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公开(公告)号:US20220082607A1
公开(公告)日:2022-03-17
申请号:US17535367
申请日:2021-11-24
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor: Jarie Bolander , Keith Fife , Mark Milgrew
IPC: G01R31/26 , G01R31/28 , G01N27/414
Abstract: The invention provides testing of a chemically-sensitive transistor device, such as an ISFET device, without exposing the device to liquids. In one embodiment, the invention performs a first test to calculate a resistance of the transistor. Based on the resistance, the invention performs a second test to transition the testing transistor among a plurality of modes. Based on corresponding measurements, a floating gate voltage is then calculated with little or no circuitry overhead. In another embodiment, the parasitic capacitance of at least either the source or drain is used to bias the floating gate of an ISFET. A driving voltage and biasing current are applied to exploit the parasitic capacitance to test the functionality of the transistor.
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公开(公告)号:US11028438B2
公开(公告)日:2021-06-08
申请号:US16866653
申请日:2020-05-05
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor: Todd Rearick , Mark Milgrew , Jonathan Schultz , Chris Papalias , Kim Johnson
IPC: C12Q1/6874 , G16B30/00
Abstract: In one implementation, a method is described. The method includes determining an operational characteristic of sensors of a sensor array. The method further includes selecting a group of sensors in the array based on the operational characteristic of sensors in the group. The method further includes enabling readout of the sensors in the selected group. The method further includes receiving output signals from the enabled sensors.
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公开(公告)号:US10718733B2
公开(公告)日:2020-07-21
申请号:US16459515
申请日:2019-07-01
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor: Mark Milgrew , Jonathan Rothberg , James Bustillo
IPC: G01N27/414 , G01N27/27 , C12Q1/6869 , C12Q1/6874
Abstract: Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.
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公开(公告)号:US10655175B2
公开(公告)日:2020-05-19
申请号:US16153898
申请日:2018-10-08
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor: Todd Rearick , Mark Milgrew , Jonathan Schultz , Chris Papalias , Kim Johnson
IPC: C12Q1/6874 , G16B30/00
Abstract: In one implementation, a method is described. The method includes determining an operational characteristic of sensors of a sensor array. The method further includes selecting a group of sensors in the array based on the operational characteristic of sensors in the group. The method further includes enabling readout of the sensors in the selected group. The method further includes receiving output signals from the enabled sensors, the output signals indicating chemical reactions occurring proximate to the sensors of the sensor array.
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公开(公告)号:US11231451B2
公开(公告)日:2022-01-25
申请号:US15979439
申请日:2018-05-14
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor: Jarie Bolander , Keith Fife , Mark Milgrew
IPC: G01R31/26 , G01R31/28 , G01N27/414
Abstract: The invention provides testing of a chemically-sensitive transistor device, such as an ISFET device, without exposing the device to liquids. In one embodiment, the invention performs a first test to calculate a resistance of the transistor. Based on the resistance, the invention performs a second test to transition the testing transistor among a plurality of modes. Based on corresponding measurements, a floating gate voltage is then calculated with little or no circuitry overhead. In another embodiment, the parasitic capacitance of at least either the source or drain is used to bias the floating gate of an ISFET. A driving voltage and biasing current are applied to exploit the parasitic capacitance to test the functionality of the transistor.
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公开(公告)号:US12038405B2
公开(公告)日:2024-07-16
申请号:US18324346
申请日:2023-05-26
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor: Mark Milgrew , Jonathan Rothberg , James Bustillo
IPC: G01N27/414 , C12Q1/6869 , C12Q1/6874 , G01N27/27
CPC classification number: G01N27/4145 , C12Q1/6869 , C12Q1/6874 , G01N27/27 , G01N27/414 , Y10T29/49002
Abstract: Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.
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公开(公告)号:US20170146484A1
公开(公告)日:2017-05-25
申请号:US15344081
申请日:2016-11-04
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor: Mark Milgrew , Jonathan Rothberg , James Bustillo
IPC: G01N27/414 , C12Q1/68 , G01N27/27
CPC classification number: G01N27/4145 , C12Q1/6869 , C12Q1/6874 , G01N27/27 , G01N27/414 , Y10T29/49002
Abstract: Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.
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公开(公告)号:US20170097317A1
公开(公告)日:2017-04-06
申请号:US15292795
申请日:2016-10-13
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor: Kim Johnson , Jeremy Jordan , Peter Levine , Mark Milgrew
IPC: G01N27/414 , C12Q1/68
Abstract: The described embodiments may provide a chemical detection circuit that may comprise a plurality of first output circuits at a first side and a plurality of second output circuits at a second side of the chemical detection circuit. The chemical detection circuit may further comprise a plurality of tiles of pixels each placed between respective pairs of first and second output circuits. Each tile may include four quadrants of pixels. Each quadrant may have columns with designated first columns interleaved with second columns. Each first column may be coupled to a respective first output circuit in first and second quadrants, and to a respective second output circuit in third and fourth quadrants. Each second column may be coupled to a respective second output circuit in first and second quadrants, and to a respective first output circuit in third and fourth quadrants.
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