公开(公告)号：US20170008975A1

公开(公告)日：2017-01-12

申请号：US15114272

申请日：2015-01-28

Applicant: LANKENAU INSTITUTE FOR MEDICAL RESEARCH

Inventor： U. Margaretha Wallon ,  George C. Prendergast

IPC: C07K16/40 ,  G01N33/574 ,  A61K31/704 ,  A61K39/395 ,  A61K45/06

CPC classification number: C07K16/40 ,  A61K31/704 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/30 ,  G01N33/57415 ,  G01N33/57484 ,  G01N2333/8146 ,  G01N2333/96486 ,  G01N2800/50

Abstract: Compositions and methods for treating diseases and disorders expressing tissue inhibitor of metalloproteinase-4 (TIMP-4) are provided.

Abstract translation: 提供了用于治疗表达金属蛋白酶-4组织抑制剂（TIMP-4）的疾病和病症的组合物和方法。

公开(公告)号：US09522164B2

公开(公告)日：2016-12-20

申请号：US14084064

申请日：2013-11-19

Applicant: Lankenau Institute for Medical Research

Inventor： Iraimoudi S. Ayene ,  George C. Prendergast

IPC: A61K31/10 ,  A61K31/198 ,  A61K33/24 ,  A61K9/00 ,  A61K31/194 ,  A61K45/06 ,  A61K31/7048

CPC classification number: A61K33/24 ,  A61K9/0019 ,  A61K31/10 ,  A61K31/194 ,  A61K31/198 ,  A61K31/7048 ,  A61K45/06 ,  A61K2300/00

Abstract: Compositions and methods for the treatment of cancer are provided.

公开(公告)号：US20240156795A1

公开(公告)日：2024-05-16

申请号：US18550919

申请日：2022-03-17

Applicant: Lankenau Institute for Medical Research

Inventor： Melvin Reichman ,  George C. Prendergast

IPC: A61K31/4418 ,  A61K9/00 ,  A61K31/155 ,  A61K31/22 ,  A61K31/405 ,  A61K31/4178 ,  A61K33/18 ,  A61K47/14 ,  A61K47/20 ,  A61P17/00 ,  A61P31/10

CPC classification number: A61K31/4418 ,  A61K9/0014 ,  A61K31/155 ,  A61K31/22 ,  A61K31/405 ,  A61K31/4178 ,  A61K33/18 ,  A61K47/14 ,  A61K47/20 ,  A61P17/00 ,  A61P31/10

Abstract: Compositions and methods for the treatment of topical infections such as onychomycosis are disclosed.

公开(公告)号：US20220364179A1

公开(公告)日：2022-11-17

申请号：US17642108

申请日：2020-09-14

Applicant: Lankenau Institute for Medical Research

Inventor： George C. Prendergast

IPC: C12Q1/6886 ,  G01N33/574

Abstract: A method of predicting the responsiveness of a subject having a disease to a treatment with an inhibitor of Indoleamine 2,3-dioxygenase 2 (IDO), an inhibitor of tryptophan 2,3-dioxygenase (TDO), or an inhibitor of the IDO/TDO pathway and/or an additional therapy comprises performing a genotype assay to determine the presence, absence or mutation of the Indoleamine 2,3-dioxygenase 2 (ID02) gene at the single nucleotide polymorphism (SNP) site rs4503084 and the SNP site rs10109853.

公开(公告)号：US20220357710A1

公开(公告)日：2022-11-10

申请号：US17874859

申请日：2022-07-27

Applicant: LANKENAU INSTITUTE FOR MEDICAL RESEARCH

Inventor： Barbara Wadsworth ,  George C. Prendergast ,  Barbara Merle Gilmore ,  Aidan Hyde ,  Andrew Mazzotta ,  Dylan Paproski ,  Christopher Scholl

IPC: G05B15/02

Abstract: A personal injury mitigation device for sensing a fall condition and responsively deploying a protective device in bathrooms or other elevated-risk spatial environments. A fall sensing system of the device includes a sensor and an analysis module that processes a signal from the sensor to determine whether a fall condition exists, and if so, transmits a trigger signal to a deployment system. The deployment system includes a stored energy system and an actuation system operable to release stored energy in response to receipt of the trigger signal. An impact mitigation device receives the released energy from the deployment system, which causes deployment of a protective device (such as an airbag) from a housing in which the protective device is stored in a compact state. In the deployed state, the protective device is operable to protect a person against injury due to impact resulting from a fall.

公开(公告)号：US20200261414A1

公开(公告)日：2020-08-20

申请号：US16647260

申请日：2018-09-14

Applicant: Lankenau Institute for Medical Research

Inventor： Alexander J. Muller ,  Arpita Mondal ,  Souvik Dey ,  George C. Prendergast

IPC: A61K31/405 ,  A61K31/519 ,  A61P35/04 ,  A61K31/664 ,  A61K31/661 ,  A61K31/10 ,  A61K31/197

Abstract: Compositions and methods for the treatment of cancer are disclosed.

公开(公告)号：US20130183388A1

公开(公告)日：2013-07-18

申请号：US13777383

申请日：2013-02-26

Applicant: Lankenau Institute for Medical Research

Inventor： George C. Prendergast ,  William P. Malachowski ,  Alexander J. Muller

IPC: C07D311/92 ,  A61K45/06 ,  C07D409/04 ,  A61K31/381 ,  C07D491/08 ,  A61K31/337 ,  A61K33/24 ,  A61K31/555 ,  A61K31/4745 ,  A61K31/519 ,  A61K31/664 ,  A61K31/513 ,  A61K31/7068 ,  A61K31/565 ,  A61K31/704 ,  A61K33/36 ,  A61K31/7048 ,  A61K31/352

CPC classification number: C07D311/92 ,  A61K31/337 ,  A61K31/352 ,  A61K31/381 ,  A61K31/4745 ,  A61K31/513 ,  A61K31/519 ,  A61K31/555 ,  A61K31/565 ,  A61K31/664 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7068 ,  A61K33/24 ,  A61K33/36 ,  A61K45/06 ,  C07D409/04 ,  C07D491/08 ,  C07D493/04

Abstract: Novel indoleamine 2,3-dioxygenase (IDO) inhibitors, compositions comprising the same, and methods of use thereof are disclosed.

Abstract translation: 公开了新的吲哚胺2,3-双加氧酶（IDO）抑制剂，包含它们的组合物及其使用方法。

公开(公告)号：US20240191212A1

公开(公告)日：2024-06-13

申请号：US18491078

申请日：2023-10-20

Applicant: LANKENAU INSTITUTE FOR MEDICAL RESEARCH

Inventor： George C. Prendergast ,  Richard Metz

IPC: C12N9/02 ,  A01K67/0276 ,  C12Q1/26

CPC classification number: C12N9/0069 ,  A01K67/0276 ,  C12Q1/26 ,  C07K2319/21 ,  C07K2319/40 ,  C12N2830/006

Abstract: The nucleotide and amino acid sequences of indoleamine 2,3-dioxygenase-2 (IDO2) and methods of use thereof are provided.

公开(公告)号：US20210040230A1

公开(公告)日：2021-02-11

申请号：US17011852

申请日：2020-09-03

Applicant: Lankenau Institute for Medical Research

Inventor： Lisa Laury-Kleintop ,  Laura Mandik-Nayak ,  George C. Prendergast ,  James Duhadaway

IPC: C07K16/40 ,  C07K14/00 ,  C07K7/06 ,  A61K39/395 ,  C07K7/08 ,  A61K45/06 ,  A61K39/00

Abstract: Compositions and methods for the treatment of autoimmune and inflammatory diseases are disclosed.

公开(公告)号：US11345747B2

公开(公告)日：2022-05-31

申请号：US16700471

申请日：2019-12-02

Applicant: LANKENAU INSTITUTE FOR MEDICAL RESEARCH

Inventor： Thomas Sunil ,  James Mullin ,  George C. Prendergast

IPC: A61K39/395 ,  A61K45/06 ,  A61K39/00 ,  C07K16/18 ,  A61P37/00

Abstract: Compositions and methods for the treatment of a disease or disorder are disclosed. Specifically, methods for inhibiting, treating, and/or preventing inflammatory disease in patients in need thereof are provided. The methods comprise the administration of at least one antibody or antibody fragment immunologically specific for bridging integrator I (Bin 1), particularly the Myc binding domain.