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    Angiogenic tissue implant systems and methods
    4.
    发明授权
    Angiogenic tissue implant systems and methods 失效
    血管生成组织植入系统和方法

    公开(公告)号：US06773458B1

    公开(公告)日：2004-08-10

    申请号：US08356787

    申请日：1994-12-12

    申请人： James H. Brauker ,  Ronald S. Hill ,  Robert C. Johnson ,  Laura A. Martinson ,  William D. Johnston

    发明人： James H. Brauker ,  Ronald S. Hill ,  Robert C. Johnson ,  Laura A. Martinson ,  William D. Johnston

    IPC分类号： A61F202

    CPC分类号： A61K9/0024 ,  A61B5/14532 ,  A61F2/022 ,  A61L27/3886 ,  A61L27/56 ,  A61L29/005 ,  A61L29/085 ,  A61L29/146

    摘要： Implant assemblies and methodologies provide immuno-protection for implanted allografts, xenografts, and isografts. The assemblies and methodologies establish an improved boundary between the host and the implanted cells. The boundary has a pore size, an ultimate strength, and a metabolic transit value that assures the survival of the cells during the critical ischemic period and afterward. The boundary allows the fabrication and clinical use of implant assemblies and methodologies that can carry enough cells to be of therapeutic value to the host, yet occupy a relatively small, compact area within the host.

    摘要翻译： 植入组件和方法为植入的同种异体移植物，异种移植物和同种移植物提供免疫保护。 组件和方法建立了主机和植入细胞之间的改进的边界。 该边界具有孔隙尺寸，极限强度和代谢转运值，其确保在临界缺血期和之后细胞的存活。 该边界允许植入组件和方法的制造和临床使用，其可以携带足够的细胞以对主体具有治疗价值，但占据主机内相对较小，紧凑的区域。

    Optimized sensor geometry for an implantable glucose sensor
    10.
    发明授权
    Optimized sensor geometry for an implantable glucose sensor 有权
    优化的植入式葡萄糖传感器的传感器几何

    公开(公告)号：US07881763B2

    公开(公告)日：2011-02-01

    申请号：US11415631

    申请日：2006-05-02

    申请人： James H. Brauker ,  Victoria Carr-Brendel ,  Paul V. Neale ,  Laura A. Martinson ,  Mark A. Tapsak

    发明人： James H. Brauker ,  Victoria Carr-Brendel ,  Paul V. Neale ,  Laura A. Martinson ,  Mark A. Tapsak

    IPC分类号： A61B5/1473

    CPC分类号： A61B5/6882 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1486 ,  A61B5/415 ,  A61B5/418 ,  A61B2562/187

    摘要： An implantable sensor for use in measuring a concentration of an analyte such as glucose in a bodily fluid, including a body with a sensing region adapted for transport of analytes between the sensor and the bodily fluid, wherein the sensing region is located on a curved portion of the body such that when a foreign body capsule forms around the sensor, a contractile force is exerted by the foreign body capsule toward the sensing region. The body is partially or entirely curved, partially or entirely covered with an anchoring material for supporting tissue ingrowth, and designed for subcutaneous tissue implantation. The geometric design, including curvature, shape, and other factors minimize chronic inflammatory response at the sensing region and contribute to improved performance of the sensor in vivo.

    摘要翻译： 一种用于测量体液中诸如葡萄糖的分析物的浓度的植入式传感器，其包括具有适于在所述传感器和所述体液之间输送分析物的感测区域的身体，其中所述感测区域位于弯曲部分上 使得当异物体胶囊围绕传感器形成时，异物胶囊朝向感测区域施加收缩力。 身体部分或完全弯曲，部分或完全覆盖有用于支撑组织向内生长的锚固材料，并被设计用于皮下组织植入。 几何设计，包括曲率，形状和其他因素最大限度地减少传感区域的慢性炎症反应，并有助于改善体内传感器的性能。