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    Single use bioreactor
    3.
    发明授权
    Single use bioreactor 有权

    公开(公告)号：US10801003B2

    公开(公告)日：2020-10-13

    申请号：US15613954

    申请日：2017-06-05

    申请人： Lonza Ltd

    发明人： Colin Mark Jaques ,  Mohsan Waseem Khan ,  Rita D'Ornelas P. De Barros Costa ,  Anthony Beaney ,  David Valentine

    IPC分类号： C12M1/00 ,  C12M1/06 ,  B01F7/00 ,  B01F3/04 ,  B01F15/00 ,  B01F7/16

    摘要： A single-use bioreactor is provided. The single-use bioreactor may include a bioprocess container, a shell, at least one agitator, at least one sparger, at least one gas filter inlet port for the sparger(s) and headspace overlay, at least one fill port, at least one harvest port, at least one sample port, and at least one probe. In examples, at least one controller may monitor and control one or more parameters associated with the single-use bioreactor A method to cultivate and propagate mammalian cells is also provided. The method may include cultivating under suitable conditions and in a suitable culture medium in a first single-use bioreactor, transferring the medium containing the cells obtained by propagation from the at least one mammalian cell is into a second single-use bioreactor, transferring the medium containing the cells obtained by propagation from the at least one mammalian cell is into a third single-use bioreactor, and cultivating the cells in the third bioreactor.

    Single Use Bioreactor
    5.
    发明申请
    Single Use Bioreactor 有权

    公开(公告)号：US20230045226A1

    公开(公告)日：2023-02-09

    申请号：US17850452

    申请日：2022-06-27

    申请人： Lonza Ltd

    发明人： Colin Mark Jaques ,  Mohsan Waseem Khan ,  Rita D'Ornelas P. De Barros Costa ,  Anthony Beaney ,  David Valentine

    IPC分类号： C12M1/00 ,  C12M1/06 ,  B01F23/231 ,  B01F27/053 ,  B01F27/86 ,  B01F27/191 ,  B01F27/113 ,  B01F35/513

    摘要： A single-use bioreactor is provided. The single-use bioreactor may include a bioprocess container, a shell, at least one agitator, at least one sparger, at least one gas filter inlet port for the sparger(s) and headspace overlay, at least one fill port, at least one harvest port, at least one sample port, and at least one probe. In examples, at least one controller may monitor and control one or more parameters associated with the single-use bioreactor A method to cultivate and propagate mammalian cells is also provided. The method may include cultivating under suitable conditions and in a suitable culture medium in a first single-use bioreactor, transferring the medium containing the cells obtained by propagation from the at least one mammalian cell is into a second single-use bioreactor, transferring the medium containing the cells obtained by propagation from the at least one mammalian cell is into a third single-use bioreactor, and cultivating the cells in the third bioreactor.

    Single use bioreactor
    6.
    发明授权
    Single use bioreactor 有权

    公开(公告)号：US11371002B2

    公开(公告)日：2022-06-28

    申请号：US17019516

    申请日：2020-09-14

    申请人： Lonza Ltd

    发明人： Colin Mark Jaques ,  Mohsan Waseem Khan ,  Rita D'Ornelas P. De Barros Costa ,  Anthony Beaney ,  David Valentine

    IPC分类号： C12M1/00 ,  C12M1/06 ,  B01F23/231 ,  B01F27/053 ,  B01F27/86 ,  B01F27/191 ,  B01F27/113 ,  B01F35/513

    摘要： A single-use bioreactor is provided. The single-use bioreactor may include a bioprocess container, a shell, at least one agitator, at least one sparger, at least one gas filter inlet port for the sparger(s) and headspace overlay, at least one fill port, at least one harvest port, at least one sample port, and at least one probe. In examples, at least one controller may monitor and control one or more parameters associated with the single-use bioreactor A method to cultivate and propagate mammalian cells is also provided. The method may include cultivating under suitable conditions and in a suitable culture medium in a first single-use bioreactor, transferring the medium containing the cells obtained by propagation from the at least one mammalian cell is into a second single-use bioreactor, transferring the medium containing the cells obtained by propagation from the at least one mammalian cell is into a third single-use bioreactor, and cultivating the cells in the third bioreactor.

    Single Use Bioreactor
    7.
    发明申请
    Single Use Bioreactor 有权

    公开(公告)号：US20210002597A1

    公开(公告)日：2021-01-07

    申请号：US17019516

    申请日：2020-09-14

    申请人： Lonza Ltd

    发明人： Colin Mark Jaques ,  Mohsan Waseem Khan ,  Rita D'Ornelas P. De Barros Costa ,  Anthony Beaney ,  David Valentine

    IPC分类号： C12M1/00 ,  C12M1/06 ,  B01F7/00 ,  B01F3/04 ,  B01F15/00 ,  B01F7/16

    摘要： A single-use bioreactor is provided. The single-use bioreactor may include a bioprocess container, a shell, at least one agitator, at least one sparger, at least one gas filter inlet port for the sparger(s) and headspace overlay, at least one fill port, at least one harvest port, at least one sample port, and at least one probe. In examples, at least one controller may monitor and control one or more parameters associated with the single-use bioreactor A method to cultivate and propagate mammalian cells is also provided. The method may include cultivating under suitable conditions and in a suitable culture medium in a first single-use bioreactor, transferring the medium containing the cells obtained by propagation from the at least one mammalian cell is into a second single-use bioreactor, transferring the medium containing the cells obtained by propagation from the at least one mammalian cell is into a third single-use bioreactor, and cultivating the cells in the third bioreactor.