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1.发明授权Peptide and formulations thereof inhibiting elevations of triglyceride levels in blood 失效肽及其制剂抑制血液中甘油三酯水平的升高
公开(公告)号：US5958885A
公开(公告)日：1999-09-28
申请号：US973539
申请日：1997-11-24
申请人： Kyoichi Kagawa , Hisako Matsutaka , Chizuko Fukuhama , Hiroaki Fujino , Masahiro Numata , Kazuhisa Honda , Toyoo Nakamura
发明人： Kyoichi Kagawa , Hisako Matsutaka , Chizuko Fukuhama , Hiroaki Fujino , Masahiro Numata , Kazuhisa Honda , Toyoo Nakamura
IPC分类号： A23K1/16 , A23L1/305 , A61K38/00 , A61P3/04 , A61P3/06 , C07K1/20 , C07K5/103 , C07K14/415 , C07K5/10 , C07K7/04
CPC分类号： C07K5/101 , A23K20/147 , A23L33/18 , A61K38/00 , Y10S514/909
摘要： The present invention relates to a peptide having an amino acid sequence of Val-Val-Tyr-Pro as well as an agent for inhibiting elevation of triglyceride levels in blood, a food for specified health use (the so-called physiologically functional food) and a feed comprising the above peptide as an active component. According to the present invention, a peptide inhibiting elevation of triglyceride levels in blood as well as an agent for inhibiting elevation of triglyceride levels in blood, a physiologically functional food and a feed, all comprising the peptide as an active component are obtained. With these products of the invention, it becomes possible to prevent or treat obesity and hyperlipemia of human and animals as well as circulatory system diseases such as hypertension and arteriosclerosis associated therewith. Furthermore, the materials of the invention make it possible to improve the meat quality of livestock and hatchery fish.
摘要翻译： PCT No.PCT / JP96 / 01570 Sec。 371日期：1997年11月24日 102（e）1997年11月24日PCT PCT 1996年6月10日PCT公布。 第WO97 / 35875号公报 日期：1997年10月2日本发明涉及具有Val-Val-Tyr-Pro的氨基酸序列的肽以及用于抑制血液中甘油三酯水平升高的药剂，用于特定健康用途的食物（所谓的 生理功能食品）和包含上述肽作为活性成分的饲料。 根据本发明，获得抑制血液中甘油三酯水平升高的肽以及抑制血液中甘油三酯水平升高的药剂，生理功能性食品和饲料，其全部包含肽作为活性成分。 利用本发明的这些产品，可以预防或治疗人类和动物的肥胖症和高脂血症以及与其相关的循环系统疾病如高血压和动脉硬化。 此外，本发明的材料可以提高牲畜和孵化场的肉质。
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公开(公告)号：US6046168A
公开(公告)日：2000-04-04
申请号：US981384
申请日：1997-12-23
申请人： Kyoichi Kagawa , Chizuko Fukuhama , Hisako Matsutaka , Toyoo Nakamura , Masahiro Numata , Shigeaki Watanabe , Kazuhisa Honda
发明人： Kyoichi Kagawa , Chizuko Fukuhama , Hisako Matsutaka , Toyoo Nakamura , Masahiro Numata , Shigeaki Watanabe , Kazuhisa Honda
IPC分类号： A23C9/152 , A23G1/00 , A23G1/42 , A23G1/44 , A23K1/16 , A23K1/18 , A23L1/305 , A61K38/00 , C07K5/083 , C07K5/08 , A61K38/06 , A61K38/08 , C07K7/06
CPC分类号： A23G1/44 , A23C9/1526 , A23G1/423 , A23K20/147 , A23K50/80 , A23L33/18 , C07K5/0808 , A61K38/00
摘要： The present invention relates to a peptide having the amino acid sequence shown in the sequence listing; an agent for inhibiting elevations of triglyceride levels in blood comprising the above peptide, a peptide Val-Tyr-Pro and/or a peptide Val-Thr-Leu as an active component; a food for specified health use which is endowed with a function of inhibiting elevations of triglyceride levels in blood by comprising these peptides as an active component; and a feed which is endowed with a function of inhibiting elevations of triglyceride levels in blood by comprising these peptides as an active component. According to the present invention, it becomes possible to prevent or treat obesity and hyperlipemia in humans and animals as well as cardiovascular diseases such as hypertension and arteriosclerosis associated therewith. Furthermore, it becomes possible to improve the meat quality of livestock and hatchery fish.
摘要翻译： PCT No.PCT / JP95 / 01264 Sec。 371 1997年12月23日第 102（e）日期1997年12月23日PCT提交1995年6月23日PCT公布。 第WO97 / 00890号公报 日期1997年1月9日本发明涉及具有序列表所示氨基酸序列的肽。 包含上述肽，肽Val-Tyr-Pro和/或肽Val-Thr-Leu作为活性成分的血液中甘油三酯水平升高的药剂; 具有通过包含这些肽作为活性组分而具有抑制血液中甘油三酯水平升高的功能的用于特定健康用途的食物; 以及具有通过包含这些肽作为活性成分而抑制血液中甘油三酯水平升高的功能的饲料。 根据本发明，可以预防或治疗人和动物中的肥胖症和高脂血症以及与其相关的心血管疾病如高血压和动脉硬化。 此外，可以提高牲畜和孵化场的鱼肉质量。
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3.发明授权
公开(公告)号：US5756467A
公开(公告)日：1998-05-26
申请号：US525515
申请日：1995-09-25
申请人： Kyoichi Kagawa , Chizuko Fukuhama , Hisako Matsutaka , Toru Iguchi , Toyoo Nakamura , Masahiro Numata , Shigeaki Watanabe
发明人： Kyoichi Kagawa , Chizuko Fukuhama , Hisako Matsutaka , Toru Iguchi , Toyoo Nakamura , Masahiro Numata , Shigeaki Watanabe
IPC分类号： A23C9/152 , A23G1/00 , A23G1/42 , A23G1/44 , A23K1/16 , A23K1/18 , A23L1/305 , A61K38/00 , A61P3/04 , A61P9/10 , A61P9/12 , A61P43/00 , C07K5/08 , C07K5/083
CPC分类号： A23G1/44 , A23C9/1526 , A23G1/423 , A23K20/147 , A23K50/80 , A23L33/18 , C07K5/0808 , A61K38/00
摘要： This invention aims to provide a peptide having an amino acid sequence of Val-Tyr-Pro or Val-Thr-Leu and having the ability to inhibit adipocyte differentiations, adipocyte differentiation inhibiting agent incorporating therein as an active component the peptide or a proteolysate characterized by containing not less than 0.1% by weight of the peptide, a specific health food, and a feed. This invention permits prevention and therapy of obesity and cardiovascular diseases attendant on obesity such as hypertension and arteriosclerosis in men and animals. It also allows improvement of the meat quality in domestic animals and culured fish.
摘要翻译： PCT No.PCT / JP94 / 00297 Sec。 371 1995年9月25日第 102（e）1995年9月25日PCT PCT 1994年2月24日PCT公布。 公开号WO94 / 21671 日期：1994年9月29日本发明旨在提供具有Val-Tyr-Pro或Val-Thr-Leu氨基酸序列的肽并具有抑制脂肪细胞分化能力的脂肪细胞分化抑制剂作为活性成分的肽 或蛋白水解物，其特征在于含有不少于0.1重量％的肽，特定保健食品和饲料。 本发明允许预防和治疗伴随着肥胖症的肥胖症和心血管疾病，例如男性和动物中的高血压和动脉硬化。 它还可以提高家畜和养鱼的肉质。
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公开(公告)号：US5707406A
公开(公告)日：1998-01-13
申请号：US791931
申请日：1997-01-29
申请人： Motohiko Asano , Masahiro Numata , Koji Okamoto , Takashi Goda
发明人： Motohiko Asano , Masahiro Numata , Koji Okamoto , Takashi Goda
CPC分类号： C01F7/50 , C01P2004/32 , C01P2004/52 , C01P2004/61
摘要： A method of manufacturing aluminum fluoride anhydride by means of a wet method. This method is featured in that a seed crystal of AlF.sub.3.3H.sub.2 O containing not more than 5% of fine particle 40 .mu.m or less in diameter is added into the super-saturated solution of aluminum fluoride in such a ratio that the total surface area of the seed crystal is in the range of 40-100 m.sup.2 per 1 kg of AlF.sub.3.3H.sub.2 O to be precipitated until an initial concentration of the super-saturated solution is reduced to 1.6%. The initial concentration of the super-saturated solution is adjusted to 8 to 15%. Resultant slurry is heated under agitation, thereby precipitating in batch-wise large AlF.sub.3.3H.sub.2 O particles which are then separated, dried and dehydrated.
摘要翻译： 一种通过湿法制造氟化铝酐的方法。 该方法的特征在于，将含有不超过5％的直径为40μm以下的微粒的5％以下的AlF 3·3H 2 O的晶种添加到氟化铝的超饱和溶液中， 籽晶在每1kg AlF 3·3H 2 O 40-100m 2的范围内进行沉淀，直到超饱和溶液的初始浓度降至1.6％。 将超饱和溶液的初始浓度调节至8〜15％。 在搅拌下加热所得浆料，分批沉淀出大量AlF3.3H2O颗粒，然后分离，干燥脱水。
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5.发明授权公开(公告)号：US07507428B2
公开(公告)日：2009-03-24
申请号：US11797543
申请日：2007-05-04
申请人： Masahiro Numata , Junichi Wakamatsu
发明人： Masahiro Numata , Junichi Wakamatsu
摘要： The present inventors found that a natural red pigment can be obtained from hemoglobin and myoglobin whose metalloporphyrin moiety is zinc protoporphyrin, and made meat products, whale meat products, fish meat products and fish paste products that were colored with the natural red pigment. Consequently, it was possible to obtain food products stable to oxidation and exhibiting an excellent color tone without the need to use a color fixative, e.g. nitrite.
摘要翻译： 本发明人发现天然红色素可以由金属卟啉部分为锌原卟啉的血红蛋白和肌红蛋白得到，并制成用天然红色素着色的肉制品，鲸鱼肉制品，鱼肉制品和鱼酱制品。 因此，可以获得对氧化稳定的食品，并且显示出优异的色调，而不需要使用固色剂，例如颜料固定剂。 亚硝酸盐
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6.发明申请公开(公告)号：US20070212458A1
公开(公告)日：2007-09-13
申请号：US11797543
申请日：2007-05-04
申请人： Masahiro Numata , Junichi Wakamatsu
发明人： Masahiro Numata , Junichi Wakamatsu
IPC分类号： A23L1/27
摘要： The present inventors found that a natural red pigment can be obtained from hemoglobin and myoglobin whose metalloporphyrin moiety is zinc protoporphyrin, and made meat products, whale meat products, fish meat products and fish paste products that were colored with the natural red pigment. Consequently, it was possible to obtain food products stable to oxidation and exhibiting an excellent color tone without the need to use a color fixative, e.g. nitrite.
摘要翻译： 本发明人发现天然红色素可以由金属卟啉部分为锌原卟啉的血红蛋白和肌红蛋白得到，并制成用天然红色素着色的肉制品，鲸鱼肉制品，鱼肉制品和鱼酱制品。 因此，可以获得对氧化稳定的食品，并且显示出优异的色调，而不需要使用固色剂，例如颜料固定剂。 亚硝酸盐
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7.发明申请公开(公告)号：US20050089607A1
公开(公告)日：2005-04-28
申请号：US10503338
申请日：2003-01-30
申请人： Masahiro Numata , Junichi Wakamatsu
发明人： Masahiro Numata , Junichi Wakamatsu
摘要： The present inventors found that a natural red pigment can be obtained from hemoglobin and myoglobin whose metalloporphyrin moiety is zinc protoporphyrin, and made meat products, whale meat products, fish meat products and fish paste products that were colored with the natural red pigment. Consequently, it was possible to obtain food products stable to oxidation and exhibiting an excellent color tone without the need to use a color fixative, e.g. nitrite.
摘要翻译： 本发明人发现天然红色素可以由金属卟啉部分为锌原卟啉的血红蛋白和肌红蛋白得到，并制成用天然红色素着色的肉制品，鲸鱼肉制品，鱼肉制品和鱼酱制品。 因此，可以获得对氧化稳定的食品，并且显示出优异的色调，而不需要使用固色剂，例如颜料固定剂。 亚硝酸盐
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公开(公告)号：US6080210A
公开(公告)日：2000-06-27
申请号：US970474
申请日：1997-11-14
申请人： Motohiko Asano , Toyohiro Nawata , Masahiro Numata , Koji Okamoto , Takashi Goda , Kazuyoshi Kamata
发明人： Motohiko Asano , Toyohiro Nawata , Masahiro Numata , Koji Okamoto , Takashi Goda , Kazuyoshi Kamata
CPC分类号： C01F7/50 , C01P2004/61 , C01P2006/20
摘要： A process for producing aluminum fluoride particles having a smooth surface, comprising the steps of adding aluminum fluoride seed crystals to a super-saturated solution of aluminium fluoride; allowing aluminum fluoride particles to be precipitated under heating and agitation; collecting the aluminium fluoride particles by filtration; and drying them, wherein: a super-saturated solution of aluminium fluoride containing 0.6 to 1.3 wt % of fluosilicic acid which is preferably obtained by reacting aluminum hydroxide with fluosilicic acid in an [Al(OH).sub.3 /H.sub.2 SiF.sub.6 ] molar ratio of 1.80 to 1.90 is used as the crystallization mother liquor.
摘要翻译： 一种具有光滑表面的氟化铝颗粒的制造方法，包括以下步骤：将氟化铝晶种添加到氟化铝的过饱和溶液中; 使氟化铝颗粒在加热和搅拌下沉淀; 过滤收集氟化铝颗粒; 并干燥，其中：含有0.6〜1.3重量％氟硅酸的过饱和溶液，其优选通过使氢氧化铝与[Al（OH）3 / H 2 SiF 6]摩尔比为1.80的氟硅酸与1.80的摩尔比反应 1.90用作结晶母液。
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