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    Porous implant grain or granule
    1.
    发明申请
    Porous implant grain or granule 有权
    多孔植入物颗粒或颗粒

    公开(公告)号：US20080294271A1

    公开(公告)日：2008-11-27

    申请号：US12071507

    申请日：2008-02-21

    申请人： Lars Magnus Bjursten ,  Bengt Mjoberg ,  Niklas Axen

    发明人： Lars Magnus Bjursten ,  Bengt Mjoberg ,  Niklas Axen

    IPC分类号： A61F2/02

    CPC分类号： A61L27/06 ,  A61F2/28 ,  A61F2002/3092 ,  A61F2310/00023 ,  A61F2310/00616 ,  A61K9/0024 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/412

    摘要： The present invention is related to an implant with anti-inflammatory or antibacterial effects, or both, the implant being intended for implantation in a human or an animal body, the implant comprising at least one porous grain or granule, wherein the at least one porous grain or granule comprises titanium, one or more titanium oxides or titanium alloy and has a titanium oxide layer on its surface; has a mean length from one side to the opposite side, through a geometrical centre, of up to 5 mm; has a mean specific surface area of at least 0.15 m2/g according to the BET method. Moreover, disclosed is also a method for treating a condition comprising an inflammation or/and an infection present in a human or animal body with implants according to the invention.Described is also a method for producing implants according to the invention from a piece of a crude titanium or titanium alloy sponge, comprising the steps of: choosing and removing a porous peripheral, but not most outer, part of the piece of the crude titanium or titanium alloy sponge; analysing that part in view of the chemical composition for potential impurities; crushing that part, if pure, and; finally selecting the implants by sieving and analysis in batches, the analysis in batches being performed by scanning electron microscopy (SEM) or by gas absorption with nitrogen, the Hg method and/or the BET method.

    摘要翻译： 本发明涉及一种植入物，其具有抗炎或抗菌效果，或两者都用于植入人或动物体内，所述植入物包括至少一个多孔颗粒或颗粒，其中所述至少一种多孔 颗粒或颗粒包括钛，一种或多种钛氧化物或钛合金，并且在其表面上具有氧化钛层; 具有从一侧到另一侧的平均长度，通过几何中心至多5mm; 根据BET法，平均比表面积至少为0.15m 2 / g。 此外，还公开了一种用于根据本发明用植入物治疗包含存在于人或动物体内的炎症或/和感染的病症的方法。 本发明还描述了一种由钛或钛合金海绵制成的根据本发明的植入物的方法，该方法包括以下步骤：选择和除去粗钛片的多孔外周部分，但不除外， 钛合金海绵; 鉴于潜在杂质的化学成分分析该部分; 破碎那部分，如果纯净，和; 最后通过筛选和分批批量选择种植体，分批采用扫描电子显微镜（SEM）或通过氮气吸收，Hg法和/或BET法进行分析。

    Method of making structured ceramic coatings and coated devices prepared with the method
    2.
    发明授权
    Method of making structured ceramic coatings and coated devices prepared with the method 有权
    用该方法制备结构化陶瓷涂层和涂层装置的方法

    公开(公告)号：US07048792B2

    公开(公告)日：2006-05-23

    申请号：US10691542

    申请日：2003-10-24

    申请人： Niklas Axen ,  Kajsa Bjorklund ,  Leif Hermansson ,  Hakan Engqvist

    发明人： Niklas Axen ,  Kajsa Bjorklund ,  Leif Hermansson ,  Hakan Engqvist

    IPC分类号： C04B11/28 ,  A61F2/02

    CPC分类号： A61L27/32 ,  A61L2420/02 ,  C23C4/02 ,  C23C26/00 ,  C23C28/048 ,  C23C30/00 ,  Y10T428/25

    摘要： The invention describes a low temperature method for producing multi-layered or multi-phased coatings. With the technique according to the present invention, surface coatings with controlled variations in terms of chemical composition, phase composition, porosity, surface roughness, mechanical properties, biocompatibility, etc can be achieved. The method of coating a substrate surface comprising the steps of preparing one powder mixture, or several powder mixtures having different chemical composition, wherein at least one of said powder mixtures comprise a non-hydrated hydraulic ceramic powder binder phase, pre-treating a substrate surface, to increase the adhesion between the substrate and the ceramic coating, applying one or more different layers on top of each other of the non-hydrated powder mixture on the substrate, and finally, hydrating the powder layer/layers in a curing agent containing ions of carbonates, phosphates or fluorides.

    摘要翻译： 本发明描述了用于生产多层或多相涂层的低温方法。 根据本发明的技术，可以实现在化学成分，相组成，孔隙率，表面粗糙度，机械性能，生物相容性等方面受控变化的表面涂层。 涂覆基材表面的方法包括制备一种粉末混合物或具有不同化学组成的几种粉末混合物的步骤，其中至少一种所述粉末混合物包含非水合水硬性陶瓷粉末粘合剂相，预处理基材表面 ，以增加基底和陶瓷涂层之间的粘合力，在基底上施加一个或多个不同层的非水合粉末混合物的顶部，最后使含有离子的固化剂中的粉末层/层水合 的碳酸盐，磷酸盐或氟化物。

    COMPOSITION COMPRISING BIODEGRADABLE HYDRATING CERAMICS FOR CONTROLLED DRUG DELIVERY
    3.
    发明申请
    COMPOSITION COMPRISING BIODEGRADABLE HYDRATING CERAMICS FOR CONTROLLED DRUG DELIVERY 有权
    包含用于控制药物递送的生物可降解水泥陶瓷的组合物

    公开(公告)号：US20090036392A1

    公开(公告)日：2009-02-05

    申请号：US10576857

    申请日：2004-10-21

    申请人： Hans Lennernas ,  Bo Lennernas ,  Jonas Hugosson ,  Niklas Axen

    发明人： Hans Lennernas ,  Bo Lennernas ,  Jonas Hugosson ,  Niklas Axen

    IPC分类号： A61K31/56 ,  A61K31/7088 ,  A61P35/00

    CPC分类号： A61K45/06 ,  A61K9/1611 ,  A61K9/1617 ,  A61K9/1652 ,  A61K31/00 ,  A61K31/167 ,  A61K2300/00

    摘要： The present invention relates to a drug carrier composition comprising i) one or more biodegradable hydrating ceramics ii) one or more expandable agents, and iii) sorbed aqueous medium which in solid form has a ruptured structure. The function of the expandable agent is to create a ruptured structure in the solidified composition, either a foam-like structure or a disintegrated structure where it is split into a large number of parts, particles, units, granules or pieces, so as to obtain an enlarged apparent surface area that is exposed to degradation or erosion upon administration. Suitable substances to obtain this surface enlarging effect are gas-forming agents or swelling agents, gelling agents or disintegrants, here referred to as expandable agents. The expandable agents may be bioresorbable or non-bioresorbable.

    摘要翻译： 本发明涉及药物载体组合物，其包含i）一种或多种可生物降解的水合陶瓷ii）一种或多种可发性剂，和iii）固体形式的具有破裂结构的吸水性水性介质。 可膨胀剂的功能是在凝固组合物中产生断裂结构，泡沫状结构或分解结构，其中其被分成大量的部分，颗粒，单位，颗粒或块，以获得 在施用时暴露于降解或侵蚀的扩大的表观表面积。 获得这种表面扩大效果的合适物质是气体形成剂或溶胀剂，胶凝剂或崩解剂，这里称为可膨胀剂。 可膨胀剂可以是生物可再吸收的或非生物可再吸收的。

    Method for Treating Prostate Diseases Based on Local Delivery of Active Substances
    4.
    发明申请
    Method for Treating Prostate Diseases Based on Local Delivery of Active Substances 有权
    基于活性物质的局部输送治疗前列腺疾病的方法

    公开(公告)号：US20080286205A1

    公开(公告)日：2008-11-20

    申请号：US11910162

    申请日：2006-03-31

    申请人： Hans Lennernas ,  Bo Lennernas ,  Jonas Hugosson ,  Niklas Axen

    发明人： Hans Lennernas ,  Bo Lennernas ,  Jonas Hugosson ,  Niklas Axen

    IPC分类号： A61K49/00 ,  A61K47/02 ,  A61K49/06 ,  A61K31/566 ,  A61K38/22 ,  A61K31/167 ,  A61K31/4166 ,  A61K38/18 ,  A61K48/00 ,  A61K49/22 ,  A61K49/04

    CPC分类号： A61K9/1647

    摘要： A method for treating prostate related diseases in a subject, the method comprising i) optionally administering to subject an initial boost dose of one or more active substances and/or prodrugs, and ii) administering locally into the prostate a controlled release pharmaceutical composition comprising one or more active substances in a biodegradable ceramic carrier. The biodegradable hydrating ceramic may be selected from the group consisting of non-hydrated or hydrated calcium sulphate, calcium phosphate, calcium carbonate, calcium fluoride, calcium silicate, magnesium sulphate, magnesium phosphate, magnesium carbonate, magnesium fluoride, magnesium silicate, barium sulphate, barium phosphate, barium carbonate, barium fluoride, barium silicate, or mixtures thereof. In a specific embodiment, the biodegradable hydrating ceramic is non-hydrated or hydrated calcium sulphate.

    摘要翻译： 一种用于治疗受试者中前列腺相关疾病的方法，所述方法包括i）任选地施用受试者初始增强剂量的一种或多种活性物质和/或前药，以及ii）局部施用于前列腺中的控释药物组合物，其包含一种 或更多的活性物质在可生物降解的陶瓷载体中。 可生物降解的水合陶瓷可以选自非水合或水合硫酸钙，磷酸钙，碳酸钙，氟化钙，硅酸钙，硫酸镁，磷酸镁，碳酸镁，氟化镁，硅酸镁，硫酸钡， 磷酸钡，碳酸钡，氟化钡，硅酸钡或其混合物。 在一个具体实施方案中，可生物降解的水合陶瓷是非水合或水合硫酸钙。

    Displacement device, use and system therefore
    5.
    发明授权
    Displacement device, use and system therefore 失效
    位移装置，因此使用和系统

    公开(公告)号：US08764800B2

    公开(公告)日：2014-07-01

    申请号：US12994654

    申请日：2009-05-28

    申请人： Erik Johansson ,  Niklas Axen ,  Sven Olerud ,  Staffan Bowald ,  Hans Jacobsen

    发明人： Erik Johansson ,  Niklas Axen ,  Sven Olerud ,  Staffan Bowald ,  Hans Jacobsen

    IPC分类号： A61B17/70

    CPC分类号： A61B17/7077 ,  A61B2090/3937

    摘要： Embodiments of the present disclosure are directed to a systems, devices and methods for displacing bones of a living mammal. In some embodiments, a device is provided which includes at least two engagement elements positioned at a distance from each other for engagement with two separate bones Each of the engagement elements may be carried by a support part which in turn is supported in a support portion of a distance unit (5). The said support part and support portion form a support unit, where each engagement element extends at an angle (α) with respect to a straight line (L) between two support units. At least one of the support units includes an arrangement for altering the angle which includes an actuating unit maneuverable for adjustment of the angle (α). Some embodiments of the disclosure are directed to a system for engagement with vertebrae including such devices (noted above), as well as uses of the device and associated methods of treatment.

    摘要翻译： 本公开的实施例涉及用于移动活的哺乳动物的骨骼的系统，装置和方法。 在一些实施例中，提供了一种装置，其包括至少两个彼此相隔一定距离的接合元件，用于与两个单独的骨头接合。每个接合元件可以由支撑部件承载，支撑部件又被支撑在 距离单位（5）。 所述支撑部分和支撑部分形成支撑单元，其中每个接合元件相对于两个支撑单元之间的直线（L）成角度（α）延伸。 支撑单元中的至少一个包括用于改变角度的装置，该装置包括可调节角度（α）的操作单元。 本公开的一些实施例涉及用于与包括这种装置（如上所述）的椎骨接合的系统，以及该装置的使用和相关联的治疗方法。

    Mixing system and mixing method for medical purposes
    6.
    发明授权
    Mixing system and mixing method for medical purposes 有权
    用于医疗用途的混合系统和混合方法

    公开(公告)号：US08267571B2

    公开(公告)日：2012-09-18

    申请号：US12384805

    申请日：2009-04-08

    申请人： Erik Johansson ,  Niklas Axen ,  Staffan Bowald ,  Sven Olerud ,  Hans Jacobsen

    发明人： Erik Johansson ,  Niklas Axen ,  Staffan Bowald ,  Sven Olerud ,  Hans Jacobsen

    IPC分类号： B01F3/12 ,  B01F13/06 ,  B01F11/00 ,  B01F15/02

    CPC分类号： A61J1/2096 ,  A61J1/2075 ,  A61J1/2082 ,  A61M5/1782 ,  B01F11/0054 ,  B01F11/0082 ,  B01F13/002 ,  B01F13/0023 ,  Y10T137/0318 ,  Y10T137/86075

    摘要： A system and a method for making an injectable mixture using at least one first pulverulent component and a second liquid component with a first piston/cylinder arrangement with a cylinder with an axial extension and a piston, wherein the cylinder includes a measured amount of the pulverulent component, a separate reservoir including a corresponding measured amount of the liquid component, and a transfer device for sealed transfer of said amount of the liquid component to the cylinder for subsequent mixing and injection of the completed mixture. The first piston/cylinder arrangement is an injection syringe. A mixing element being manoeuvrable by a user is positioned inside the cylinder. At least one gas transferring channel means leading to the cylinder is arranged at the cylinder. Engagement means are arranged for connecting the first injection syringe to the separate reservoir during transfer of the liquid component.

    摘要翻译： 一种使用至少一种第一粉状组分和第二液体组分制备可注射混合物的系统和方法，所述第一粉末组分和第二液体组分具有带有轴向延伸的气缸和活塞的第一活塞/气缸装置，其中气缸包括测量量的粉状 组件，包括对应的测量量的液体组分的单独容器，以及用于将所述量的液体组分密封转移到气缸中用于随后混合和注入完成的混合物的转移装置。 第一活塞/气缸装置是注射器。 由使用者操作的混合元件位于气缸内。 通向气缸的至少一个气体传送通道装置设置在气缸上。 接合装置布置成用于在液体部件的传送期间将第一注射器连接到单独的储存器。

    Mixing system and mixing method for medical purposes
    7.
    发明申请
    Mixing system and mixing method for medical purposes 有权
    用于医疗用途的混合系统和混合方法

    公开(公告)号：US20090266420A1

    公开(公告)日：2009-10-29

    申请号：US12384805

    申请日：2009-04-08

    申请人： Erik Johansson ,  Niklas Axen ,  Staffan Bowald ,  Sven Olerud ,  Hans Jacobsen

    发明人： Erik Johansson ,  Niklas Axen ,  Staffan Bowald ,  Sven Olerud ,  Hans Jacobsen

    IPC分类号： F04F5/00

    CPC分类号： A61J1/2096 ,  A61J1/2075 ,  A61J1/2082 ,  A61M5/1782 ,  B01F11/0054 ,  B01F11/0082 ,  B01F13/002 ,  B01F13/0023 ,  Y10T137/0318 ,  Y10T137/86075

    摘要： A system and a method for making an injectable mixture using at least one first pulverulent component and a second liquid component with a first piston/cylinder arrangement with a cylinder with an axial extension and a piston, wherein the cylinder includes a measured amount of the pulverulent component, a separate reservoir including a corresponding measured amount of the liquid component, and a transfer device for sealed transfer of said amount of the liquid component to the cylinder for subsequent mixing and injection of the completed mixture. The first piston/cylinder arrangement is an injection syringe. A mixing element being manoeuvrable by a user is positioned inside the cylinder. At least one gas transferring channel means leading to the cylinder is arranged at the cylinder. Engagement means are arranged for connecting the first injection syringe to the separate reservoir during transfer of the liquid component.

    摘要翻译： 一种使用至少一种第一粉状组分和第二液体组分制备可注射混合物的系统和方法，所述第一粉末组分和第二液体组分具有带有轴向延伸的气缸和活塞的第一活塞/气缸装置，其中气缸包括测量量的粉状 组件，包括对应的测量量的液体组分的单独容器，以及用于将所述量的液体组分密封转移到气缸中用于随后混合和注入完成的混合物的转移装置。 第一活塞/气缸装置是注射器。 由使用者操作的混合元件位于气缸内。 通向气缸的至少一个气体传送通道装置设置在气缸上。 接合装置布置成用于在液体部件的传送期间将第一注射器连接到单独的储存器。

    Bioresorbable Controlled-Release Composition
    9.
    发明申请
    Bioresorbable Controlled-Release Composition 有权
    生物可吸收的控制释放组合物

    公开(公告)号：US20090118215A1

    公开(公告)日：2009-05-07

    申请号：US12224942

    申请日：2007-03-14

    申请人： Hans Lennernas ,  Niklas Axen

    发明人： Hans Lennernas ,  Niklas Axen

    IPC分类号： A61K31/7088 ,  A61K47/04 ,  A61K31/165 ,  A61K31/56 ,  A61K31/4166 ,  A61P35/00

    CPC分类号： A61K9/0024 ,  A61K9/0034 ,  A61K9/1611 ,  A61K9/1694

    摘要： A novel method for the preparation of a highly densified and at least partly, preferably fully or almost fully hydrated ceramic for use in the preparation of a pharmaceutical composition notably for controlled-release of one or more therapeutically, prophylactically and/or diagnostically active substance. The method involves a concomitant step of hydrating and densifying a bioresorbable and hydratable ceramic such as calcium sulphate. The invention also relates to compositions comprising such a highly densified ceramic. The pharmaceutical composition is useful for targeted and controlled local prolonged release of active substances, e.g. anti-cancer agents, whereby the spectrum and severity of side effects are minimized due to an optimized local concentration-time profile.

    摘要翻译： 一种用于制备高致密化和至少部分，优选完全或几乎完全水合的陶瓷的新方法，用于制备药物组合物，特别是用于控制释放一种或多种治疗，预防和/或诊断活性物质。 该方法包括水合和致密化生物可再吸收和可水合的陶瓷如硫酸钙的伴随步骤。 本发明还涉及包含这种高密度陶瓷的组合物。 药物组合物可用于靶向和受控局部延长的活性物质的释放，例如， 由于优化的局部浓度 - 时间曲线，抗癌剂的副作用的频谱和严重程度被最小化。