公开(公告)号：US11680905B2

公开(公告)日：2023-06-20

申请号：US17572926

申请日：2022-01-11

Applicant: LIFE TECHNOLOGIES HOLDINGS PTE LIMITED ,  LIFE TECHNOLOGIES CORPORATION

Inventor： Ming Song Chen ,  Chee Woei Chong ,  Wuh Ken Loh ,  Wern Yuh Foo ,  Kuan Moon Boo ,  Norbert Leclerc ,  Kristina Uhlendorf ,  Reiner Koellner ,  Torsten Fuchs ,  Stefan Breitfelder

IPC: G01N21/64

CPC classification number: G01N21/6452 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/6478

Abstract: A biological analysis system can include an excitation module and an emission module. The excitation module can include a collimator element for receiving excitation light from the excitation light source and transmitting collimated excitation light in a first direction, and a plurality of excitation mirrors arrayed along the excitation light path, each excitation mirror disposed at an acute angle relative to the first direction and configured to reflect collimated excitation light along a second direction. The emission module can be positioned to receive excitation light transmitted along the second direction and can include a sample block comprising a plurality of sample receptacles positioned to receive a beam of collimated excitation light, and a plurality of photodetectors configured to receive emission light transmitted from a respective sample receptacle in a direction transverse to the second direction of the excitation light path.

公开(公告)号：US12140544B2

公开(公告)日：2024-11-12

申请号：US18308177

申请日：2023-04-27

Applicant: LIFE TECHNOLOGIES HOLDINGS PTE LIMITED ,  LIFE TECHNOLOGIES CORPORATION

Inventor： Ming Song Chen ,  Chee Woei Chong ,  Wuh Ken Loh ,  Wern Yuh Foo ,  Kuan Moon Boo ,  Norbert Leclerc ,  Kristina Uhlendorf ,  Reiner Koellner ,  Torsten Fuchs ,  Stefan Breitfelder

IPC: G01N21/64

Abstract: A biological analysis system can include an excitation module and an emission module. The excitation module can include a collimator element for receiving excitation light from the excitation light source and transmitting collimated excitation light in a first direction, and a plurality of excitation mirrors arrayed along the excitation light path, each excitation mirror disposed at an acute angle relative to the first direction and configured to reflect collimated excitation light along a second direction. The emission module can be positioned to receive excitation light transmitted along the second direction and can include a sample block comprising a plurality of sample receptacles positioned to receive a beam of collimated excitation light, and a plurality of photodetectors configured to receive emission light transmitted from a respective sample receptacle in a direction transverse to the second direction of the excitation light path.

公开(公告)号：US11237108B2

公开(公告)日：2022-02-01

申请号：US16904784

申请日：2020-06-18

Applicant: LIFE TECHNOLOGIES HOLDINGS PTE LIMITED ,  LIFE TECHNOLOGIES CORPORATION

Inventor： Ming Song Chen ,  Chee Woei Chong ,  Wuh Ken Loh ,  Wern Yuh Foo ,  Kuan Moon Boo ,  Norbert Leclerc ,  Kristina Uhlendorf ,  Reiner Koellner ,  Torsten Fuchs ,  Stefan Breitfelder

IPC: G01N21/64

Abstract: A biological analysis system can include an excitation module and an emission module. The excitation module can include a collimator element for receiving excitation light from the excitation light source and transmitting collimated excitation light in a first direction, and a plurality of excitation mirrors arrayed along the excitation light path, each excitation mirror disposed at an acute angle relative to the first direction and configured to reflect collimated excitation light along a second direction. The emission module can be positioned to receive excitation light transmitted along the second direction and can include a sample block comprising a plurality of sample receptacles positioned to receive a beam of collimated excitation light, and a plurality of photodetectors configured to receive emission light transmitted from a respective sample receptacle in a direction transverse to the second direction of the excitation light path.

公开(公告)号：US11339425B2

公开(公告)日：2022-05-24

申请号：US16382294

申请日：2019-04-12

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Jacob K. Freudenthal ,  Geoffrey Dahlhoff ,  Kevin Maher ,  Ming Song Chen ,  Gary Lim ,  Ronald Danehy ,  David Fortescue ,  Ming Shen ,  Woon Liang Soh ,  Francis T. Cheng ,  Ruoyun Wu ,  Thiam Chye Lee ,  Gary A. Chappell ,  Chee Kiong Lim ,  Jeff Dere ,  Ted Straub ,  Jorge Fonseca ,  Kuan Moon Boo ,  Soo Yong Lau

IPC: C12Q1/686 ,  B01L3/00 ,  B01L7/00

Abstract: A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lends can be a bi-convex lens.

公开(公告)号：US10323274B2

公开(公告)日：2019-06-18

申请号：US14348504

申请日：2012-09-28

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Jacob K. Freudenthal ,  Kevin Maher ,  Ming Song Chen ,  Theodore E. Straub ,  Kuan Moon Boo ,  Soo Yong Lau

IPC: C12Q1/686 ,  B01L3/00 ,  B01L7/00

Abstract: A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lens can be a bi-convex lens.

公开(公告)号：US20140213487A1

公开(公告)日：2014-07-31

申请号：US14348504

申请日：2012-09-28

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Jacob K. Freudenthal ,  Geoffrey Dahlhoff ,  Kevin Maher ,  Ming Song Chen ,  Gary Lim ,  Ronald Danehy ,  David Fortescue ,  Ming Shen ,  Woon Liang Soh ,  Francis T. Cheng ,  Ruoyun Wu ,  Thiam Chye Lee ,  Gary A. Chappell ,  Chee Kiong Lim ,  Jeff Dere ,  Theodore E. Straub ,  Jorge Fonseca ,  Kuan Moon Boo ,  Soo Yong Lau

IPC: B01L7/00 ,  C12Q1/68

CPC classification number: C12Q1/686 ,  B01L3/50855 ,  B01L3/50857 ,  B01L7/52 ,  B01L2200/023 ,  B01L2200/025 ,  B01L2200/028 ,  B01L2200/143 ,  B01L2300/021 ,  B01L2300/046 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/1827 ,  B01L2300/1844

Abstract: A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lens can be a bi-convex lens.

Abstract translation: 提供生物分析系统。 该系统包括被配置为容纳多个样品保持器中的任何一个的可互换组件，每个样品保持器被配置为接收多个样品。 该系统还包括被配置为使多个样品循环通过一系列温度的控制系统。 该系统还包括被配置为检测从多个样本发射的荧光信号的光学系统。 特别地，光学系统可以包括单个场透镜，激发源，光学传感器和多个滤光器组件。 激发源可以是一个或多个发光二极管。 场透镜可以是双凸透镜。