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    Vectors for tissue-specific replication
    5.
    发明申请
    Vectors for tissue-specific replication 审中-公开
    用于组织特异性复制的载体

    公开(公告)号：US20080076172A1

    公开(公告)日：2008-03-27

    申请号：US11977533

    申请日：2007-10-24

    申请人： Paul Hallenbeck ,  Yung-Nien Chang ,  Yawen Chiang

    发明人： Paul Hallenbeck ,  Yung-Nien Chang ,  Yawen Chiang

    IPC分类号： C12N15/00

    CPC分类号： C12N15/86 ,  A61K48/00 ,  A61K48/0058 ,  C12N2710/10343 ,  C12N2820/002 ,  C12N2830/002 ,  C12N2830/008 ,  C12N2830/32 ,  C12N2830/85 ,  C12N2840/20

    摘要： The invention generally relates to targeted gene therapy using recombinant vectors and particularly adenovirus vectors. The invention specifically relates to replication-conditional vectors and methods for using them. Such vectors are able to selectively replicate in a target tissue to provide a therapeutic benefit from the presence of the vector per se or from heterologous gene products expressed from the vector and distributed throughout the tissue. In such vectors, a gene essential for replication is placed under the control of a heterologous tissue-specific transcriptional regulatory sequence. Thus, replication is conditioned on the presence of a factor(s) that induces transcription or the absence of a factor(s) that inhibits trancription of the gene by means of the transcriptional regulatory sequence with this vector; therefore, a target tissue can be selectively treated.

    摘要翻译： 本发明一般涉及使用重组载体，特别是腺病毒载体的靶向基因治疗。 本发明具体涉及复制条件向量及其使用方法。 这样的载体能够在靶组织中选择性地复制以从载体本身的存在或从载体表达的分布在整个组织中的异源基因产物提供治疗益处。 在这样的载体中，将复制必需的基因置于异源组织特异性转录调控序列的控制之下。 因此，复制受到诱导转录或不存在通过用该载体通过转录调控序列抑制基因转录的因子的因子的影响; 因此，可以选择性地处理靶组织。

    Tissue-vectors specific replication and gene expression
    7.
    发明授权
    Tissue-vectors specific replication and gene expression 失效
    用于组织特异性复制和基因表达的载体

    公开(公告)号：US06638762B1

    公开(公告)日：2003-10-28

    申请号：US08974391

    申请日：1997-11-19

    申请人： Yung-Nien Chang ,  Paul L. Hallenbeck ,  Carl M. Hay ,  David A. Stewart

    发明人： Yung-Nien Chang ,  Paul L. Hallenbeck ,  Carl M. Hay ,  David A. Stewart

    IPC分类号： C12N1500

    CPC分类号： C12N15/86 ,  A61K48/00 ,  C12N2710/10343 ,  C12N2830/008 ,  C12N2830/15 ,  C12N2830/30 ,  C12N2830/32 ,  C12N2830/85 ,  C12N2840/20 ,  C12N2840/44

    摘要： The invention generally relates to cell-specific expression vectors. It particularly relates to targeted gene therapy using recombinant expression vectors and particularly adenovirus vectors. The invention specifically relates to replication-conditional expression vectors and methods for using them. Such vectors are able to selectively replicate in a target cell or tissue to provide a therapeutic benefit in a tissue from the presence of the vector per se or from one or more heterologous gene products expressed from the vector and distributed throughout the tissue. In such vectors, a gene essential for replication is placed under the control of a heterologous tissue-specific transcriptional regulatory sequence. Thus, replication is conditioned on the presence of a factor(s) that induces transcription or the absence of a factor(s) that inhibits transcription of the gene by means of the transcriptional regulatory sequence with this vector; therefore, a target tissue can be selectively treated.

    摘要翻译： 本发明一般涉及细胞特异性表达载体。 它特别涉及使用重组表达载体，特别是腺病毒载体的靶向基因治疗。 本发明具体涉及复制条件表达载体及其使用方法。 这样的载体能够在靶细胞或组织中选择性复制，以从载体本身的存在或从载体表达的一种或多种异源基因产物提供组织中的治疗益处并且分布在整个组织中。 在这样的载体中，将复制必需的基因置于异源组织特异性转录调控序列的控制之下。 因此，复制受到诱导转录或不存在通过与该载体的转录调控序列抑制基因转录的因子的因素的制约; 因此，可以选择性地处理靶组织。

    Vectors for tissue-specific replication
    8.
    发明申请
    Vectors for tissue-specific replication 审中-公开
    用于组织特异性复制的载体

    公开(公告)号：US20080213884A1

    公开(公告)日：2008-09-04

    申请号：US11977902

    申请日：2007-10-25

    申请人： Paul L. Hallenbeck ,  Yung-Nien Chang ,  Yawen L. Chiang

    发明人： Paul L. Hallenbeck ,  Yung-Nien Chang ,  Yawen L. Chiang

    IPC分类号： C12N5/06

    CPC分类号： C12N15/86 ,  A61K48/00 ,  A61K48/0058 ,  C12N2710/10343 ,  C12N2820/002 ,  C12N2830/002 ,  C12N2830/008 ,  C12N2830/32 ,  C12N2830/85 ,  C12N2840/20

    摘要： The invention generally relates to targeted gene therapy using recombinant vectors and particularly adenovirus vectors. The invention specifically relates to replication-conditional vectors and methods for using them. Such vectors are able to selectively replicate in a target tissue to provide a therapeutic benefit from the presence of the vector per se or from heterologous gene products expressed from the vector and distributed throughout the tissue. In such vectors, a gene essential for replication is placed under the control of a heterologous tissue-specific transcriptional regulatory sequence. Thus, replication is conditioned on the presence of a factor(s) that induces transcription or the absence of a factor(s) that inhibits transcription of the gene by means of the transcriptional regulatory sequence with this vector, therefore, a target tissue can be selectively treated.

    摘要翻译： 本发明一般涉及使用重组载体，特别是腺病毒载体的靶向基因治疗。 本发明具体涉及复制条件向量及其使用方法。 这样的载体能够在靶组织中选择性地复制以从载体本身的存在或从载体表达的分布在整个组织中的异源基因产物提供治疗益处。 在这样的载体中，将复制必需的基因置于异源组织特异性转录调控序列的控制之下。 因此，复制受到诱导转录的因子的存在或不存在通过该载体通过转录调节序列抑制基因转录的因子的因素，因此，靶组织可以是 选择性处理。

    Vectors for tissue-specific replication
    9.
    发明申请
    Vectors for tissue-specific replication 审中-公开
    用于组织特异性复制的载体

    公开(公告)号：US20080103109A1

    公开(公告)日：2008-05-01

    申请号：US11977903

    申请日：2007-10-25

    申请人： Paul Hallenbeck ,  Yung-Nien Chang ,  Yawen Chiang

    发明人： Paul Hallenbeck ,  Yung-Nien Chang ,  Yawen Chiang

    IPC分类号： A61K31/70 ,  A61P43/00

    CPC分类号： C12N15/86 ,  A61K48/00 ,  A61K48/0058 ,  C12N2710/10343 ,  C12N2820/002 ,  C12N2830/002 ,  C12N2830/008 ,  C12N2830/32 ,  C12N2830/85 ,  C12N2840/20

    摘要： The invention generally relates to targeted gene therapy using recombinant vectors and particularly adenovirus vectors. The invention specifically relates to replication-conditional vectors and methods for using them. Such vectors are able to selectively replicate in a target tissue to provide a therapeutic benefit from the presence of the vector per se or from heterologous gene products expressed from the vector and distributed throughout the tissue. In such vectors, a gene essential for replication is placed under the control of a heterologous tissue-specific transcriptional regulatory sequence. Thus, replication is conditioned on the presence of a factor(s) that induces transcription or the absence of a factor(s) that inhibits transcription of the gene by means of the transcriptional regulatory sequence with this vector; therefore, a target tissue can be selectively treated.

    摘要翻译： 本发明一般涉及使用重组载体，特别是腺病毒载体的靶向基因治疗。 本发明具体涉及复制条件向量及其使用方法。 这样的载体能够在靶组织中选择性地复制以从载体本身的存在或从载体表达的分布在整个组织中的异源基因产物提供治疗益处。 在这样的载体中，将复制必需的基因置于异源组织特异性转录调控序列的控制之下。 因此，复制受到诱导转录或不存在通过与该载体的转录调控序列抑制基因转录的因子的因素的制约; 因此，可以选择性地处理靶组织。

    Vectors for tissue-specific replication
    10.
    发明授权
    Vectors for tissue-specific replication 失效
    用于组织特异性复制的载体

    公开(公告)号：US06551587B2

    公开(公告)日：2003-04-22

    申请号：US09210936

    申请日：1998-12-15

    申请人： Paul L. Hallenbeck ,  Yung-Nien Chang ,  Yawen L. Chiang

    发明人： Paul L. Hallenbeck ,  Yung-Nien Chang ,  Yawen L. Chiang

    IPC分类号： H61K4800

    CPC分类号： C12N15/86 ,  A61K48/00 ,  A61K48/0058 ,  C12N2710/10343 ,  C12N2820/002 ,  C12N2830/002 ,  C12N2830/008 ,  C12N2830/32 ,  C12N2830/85 ,  C12N2840/20

    摘要： The invention generally relates to targeted gene therapy using recombinant vectors and particularly adenovirus vectors. The invention specifically relates to replication-conditional vectors and methods for using them. Such vectors are able to selectively replicate in a target tissue to provide a therapeutic benefit from the presence of the vector per se or from heterologous gene products expressed from the vector and distributed throughout the tissue. In such vectors, a gene essential for replication is placed under the control of a heterologous tissue-specific transcriptional regulatory sequence. Thus, replication is conditioned on the presence of a factor(s) that induces transcription or the absence of a factor(s) that inhibits transcription of the gene by means of the transcriptional regulatory sequence with this vector, therefore, a target tissue can be selectively treated.

    摘要翻译： 本发明一般涉及使用重组载体，特别是腺病毒载体的靶向基因治疗。 本发明具体涉及复制条件向量及其使用方法。 这样的载体能够在靶组织中选择性地复制以从载体本身的存在或从载体表达的分布在整个组织中的异源基因产物提供治疗益处。 在这样的载体中，将复制必需的基因置于异源组织特异性转录调控序列的控制之下。 因此，复制受到诱导转录的因子的存在或不存在通过该载体通过转录调节序列抑制基因转录的因子的因素，因此，靶组织可以是 选择性处理。