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公开(公告)号：US20050154042A1
公开(公告)日：2005-07-14
申请号：US11002821
申请日：2004-12-02
申请人： Larry Bratton , Xue-Min Cheng , Chitase Lee , Steven Miller , Jeffrey Pfefferkorn , Toni-Jo Poel , Roderick Sorenson , Yuntao Song , Kuai-Lin Sun , Bharat Trivedi , Paul Unangst
发明人： Larry Bratton , Xue-Min Cheng , Chitase Lee , Steven Miller , Jeffrey Pfefferkorn , Toni-Jo Poel , Roderick Sorenson , Yuntao Song , Kuai-Lin Sun , Bharat Trivedi , Paul Unangst
IPC分类号： A61K31/40 , C07D207/34 , C07D207/46 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D413/12
CPC分类号： C07D207/34 , C04B35/632 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D413/12
摘要： HMGCo-A reductase inhibitor compounds useful as hypocholesterolemic and hypolipidemic compounds are provided. Also provided are pharmaceutical compositions of the compounds. Methods of making and methods of using the compounds are also provided.
摘要翻译： 提供了可用作低胆固醇血症和降血脂化合物的HMGCo-A还原酶抑制剂化合物。 还提供了化合物的药物组合物。 还提供了制备方法和使用该化合物的方法。
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公开(公告)号：US20070088069A1
公开(公告)日：2007-04-19
申请号：US11546168
申请日：2006-10-11
申请人： Xue-Min Cheng , Richard Hutchings , Walter Howard , Robert Kennedy , William Park , Yuntao Song , Bharat Trivedi
发明人： Xue-Min Cheng , Richard Hutchings , Walter Howard , Robert Kennedy , William Park , Yuntao Song , Bharat Trivedi
IPC分类号： A61K31/4164 , C07D233/66
CPC分类号： C07D233/90
摘要： Novel imidazole compounds and pharmaceutical compositions are described, as are methods of using such compounds, alone or in combination with another pharmaceutically active agent, to treat subjects, including humans, suffering from hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and atherosclerosis.
摘要翻译： 还描述了新的咪唑化合物和药物组合物，以及使用这些化合物单独或与另一种药物活性剂组合来治疗患有高脂血症，高胆固醇血症，高甘油三酯血症和动脉粥样硬化的受试者，包括人的方法。
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公开(公告)号：US20050107442A1
公开(公告)日：2005-05-19
申请号：US11025271
申请日：2004-12-24
申请人： Xue-Min Cheng , Gary Filzen , Andrew Geyer , Chitase Lee , Bharat Trivedi
发明人： Xue-Min Cheng , Gary Filzen , Andrew Geyer , Chitase Lee , Bharat Trivedi
IPC分类号： A61K31/426 , A61K31/427 , A61K31/4725 , A61P3/00 , A61P3/06 , A61P3/10 , A61P9/10 , C07D277/26 , C07D277/30 , C07D417/12 , C07D277/18 , A61K31/4025 , A61K31/4164 , A61K31/4178 , A61K31/421 , A61K31/4439 , C07D263/02
CPC分类号： C07D417/12 , C07D277/26
摘要： This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing hyperlipidemia and hypercholesteremia in a mammal. The present invention also discloses method for making the disclosed compounds.
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公开(公告)号：US20050113422A1
公开(公告)日：2005-05-26
申请号：US11020391
申请日：2004-12-22
申请人： Xue-Min Cheng , Gary Filzen , Andrew Geyer , Chitase Lee , Bharat Trivedi
发明人： Xue-Min Cheng , Gary Filzen , Andrew Geyer , Chitase Lee , Bharat Trivedi
IPC分类号： A61K31/426 , A61K31/427 , A61K31/4725 , A61P3/00 , A61P3/06 , A61P3/10 , A61P9/10 , C07D277/26 , C07D277/30 , C07D417/12 , A61K31/4439 , A61K31/421 , C07D413/04 , C07D417/04
CPC分类号： C07D417/12 , C07D277/26
摘要： This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing hyperlipidemia and hypercholesteremia in a mammal. The present invention also discloses method for making the disclosed compounds.
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公开(公告)号：US06867224B2
公开(公告)日：2005-03-15
申请号：US10324266
申请日：2002-12-19
IPC分类号： A61K31/426 , A61K31/427 , A61K31/4725 , A61P3/00 , A61P3/06 , A61P3/10 , A61P9/10 , C07D277/26 , C07D277/30 , C07D417/12
CPC分类号： C07D417/12 , C07D277/26
摘要： This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing hyperlipidemia and hypercholesteremia in a mammal. The present invention also discloses method for making the disclosed compounds.
摘要翻译： 本发明公开了改变PPAR活性的化合物。 本发明还公开了化合物的药学上可接受的盐，包含化合物或其盐的药学上可接受的组合物，以及使用它们作为治疗或预防哺乳动物高脂血症和高胆固醇血症的治疗剂的方法。 本发明还公开了制备所公开的化合物的方法。
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公开(公告)号：US06833380B2
公开(公告)日：2004-12-21
申请号：US10324278
申请日：2002-12-19
申请人： Xue-Min Cheng , Noe Erasga , Gary Frederick Filzen , Andrew Geyer , Chitase Lee , Bharat Kalidas Trivedi
发明人： Xue-Min Cheng , Noe Erasga , Gary Frederick Filzen , Andrew Geyer , Chitase Lee , Bharat Kalidas Trivedi
IPC分类号： A61K3142
CPC分类号： C07D417/12 , C07D277/26
摘要： This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing hyperlipidemia and hypercholesteremia in a mammal. The present invention also discloses method for making the disclosed compounds.
摘要翻译： 本发明公开了改变PPAR活性的化合物。 本发明还公开了化合物的药学上可接受的盐，包含化合物或其盐的药学上可接受的组合物，以及使用它们作为治疗或预防哺乳动物高脂血症和高胆固醇血症的治疗剂的方法。 本发明还公开了制备所公开的化合物的方法。
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7.发明授权Certain benzothiazine dioxide endothelin antagonists and processes for their preparation 失效某些苯并噻嗪二氧化物内皮素拮抗剂及其制备方法公开(公告)号：US06545150B2
公开(公告)日：2003-04-08
申请号：US10006589
申请日：2001-12-05
申请人： Amy Mae Bunker , Xue-Min Cheng , Annette Marian Doherty , Jeremy John Edmunds , Gerald David Kanter , Chitase Lee , Joseph Thomas Repine , Richard William Skeean
发明人： Amy Mae Bunker , Xue-Min Cheng , Annette Marian Doherty , Jeremy John Edmunds , Gerald David Kanter , Chitase Lee , Joseph Thomas Repine , Richard William Skeean
IPC分类号： C07D27916
CPC分类号： C07D417/04 , C07C303/40 , C07D279/02 , C07D417/10 , C07C311/21
摘要： The instant invention is a series of benzothiazine dioxides, or a pharmaceutically acceptable salt thereof, which are potent endothelin A antagonists with profound in vitro activity, and improved syntheses for the Formula 1 The compounds are useful in treating elevated levels of endothelin, essential renovascular malignant and pulmonary hypertension, cerebral infarction, cerebral ischemia, congestive heart failure, and subarachnoid hemorrhage.
摘要翻译： 本发明是一系列苯并噻嗪二氧化物或其药学上可接受的盐，其是具有深度体外活性的有效的内皮素A拮抗剂，以及式1的改进的合成。该化合物可用于治疗升高的内皮素水平，必需的血管性恶性和 肺动脉高压，脑梗塞，脑缺血，充血性心力衰竭和蛛网膜下腔出血。
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公开(公告)号：US06265399B1
公开(公告)日：2001-07-24
申请号：US09445504
申请日：1999-12-08
申请人： Amy Mae Bunker , Xue-Min Cheng , Annette Marian Doherty , Jeremy John Edmunds , Gerald David Kanter , Chitase Lee , Joseph Thomas Repine , Richard William Skeean
发明人： Amy Mae Bunker , Xue-Min Cheng , Annette Marian Doherty , Jeremy John Edmunds , Gerald David Kanter , Chitase Lee , Joseph Thomas Repine , Richard William Skeean
IPC分类号： C07D27902
CPC分类号： C07D417/04 , C07C303/40 , C07D279/02 , C07D417/10 , C07C311/21
摘要： The instant invention is a series of benzothiazine dioxides, or a pharmaceutically acceptable salt thereof, which are potent endothelin A antagonists with profound in vitro activity, and improved syntheses for the Formula 1 The compounds are useful in treating elevated levels of endothelin, essential renovascular malignant and pulmonary hypertension, cerebral infarction, cerebral ischemia, congestive heart failure, and subarachnoid hemorrhage.
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公开(公告)号：US07109222B2
公开(公告)日：2006-09-19
申请号：US11025271
申请日：2004-12-24
IPC分类号： A61K31/426 , C07D277/30
CPC分类号： C07D417/12 , C07D277/26
摘要： This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing hyperlipidemia and hypercholesteremia in a mammal. The present invention also discloses method for making the disclosed compounds.
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公开(公告)号：US5773444A
公开(公告)日：1998-06-30
申请号：US837176
申请日：1997-04-14
申请人： Kyunghye Ahn , Xue-Min Cheng , Annette Marian Doherty , Edward Faith Elslager , Brian Kornberg , Chitase Lee , Daniele Leonard , Sham Nikam , Leslie Morton Werbel
发明人： Kyunghye Ahn , Xue-Min Cheng , Annette Marian Doherty , Edward Faith Elslager , Brian Kornberg , Chitase Lee , Daniele Leonard , Sham Nikam , Leslie Morton Werbel
IPC分类号： C07D239/74 , A61K31/505 , A61K31/517 , A61P43/00 , C07D239/90 , C07D239/91 , C07D239/94 , C07D401/12 , C07D403/12 , C07D453/02 , A61K31/495 , A61K31/535
CPC分类号： C07D401/12 , C07D239/94 , C07D403/12 , C07D453/02
摘要： Novel quinazoline inhibitors of endothelin converting enzyme are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin and in controlling hypertension, myocardial infarction and ischemia, metabolic, endocrinological, and neurological disorders, congestive heart failure, endotoxic and hemorrhagic shock, septic shock, subarachnoid hemorrhage, arrhythmias, asthma, acute and chronic renal failure, cyclosporin-A induced nephrotoxicity, angina, gastric mucosal damage, ischemic bowel disease, cancer, pulmonary hypertension, preeclampsia, atherosclerotic disorders including Raynaud's disease and restenosis, cerebral ischemia and vasospasm, and diabetes.
摘要翻译： 描述了内皮素转化酶的新型喹唑啉抑制剂，以及其制备方法及其药物组合物，其可用于治疗高水平的内皮素和控制高血压，心肌梗死和缺血，代谢，内分泌和神经障碍 ，充血性心力衰竭，内毒素性和出血性休克，败血性休克，蛛网膜下腔出血，心律失常，哮喘，急性和慢性肾功能衰竭，环孢菌素A诱导的肾毒性，心绞痛，胃粘膜损伤，缺血性肠病，癌症，肺动脉高压，先兆子痫，动脉粥样硬化 疾病包括雷诺氏病和再狭窄，脑缺血和血管痉挛以及糖尿病。
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