Benzothiophen-2-carbonylguanidine derivatives, preparation thereof, and pharmaceutical composition containing the same
    1.
    发明申请
    Benzothiophen-2-carbonylguanidine derivatives, preparation thereof, and pharmaceutical composition containing the same 有权
    苯并噻吩-2-羰基胍衍生物及其制备方法和含有它们的药物组合物

    公开(公告)号:US20100004466A1

    公开(公告)日:2010-01-07

    申请号:US11794238

    申请日:2005-12-27

    IPC分类号: C07D333/54

    CPC分类号: C07D333/70

    摘要: The present invention is related to benzothiophen-2-carbonylguanidine derivatives, a preparation method thereof, and pharmaceutical compositions containing the same. The derivatives have potent inhibitory effect on the sodium/hydrogen exchanger NHE-I, improve the functional recovery of ischemia/reperfusion-induced heart injury in isolated ischemic heart models, and significantly reduce the myocardiac infarct size in in vivo ischemic animal models, thereby showing excellent cardioprotective effects. Also, the derivatives are protective of both neuronal cells and the brain as proven by their protective effects on neuronal cells from necrosis and apoptosis and by their ability to significantly reduce cerebral infarct sizes in in vivo ischemic brain models. The derivatives can be effectively used for the prevention and treatment of ischemic heart diseases such as myocardiac infarction, arrhythmia, angina pectoris and the like, and cerebrovascular diseases such as cerebral stroke and be used as cardioprotective agents to the patients undergoing reperfusion therapy including chemicals such as thrombolytic agents, or surgery such as coronary artery bypass and percutaneous transluminal coronary angioplasty.

    摘要翻译: 本发明涉及苯并噻吩-2-羰基胍衍生物,其制备方法和含有它们的药物组合物。 该衍生物对钠/氢交换器NHE-1具有有效的抑制作用,改善了分离缺血心脏模型缺血/再灌注诱导的心脏损伤的功能恢复,并显着降低了体内缺血动物模型中的心肌梗死面积,从而显示 良好的心脏保护作用。 此外,衍生物保护神经元细胞和脑,如通过其对来自坏死和凋亡的神经元细胞的保护作用以及通过其在体内缺血性脑模型中显着降低脑梗塞大小的能力所证明的。 该衍生物可以有效地用于预防和治疗心肌梗塞,心律失常,心绞痛等缺血性心脏病,脑血管疾病如脑卒中,并用作心脏保护剂,用于接受再灌注治疗的患者,包括化学药剂 作为溶栓剂,或手术如冠状动脉旁路和经皮腔内冠状动脉成形术。

    Wireless receiver for receiving multi-contents file and method for outputting data using the same
    2.
    发明授权
    Wireless receiver for receiving multi-contents file and method for outputting data using the same 有权
    用于接收多内容文件的无线接收器及使用其的数据输出方法

    公开(公告)号:US07519686B2

    公开(公告)日:2009-04-14

    申请号:US10448054

    申请日:2003-05-30

    IPC分类号: G06F13/00

    摘要: A wireless receiver for receiving a multi-contents file and a method for outputting data using the same, which can receive, navigation information for providing intuitively recognizable search interfaces to a user by radio in real time, receive various types of contents files by radio in real time, and output the received information and files through an AV device. A video decoder decodes a video stream on the basis of an MPEG standard. An audio decoder decodes an audio contents file. An OSD processor processes a text file and additional information. A video output unit selectively configures decoded video data and text data on one screen and performs encoding and outputting operations based on the format of a display unit. An audio output unit outputs decoded audio data. A user interface receives a user's command. A WLAN card communicates WLAN data with a computer system. A controller requests the computer system to transmit navigation screen information, at least one contents file or additional information of the contents file edited and processed by the computer system, analyzes a data stream received by radio from the computer system responsive to the request, and performs a control operation so that a result of the analysis is inputted into the decoder or OSD processor. A memory stores the stream and control program data.

    摘要翻译: 一种用于接收多内容文件的无线接收器和用于输出数据的方法,其可以通过无线电实时地接收用于向用户提供直观可识别的搜索接口的导航信息,通过无线电接收各种类型的内容文件 并通过AV设备输出收到的信息和文件。 视频解码器基于MPEG标准解码视频流。 音频解码器解码音频内容文件。 OSD处理器处理文本文件和附加信息。 视频输出单元在一个屏幕上选择性地配置解码的视频数据和文本数据,并且基于显示单元的格式执行编码和输出操作。 音频输出单元输出解码音频数据。 用户界面接收用户的命令。 WLAN卡与计算机系统通信WLAN数据。 控制器请求计算机系统发送导航屏幕信息,由计算机系统编辑和处理的至少一个内容文件或内容文件的附加信息,响应于该请求,从计算机系统分析由无线电接收的数据流,并执行 使得分析结果被输入到解码器或OSD处理器的控制操作。 存储器存储流和控制程序数据。

    Lightweight Silicone Implant and Manufacturing Method Thereof
    3.
    发明申请
    Lightweight Silicone Implant and Manufacturing Method Thereof 审中-公开
    轻质硅胶植入物及其制造方法

    公开(公告)号:US20080215149A1

    公开(公告)日:2008-09-04

    申请号:US11848120

    申请日:2007-08-30

    IPC分类号: A61F2/02

    CPC分类号: A61F2/12 A61F2/0059 A61F2/02

    摘要: Disclosed herein are a lightweight silicone implant which is manufactured by filling a foamed silicone sponge and/or vacant silicone capsules in a silicone bag or a cohesive gel bag and sealing the bag, and a method for manufacturing the same.

    摘要翻译: 本文公开了一种轻质硅树脂植入物,其通过在硅树脂袋或粘性凝胶袋中填充泡沫硅氧烷海绵和/或空的硅酮胶囊并密封袋而制造,及其制造方法。

    Furancarbonylguanidine derivatives, their preparation and pharmaceutical compositions containing them
    4.
    发明授权
    Furancarbonylguanidine derivatives, their preparation and pharmaceutical compositions containing them 失效
    呋喃羰基胍衍生物,其制备方法和含有它们的药物组合物

    公开(公告)号:US07351843B2

    公开(公告)日:2008-04-01

    申请号:US10581799

    申请日:2004-12-24

    CPC分类号: C07D307/68

    摘要: The present invention relates to furancarbonylguanidine derivatives, a preparation method thereof and a pharmaceutical composition comprising the same.Furancarbonylguanidine derivatives of the present invention inhibit NHE-1 (sodium-hydrogen exchanger isoform 1), which helps recovery of heart function damaged from ischemia/reperfusion and decreases myocardial infarction rate, indicating that they have protective effect on myocardial cells. Thus, furancarbonylguanidine derivatives of the present invention can be effectively used for the prevention and the treatment of ischemic heart diseases such as myocardial infarction, arrhythmia, angina pectoris, etc, and also a promising candidate for a heart protecting agent applied to reperfusion therapy including thrombolytics or cardiac surgery including coronary artery bypass graft, percutaneous transluminal coronary angioplasty, etc.

    摘要翻译: 本发明涉及呋喃羰基胍衍生物,其制备方法和包含其的药物组合物。 本发明的呋喃羰基胍衍生物抑制NHE-1(钠氢交换异构体1),其有助于恢复从缺血/再灌注损伤的心脏功能,并降低心肌梗死率,表明它们对心肌细胞具有保护作用。 因此,本发明的呋喃羰基胍衍生物可以有效地用于预防和治疗心肌梗死,心律失常,心绞痛等缺血性心脏病,也是应用于再灌注治疗的心脏保护剂的有希望的候选物,包括溶栓剂 或心脏手术,包括冠状动脉旁路移植术,经皮腔内冠状动脉血管成形术等

    Imidazole derivatives and processes for the preparation thereof
    6.
    发明授权
    Imidazole derivatives and processes for the preparation thereof 失效
    咪唑衍生物及其制备方法

    公开(公告)号:US5665738A

    公开(公告)日:1997-09-09

    申请号:US737563

    申请日:1996-11-13

    CPC分类号: C07D401/14

    摘要: Novel imidazole derivatives of formula(I) inhibit effectively the action of angiotensin II and have a superior antihypertensive activity: ##STR1## wherein: A is a straight, branched or cyclic C.sub.1 -C.sub.6 alkyl group, or OR.sub.1 wherein R.sub.1 is a hydrogen, or a straight, branched or cyclic C.sub.1 -C.sub.6 alkyl radical; B is a halogen, CF.sub.3 or CF.sub.2 CF.sub.3 ; X is N or N-oxide; Y is --CH.sub.2 --, --CH(OR.sub.1)-- wherein R.sub.1 is the same as defined above, or --C(.dbd.O)--; n is 0 or an integer of 1 to 4; Z is a halogen, --OH, --OR.sub.1, --NR.sub.1 R.sub.2, --N(.dbd.O)R.sub.3 R.sub.4, --C(.dbd.O)R.sub.1, --C(.dbd.O)OR.sub.1, --CH(OR.sub.1).sub.2 or --C(.dbd.O)N.sub.1 N.sub.2 wherein R.sub.1 is the same as defined above, R.sub.2 is, independently of R.sub.1, a hydrogen, or a straight, branched or cyclic C.sub.1 -C.sub.6 alkyl radical, and R.sub.3 and R.sub.4 are independently a straight, branched or cyclic C.sub.1 -C.sub.6 alkyl radical; and D is a hydrogen, or a straight, branched or cyclic C.sub.1 -C.sub.6 alkyl radical.

    摘要翻译: PCT No.PCT / KR95 / 00058 Sec。 371日期:1996年11月13日 102(e)1996年11月13日PCT PCT 1995年5月19日PCT公布。 公开号WO95 / 32198 日期:1995年11月30日公式(I)的新型咪唑衍生物有效抑制血管紧张素II的作用并具有优异的抗高血压活性:其中:A是直链,支链或环状的C 1 -C 6烷基,或 OR1,其中R1是氢或直链,支链或环状的C1-C6烷基; B是卤素,CF 3或CF 2 CF 3; X是N或N-氧化物; Y是-CH 2 - , - CH(OR 1) - ,其中R 1与上述定义相同,或-C(= O) - ; n为0或1〜4的整数, Z是卤素,-OH,-OR1,-NR1R2,-N(= O)R3R4,-C(= O)R1,-C(= O)OR1,-CH(OR1)2或-C )N1N2其中R1与上述定义相同,R2独立地为R1,氢或直链,支链或环状的C1-C6烷基,R3和R4独立地为直链,支链或环状的C 1 -C 6烷基 激进; 并且D是氢或直链,支链或环状的C 1 -C 6烷基。

    Hydraulic circuit to prevent bucket separation from bucket rest during traveling of heavy equipment
    7.
    发明授权
    Hydraulic circuit to prevent bucket separation from bucket rest during traveling of heavy equipment 有权
    液压回路,用于在重型设备行驶期间防止铲斗与斗环分离

    公开(公告)号:US08104276B2

    公开(公告)日:2012-01-31

    申请号:US12075590

    申请日:2008-03-12

    申请人: Byung Ho Lee

    发明人: Byung Ho Lee

    IPC分类号: F16D31/02

    摘要: A hydraulic circuit for preventing a change of stroke of a boom cylinder or an arm cylinder during transportation. The hydraulic circuit includes first and second hydraulic pumps, a boom cylinder, an arm cylinder, a boom confluence logic valve, a first port connected with a chamber of the boom cylinder in a housing in which a spool for the boom cylinder is shiftably installed, a second port connected with a hydraulic tank in the housing, and a first orifice formed between the housing and a land part of the spool for the boom cylinder located between the first port and the second port. During transportation, a small amount of hydraulic fluid fed from the second hydraulic pump to the large chamber of the boom cylinder drains to the hydraulic tank through the first orifice to prevent a change of stroke of the boom cylinder.

    摘要翻译: 一种液压回路,用于防止在运输过程中动臂缸或手臂缸的行程变化。 液压回路包括第一和第二液压泵,起重臂液压缸,悬臂气缸,起重臂汇合逻辑阀,与动臂缸的腔室连接的壳体中的第一端口,其中用于悬臂液压缸的阀芯可移动地安装, 与所述壳体中的液压箱连接的第二端口,以及形成在所述壳体和位于所述第一端口和所述第二端口之间的所述悬臂缸的所述线轴的台架部分之间的第一孔。 在运输过程中,从第二液压泵供给到动臂缸的大腔的少量液压油通过第一孔排入液压缸,以防止动臂缸的行程改变。

    Image sensor and method for manufacturing the same
    8.
    发明授权
    Image sensor and method for manufacturing the same 失效
    图像传感器及其制造方法

    公开(公告)号:US08076742B2

    公开(公告)日:2011-12-13

    申请号:US12611208

    申请日:2009-11-03

    申请人: Byung-Ho Lee

    发明人: Byung-Ho Lee

    IPC分类号: H01L31/0232 H01L29/04

    摘要: An image sensor according to embodiments may include a semiconductor substrate, photodiodes disposed over the semiconductor substrate, a dielectric layer formed over the photodiodes, a color filter layer formed over the dielectric layer, a planarization layer formed over the color filter layer, a phase change material formed over the planarization layer, and a plurality of microlenses formed over the planarization layer, wherein the phase change material is positioned in the microlens. Further, a method for manufacturing an image sensor according to embodiments may include forming a dielectric layer over a semiconductor substrate with a plurality of photodiodes, sequentially forming a color filter layer and a planarization layer over the dielectric layer, forming a phase change material over the planarization layer, forming a patterned phase change material by partially etching the phase change material, and forming microlenses over the planarization layer and the phase change material.

    摘要翻译: 根据实施例的图像传感器可以包括半导体衬底,设置在半导体衬底上的光电二极管,形成在光电二极管上的电介质层,形成在电介质层上的滤色器层,形成在滤色器层上的平坦化层,相变 在平坦化层上形成的材料,以及形成在平坦化层上的多个微透镜,其中相变材料位于微透镜中。 此外,根据实施例的用于制造图像传感器的方法可以包括在半导体衬底上形成具有多个光电二极管的介电层,在电介质层上顺序​​地形成滤色器层和平坦化层,在该介电层上形成相变材料 平坦化层,通过部分蚀刻相变材料形成图案化的相变材料,以及在平坦化层和相变材料上形成微透镜。

    Semiconductor device and method for fabricating the same
    9.
    发明授权
    Semiconductor device and method for fabricating the same 失效
    半导体装置及其制造方法

    公开(公告)号:US07867804B2

    公开(公告)日:2011-01-11

    申请号:US12168088

    申请日:2008-07-04

    申请人: Byung-Ho Lee

    发明人: Byung-Ho Lee

    IPC分类号: H01L21/06

    摘要: A semiconductor device that includes a phase change material for protecting the device from failure caused by overheating. The semiconductor device is adapted to detect a rapid increase in current due to heat and also adapted to break a circuit in the detected rapid increase in current by depositing a phase change material inside or outside a cell actually operated in the semiconductor device.

    摘要翻译: 一种半导体器件,包括用于保护器件免于过热引起的相变材料。 半导体器件适于检测由于热量引起的电流的快速增加,并且还适于通过在实际操作在半导体器件中的电池内部或外部沉积相变材料来破坏检测到的电流快速增加中的电路。

    SEMICONDUCTOR DEVICE AND MANUFACTURING METHOD THEREOF
    10.
    发明申请
    SEMICONDUCTOR DEVICE AND MANUFACTURING METHOD THEREOF 有权
    半导体器件及其制造方法

    公开(公告)号:US20100108979A1

    公开(公告)日:2010-05-06

    申请号:US12608055

    申请日:2009-10-29

    申请人: Byung-Ho Lee

    发明人: Byung-Ho Lee

    IPC分类号: H01L45/00 H01L21/06

    摘要: Embodiments relate to a semiconductor device, and more particularly, to a semiconductor device and a manufacturing method thereof that can reduce RC delay within the semiconductor device. Embodiments provide a semiconductor device including: a first interlayer dielectric layer formed over the a semiconductor substrate, a first metal wire and a second metal wire formed over the first interlayer dielectric layer, a second interlayer dielectric layer formed over the first and second metal wires, and a phase change material layer formed between the first and second metal wires.

    摘要翻译: 实施例涉及半导体器件,更具体地,涉及可以减少半导体器件内的RC延迟的半导体器件及其制造方法。 实施例提供一种半导体器件,包括:形成在半导体衬底上的第一层间电介质层,形成在第一层间电介质层上的第一金属线和第二金属线,形成在第一和第二金属线上的第二层间电介质层, 以及形成在第一和第二金属线之间的相变材料层。