公开(公告)号：US4326783A

公开(公告)日：1982-04-27

申请号：US247189

申请日：1981-03-24

申请人： Kunio Kawamura ,  Hiroshi Ueda

发明人： Kunio Kawamura ,  Hiroshi Ueda

IPC分类号： G03B13/36 ,  G02B7/08 ,  G02B7/09 ,  G03B19/12 ,  G03B3/10 ,  G03B7/08

CPC分类号： G03B19/12 ,  G02B7/08

摘要： A single lens reflex camera includes a vertical open topped U-shaped bracket mounted in the camera body below the pentaprism, a forwardly located lens mount separably coupled to an objective lens and pairs of links mutually pivoted between their ends connected between the bracket arms and corresponding edges of the lens mount to support the latter in a fixed orientation for linear longitudinal movement along the camera optical axis. A light tight collapsible conduit extends between the camera body and lens mounts and includes telescoping members with relatively slidable side and bottom walls and an accordian top wall. A rack carrying slide arm projects rearwardly from the lens mount and is engaged by a motor driven gear to longitudinally shift the lens mount. The motor is controlled manually or in response to a focus detecting device and the lens mount may be motor advanced and retracted or motor advanced and spring retracted. The lens diaphragm is automatically stopped down by a camera housed mechanism and diaphragm control information is transmitted from the lens mount to the camera body.

摘要翻译： 单镜头反光照相机包括安装在五棱镜下方的照相机主体中的垂直敞开的顶部U形支架，可分离地联接到物镜的前向位置的透镜架，以及在它们的端部之间相互枢转的成对的连接在支架臂和相应的 透镜座的边缘以固定方向支撑后者，以沿着照相机光轴的线性纵向移动。 一个不透光的可折叠导管延伸在照相机主体和透镜座之间，并且包括具有相对滑动的侧壁和底壁以及一个侧面顶壁的伸缩构件。 承载滑动臂的支架从透镜支架向后突出，并由电动机驱动的齿轮接合以纵向移动透镜支架。 电动机是手动控制的或响应于焦点检测装置，并且透镜支架可以是电动机前进和后退或电动机前进和弹簧缩回。 镜头光阑由照相机容纳机构自动停止，光阑控制信息从镜头座传送到相机主体。

公开(公告)号：US4322142A

公开(公告)日：1982-03-30

申请号：US227794

申请日：1981-01-23

申请人： Kunio Kawamura ,  Hiroshi Ueda

发明人： Kunio Kawamura ,  Hiroshi Ueda

IPC分类号： G03B7/28 ,  G02B7/28 ,  G02B7/30 ,  G03B7/099 ,  G03B7/0997 ,  G03B13/36 ,  G03B17/18 ,  G03B3/10 ,  G03B7/26

CPC分类号： G02B7/30 ,  G03B7/09972

摘要： An electrical shutter type TTL single-lens reflex camera, with a movable mirror diagonally located within the photographic optical path to project object light to a viewfinder system during object observation and retractable from the optical path during photographic exposure, incorporates a light measurement device with a first light measuring element arranged for average light measurement of the light reflected from the movable mirror during object observation, at least part of the movable mirror being made transparent, or of a half mirror, to divide the object light into reflected light and light projected through the plane of the mirror. A second light measuring element is located to carry out spot metering on an object from the light projected through the plane of the movable mirror during object observation. A third light measuring element is located to receive reflected object light from a shutter curtain surface and/or the film surface for selection of average light measurement and spot metering on the object during photographic exposure. A manually operable selector selectively connects either the first or second light measuring element to an exposure information indicating device. The third light measuring element is adapted to be changed from average light measurement or to spot metering and to provide respective outputs representative thereof, such that exposure control with average light measurement or spot metering is obtainable from an exposure control circuit responsive to either output of the third light measuring element. In response to the selection of the first light measuring element by the manually operable selector, the third light measuring element is changed over for average light measurement, and in response to the selection of the second light measuring element, the third light measuring element is changed over for spot metering.

摘要翻译： 一种电动快门式TTL单镜头反光相机，其具有对角位于摄影光路内的可移动镜，以在物体观察期间将物体光投射到取景器系统，并且在照相曝光期间可从光路缩回，并入有光测量装置 第一光测量元件，其被布置用于在物体观察期间从可移动镜反射的光的平均光测量，至少部分可移动镜被制成透明的或半透明的镜，以将物体光分成反射光和投射到的光 镜子的飞机。 第二个光测量元件位于在物体观察期间，通过可移动镜的平面投射的光进行物体上的点测光。 第三光测量元件被定位成接收来自快门帘表面和/或胶片表面的反射物体光，用于在照相曝光期间选择物体上的平均光测量和点测光。 手动操作的选择器选择性地将第一或第二光测量元件连接到曝光信息指示装置。 第三光测量元件适于从平均光测量或点测光改变，并提供代表其的相应输出，使得可以从曝光控制电路获得具有平均光测量或点测光的曝光控制，该曝光控制电路响应于 第三光测量元件。 响应于通过手动选择器选择第一光测量元件，第三光测量元件被切换以用于平均光测量，并且响应于第二光测量元件的选择，第三光测量元件被改变 结束点测光。

公开(公告)号：US4140380A

公开(公告)日：1979-02-20

申请号：US804290

申请日：1977-06-07

申请人： Hiroshi Ueda ,  Kunio Kawamura ,  Keiji Yamazaki

发明人： Hiroshi Ueda ,  Kunio Kawamura ,  Keiji Yamazaki

IPC分类号： G03B7/20 ,  G03B17/18 ,  G03B17/20

CPC分类号： G03B17/20

摘要： An exposure indicating device for single lens reflex cameras which are selectively settable to automatic aperture control or automatic shutter speed control modes includes an exchangeable lens which has first and second information transmitting members, and a diaphragm setting member settable to one of a number of manually set aperture positions and to an automatic aperture control position. The first transmitting member transmits to a first information receiving member, first information of the step-difference from a minimum to a preset f-number of the lens independently of the set position of the diaphragm setting member. The second transmitting member transmits to a second information receiving member, second information of a maximum f-number only when the diaphragm setting member is set to the automatic aperture control position. The second transmitting member also serves as a mode selection and scale selection member which switches the camera into the automatic aperture control mode and enables observation of an aperture scale within a finder view field when the diaphragm setting member is set to the automatic aperture control position. The second transmitting member also switches the camera into the automatic shutter speed control mode and enables observation of a shutter speed scale within the finder view field when the diaphragm setting member is set to any one of the manually set aperture positions. The first information thus received enables automatic shutter speed control, and indication of an automatically controlled shutter speed prior to a stopping-down operation. The first and second information thus received are composed with each other, only in the automatic aperture control mode, to generate information of the minimum f-number of the lens, which enables indication of an f-number corresponding to an automatically controlled aperture prior to the stopping-down operation.

摘要翻译： 可选地设置为自动光圈控制或自动快门速度控制模式的单镜头反光相机的曝光指示装置包括具有第一和第二信息传输部件的可更换镜头，以及可设置为多个手动设置 光圈位置和自动光圈控制位置。 第一发送部件独立于隔膜设定部件的设定位置，向第一信息接收部件发送步进差的最小信号到最小的预设f数。 第二发送部件仅在将光阑设定部件设定为自动光圈控制位置时，向第2信息接收部件发送最大f数的第2信息。 第二传送部件还用作模式选择和缩放选择部件，其将相机切换到自动光圈控制模式，并且当光阑设置部件被设置为自动光圈控制位置时，能够在取景器视场内观察光圈标尺。 第二发送构件还将相机切换到自动快门速度控制模式，并且当光阑设置部件被设置为手动设定的孔径位置中的任何一个时，能够观察取景器视野内的快门速度标尺。 如此接收到的第一个信息可以进行自动快门速度控制，并在停机操作之前指示自动控制的快门速度。 如此接收到的第一和第二信息仅在自动光圈控制模式下相互组合，以生成最小f数的信息，其能够指示对应于自动控制孔径之前的f数 停机操作。

公开(公告)号：US4168892A

公开(公告)日：1979-09-25

申请号：US857033

申请日：1977-12-02

申请人： Hiroshi Ueda ,  Kunio Kawamura

发明人： Hiroshi Ueda ,  Kunio Kawamura

IPC分类号： G03B7/081 ,  G03B7/20 ,  G03B17/20

CPC分类号： G03B7/20 ,  G03B7/087

摘要： A lens-exchangeable, single lens reflex camera of the TTL light measurement type, which is selectively settable to a shutter speed priority diaphragm automatic control mode, a diaphragm priority shutter speed automatic control mode, and a manual exposure control mode, includes a locking device arranged on a camera body for locking a diaphragm presetting member of an exchangeable lens at a specific position wherein indication of a f-number representative of an automatically controlled diaphragm aperture is allowed with a diaphragm of the exchangeable lens being held at its fully open aperture. An exposure mode change-over mechanism may be interlocked with the locking device such that the camera is set to the shutter speed priority diaphragm automatic control mode when the locking device is brought into its operative condition to lock the diaphragm presetting member at the specific position. The locking device can be brought into its inoperative condition to release the diaphragm presetting member by manipulation thereof, or in association with releasing of the exchangeable lens from its locked condition for removing the same from the camera body.

摘要翻译： 可选择地设置为快门速度优先光圈自动控制模式，光阑优先快门速度自动控制模式和手动曝光控制模式的可透镜交换的TTL光测量型单反相机，包括锁定装置 布置在照相机主体上，用于将可交换透镜的隔膜预置构件锁定在特定位置，其中表示可自动控制的光阑孔径的f数的指示允许可更换镜片的光阑保持在其完全打开的孔。 曝光模式切换机构可以与锁定装置互锁，使得当锁定装置进入其操作状态以将隔膜预置构件锁定在特定位置时，照相机被设置为快门速度优先光阑自动控制模式。 锁定装置可以进入其不工作状态，以通过操纵来释放隔膜预置构件，或者与可更换镜片从其锁定状态释放相关联，以将其从照相机主体移走。

公开(公告)号：US09023835B2

公开(公告)日：2015-05-05

申请号：US13390058

申请日：2010-08-09

申请人： Hiroshi Ueda

发明人： Hiroshi Ueda

IPC分类号： A61K38/22 ,  A61K45/06

CPC分类号： A61K38/2292 ,  A61K45/06 ,  A61K2300/00

摘要： The invention provides a method of ameliorating a blood-brain barrier disorder, as well as a method of treating a disease accompanied by a blood-brain barrier disorder and a method of treating a cerebral ischemic disease, by administering a prothymosin α, or a protein or polypeptide possessing the same function as the prothymosin α. The invention also provides polypeptides useful in the context of the aforesaid methods.

摘要翻译： 本发明提供一种改善血脑屏障障碍的方法，以及治疗伴有血脑屏障障碍的疾病的方法和治疗脑缺血疾病的方法，通过施用孕激素α或蛋白质 或具有与胸腺素α相同功能的多肽。 本发明还提供了在上述方法的上下文中有用的多肽。

公开(公告)号：US20130203738A1

公开(公告)日：2013-08-08

申请号：US13578230

申请日：2011-02-09

申请人： Yoshifumi Nishimura ,  Aritaka Nagadoi ,  Yuuka Hirao ,  Yoshio Goshima ,  Naoya Yamashita ,  Naoki Miyata ,  Takayoshi Suzuki ,  Ryuta Hiraishi ,  Hiroshi Ueda

发明人： Yoshifumi Nishimura ,  Aritaka Nagadoi ,  Yuuka Hirao ,  Yoshio Goshima ,  Naoya Yamashita ,  Naoki Miyata ,  Takayoshi Suzuki ,  Ryuta Hiraishi ,  Hiroshi Ueda

IPC分类号： C07D211/16 ,  C07D211/10 ,  C07D265/30 ,  C07D207/06 ,  C07D223/04 ,  C07D225/02 ,  C07D211/14 ,  C07C233/65

CPC分类号： C07D211/16 ,  A61K31/445 ,  C07C233/65 ,  C07C233/66 ,  C07C2601/14 ,  C07D207/06 ,  C07D211/10 ,  C07D211/14 ,  C07D211/96 ,  C07D223/04 ,  C07D225/02 ,  C07D265/30 ,  C07D295/192

摘要： The present invention identifies a compound which binds to the PAH1 domain of mSin3B that specifically binds to neural restrictive silencer factor NRSF, and uses the compound as a prophylactic and/or a therapeutic for diseases associated with abnormal expression of neural restrictive silencer factor NRSF/REST or abnormal expression of genes targeted by NRSF/REST, such as Huntington's disease, medulloblastoma and neuropathic pain.The present invention provides a pharmaceutical composition comprising a substance capable of binding to the PAH1 domain of mSin3B, e.g., a compound represented by the following formula (I), a pharmacologically acceptable salt thereof, or a pharmacologically acceptable ester thereof: wherein n represents 0 or 1; R1, R2, R3, R4 and R5 each independently represent a hydrogen atom, a hydrocarbon group or a functional group; Y represents a single bond, a carbonyl group, —CONH—, —NHCO— or a sulfonyl group; and Z represents a nitrogen-containing heterocyclic group which may have a substituent, an amino group which may have a hydrocarbon group or an aromatic hydrocarbon group, or a nitrogen and oxygen-containing heterocyclic group which may have a substituent.

摘要翻译： 本发明鉴定了与特异性结合神经限制性沉默因子NRSF的mSin3B的PAH1结构域结合的化合物，并且将该化合物用作与神经限制性消音因子NRSF / REST的异常表达相关的疾病的预防和/或治疗 或NRSF / REST靶向的基因异常表达，如亨廷顿氏病，成神经管细胞瘤和神经性疼痛。 本发明提供一种药物组合物，其包含能够结合mSin3B的PAH1结构域的物质，例如下式（I）表示的化合物，其药理学上可接受的盐或其药理学上可接受的酯：其中n表示0 或1; R1，R2，R3，R4和R5各自独立地表示氢原子，烃基或官能团; Y表示单键，羰基，-CONH-，-NHCO-或磺酰基; Z表示可以具有取代基的含氮杂环基，可以具有烃基或芳香族烃基的氨基或可以具有取代基的含氮和含氧杂环基。

公开(公告)号：US08411196B2

公开(公告)日：2013-04-02

申请号：US12095818

申请日：2006-11-30

申请人： Hiroshi Ueda ,  Kenichi Honjo ,  Naoto Yumiki ,  Toshio Makabe ,  Kenji Maeda ,  Kaoru Mokunaka ,  Kazuhiko Ishimaru

发明人： Hiroshi Ueda ,  Kenichi Honjo ,  Naoto Yumiki ,  Toshio Makabe ,  Kenji Maeda ,  Kaoru Mokunaka ,  Kazuhiko Ishimaru

IPC分类号： H04N5/232

CPC分类号： H04N5/23203 ,  G03B19/00 ,  G03B19/12 ,  H04N5/2254 ,  H04N5/23212 ,  H04N5/23245 ,  H04N5/23293 ,  H04N5/238

摘要： A digital camera of the present invention includes a microcomputer 110 having a live view mode controlling so that image data generated by a CMOS sensor 130 or image data obtained by subjecting the image data generated by the CMOS sensor 130 to predetermined processing is displayed on a liquid crystal monitor 150 as a moving image in real time, wherein when a release button 141 receives an instruction regarding start of an autofocus operation in a live view mode, the microcomputer 110 controls a movable mirror to enter an optical path to measure by an AF sensor 132, and thereafter, allow the movable mirror to retract from the optical path to return the digital camera to the live view mode. Due to this configuration, in a digital camera that includes a movable mirror and is capable of displaying a subject image in a live view through an electronic viewfinder, the operability thereof can be enhanced.

摘要翻译： 本发明的数码相机包括具有实时取景模式控制的微型计算机110，使得由CMOS传感器130生成的图像数据或通过对由CMOS传感器130生成的图像数据进行预定处理而获得的图像数据显示在液体 晶体监视器150作为运动图像实时地实现，其中当释放按钮141接收到关于在实时取景模式中的自动对焦操作的开始的指令时，微型计算机110控制可移动反射镜进入光学路径以由AF传感器 132，然后允许可移动镜从光路缩回以将数字照相机返回到实时取景模式。 由于这种结构，在包括可移动镜并且能够通过电子取景器在实时取景中显示被摄体图像的数码相机中，可以提高其可操作性。

公开(公告)号：US20120270338A1

公开(公告)日：2012-10-25

申请号：US13510105

申请日：2010-11-19

申请人： Hiroshi Ueda ,  Ryoji Abe ,  Masaki Ihara ,  Hiroaki Takagi

发明人： Hiroshi Ueda ,  Ryoji Abe ,  Masaki Ihara ,  Hiroaki Takagi

IPC分类号： G01N21/76 ,  C07K17/02

CPC分类号： G01N33/582 ,  A61K49/0058 ,  C07K16/18 ,  C07K16/44 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/92 ,  G01N21/6428 ,  G01N33/6857 ,  G01N2021/6439

摘要： An object is to provide an immunoassay method requiring neither a solid-phase immobilization step nor a washing step, enabling quick and simple quantitative measurement of a target substance in a liquid phase and capable of visualizing an antigen. Such an object is attained by measuring the concentration of a target antigen present in a test substance by sequentially performing a step (a) of bringing an antibody light-chain variable region polypeptide and an antibody heavy-chain variable region polypeptide labeled with a fluorescent dye into contact with an antigen in a test substance in a liquid phase; or bringing an antibody heavy-chain variable region polypeptide and an antibody light-chain variable region polypeptide labeled with a fluorescent dye into contact with an antigen in a test substance in a liquid phase; a step (b) of measuring the fluorescence intensity of the fluorescent dye; and a step (c) of computationally obtaining the level of the antigen contained in the test substance with reference to a positive correlation between the concentration of the antigen in a liquid phase and the fluorescence intensity of the fluorescent dye.

摘要翻译： 本发明的目的是提供一种不需要固相固定步骤和洗涤步骤的免疫测定方法，能够快速和简单地定量测定液相中的目标物质并能够使抗原呈现。 通过依次进行使荧光染料标记的抗体轻链可变区多肽和抗体重链可变区多肽的步骤（a），测定待测物质中存在的靶抗原的浓度， 与液相中测试物质中的抗原接触; 或使用荧光染料标记的抗体重链可变区多肽和抗体轻链可变区多肽与液相中的测试物质中的抗原接触; 测量荧光染料的荧光强度的步骤（b）; 和（c）参考在液相中的抗原浓度与荧光染料的荧光强度之间的正相关性来计算获得测试物质中含有的抗原水平的步骤（c）。

公开(公告)号：US08223263B2

公开(公告)日：2012-07-17

申请号：US12831001

申请日：2010-07-06

申请人： Hiroshi Ueda ,  Kenichi Honjo ,  Naoto Yumiki ,  Toshio Makabe ,  Kenji Maeda ,  Kaoru Mokunaka ,  Kazuhiko Ishimaru

发明人： Hiroshi Ueda ,  Kenichi Honjo ,  Naoto Yumiki ,  Toshio Makabe ,  Kenji Maeda ,  Kaoru Mokunaka ,  Kazuhiko Ishimaru

IPC分类号： H04N5/225

CPC分类号： H04N5/23203 ,  G03B19/00 ,  G03B19/12 ,  H04N5/2254 ,  H04N5/23212 ,  H04N5/23245 ,  H04N5/23293 ,  H04N5/238

摘要： A digital camera of the present invention includes a microcomputer 110 having a live view mode controlling so that image data generated by a CMOS sensor 133 or image data obtained by subjecting the image data generated by the CMOS sensor 133 to predetermined processing is displayed on a liquid crystal monitor 150 as a moving image in real time, wherein the microcomputer 110 controls so that, when the live view mode is set, the digital camera comes out of the live view mode, and setting information on the digital camera is displayed on the liquid crystal monitor 150, in accordance with the manipulation of the manipulation portion 140. Due to this configuration, in a digital camera that includes a movable mirror and is capable of displaying a subject image in a live view through an electronic viewfinder, the operability thereof can be enhanced.

公开(公告)号：US08077560B2

公开(公告)日：2011-12-13

申请号：US12608173

申请日：2009-10-29

申请人： Hiroshi Ueda ,  Motoshi Ito

发明人： Hiroshi Ueda ,  Motoshi Ito

IPC分类号： G11B7/00

CPC分类号： G11B27/105 ,  G11B7/00736 ,  G11B20/1217 ,  G11B27/329 ,  G11B2220/218 ,  G11B2220/2562

摘要： An additionally recordable information recording medium has a complicated management structure for managing an unrecorded area. Therefore, there are problems that it takes a long time for a disk to startup and it is difficult to build a recording/reproducing system. The additionally recordable information recording medium according to the present invention includes a simple data structure for managing a location information for a recorded area located at the rearmost location in a user data area. An additionally recordable apparatus according to the present invention also includes means for updating the location information of the recorded area so that the recorded area located at the rearmost location in the user data area is always managed.

摘要翻译： 另外可记录的信息记录介质具有用于管理未记录区域的复杂管理结构。 因此，存在磁盘启动需要很长时间并且难以构建记录/再现系统的问题。 根据本发明的另外可记录的信息记录介质包括用于管理位于用户数据区域中最后位置的记录区域的位置信息的简单数据结构。 根据本发明的另外可记录的装置还包括用于更新记录区域的位置信息的装置，使得位于用户数据区域中的最后位置的记录区域总是被管理。