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公开(公告)号：US20230022224A1
公开(公告)日：2023-01-26
申请号：US17861854
申请日：2022-07-11
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Harrison LEONG , Nivedita Sumi MAJUMDAR , Jeffrey A. MARKS , Theodore E. STRAUB , Ryan J. TALBOT , Kevin S. BODNER , David HOARD
Abstract: A method comprises displaying, on a graphical user interface (GUI), a first data visualization comprising a positional representation of a plurality of reaction sites from at least a portion of a substrate, wherein the positional representation of the first data visualization simultaneously indicates relative data quality of the plurality of reaction sites; and altering the first data visualization displayed on the GUI to a second data visualization, the second data visualization comprising the positional representation of the plurality of reaction sites from the at least the portion of the substrate, wherein the positional representation of the second data visualization simultaneously indicates relative data quality of the plurality of reaction sites from at least the portion of the substrate based on a comparison of the data quality values of the plurality of reaction sites an adjusted quality value threshold.
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公开(公告)号：US20230030218A1
公开(公告)日：2023-02-02
申请号：US17963135
申请日：2022-10-10
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Eliodor GHENCIU , Theodore E. STRAUB , Evan W. FOSTER , Michael C. PALLAS
Abstract: An apparatus for biological reactions is provided. The apparatus includes a substrate and a plurality of reaction sites within the substrate. A surface of the substrate is configured to have a first hydrophilicity and each surface of the plurality of reaction sites is configured to have a second hydrophilicity to load a substantial number of reaction sites with a sample volume. The sample volume of each loaded reaction site is substantially confined to its respective reaction site. The sample volume is configured to undergo a biological reaction within the reaction site.
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Patent Agency Ranking
公开(公告)号：US20200319221A1
公开(公告)日：2020-10-08
申请号：US16852830
申请日：2020-04-20
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Eliodor GHENCIU , Theodore E. STRAUB , Evan W. FOSTER , Michael C. PALLAS
Abstract: An apparatus for biological reactions is provided. The apparatus includes a substrate and a plurality of reaction sites within the substrate. A surface of the substrate is configured to have a first hydrophilicity and each surface of the plurality of reaction sites is configured to have a second hydrophilicity to load a substantial number of reaction sites with a sample volume. The sample volume of each loaded reaction site is substantially confined to its respective reaction site. The sample volume is configured to undergo a biological reaction within the reaction site.
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公开(公告)号：US20170081712A1
公开(公告)日：2017-03-23
申请号：US15273200
申请日：2016-09-22
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Shifeng LI , Shoulian DONG , Theodore E. STRAUB , David N. KEYS
IPC: C12Q1/68 , G01N27/30 , G01N27/414
CPC classification number: C12Q1/6825 , C12Q1/6837 , C12Q1/6851 , G01N27/301 , G01N27/4145 , C12Q2531/113 , C12Q2563/116 , C12Q2563/159 , C12Q2565/607
Abstract: A system for detecting one or more target molecules includes a reaction device and a temperature controller. The reaction device comprises a plurality of reaction sites and plurality of field effect transistors corresponding to the plurality of reaction sites. At least two of the reaction sites may receive a reaction solution including two target molecules. The temperature controller is configured to control a temperature of at least one of the reaction sites or the reaction solution received by the at least one reaction site. At least some of the reaction sites may receive a reagent supporting an amplification reaction. When the reaction is subjected to an amplification assay, an amplified product is produced in the at least some of the reaction sites. The plurality of field effect transistors are configured to detect at least one of the amplified products.
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公开(公告)号：US20230127610A1
公开(公告)日：2023-04-27
申请号：US17947445
申请日：2022-09-19
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Nivedita Sumi MAJUMDAR , Harrison LEONG , Theodore E. STRAUB , David HOARD
IPC: G06F16/2457 , G06F16/248 , G16B45/00
Abstract: A computer-implemented method for generating a data visualization for operating a digital polymerase chain reaction (dPCR) system comprises, the method comprising receiving fluorescent emission data comprising a plurality of data points corresponding to fluorescence emission from a plurality of reaction sites of a substrate, the fluorescent emission data indicative of presence or absence of amplification product of a dPCR. The method further comprises displaying a data visualization of the plurality of data points in a spatial representation of the substrate such that each data point is displayed at a relative spatial location of its corresponding reaction site of the plurality of reaction sites of the substrate, a first set of data points being displayed with a first indication based on meeting a first quality value threshold and second set of data points being displayed with a second indication, differing from the first indication, based on a second quality value threshold.
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公开(公告)号：US20210042972A1
公开(公告)日：2021-02-11
申请号：US16937634
申请日：2020-07-24
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Harrison LEONG , Nivedita Sumi MAJUMDAR , Jeffrey A. MARKS , Theodore E. STRAUB , Ryan J. TALBOT , Kevin S. BODNER , David HOARD
Abstract: A method for generating a data visualization is provided. The method includes displaying a representation of a portion of detected data from a substrate to a user. The method further includes generating a data quality value for the portion of detected data and displaying, along with the representation of the portion of detected data, an indication of data quality value for the portion of detected data. The method further includes selecting, by the user, a quality value threshold, and displaying an adjusted indication of data quality value for the portion of detected data meeting the quality value threshold.
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公开(公告)号：US20170088879A1
公开(公告)日：2017-03-30
申请号：US15280160
申请日：2016-09-29
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： David N. KEYS , Nivedita Sumi MAJUMDAR , Theodore E. STRAUB
IPC: C12Q1/68
CPC classification number: C12Q1/686 , B01L7/52 , B01L2300/024 , B01L2300/0829 , C12Q1/6851 , C12Q2527/107 , C12Q2545/114 , C12Q2561/113 , C12Q2563/159
Abstract: Systems and methods are described for quantifying a target nucleic acid. A sample comprising a target nucleic acid is segregated into a first plurality of the reaction volumes containing at least one target nucleic acid molecule and a second plurality of the reaction volumes containing no target nucleic acid molecules. The reaction volumes are subjected to an amplification assay, wherein the amplification assay is configured to amplify the target nucleic acid. An indicator of amplification is detected or measured in at least some of the plurality of reaction volumes. The target nucleic acid is quantified based on the detection or measurement. After discontinuing the amplification assay, the plurality of reaction volumes may be heated and changes in the indicators of amplification of two or more of the at least some of the reaction volumes may be detected or measured.
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