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    Furancarbonylguanidine derivatives, their preparation and pharmaceutical compositions containing them
    1.
    发明授权
    Furancarbonylguanidine derivatives, their preparation and pharmaceutical compositions containing them 失效
    呋喃羰基胍衍生物，其制备方法和含有它们的药物组合物

    公开(公告)号：US07351843B2

    公开(公告)日：2008-04-01

    申请号：US10581799

    申请日：2004-12-24

    申请人： Kyu Yang Yi ,  Sun Kyung Lee ,  Nak Jeong Kim ,  Jee Hee Suh ,  Soon Hee Hwang ,  Byung Ho Lee ,  Ho Won Seo ,  Sun Kyung Hwang ,  Sung Eun Yoo ,  Kyung Hee Lee

    发明人： Kyu Yang Yi ,  Sun Kyung Lee ,  Nak Jeong Kim ,  Jee Hee Suh ,  Soon Hee Hwang ,  Byung Ho Lee ,  Ho Won Seo ,  Sun Kyung Hwang ,  Sung Eun Yoo ,  Kyung Hee Lee

    IPC分类号： C07D307/02 ,  A61K31/34 ,  A01N43/08

    CPC分类号： C07D307/68

    摘要： The present invention relates to furancarbonylguanidine derivatives, a preparation method thereof and a pharmaceutical composition comprising the same.Furancarbonylguanidine derivatives of the present invention inhibit NHE-1 (sodium-hydrogen exchanger isoform 1), which helps recovery of heart function damaged from ischemia/reperfusion and decreases myocardial infarction rate, indicating that they have protective effect on myocardial cells. Thus, furancarbonylguanidine derivatives of the present invention can be effectively used for the prevention and the treatment of ischemic heart diseases such as myocardial infarction, arrhythmia, angina pectoris, etc, and also a promising candidate for a heart protecting agent applied to reperfusion therapy including thrombolytics or cardiac surgery including coronary artery bypass graft, percutaneous transluminal coronary angioplasty, etc.

    摘要翻译： 本发明涉及呋喃羰基胍衍生物，其制备方法和包含其的药物组合物。 本发明的呋喃羰基胍衍生物抑制NHE-1（钠氢交换异构体1），其有助于恢复从缺血/再灌注损伤的心脏功能，并降低心肌梗死率，表明它们对心肌细胞具有保护作用。 因此，本发明的呋喃羰基胍衍生物可以有效地用于预防和治疗心肌梗死，心律失常，心绞痛等缺血性心脏病，也是应用于再灌注治疗的心脏保护剂的有希望的候选物，包括溶栓剂 或心脏手术，包括冠状动脉旁路移植术，经皮腔内冠状动脉血管成形术等

    Benzopyran derivatives substituted with a thioxobenzoxazole derivative, pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containingthem
    6.
    发明申请
    Benzopyran derivatives substituted with a thioxobenzoxazole derivative, pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containingthem 失效
    被噻吩并恶唑衍生物取代的苯并吡喃衍生物，其药学上可接受的盐，其制剂和药物组合物

    公开(公告)号：US20070093481A1

    公开(公告)日：2007-04-26

    申请号：US10558111

    申请日：2004-05-28

    申请人： Sun Kyung Hwang

    发明人： Sun Kyung Hwang

    IPC分类号： A61K31/535 ,  C07D211/68 ,  C07D211/80 ,  C07D277/82 ,  C07D213/02

    CPC分类号： C07D413/04

    摘要： The present invention relates to benzopyran derivatives substituted with a thioxobenzoxazole derivative, or pharmaceutically acceptable salts thereof, processes for preparing the same and a pharmaceutical composition containing the above as an effective ingredient Benzopyran derivatives substituted with thioxobenzoxazole derivatives, represented in , have the function of protecting heart from ischemia-reperfusion both in vivo and in vitro, so that a pharmaceutical composition containing benzopyran derivatives substituted with thioxobenzoxoazole derivatives or pharmaceutically acceptable salts thereof of the present invention as an effective ingredient can be effectively used for the protection of tissues influenced by ischemia-reperfusion, for example, for the protection of heart, nervous cells, brain, retinal cells, storage organs, etc, and for the treatment of diseases caused by ischemia-reperfusion.

    摘要翻译： 本发明涉及用硫代苯并恶唑衍生物取代的苯并吡喃衍生物或其药学上可接受的盐，其制备方法和含有上述作为有效成分的药物组合物用<式1>所示的噻吩并恶唑衍生物取代的苯并吡喃衍生物具有 在体内和体外保护心脏免于缺血 - 再灌注的功能，使得含有本发明的噻唑并苯并恶唑衍生物或其可药用盐取代的苯并吡喃衍生物的药物组合物作为有效成分可以有效地用于保护组织 受缺血再灌注的影响，例如保护心脏，神经细胞，脑，视网膜细胞，储存器官等，以及治疗由局部缺血 - 再灌注引起的疾病。