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    Pegylated CD154 peptides and methods of inhibiting CD40 interacations with CD154
    2.
    发明授权
    Pegylated CD154 peptides and methods of inhibiting CD40 interacations with CD154 有权
    聚乙二醇化CD154肽和用CD154抑制CD40相互作用的方法

    公开(公告)号：US09562088B2

    公开(公告)日：2017-02-07

    申请号：US13880387

    申请日：2011-10-19

    申请人： David Wagner

    发明人： David Wagner

    IPC分类号： A61K38/00 ,  C07K7/00 ,  C07K14/705 ,  A61K38/08 ,  A61K38/10 ,  A61K38/17

    CPC分类号： C07K14/70575 ,  A61K38/08 ,  A61K38/10 ,  A61K38/1774

    摘要： The present invention provides methods and materials for treating and preventing autoimmune diseases. In particular, the present invention relates to the discovery that small peptides are capable of interacting with CD40, thereby interfering with the ability of CD40 to interact with CD 154, which is important in inflammation. The present invention also relate to the use of such peptides in reducing the inflammatory response, and in particular, the autoimmune inflammatory response. The present invention also relates to the use of such short peptides to prevent or reverse autoimmune disease, and particular, diabetes, in individuals suffering from such disease. It also relates to methods and materials for detecting T-cells that express CD40 (Th40 cells). Also provided are kits for reducing inflammation, treating autoimmune diseases, or detecting Th40 cells.

    摘要翻译： 本发明提供治疗和预防自身免疫疾病的方法和材料。 特别地，本发明涉及小肽能够与CD40相互作用的发现，从而干扰CD40与CD154相互作用的能力，这在炎症中是重要的。 本发明还涉及这些肽在减少炎症反应，特别是自身免疫性炎症反应中的用途。 本发明还涉及这种短肽在预防或逆转患有这种疾病的个体中的自身免疫性疾病，特别是糖尿病的用途。 它还涉及用于检测表达CD40（Th40细胞）的T细胞的方法和材料。 还提供用于减少炎症，治疗自身免疫疾病或检测Th40细胞的试剂盒。

    Commercial shelf product alignment device
    3.
    发明授权
    Commercial shelf product alignment device 有权
    商品货架对位装置

    公开(公告)号：US09510697B2

    公开(公告)日：2016-12-06

    申请号：US14706769

    申请日：2015-05-07

    申请人： David Wagner

    发明人： David Wagner

    IPC分类号： F24B15/00 ,  A47F13/06 ,  B25J1/04

    CPC分类号： A47F13/06

    摘要： A commercial shelf product alignment device for facilitating neat and straight alignment of commercial products on a shelf in a market includes a handle having a first end and a second end. An elongated shaft is coupled to and extends from the handle. A bend is positioned in the shaft defining a first section and a second section of the shaft. The first section defines a right angle with the second section wherein the shaft is configured for aligning products on a commercial shelf by abutting the products against the first section of the shaft.

    摘要翻译： 用于促进市场上的商品的商业产品的整齐和直线对准的商业货架产品对准装置包括具有第一端和第二端的手柄。 细长的轴联接到手柄并从手柄延伸。 弯曲部定位在轴中，限定轴的第一部分和第二部分。 第一部分与第二部分形成直角，其中轴构造成通过使产品抵靠轴的第一部分将产品对准在商业货架上。

    Copper plating method
    4.
    发明授权
    Copper plating method 有权
    镀铜方法

    公开(公告)号：US09103012B2

    公开(公告)日：2015-08-11

    申请号：US12931854

    申请日：2011-02-11

    申请人： Chao-Peng Chen ,  Jas Chudasama ,  Chien-Li Lin ,  David Wagner

    发明人： Chao-Peng Chen ,  Jas Chudasama ,  Chien-Li Lin ,  David Wagner

    IPC分类号： C25D5/34 ,  C23C2/02 ,  C23C14/58 ,  C25D5/02 ,  G11B5/17 ,  C23F1/12

    CPC分类号： C23F1/12 ,  C23C2/02 ,  C23C14/5873 ,  C25D5/022 ,  C25D5/34 ,  G11B5/17

    摘要： A method of activating a copper seed layer during a plating process is disclosed that comprises application of vapor generated by an ultrasonic wave nebulizer. The energized vapor droplets include water and a weak organic acid such as acetic acid, lactic acid, citric acid, uric acid, oxalic acid, or formic acid that have a vapor pressure proximate to that of water. The weak organic acid preferably has a pKa high enough to avoid Cu etching but is sufficiently acidic to remove copper oxide at a rate that is compatible with high throughput manufacturing. In one embodiment, weak acid/water vapor is applied to a substrate in a spin bowl and is followed by a deionized water rinse step in the same spin bowl. Improved wettability results in improved uniformity in subsequently plated copper films. Considerable cost savings is realized as a result of reduced chemical consumption and higher product yields.

    摘要翻译： 公开了一种在镀覆工艺期间激活铜籽晶层的方法，其包括施加由超声波雾化器产生的蒸气。 通电的蒸气滴包括水和弱的有机酸如乙酸，乳酸，柠檬酸，尿酸，草酸或甲酸，其蒸气压接近于水。 弱有机酸优选具有足够高的pKa以避免Cu蚀刻，但是足够的酸性以与高通量制造相容的速率除去氧化铜。 在一个实施方案中，将弱酸/水蒸汽施加到旋转碗中的基底上，然后在同一旋转碗中进行去离子水漂洗步骤。 改进的润湿性导致随后镀覆的铜膜的均匀性提高。 由于化学品消耗减少和产品产量提高，实现了大量的成本节约。

    Bitmap compare mechanism
    5.
    发明授权
    Bitmap compare mechanism 有权
    位图比较机制

    公开(公告)号：US08705071B2

    公开(公告)日：2014-04-22

    申请号：US13438578

    申请日：2012-04-03

    申请人： David Wagner

    发明人： David Wagner

    IPC分类号： H04N1/60 ,  H04N1/00

    CPC分类号： H04N1/00 ,  G06T7/001 ,  G06T2207/30144

    摘要： A computer generated method disclosed. The method includes performing an exact comparison between a first bitmap and a second bitmap, calculating a number of miscompared pixels that occurred during the comparison and calculating a quantity value representing a characteristic of the miscompared pixels.

    摘要翻译： 公开了一种计算机生成方法。 该方法包括执行第一位图和第二位图之间的精确比较，计算在比较期间发生的错误比较的像素的数量，以及计算表示错误比较像素的特征的数量值。

    DEVICE FOR ACTIVE WHEEL ALIGNMENT
    7.
    发明申请
    DEVICE FOR ACTIVE WHEEL ALIGNMENT 失效
    主动轮对准装置

    公开(公告)号：US20110193301A1

    公开(公告)日：2011-08-11

    申请号：US12858106

    申请日：2010-08-17

    申请人： Ullrich Hammelmeier ,  Felix Wulf ,  Christian Voy ,  Rodscha Drabon ,  David Wagner

    发明人： Ullrich Hammelmeier ,  Felix Wulf ,  Christian Voy ,  Rodscha Drabon ,  David Wagner

    IPC分类号： B62D17/00

    CPC分类号： B60G17/08 ,  B60G7/006 ,  B60G17/0162 ,  B60G2202/24 ,  B60G2202/413 ,  B60G2300/60 ,  B60G2800/24 ,  B62D7/146 ,  B62D17/00

    摘要： A device for active wheel alignment of wheels arranged on a wheel axle of a motor vehicle includes two hydraulic body dampers arranged between a vehicle body and the wheel axle. Each body damper is configured as a differential cylinder having a cylinder and a dividing piston which is guided in the cylinder. A throttle is arranged outside the cylinder of the body damper. Operably connected with the body dampers via hydraulic lines is a hydraulic servo unit, wherein hydraulic fluid is transferable via the throttle from one side of the dividing piston to the servo unit and from the servo unit via a returning one of the hydraulic lines back to another side of the dividing piston.

    摘要翻译： 设置在机动车辆的车轮轴上的车轮的主动车轮对准的装置包括布置在车体和轮轴之间的两个液压体阻尼器。 每个主体阻尼器构造为具有在气缸中引导的气缸和分隔活塞的差速缸。 节气门布置在主体阻尼器的气缸外部。 液压伺服单元通过液压伺服单元可操作地与主体阻尼器连接，液压伺服单元可以通过节流阀从分隔活塞的一侧向伺服单元传输液压流体，并通过返回的一个液压管路将伺服单元传回给另一个 侧分隔活塞。

    Methods for distinguishing type-1 from type-2 diabetes
    8.
    发明申请
    Methods for distinguishing type-1 from type-2 diabetes 审中-公开
    区分1型与2型糖尿病的方法

    公开(公告)号：US20060234316A1

    公开(公告)日：2006-10-19

    申请号：US11399384

    申请日：2006-04-07

    申请人： David Wagner

    发明人： David Wagner

    IPC分类号： G01N33/567

    CPC分类号： G01N33/564 ,  C07K16/2812 ,  C07K16/2878 ,  G01N33/505 ,  G01N33/6893 ,  G01N2333/70514 ,  G01N2333/70578 ,  G01N2800/042 ,  G01N2800/24

    摘要： The present invention provides a new method for the prediction of, or diagnosis of, auto-immune diseases, thereby alerting the subject to the presence of, or propensity to develop, an auto-immune disease so that preventative or therapeutic regiments may be initiated or changed so as to treat, modulate or prevent expansion of the CD4loCD40hi T cell population responsible for the destructive inflammation. The invention also discloses agents which modulate, treat or prevent expansion of CD4loCD40hi T cells. In one embodiment, the method is predictive of type 1 diabetes. Furthermore, the present invention provides a new method for distinguishing type 1 from type 2 diabetes.

    摘要翻译： 本发明提供了一种用于预测或诊断自身免疫疾病的新方法，从而提醒受试者存在或倾向于发展自身免疫疾病，从而可能启动预防或治疗团 改变以便治疗，调节或预防负责破坏性炎症的CD4细胞高CD4 T细胞的扩增。 本发明还公开了调节，治疗或预防CD4细胞增高T细胞扩增的药剂。 在一个实施方案中，该方法是预测1型糖尿病。 此外，本发明提供了区分1型与2型糖尿病的新方法。

    Bumper cross-section with hinges
    9.
    发明授权
    Bumper cross-section with hinges 有权
    带铰链的保险杠横截面

    公开(公告)号：US07066508B1

    公开(公告)日：2006-06-27

    申请号：US11095357

    申请日：2005-03-31

    申请人： Ridha Baccouche ,  Hikmat Mahmood ,  Chelliah Madasamy ,  David Wagner

    发明人： Ridha Baccouche ,  Hikmat Mahmood ,  Chelliah Madasamy ,  David Wagner

    IPC分类号： B60R19/18

    CPC分类号： B60R19/18 ,  B60R2019/1826

    摘要： A bumper beam is formed from a tailor welded blank with thinner gage sheet metal laser welded to thicker gage sheet metal at opposing sides thereof. The tailor welded blank is then formed into a bumper beam having a uniform B-shaped cross-sectional configuration from one terminal end to the other. Each fore-and-aft extending wall of each cell of the B-shaped cross-sectional configuration is formed with first and second hinges at a bend line between substantially horizontal portions of the wall and an intermediate transitional portion such that the horizontal portions are at different vertically spaced positions. Upon receipt of an impact, the first hinges bend into the corresponding cell while the second hinges bend outwardly. The second hinges on the corresponding inner walls of the two cells contacting upon deep collapse to enhance energy absorption.

    摘要翻译： 保险杠梁由裁缝焊接的坯料形成，较薄的金属片金属激光焊接在较厚的金属片金属片的相对侧。 然后将裁缝焊接坯件形成为具有从一个终端到另一终端的均匀B形横截面构造的保险杠梁。 B形横截面构造的每个单元的每个前后延伸壁在第一和第二铰链处形成有在壁的基本水平部分和中间过渡部分之间的弯曲线处，使得水平部分处于 不同的垂直间隔位置。 当接收到冲击时，第一铰链弯曲成相应的电池，而第二铰链向外弯曲。 第二个铰链在两个细胞的相应内壁上，在深塌陷时接触以增强能量吸收。