(公告)号:USD549362S1
公开(公告)日:2007-08-21
申请号:US29277503
申请日:2007-02-28
申请人: Ernest Kin Man To , Kun Peng , Jiali Xu
设计人: Ernest Kin Man To , Kun Peng , Jiali Xu
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公开(公告)号:USD549361S1
公开(公告)日:2007-08-21
申请号:US29277502
申请日:2007-02-28
申请人: Ernest Kin Man To , Kun Peng , Jiali Xu
设计人: Ernest Kin Man To , Kun Peng , Jiali Xu
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公开(公告)号:US08129434B2
公开(公告)日:2012-03-06
申请号:US12333190
申请日:2008-12-11
申请人: Yuanwei Chen , Kun Peng , Lili Zhang , Binhua Lv , Baihua Xu , Jiajia Dong , Jiyan Du , Yan Feng , Ge Xu , Vasanthakumar Rajappan , Brian Seed
发明人: Yuanwei Chen , Kun Peng , Lili Zhang , Binhua Lv , Baihua Xu , Jiajia Dong , Jiyan Du , Yan Feng , Ge Xu , Vasanthakumar Rajappan , Brian Seed
IPC分类号: A61K31/015 , C07C15/12
CPC分类号: C07H7/04
摘要: Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译: 提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。 本发明还提供药物组合物,制备化合物的方法,合成中间体,以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。
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公开(公告)号:USD842845S1
公开(公告)日:2019-03-12
申请号:US29614505
申请日:2017-08-21
申请人: Cong Lin , Kun Peng , Fuquan Liu , Xinke Lyu
设计人: Cong Lin , Kun Peng , Fuquan Liu , Xinke Lyu
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公开(公告)号:US20100063141A1
公开(公告)日:2010-03-11
申请号:US12503384
申请日:2009-07-15
申请人: Brian Seed , Binhua LV , Jacques Y. Roberge , Yuanwei Chen , Kun Peng , Jiajia Dong , Baihua Xu , Jiyan Du , Lili Zhang , Xinxing Tang , Ge Xu , Yan Feng , Min Xu
发明人: Brian Seed , Binhua LV , Jacques Y. Roberge , Yuanwei Chen , Kun Peng , Jiajia Dong , Baihua Xu , Jiyan Du , Lili Zhang , Xinxing Tang , Ge Xu , Yan Feng , Min Xu
IPC分类号: A61K31/35 , C07D315/00 , C07C15/16
CPC分类号: A61K45/06 , A61K31/35 , C07D309/10 , A61K2300/00
摘要: Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions that are affected by SGLT inhibition.
摘要翻译: 提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。 本发明还提供药物组合物,制备化合物的方法,合成中间体,以及独立地或与其它治疗剂组合使用该化合物用于治疗受SGLT抑制影响的疾病和病症的方法。
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公开(公告)号:US09061060B2
公开(公告)日:2015-06-23
申请号:US12503384
申请日:2009-07-15
申请人: Brian Seed , Binhua Lv , Jacques Y. Roberge , Yuanwei Chen , Kun Peng , Jiajia Dong , Baihua Xu , Jiyan Du , Lili Zhang , Xinxing Tang , Ge Xu , Yan Feng , Min Xu
发明人: Brian Seed , Binhua Lv , Jacques Y. Roberge , Yuanwei Chen , Kun Peng , Jiajia Dong , Baihua Xu , Jiyan Du , Lili Zhang , Xinxing Tang , Ge Xu , Yan Feng , Min Xu
IPC分类号: A01N43/16 , A61K31/35 , C07D315/00 , A61K45/06 , C07D309/10
CPC分类号: A61K45/06 , A61K31/35 , C07D309/10 , A61K2300/00
摘要: Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions that are affected by SGLT inhibition.
摘要翻译: 提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。 本发明还提供药物组合物,制备化合物的方法,合成中间体,以及独立地或与其它治疗剂组合使用该化合物用于治疗受SGLT抑制影响的疾病和病症的方法。
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公开(公告)号:US20090156516A1
公开(公告)日:2009-06-18
申请号:US12333190
申请日:2008-12-11
申请人: Yuanwei Chen , Kun Peng , Lili Zhang , Binhua Lv , Baihua Xu , Jiajia Dong , Jiyan Du , Yan Feng , Ge Xu , Vasanthakumar Rajappan , Brian Seed
发明人: Yuanwei Chen , Kun Peng , Lili Zhang , Binhua Lv , Baihua Xu , Jiajia Dong , Jiyan Du , Yan Feng , Ge Xu , Vasanthakumar Rajappan , Brian Seed
IPC分类号: A61K31/7034 , C07H7/04 , A61P3/10
CPC分类号: C07H7/04
摘要: Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译: 提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。 本发明还提供药物组合物,制备化合物的方法,合成中间体,以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。
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公开(公告)号:US20080294396A1
公开(公告)日:2008-11-27
申请号:US12052677
申请日:2008-03-20
申请人: Shingchi Hsu , Kun Peng , James Stephens
发明人: Shingchi Hsu , Kun Peng , James Stephens
IPC分类号: G06F17/50
CPC分类号: G06F17/50
摘要: A system, method, and computer program for design validation, comprising defining a plurality of requirements; extracting said plurality of requirements; comparing a design against said plurality of requirements; and reporting a result of said comparison, and appropriate means and computer-readable instructions.
摘要翻译: 一种用于设计验证的系统,方法和计算机程序,包括定义多个要求; 提取所述多个要求; 将设计与所述多个要求进行比较; 并报告所述比较的结果,以及适当的手段和计算机可读指令。
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公开(公告)号:US07202043B2
公开(公告)日:2007-04-10
申请号:US11244256
申请日:2005-10-04
申请人: Yun-Jung Choi , Kun Peng , Linda Kauffman , Rajendra Singh
发明人: Yun-Jung Choi , Kun Peng , Linda Kauffman , Rajendra Singh
IPC分类号: G01N33/53
CPC分类号: C12Q1/37 , G01N33/5005 , G01N33/567 , G01N2333/924 , G01N2333/976 , Y10S435/962 , Y10S435/963
摘要: Methods and reagents are provided for determining endocytosis, using a cell expressing an externally polypeptide labeled cell membrane receptor, and as a reagent an antibody to said label conjugated to a fragment of an enzyme fragment complementation pair. Compounds are tested for their effect on endocytosis by complexing the reagent with said cells, adding the test compound at any time in relation to the complexing, allowing any endocytosis to occur, proteolytically degrading external enzyme fragment, adding protease inhibitor and the complementary member of the enzyme fragment complementation pair and substrate. The product provides a detectable signal related to the amount of endocytosis that occurred. The method is readily automated as all steps can occur in a single vessel without separations and washings.
摘要翻译: 提供了用于确定内吞作用的方法和试剂,使用表达外部多肽标记的细胞膜受体的细胞,以及作为与所述酶标记片段互补对的片段缀合的所述标记的抗体作为试剂。 通过使试剂与所述细胞络合来测试化合物对内吞作用的影响,在任何时间加入测试化合物与复合相关,允许发生任何内吞作用,蛋白水解降解外部酶片段,加入蛋白酶抑制剂和补体成员 酶片段互补对和底物。 该产品提供与发生的胞吞作用量相关的可检测信号。 该方法易于自动化,因为所有步骤都可以发生在没有分离和洗涤的单个容器中。
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