摘要:
The present invention pertains to injectable heat generating biocompatible ceramic compositions based on hydraulic calcium aluminate, which can be used for therapeutic treatment in vivo, such as tumour treatment, pain control, vascular treatment, drug activation etc, when curing in situ, and which form a biocompatible solid material that can be left in the body for prolonged periods of time without causing negative health effects. The present invention can also be used to restore the mechanical properties of the skeleton after cancerous diseases.
摘要:
Embodiments of the present disclosure are directed to a systems, devices and methods for displacing bones of a living mammal. In some embodiments, a device is provided which includes at least two engagement elements positioned at a distance from each other for engagement with two separate bones Each of the engagement elements may be carried by a support part which in turn is supported in a support portion of a distance unit (5). The said support part and support portion form a support unit, where each engagement element extends at an angle (α) with respect to a straight line (L) between two support units. At least one of the support units includes an arrangement for altering the angle which includes an actuating unit maneuverable for adjustment of the angle (α). Some embodiments of the disclosure are directed to a system for engagement with vertebrae including such devices (noted above), as well as uses of the device and associated methods of treatment.
摘要:
A system and a method for making an injectable mixture using at least one first pulverulent component and a second liquid component with a first piston/cylinder arrangement with a cylinder with an axial extension and a piston, wherein the cylinder includes a measured amount of the pulverulent component, a separate reservoir including a corresponding measured amount of the liquid component, and a transfer device for sealed transfer of said amount of the liquid component to the cylinder for subsequent mixing and injection of the completed mixture. The first piston/cylinder arrangement is an injection syringe. A mixing element being manoeuvrable by a user is positioned inside the cylinder. At least one gas transferring channel means leading to the cylinder is arranged at the cylinder. Engagement means are arranged for connecting the first injection syringe to the separate reservoir during transfer of the liquid component.
摘要:
A system and a method for making an injectable mixture using at least one first pulverulent component and a second liquid component with a first piston/cylinder arrangement with a cylinder with an axial extension and a piston, wherein the cylinder includes a measured amount of the pulverulent component, a separate reservoir including a corresponding measured amount of the liquid component, and a transfer device for sealed transfer of said amount of the liquid component to the cylinder for subsequent mixing and injection of the completed mixture. The first piston/cylinder arrangement is an injection syringe. A mixing element being manoeuvrable by a user is positioned inside the cylinder. At least one gas transferring channel means leading to the cylinder is arranged at the cylinder. Engagement means are arranged for connecting the first injection syringe to the separate reservoir during transfer of the liquid component.
摘要:
A positioning device (1) for placing a prosthesis device (2) in a spinal column of a living mammal, including at least one holding device (6) for cooperation with the prosthesis device and for guiding thereof during positioning, wherein it includes fixing means (7) for fixation with respect to at least one vertebra (3,3′), and said fixing means includes locking means (9), which in a first, free state, allows adjustment movement of said holding means (6) and thereby of the prosthesis device (2), and in a second, locked state, fixes said holding device (6) and thereby the prosthesis device (2) in a selected position. The invention also concerns a system.
摘要:
A novel method for the preparation of a highly densified and at least partly, preferably fully or almost fully hydrated ceramic for use in the preparation of a pharmaceutical composition notably for controlled-release of one or more therapeutically, prophylactically and/or diagnostically active substance. The method involves a concomitant step of hydrating and densifying a bioresorbable and hydratable ceramic such as calcium sulphate. The invention also relates to compositions comprising such a highly densified ceramic. The pharmaceutical composition is useful for targeted and controlled local prolonged release of active substances, e.g. anti-cancer agents, whereby the spectrum and severity of side effects are minimized due to an optimized local concentration-time profile.
摘要:
The present invention pertains to injectable heat generating biocompatible ceramic compositions based on hydraulic calcium aluminate, which can be used for therapeutic treatment in vivo, such as tumour treatment, pain control, vascular treatment, drug activation etc, when curing in situ, and which form a biocompatible solid material that can be left in the body for prolonged periods of time without causing negative health effects. The present invention can also be used to restore the mechanical properties of the skeleton after cancerous diseases.
摘要:
The invention describes a low temperature method for producing multi-layered or multi-phased coatings. With the technique according to the present invention, surface coatings with controlled variations in terms of chemical composition, phase composition, porosity, surface roughness, mechanical properties, biocompatibility, etc can be achieved. The method of coating a substrate surface comprising the steps of preparing one powder mixture, or several powder mixtures having different chemical composition, wherein at least one of said powder mixtures comprise a non-hydrated hydraulic ceramic powder binder phase, pre-treating a substrate surface, to increase the adhesion between the substrate and the ceramic coating, applying one or more different layers on top of each other of the non-hydrated powder mixture on the substrate, and finally, hydrating the powder layer/layers in a curing agent containing ions of carbonates, phosphates or fluorides.
摘要:
The present invention relates to a drug carrier composition comprising i) one or more biodegradable hydrating ceramics ii) one or more expandable agents, and iii) sorbed aqueous medium which in solid form has a ruptured structure. The function of the expandable agent is to create a ruptured structure in the solidified composition, either a foam-like structure or a disintegrated structure where it is split into a large number of parts, particles, units, granules or pieces, so as to obtain an enlarged apparent surface area that is exposed to degradation or erosion upon administration. Suitable substances to obtain this surface enlarging effect are gas-forming agents or swelling agents, gelling agents or disintegrants, here referred to as expandable agents. The expandable agents may be bioresorbable or non-bioresorbable.
摘要:
The present invention is related to an implant with anti-inflammatory or antibacterial effects, or both, the implant being intended for implantation in a human or an animal body, the implant comprising at least one porous grain or granule, wherein the at least one porous grain or granule comprises titanium, one or more titanium oxides or titanium alloy and has a titanium oxide layer on its surface; has a mean length from one side to the opposite side, through a geometrical centre, of up to 5 mm; has a mean specific surface area of at least 0.15 m2/g according to the BET method. Moreover, disclosed is also a method for treating a condition comprising an inflammation or/and an infection present in a human or animal body with implants according to the invention.Described is also a method for producing implants according to the invention from a piece of a crude titanium or titanium alloy sponge, comprising the steps of: choosing and removing a porous peripheral, but not most outer, part of the piece of the crude titanium or titanium alloy sponge; analysing that part in view of the chemical composition for potential impurities; crushing that part, if pure, and; finally selecting the implants by sieving and analysis in batches, the analysis in batches being performed by scanning electron microscopy (SEM) or by gas absorption with nitrogen, the Hg method and/or the BET method.