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    VISUALIZATION TOOLS FOR DIGITAL PCR DATA
    1.
    发明申请
    VISUALIZATION TOOLS FOR DIGITAL PCR DATA 有权

    公开(公告)号：US20230022224A1

    公开(公告)日：2023-01-26

    申请号：US17861854

    申请日：2022-07-11

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Harrison LEONG ,  Nivedita Sumi MAJUMDAR ,  Jeffrey A. MARKS ,  Theodore E. STRAUB ,  Ryan J. TALBOT ,  Kevin S. BODNER ,  David HOARD

    IPC: G06T11/20 ,  G16B45/00

    Abstract: A method comprises displaying, on a graphical user interface (GUI), a first data visualization comprising a positional representation of a plurality of reaction sites from at least a portion of a substrate, wherein the positional representation of the first data visualization simultaneously indicates relative data quality of the plurality of reaction sites; and altering the first data visualization displayed on the GUI to a second data visualization, the second data visualization comprising the positional representation of the plurality of reaction sites from the at least the portion of the substrate, wherein the positional representation of the second data visualization simultaneously indicates relative data quality of the plurality of reaction sites from at least the portion of the substrate based on a comparison of the data quality values of the plurality of reaction sites an adjusted quality value threshold.

    SYSTEMS AND METHODS FOR THE DETERMINATION OF A COPY NUMBER OF A GENOMIC SEQUENCE
    3.
    发明申请
    SYSTEMS AND METHODS FOR THE DETERMINATION OF A COPY NUMBER OF A GENOMIC SEQUENCE 审中-公开
    用于确定基因组序列号的系统和方法

    公开(公告)号：US20130179086A1

    公开(公告)日：2013-07-11

    申请号：US13689374

    申请日：2012-11-29

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Harrison LEONG ,  Nivedita Sumi MAJUMDAR

    IPC: G06F19/22

    CPC classification number: G16B45/00 ,  G16B20/00 ,  G16B30/00

    Abstract: System and methods for the determination of a copy number of a target genomic sequence; either a target gene or genomic sequence of interest, in a biological sample are described. Various methods utilize a model drawn from a probability density function (PDF) for the assignment of a copy number of a target genomic sequence in a biological sample. Additionally, the methods provide for the determination of a confidence value for a copy number assigned to a sample based on attributes of the sample data. Additionally, various embodiments of an interactive graphical user interface (GUI) may provide an end-user with ready analysis of large sets of data representing a plurality of samples. In various embodiments of an interactive GUI, an end-user may be provided with a synchronized display of tabular and graphical sample data determined by an initial analysis according to a statistical model of a PDF. Such a synchronized display may enable an end-user to readily identify sample data for a subsequent analysis based on user input.

    Abstract translation: 用于确定靶基因组序列拷贝数的系统和方法; 描述了生物样品中的靶基因或目的基因组序列。 各种方法利用从概率密度函数（PDF）中提取的模型来分配生物样品中靶基因组序列的拷贝数。 另外，这些方法提供了基于样本数据的属性确定分配给样本的副本编号的置信度值。 另外，交互式图形用户界面（GUI）的各种实施例可以向终端用户提供表示多个样本的大量数据的准备分析。 在交互式GUI的各种实施例中，最终用户可以被提供有根据PDF的统计模型通过初始分析确定的表格和图形样本数据的同步显示。 这样的同步显示可以使最终用户能够基于用户输入容易地识别用于后续分析的样本数据。

    METHODS FOR THE ANALYSIS OF PROXIMITY BINDING ASSAY DATA
    4.
    发明申请
    METHODS FOR THE ANALYSIS OF PROXIMITY BINDING ASSAY DATA 审中-公开

    公开(公告)号：US20190241942A1

    公开(公告)日：2019-08-08

    申请号：US16228304

    申请日：2018-12-20

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Shiaw-Min CHEN ,  David W. RUFF ,  Harrison LEONG

    IPC: C12Q1/6844 ,  G16B25/00 ,  G16B40/00

    CPC classification number: C12Q1/6844 ,  G16B25/00 ,  G16B40/00 ,  C12Q2545/114

    Abstract: Various embodiments of methods for analyzing proximity binding assay (PBA) data are disclosed. Proximity binding assays as a class of analyses offer the advantages of the sensitivity and specificity of biorecognition binding, along with the exponential signal amplification offered by a variety of oligonucleotide amplification reactions, such as the polymerase chain reaction (PCR). However, as various proximity binding assays have reaction kinetics governed by an additional step of the binding of a biorecognition probe (BRP) with a target molecule, there is a need for methods for the analysis of PBA data that are particularly suited to the unique characteristics of such data.

    Systems and Methods for the Determination of a Copy Number of a Genomic Sequence
    5.
    发明申请
    Systems and Methods for the Determination of a Copy Number of a Genomic Sequence 审中-公开
    用于确定基因组序列拷贝数的系统和方法

    公开(公告)号：US20160026760A1

    公开(公告)日：2016-01-28

    申请号：US14807764

    申请日：2015-07-23

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Harrison LEONG ,  Nivedita Sumi MAJUMDAR

    IPC: G06F19/26 ,  G06F19/18

    CPC classification number: G16B45/00 ,  G16B20/00 ,  G16B30/00

    Abstract: System and methods for the determination of a copy number of a target genomic sequence; either a target gene or genomic sequence of interest, in a biological sample are described. Various methods utilize a model drawn from a probability density function (PDF) for the assignment of a copy number of a target genomic sequence in a biological sample. Additionally, the methods provide for the determination of a confidence value for a copy number assigned to a sample based on attributes of the sample data. Additionally, various embodiments of an interactive graphical user interface (GUI) may provide an end-user with ready analysis of large sets of data representing a plurality of samples. In various embodiments of an interactive GUI, an end-user may be provided with a synchronized display of tabular and graphical sample data determined by an initial analysis according to a statistical model of a PDF. Such a synchronized display may enable an end-user to readily identify sample data for a subsequent analysis based on user input.

    Abstract translation: 用于确定靶基因组序列拷贝数的系统和方法; 描述了生物样品中的靶基因或目的基因组序列。 各种方法利用从概率密度函数（PDF）中提取的模型来分配生物样品中靶基因组序列的拷贝数。 另外，这些方法提供了基于样本数据的属性确定分配给样本的副本编号的置信度值。 另外，交互式图形用户界面（GUI）的各种实施例可以向终端用户提供表示多个样本的大量数据的准备分析。 在交互式GUI的各种实施例中，最终用户可以被提供有根据PDF的统计模型通过初始分析确定的表格和图形样本数据的同步显示。 这样的同步显示可以使最终用户能够基于用户输入容易地识别用于后续分析的样本数据。

    METHODS AND SYSTEMS FOR VISUALIZING DATA QUALITY
    6.
    发明申请
    METHODS AND SYSTEMS FOR VISUALIZING DATA QUALITY 有权

    公开(公告)号：US20230127610A1

    公开(公告)日：2023-04-27

    申请号：US17947445

    申请日：2022-09-19

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Nivedita Sumi MAJUMDAR ,  Harrison LEONG ,  Theodore E. STRAUB ,  David HOARD

    IPC: G06F16/2457 ,  G06F16/248 ,  G16B45/00

    Abstract: A computer-implemented method for generating a data visualization for operating a digital polymerase chain reaction (dPCR) system comprises, the method comprising receiving fluorescent emission data comprising a plurality of data points corresponding to fluorescence emission from a plurality of reaction sites of a substrate, the fluorescent emission data indicative of presence or absence of amplification product of a dPCR. The method further comprises displaying a data visualization of the plurality of data points in a spatial representation of the substrate such that each data point is displayed at a relative spatial location of its corresponding reaction site of the plurality of reaction sites of the substrate, a first set of data points being displayed with a first indication based on meeting a first quality value threshold and second set of data points being displayed with a second indication, differing from the first indication, based on a second quality value threshold.

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