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公开(公告)号：US20120137385A1
公开(公告)日：2012-05-31
申请号：US13366902
申请日：2012-02-06
申请人： LEONARD N. BLOKSBERG , Catherine Bryant , Marie B. Connett , Sarah Jane Emerson , Michael J. Frost , Richard Llewellyn Sydney Forster , Murray Grigor , Colleen Higgins , Annette Lasham , Steven Troy Lund , Andreas Magusin , Jonathan Phillips , Sathiah Puthigae , Stella Veerakone , Claire Westwood , Katrina Gause , Marion Wood , Ilkka Havukkala , William H. Rottman
发明人： LEONARD N. BLOKSBERG , Catherine Bryant , Marie B. Connett , Sarah Jane Emerson , Michael J. Frost , Richard Llewellyn Sydney Forster , Murray Grigor , Colleen Higgins , Annette Lasham , Steven Troy Lund , Andreas Magusin , Jonathan Phillips , Sathiah Puthigae , Stella Veerakone , Claire Westwood , Katrina Gause , Marion Wood , Ilkka Havukkala , William H. Rottman
CPC分类号： C12N15/8261 , C07K14/415 , C12N15/8255 , Y02A40/146
摘要： The invention provides polynucleotide sequences isolated from plants encoding transcription factors. Polypeptides encoded by the polynucleotides are also provided. Products and methods of use are disclosed.
摘要翻译： 本发明提供从编码转录因子的植物分离的多核苷酸序列 还提供了由多核苷酸编码的多肽。 公开了产品和使用方法。
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公开(公告)号：US07507875B2
公开(公告)日：2009-03-24
申请号：US10863905
申请日：2004-06-07
申请人： Leonard N. Bloksberg , Catherine Bryant , Marie B. Connett , Sarah Jane Emerson , Michael J. Frost , Richard Llewellyn Sydney Forster , Murray Grigor , Colleen Higgins , Annette Lasham , Steven Troy Lund , Andreas Magusin , Jonathan Phillips , Sathiah Puthigae , Stella Veerakone , Claire Westwood , Katrina Gause , Marion Wood , Ilkka Havukkala , William H. Rottmann
发明人： Leonard N. Bloksberg , Catherine Bryant , Marie B. Connett , Sarah Jane Emerson , Michael J. Frost , Richard Llewellyn Sydney Forster , Murray Grigor , Colleen Higgins , Annette Lasham , Steven Troy Lund , Andreas Magusin , Jonathan Phillips , Sathiah Puthigae , Stella Veerakone , Claire Westwood , Katrina Gause , Marion Wood , Ilkka Havukkala , William H. Rottmann
CPC分类号： C12N15/8261 , C07K14/415 , C12N15/8255 , Y02A40/146
摘要： The invention provides polynucleotide sequences isolated from plants encoding transcription factors. Polypeptides encoded by the polynucleotides are also provided. Products and methods of use are disclosed.
摘要翻译： 本发明提供从编码转录因子的植物分离的多核苷酸序列 还提供了由多核苷酸编码的多肽。 公开了产品和使用方法。
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公开(公告)号：US08110723B2
公开(公告)日：2012-02-07
申请号：US12187745
申请日：2008-08-07
申请人： Leonard N. Bloksberg , Catherine Bryant , Marie B. Connett , Sarah Jane Emerson , Michael J. Frost , Richard Llewellyn Sydney Forster , Murray Grigor , Colleen Higgins , Annette Lasham , Steven Troy Lund , Andreas Magusin , Jonathan Phillips , Sathiah Puthigae , Stella Veerakone , Claire Westwood , Katrina Gause , Marion Wood , Ilkka Havukkala , William H. Rottmann
发明人： Leonard N. Bloksberg , Catherine Bryant , Marie B. Connett , Sarah Jane Emerson , Michael J. Frost , Richard Llewellyn Sydney Forster , Murray Grigor , Colleen Higgins , Annette Lasham , Steven Troy Lund , Andreas Magusin , Jonathan Phillips , Sathiah Puthigae , Stella Veerakone , Claire Westwood , Katrina Gause , Marion Wood , Ilkka Havukkala , William H. Rottmann
CPC分类号： C12N15/8261 , C07K14/415 , C12N15/8255 , Y02A40/146
摘要： The invention provides polynucleotide sequences isolated from plants encoding transcription factors. Polypeptides encoded by the polynucleotides are also provided. Products and methods of use are disclosed.
摘要翻译： 本发明提供从编码转录因子的植物中分离的多核苷酸序列。 还提供了由多核苷酸编码的多肽。 公开了产品和使用方法。
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公开(公告)号：US08962947B2
公开(公告)日：2015-02-24
申请号：US13366902
申请日：2012-02-06
申请人： Leonard N. Bloksberg , Marie B. Connett , Sarah Jane Emerson , Michael J. Frost , Richard Llewellyn Sydney Forster , Catherine Bryant , Murray Grigor , Colleen Higgins , Annette Lasham , Steven Troy Lund , Andreas Magusin , Jonathan Phillips , Sathish Puthigae , Stella Veerakone , Claire Westwood , Katrina Gause , Marion Wood , Ilkka Havukkala , William Rottmann
发明人： Leonard N. Bloksberg , Marie B. Connett , Sarah Jane Emerson , Michael J. Frost , Richard Llewellyn Sydney Forster , Catherine Bryant , Murray Grigor , Colleen Higgins , Annette Lasham , Steven Troy Lund , Andreas Magusin , Jonathan Phillips , Sathish Puthigae , Stella Veerakone , Claire Westwood , Katrina Gause , Marion Wood , Ilkka Havukkala , William Rottmann
CPC分类号： C12N15/8261 , C07K14/415 , C12N15/8255 , Y02A40/146
摘要： The invention provides polynucleotide sequences isolated from plants encoding transcription factors. Polypeptides encoded by the polynucleotides are also provided. Products and methods of use are disclosed.
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公开(公告)号：US08293509B2
公开(公告)日：2012-10-23
申请号：US12529761
申请日：2008-03-19
申请人： Sean Dennis Simpson , Richard Llewellyn Sydney Forster , Matthew James Rowe , Phuong Loan Tran , Christophe Collet
发明人： Sean Dennis Simpson , Richard Llewellyn Sydney Forster , Matthew James Rowe , Phuong Loan Tran , Christophe Collet
摘要： The invention relates to biological processes for producing one or more desired products, including alcohols such as ethanol and butanol. The processes comprise carrying out first and second fermentations of substrates in first and second bioreactors, wherein each fermentation produces one or more desired products and/or one or more by-products that can be utilized in the other fermentation. A product and/or by-product of the first fermentation is introduced to the second bioreactor during the fermentation, and a product and/or by-product of the second fermentation is introduced to the first bioreactor during the fermentation.
摘要翻译： 本发明涉及生产一种或多种所需产物的生物方法，包括醇如乙醇和丁醇。 该方法包括在第一和第二生物反应器中进行底物的第一次和第二次发酵，其中每次发酵产生一种或多种所需产物和/或可用于其它发酵的一种或多种副产物。 在发酵期间将第一发酵的产物和/或副产物引入第二生物反应器，并且在发酵期间将第二发酵的产物和/或副产物引入第一生物反应器。
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公开(公告)号：US08119378B2
公开(公告)日：2012-02-21
申请号：US12921584
申请日：2009-02-18
申请人： Sean Dennis Simpson , Christophe Collet , Phuong Loan Tran , Bakir Al-Sinawi , Richard Llewellyn Sydney Forster , Matthew James Rowe , Gary Chan , Kelly Marie Mahar , Jennifer Mon Yee Fung
发明人： Sean Dennis Simpson , Christophe Collet , Phuong Loan Tran , Bakir Al-Sinawi , Richard Llewellyn Sydney Forster , Matthew James Rowe , Gary Chan , Kelly Marie Mahar , Jennifer Mon Yee Fung
IPC分类号： C12P7/06 , C12P7/00 , C12N1/20 , C12P1/00 , C12P1/04 , C12P7/16 , C12P7/52 , C12P7/54 , C12M1/36
摘要： The invention relates to the production of alcohols by microbial fermentation, particularly to production of alcohols by microbial fermentation of substrates comprising CO. It more particularly relates to processes for the production of alcohols from their corresponding acids in the presence of a substrate comprising CO. In particular embodiments, a fermentation reaction producing acid(s) and optionally alcohol(s) is perturbed such that at least a portion one or more of acid(s) is converted to alcohol.
摘要翻译： 本发明涉及通过微生物发酵生产醇，特别是通过微生物发酵包含CO的底物来生产醇。更具体地涉及在含有CO的底物存在下从其相应的酸生产醇的方法。 特定的实施方案中，产生酸和任选的醇的发酵反应被扰动，使得至少一部分一种或多种酸被转化成醇。
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公开(公告)号：US08658164B2
公开(公告)日：2014-02-25
申请号：US13539102
申请日：2012-06-29
IPC分类号： C12P21/06 , A61K39/395
CPC分类号： G01N33/57434 , G01N2333/4737 , G01N2333/475 , G01N2333/904 , G01N2333/916 , G01N2333/96455
摘要： Methods for diagnosing the presence of prostate cancer in a subject are provided, such methods including detecting the levels of expression of multiple polypeptide biomarkers in a biological sample obtained from the subject and comparing the levels of expression with predetermined threshold levels. Levels of expression of at least two of the polypeptide markers that are above the predetermined threshold levels are indicative of the presence of prostate cancer in the subject. Determination of the expression levels of specific combinations of biomarkers can also be used to determine the type and/or stage of prostate cancer.
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8.发明授权公开(公告)号：US08632971B2
公开(公告)日：2014-01-21
申请号：US13600048
申请日：2012-08-30
IPC分类号： C12Q1/68 , C07K16/00 , G01N33/573
CPC分类号： G01N33/57434 , C12Q1/6886 , C12Q2600/158 , G01N33/6893 , G01N2800/52
摘要： Methods for monitoring, and determining the efficacy of, a treatment for prostate cancer in a subject are provided, such methods including detecting the levels of expression of multiple polypeptide biomarkers in biological samples obtained from the subject prior to, and during, a course of treatment. Specific patterns of changes in the expression of the polypeptide biomarkers are indicative of the effectiveness of the treatment in the subject.
摘要翻译： 提供了用于监测和确定受试者中前列腺癌治疗的功效的方法，所述方法包括检测在治疗过程之前和期间从受试者获得的生物样品中多种多肽生物标志物的表达水平 。 多肽生物标志物表达变化的具体模式指示受试者中治疗的有效性。
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公开(公告)号：US20120309075A1
公开(公告)日：2012-12-06
申请号：US13537798
申请日：2012-06-29
申请人： Sean Dennis Simpson , Richard Llewellyn Sydney Forster , Phuong Loan Tran , Matthew James Rowe , Ian Linstrand Warner
发明人： Sean Dennis Simpson , Richard Llewellyn Sydney Forster , Phuong Loan Tran , Matthew James Rowe , Ian Linstrand Warner
IPC分类号： C12N1/20
CPC分类号： C12R1/145 , C12N1/20 , C12P7/065 , C12P7/08 , C12P7/54 , Y02E50/17 , Y10S435/821 , Y10S435/842
摘要： A biologically pure isolate of a selected bacterium derived from Clostridium autoethanogenum is described which has improved efficiency in the production of ethanol by anaerobic fermentation of substrates comprising carbon monoxide. The bacterium can produce ethanol and acetate at an ethanol to acetate ratio of at least 1.0 and has a productivity of at least 1.2 g of ethanol/l of fermentation broth per day. The bacterium is also characterized in that it has substantially no ability to sporulate.
摘要翻译： 描述了一种来源于自发性梭菌（Clostridium autoethanogenum）的选定细菌的生物纯的分离物，其通过包含一氧化碳的底物的厌氧发酵而提高了乙醇生产的效率。 该细菌可以以至少1.0的乙醇与乙酸酯比率生产乙醇和乙酸盐，并且每天产生至少1.2g乙醇/ l的发酵液。 细菌的特征还在于其基本上不具有孢子形成能力。
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公开(公告)号：US07972824B2
公开(公告)日：2011-07-05
申请号：US12296300
申请日：2007-04-05
摘要： The present invention relates to methods for increasing the efficiency of anaerobic fermentation processes (1) that produce acetate as a by-product in addition to a desired product, and (2) that can utilize hydrogen and/or carbon dioxide in the fermentation. The method comprises the steps of converting acetate produced by the fermentation process into hydrogen gas and carbon dioxide gas, and utilizing hydrogen gas and/or carbon dioxide gas obtained from the acetate conversion in the anaerobic fermentation process. In particular aspects, the invention relates to processes of producing alcohols, particularly ethanol.
摘要翻译： 本发明涉及提高厌氧发酵方法（1）的效率的方法（1），除了所需产物外，还可以生产作为副产物的乙酸酯，和（2）可以在发酵中利用氢和/或二氧化碳。 该方法包括以下步骤：将通过发酵过程产生的乙酸转化为氢气和二氧化碳气体，并在厌氧发酵过程中利用由乙酸酯转化得到的氢气和/或二氧化碳气体。 在具体方面，本发明涉及生产醇，特别是乙醇的方法。
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