公开(公告)号：US12234439B2

公开(公告)日：2025-02-25

申请号：US18336553

申请日：2023-06-16

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Jeremy K. Larsen ,  Jon Q. Coleman ,  David S. Rowley

IPC: B01D29/27 ,  B01D29/13 ,  B01D35/02 ,  B01D35/027 ,  B01D61/14 ,  B01D63/06 ,  C12M1/00 ,  C12M1/12 ,  C12M1/26

Abstract: A filter assembly for separating microcarriers from a fluid medium includes a collapsible container bounding a sterile compartment adapted to hold a fluid. An inlet port is attached to the container through which fluid flows into the compartment. An outlet port is attached to the container through which fluid flows out of the compartment. A filter is disposed within the compartment, the filter dividing the compartment into an inlet chamber that is fluidly coupled with the inlet port and an outlet chamber that is fluidly coupled with the outlet port, the filter allowing a medium to pass therethrough but preventing microcarriers disposed in the medium from passing therethrough.

公开(公告)号：US20240342670A1

公开(公告)日：2024-10-17

申请号：US18754057

申请日：2024-06-25

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Jeremy K. Larsen ,  Clinton C. Staheli ,  Brandon M. Knudsen

IPC: B01F27/2121 ,  B01F27/191 ,  B01F27/213 ,  B01F27/80 ,  B01F27/88 ,  B01F27/91 ,  B01F33/00 ,  B01F35/31 ,  B01F35/32 ,  B01F35/40 ,  B01F35/41 ,  B01F35/50 ,  B01F35/513

CPC classification number: B01F27/2121 ,  B01F27/191 ,  B01F27/213 ,  B01F27/88 ,  B01F27/91 ,  B01F33/86 ,  B01F35/322 ,  B01F35/3231 ,  B01F35/40 ,  B01F35/4121 ,  B01F35/513 ,  B01F27/80 ,  B01F35/31 ,  B01F35/41 ,  B01F35/4112 ,  B01F35/514

Abstract: The present disclosure relates to a mixing assembly for a fluid mixing system. The mixing assembly includes a first rotational assembly having a first casing and a first hub rotatably mounted to the first casing, a second rotational assembly having a second casing and a second hub rotatably mounted to the second casing, an elongated member having a first end coupled with the first hub and an opposing second end coupled with the second hub, and one or more impellers secured to the elongated member.

公开(公告)号：US20240044430A1

公开(公告)日：2024-02-08

申请号：US18485155

申请日：2023-10-11

Applicant: Life Technologies Corporation

Inventor： Ryan S. Beus ,  Brandon R. Burtenshaw ,  Eric Davis ,  Patrick L. Draper ,  Michael E. Goodwin ,  Brandon M. Knudsen ,  Jeremy K. Larsen ,  Kevin R. Pickup

IPC: F16L33/207 ,  F16L33/22 ,  B29C65/00 ,  B29C65/68 ,  B29C65/56 ,  A61M39/12

CPC classification number: F16L33/207 ,  F16L33/227 ,  B29C66/131 ,  B29C66/73753 ,  B29C65/68 ,  B29C65/565 ,  B29C66/1224 ,  A61M39/12 ,  B29C66/7392 ,  B29C66/5344 ,  B29C66/1222 ,  B29C66/12 ,  B29C66/7394 ,  B29C66/30321 ,  B29C66/7315 ,  B29C66/1122 ,  B29L2031/24

Abstract: A coupling assembly includes: a tubular compression collar having a tubular body made of a resiliently flexible polymeric material and having an interior surface and an opposing exterior surface; an end of a tube disposed within a throughway of the compression collar; and a tube fitting disposed within the passageway of the tube. The tube fitting includes: a tubular stem; a flange radially outwardly projecting from an exterior surface of the stem; and an annular barb encircling and radially outwardly projecting from the exterior surface of the stem, the annular barb including a frustoconical outside face that extends along and outwardly slopes away from the stem as the outside face extends toward the flange. The compression collar radially inwardly compresses the tube against the annular barb of the tube fitting so that a liquid tight seal is formed between the tube and the tube fitting.

公开(公告)号：US20230234732A1

公开(公告)日：2023-07-27

申请号：US18189994

申请日：2023-03-24

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Michael E. Goodwin ,  Jeremy K. Larsen ,  Patrick L. Draper ,  Brandon M. Knudsen

IPC: B65B1/04 ,  B65B3/00 ,  B65B3/02 ,  B65B3/04 ,  B65B51/02 ,  B65B51/22

CPC classification number: B65B1/04 ,  B65B3/003 ,  B65B3/02 ,  B65B3/04 ,  B65B51/02 ,  B65B51/225 ,  A61J1/10

Abstract: A fluid manifold system includes a first manifold having portions of opposing flexible sheets welded together to form a fluid flow path therebetween, a fluid inlet communicating with the fluid flow path. The fluid flow path of the first manifold includes: a primary flow path communicating with the fluid inlet of the first manifold; and a plurality of spaced apart secondary flow paths that branch off of the primary flow path. Each secondary flow path has a first end communicating with the primary flow path and an opposing second end, each secondary flow path having a diameter that is smaller than a diameter of the primary flow path. The fluid manifold system also includes a plurality of tubular connectors with each tubular connector being secured to the first manifold at the second end of a corresponding one of the secondary flow paths.

公开(公告)号：US20220228686A1

公开(公告)日：2022-07-21

申请号：US17712501

申请日：2022-04-04

Applicant: Life Technologies Corporation

Inventor： Ryan S. Beus ,  Brandon R. Burtenshaw ,  Eric Davis ,  Patrick L. Draper ,  Michael E. Goodwin ,  Brandon M. Knudsen ,  Jeremy K. Larsen ,  Kevin R. Pickup

IPC: F16L33/207 ,  F16L33/22 ,  B29C65/00 ,  B29C65/68 ,  B29C65/56 ,  A61M39/12

Abstract: A coupling assembly includes: a tubular compression collar having a tubular body made of a resiliently flexible polymeric material and having an interior surface and an opposing exterior surface; an end of a tube disposed within a throughway of the compression collar; and a tube fitting disposed within the passageway of the tube. The tube fitting includes: a tubular stem; a flange radially outwardly projecting from an exterior surface of the stem; and an annular barb encircling and radially outwardly projecting from the exterior surface of the stem, the annular barb including a frustoconical outside face that extends along and outwardly slopes away from the stem as the outside face extends toward the flange. The compression collar radially inwardly compresses the tube against the annular barb of the tube fitting so that a liquid tight seal is formed between the tube and the tube fitting.

公开(公告)号：US11148836B2

公开(公告)日：2021-10-19

申请号：US16385775

申请日：2019-04-16

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Michael E. Goodwin ,  Jeremy K. Larsen ,  Patrick L. Draper ,  Brandon M. Knudsen

IPC: B65B3/00 ,  B65B1/04 ,  B65B3/02 ,  B65B3/04 ,  B65B51/02 ,  B65B51/22 ,  A61J1/10

Abstract: A method of dispensing a fluid includes coupling a manifold to a fluid source, the manifold including at least portions of opposing flexible sheets welded together to form a fluid flow path therebetween; passing a fluid from the fluid source through the fluid flow path of the manifold and into a plurality of flexible bags coupled to the manifold; sealing closed each of the flexible bags; progressively collapsing the fluid flow path along a length of the manifold so as to force a portion of the fluid remaining within the fluid flow path into one of the flexible bags before all of the flexible bags are sealed closed; and removing each sealed bag from the manifold.

公开(公告)号：US10850243B2

公开(公告)日：2020-12-01

申请号：US16165650

申请日：2018-10-19

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Jeremy K. Larsen ,  Clinton C. Staheli ,  Brandon M. Knudsen

IPC: B01F7/00 ,  B01F7/22 ,  B01F15/00 ,  B01F7/16

Abstract: A fluid mixing system includes a flexible bag having a first end, an opposing second end, and an interior surface bounding a compartment. A first rotational assembly includes a first casing mounted to the first end of the flexible bag and a first hub rotatably mounted to the first casing. A second rotational assembly includes a second casing mounted to the second end of the flexible bag and a second hub rotatably mounted to the second casing. An elongated member has a first end coupled with the first hub and an opposing second end coupled with the second hub, the connector being flexible and having a uniform flexibility along its entire length. A first impeller is mounted to the connector.

公开(公告)号：US10308378B2

公开(公告)日：2019-06-04

申请号：US14728717

申请日：2015-06-02

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Michael E. Goodwin ,  Jeremy K. Larsen ,  Patrick L. Draper ,  Brandon M. Knudsen

IPC: B65B3/04 ,  B65B1/04 ,  B65B3/00 ,  B65B3/02 ,  B65B51/02 ,  B65B51/22 ,  A61J1/10

Abstract: A fluid manifold system includes a manifold having at least portions of opposing flexible sheets welded together to form a fluid flow path therebetween, a fluid inlet communicating with the fluid flow path. A plurality of receiving containers are in fluid communication with the fluid flow path of the manifold, each receiving container bounding a compartment. The receiving containers can be formed integral with the manifold by welding together a second portion of the opposing flexible sheets or can comprise separate containers that are coupled to the manifold.

公开(公告)号：US20240269628A1

公开(公告)日：2024-08-15

申请号：US18590633

申请日：2024-02-28

Applicant: Life Technologies Corporation

Inventor： Jeremy K. Larsen ,  Clinton C. Staheli ,  Brandon M. Knudsen

IPC: B01F27/2121 ,  B01F27/191 ,  B01F27/213 ,  B01F27/80 ,  B01F27/88 ,  B01F27/91 ,  B01F33/00 ,  B01F35/31 ,  B01F35/32 ,  B01F35/40 ,  B01F35/41 ,  B01F35/50 ,  B01F35/513

CPC classification number: B01F27/2121 ,  B01F27/191 ,  B01F27/213 ,  B01F27/88 ,  B01F27/91 ,  B01F33/86 ,  B01F35/322 ,  B01F35/3231 ,  B01F35/40 ,  B01F35/4121 ,  B01F35/513 ,  B01F27/80 ,  B01F35/31 ,  B01F35/41 ,  B01F35/4112 ,  B01F35/514

Abstract: A fluid mixing system includes a flexible bag having a first end, an opposing second end, and an interior surface bounding a compartment; a retainer coupled to the second end of the flexible bag, the retainer having a retention cavity formed thereon that communicates with the compartment of the flexible bag; and an elongated member having a first end rotatably coupled to the first end of the flexible bag and an opposing second end freely disposed within the retention cavity of the retainer so that the second end of the elongated member can rotate within the retention cavity relative to the retainer.

公开(公告)号：US20220136632A1

公开(公告)日：2022-05-05

申请号：US17576671

申请日：2022-01-14

Applicant: Life Technologies Corporation

Inventor： Ryan S. Beus ,  Brandon R. Burtenshaw ,  Eric Davis ,  Patrick L. Draper ,  Michael E. Goodwin ,  Brandon M. Knudsen ,  Jeremy K. Larsen ,  Kevin R. Pickup

IPC: F16L33/207 ,  F16L33/22 ,  B29C65/00 ,  B29C65/68 ,  B29C65/56 ,  A61M39/12

Abstract: A method for coupling a tube to a tube fitting includes radially outwardly expanding a tubular compression collar from a constricted state to an expanded state, the compression collar having a throughway extending there through and being made of a resiliently flexible material. An end of the tube is inserted within the throughway of the expanded compression collar, the tube bounding a passage. A tube fitting is inserted within the passage of the tube. The compression collar is allowed to resiliently rebound back towards the constricted state so that the compression collar pushes the tube against the tube fitting.