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公开(公告)号：US11703428B2
公开(公告)日：2023-07-18
申请号：US17516605
申请日：2021-11-01
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Thomas M. Baer , Michael G. Youngquist , Brian W. Donovan , Alan E. Wessel , Norbert H. Leclerc , Michael A. Smith , Craig S. Barker , George M. Dawson
CPC classification number: G01N1/2813 , G01B11/002 , G01N2001/282 , G01N2001/284 , Y10T156/10 , Y10T156/1054
Abstract: Systems and methods for automated laser microdissection are disclosed including automatic slide detection, position detection of cutting and capture lasers, focus optimization for cutting and capture lasers, energy and duration optimization for cutting and capture lasers, inspection and second phase capture and/or ablation in a quality control station and tracking information for linking substrate carrier or output microdissected regions with input sample or slide.
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公开(公告)号：US11175203B2
公开(公告)日：2021-11-16
申请号：US16790595
申请日：2020-02-13
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Thomas M. Baer , Michael G. Youngquist , Brian W. Donovan , Alan E. Wessel , Norbert H. Leclerc , Michael A. Smith , Craig S. Barker , George M. Dawson
Abstract: Systems and methods for automated laser microdissection are disclosed including automatic slide detection, position detection of cutting and capture lasers, focus optimization for cutting and capture lasers, energy and duration optimization for cutting and capture lasers, inspection and second phase capture and/or ablation in a quality control station and tracking information for linking substrate carrier or output microdissected regions with input sample or slide.
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公开(公告)号：US20220113229A1
公开(公告)日：2022-04-14
申请号：US17516605
申请日：2021-11-01
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Thomas M. Baer , Michael G. Youngquist , Brian W. Donovan , Alan E. Wessel , Norbert H. Leclerc , Michael A. Smith , Craig S. Barker , George M. Dawson
Abstract: Systems and methods for automated laser microdissection are disclosed including automatic slide detection, position detection of cutting and capture lasers, focus optimization for cutting and capture lasers, energy and duration optimization for cutting and capture lasers, inspection and second phase capture and/or ablation in a quality control station and tracking information for linking substrate carrier or output microdissected regions with input sample or slide.
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Patent Agency Ranking
公开(公告)号：US10605706B2
公开(公告)日：2020-03-31
申请号：US16208557
申请日：2018-12-03
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Thomas M. Baer , Michael G. Youngquist , Brian W. Donovan , Alan E. Wessel , Norbert H. Leclerc , Michael A. Smith , Craig S. Barker , George M. Dawson
Abstract: Systems and methods for automated laser microdissection are disclosed including automatic slide detection, position detection of cutting and capture lasers, focus optimization for cutting and capture lasers, energy and duration optimization for cutting and capture lasers, inspection and second phase capture and/or ablation in a quality control station and tracking information for linking substrate carrier or output microdissected regions with input sample or slide.
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公开(公告)号：US20140303038A1
公开(公告)日：2014-10-09
申请号：US14070402
申请日：2013-11-01
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Mark G. Erlander , Xiao-Jun Ma , Thomas M. Baer
IPC: C12Q1/68
CPC classification number: C12Q1/6876 , C12Q1/6809 , C12Q1/6851 , C12Q1/686 , C12Q2565/501
Abstract: The invention provides materials and methods for the detection of nucleic acid expression via the 3′ portion of expressed sequences. Embodiments of the invention include the use of microarrays comprising nucleic acid probes that are complementary to the 3′ end of expressed sequences and by the use of quantitative PCR (Q-PCR) based amplification of sequences found at or near the 3′ end of expressed sequences. The invention may be used to detect the presence of expressed nucleic acids encoding particular gene products (sequences present in a “transcriptome”).
Abstract translation: 本发明提供了通过表达序列的3'部分检测核酸表达的材料和方法。 本发明的实施方案包括使用包含与表达的序列的3'末端互补的核酸探针的微阵列，以及通过使用基于定量PCR（Q-PCR）的扩增在3'末端发现的序列的表达 序列。 本发明可用于检测编码特定基因产物（“转录组”中存在的序列）的表达的核酸的存在。
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公开(公告)号：US20170284907A1
公开(公告)日：2017-10-05
申请号：US15434200
申请日：2017-02-16
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Thomas M. Baer , Michael G. YOUNGQUIST , Brian W. DONOVAN , Alan E. WESSEL , Norbert H. LECLERC , Michael A. SMITH , Craig S. BARKER , George M. DAWSON
CPC classification number: G01N1/2813 , G01B11/002 , G01N2001/282 , G01N2001/284 , Y10T156/10 , Y10T156/1054
Abstract: Systems and methods for automated laser microdissection are disclosed including automatic slide detection, position detection of cutting and capture lasers, focus optimization for cutting and capture lasers, energy and duration optimization for cutting and capture lasers, inspection and second phase capture and/or ablation in a quality control station and tracking information for linking substrate carrier or output microdissected regions with input sample or slide.
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公开(公告)号：US20160194707A1
公开(公告)日：2016-07-07
申请号：US14986982
申请日：2016-01-04
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Mark G. Erlander , Xiao-Jun Ma , Thomas M. Baer
IPC: C12Q1/68
CPC classification number: C12Q1/6876 , C12Q1/6809 , C12Q1/6851 , C12Q1/686 , C12Q2565/501
Abstract: The invention provides materials and methods for the detection of nucleic acid expression via the 3′ portion of expressed sequences. Embodiments of the invention include the use of microarrays comprising nucleic acid probes that are complementary to the 3′ and of expressed sequences and by the use of quantitative PCR (Q-PCR) based amplification of sequences found at or near the 3′ end of expressed sequences. The invention may be used to detect the presence of expressed nucleic acids encoding particular gene products (sequences present in a “transcriptome”).
Abstract translation: 本发明提供了通过表达序列的3'部分检测核酸表达的材料和方法。 本发明的实施方案包括使用包含与3'和表达的序列互补的核酸探针的微阵列，以及通过使用基于定量PCR（Q-PCR）的扩增在3'末端发现的序列的表达 序列。 本发明可用于检测编码特定基因产物（“转录组”中存在的序列）的表达的核酸的存在。
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公开(公告)号：US10156501B2
公开(公告)日：2018-12-18
申请号：US15434200
申请日：2017-02-16
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Thomas M. Baer , Michael G. Youngquist , Brian W. Donovan , Alan E. Wessel , Norbert H. Leclerc , Michael A. Smith , Craig S. Barker , George M. Dawson
Abstract: Systems and methods for automated laser microdissection are disclosed including automatic slide detection, position detection of cutting and capture lasers, focus optimization for cutting and capture lasers, energy and duration optimization for cutting and capture lasers, inspection and second phase capture and/or ablation in a quality control station and tracking information for linking substrate carrier or output microdissected regions with input sample or slide.
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