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1.发明申请公开(公告)号：US20100137963A1
公开(公告)日：2010-06-03
申请号：US12640610
申请日：2009-12-17
CPC分类号： A61N1/05 , C23C28/32 , Y10T29/49204
摘要： A method for fabricating an implantable medical electrode includes roughening the electrode substrate, applying an adhesion layer, and depositing a valve metal oxide coating over the adhesion layer under conditions optimized to minimize electrode impedance and post-pulse polarization. The electrode substrate may be a variety of electrode metals or alloys including titanium, platinum, platinum-iridium, or niobium. The adhesion layer may be formed of titanium or zirconium. The valve metal oxide coating is a ruthenium oxide coating sputtered onto the adhesion layer under controlled target power, sputtering pressure, and sputter gas ratio setting optimized to minimize electrode impedance and post-pulse polarization.
摘要翻译： 一种用于制造可植入医疗电极的方法包括使电极基板粗糙化，施加粘合层，以及在优化以最小化电极阻抗和脉冲后极化的条件下，在粘附层上沉积阀金属氧化物涂层。 电极基板可以是各种电极金属或包括钛，铂，铂 - 铱或铌的合金。 粘合层可以由钛或锆形成。 阀金属氧化物涂层是在受控目标功率，溅射压力和溅射气体比设置下溅射到粘附层上的氧化钌涂层，其被优化以最小化电极阻抗和后脉冲极化。
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2.发明授权公开(公告)号：US08155754B2
公开(公告)日：2012-04-10
申请号：US11042649
申请日：2005-01-25
IPC分类号： A61N1/04
CPC分类号： A61N1/05 , C23C28/32 , Y10T29/49204
摘要： A method for fabricating an implantable medical electrode includes roughening the electrode substrate, applying an adhesion layer, and depositing a valve metal oxide coating over the adhesion layer under conditions optimized to minimize electrode impedance and post-pulse polarization. The electrode substrate may be a variety of electrode metals or alloys including titanium, platinum, platinum-iridium, or niobium. The adhesion layer may be formed of titanium or zirconium. The valve metal oxide coating is a ruthenium oxide coating sputtered onto the adhesion layer under controlled target power, sputtering pressure, and sputter gas ratio setting optimized to minimize electrode impedance and post-pulse polarization.
摘要翻译： 一种用于制造可植入医疗电极的方法包括使电极基板粗糙化，施加粘合层，以及在优化以最小化电极阻抗和脉冲后极化的条件下，在粘附层上沉积阀金属氧化物涂层。 电极基板可以是各种电极金属或包括钛，铂，铂 - 铱或铌的合金。 粘合层可以由钛或锆形成。 阀金属氧化物涂层是在受控目标功率，溅射压力和溅射气体比设置下溅射到粘附层上的氧化钌涂层，其被优化以最小化电极阻抗和后脉冲极化。
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3.发明授权Medical devices incorporating carbon nanotube material and methods of fabricating same 有权纳入碳纳米管材料的医疗器械及其制造方法公开(公告)号：US07596415B2
公开(公告)日：2009-09-29
申请号：US11038731
申请日：2005-01-20
申请人： Scott J. Brabec , Kenneth C. Gardeski , Suping Lyu , James A. Coles, Jr. , Christopher M. Hobot
发明人： Scott J. Brabec , Kenneth C. Gardeski , Suping Lyu , James A. Coles, Jr. , Christopher M. Hobot
CPC分类号： A61N1/056 , A61N1/0565 , Y10S977/905 , Y10S977/925 , Y10S977/931
摘要： The present invention relates generally to medical devices; in particular and without limitation, to unique electrodes and/or electrical lead assemblies for stimulating cardiac tissue, muscle tissue, neurological tissue, brain tissue and/or organ tissue; to electrophysiology mapping and ablation catheters for monitoring and selectively altering physiologic conduction pathways; and, wherein said electrodes, lead assemblies and catheters optionally include fluid irrigation conduit(s) for providing therapeutic and/or performance enhancing materials to adjacent biological tissue, and wherein each said device is coupled to or incorporates nanostructure or materials therein. The present invention also provides methods for fabricating, deploying, and operating such medical devices.
摘要翻译： 本发明一般涉及医疗器械; 特别是但不限于用于刺激心脏组织，肌肉组织，神经组织，脑组织和/或器官组织的独特电极和/或电引线组件; 用于电生理测绘和消融导管，用于监测和选择性地改变生理传导途径; 并且其中所述电极，引线组件和导管可选地包括用于向相邻生物组织提供治疗和/或性能增强材料的流体冲洗导管，并且其中每个所述装置与其中的纳米结构或材料耦合或结合。 本发明还提供了制造，部署和操作这种医疗装置的方法。
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公开(公告)号：US07945337B2
公开(公告)日：2011-05-17
申请号：US10648908
申请日：2003-08-27
IPC分类号： A61N1/05
CPC分类号： A61N1/0568 , A61N1/0573
摘要： An insulative housing formed about a distal end of a medical electrical lead body includes a cavity and a port; an ionically conductive medium fills the cavity and is in intimate contact with an electrode surface contained within the cavity. When a current is delivered to the electrode surface contained within the cavity, a first current density generated at the electrode surface is smaller than a second current density generated out from the port of the insulative housing; thus, the port forms a high impedance and low polarization tissue-stimulating electrode.
摘要翻译： 形成在医疗用电引线体的前端的绝缘壳体具有空腔和端口; 离子导电介质填充空腔并与包含在腔内的电极表面紧密接触。 当电流被传送到包含在空腔内的电极表面时，在电极表面处产生的第一电流密度小于从绝缘壳体的端口产生的第二电流密度; 因此，端口形成高阻抗和低极化组织刺激电极。
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5.发明申请USING FOCAL MYOCARDIAL STIMULATION TO DISTINGUISH SUPRAVENTRICULAR TACHYCARDIA FROM VENTRICULAR TACHYCARDIA 有权使用焦虑性心肌梗塞对来自心脏TACHYCARDIA的非致病性TACHYCARDIA公开(公告)号：US20120232605A1
公开(公告)日：2012-09-13
申请号：US13357646
申请日：2012-01-25
申请人： Yong-Fu Xiao , Jeffrey M. Gillberg , Paul J. DeGroot , Eduardo N. Warman , Scott J. Brabec , John L. Sommer , Jon F. Urban , Lepeng Zeng
发明人： Yong-Fu Xiao , Jeffrey M. Gillberg , Paul J. DeGroot , Eduardo N. Warman , Scott J. Brabec , John L. Sommer , Jon F. Urban , Lepeng Zeng
IPC分类号： A61N1/365
CPC分类号： A61N1/365 , A61N1/3622 , A61N1/36585
摘要： An apparatus and method to discriminate cardiac events by sensing atrial and ventricular depolarizations having associated refractory periods thereafter. A fast ventricular rate is detected in response to the sensed ventricular depolarizations. Responsive to detecting the fast ventricular rate, at least one stimulus pulse is delivered to atrial tissue within the associated refractory period of the ventricle but outside of an associated refractory period of the stimulated atrial tissue. A ventricular response to the atrial tissue stimulus pulse is determined, and the cardiac event is discriminated based on the ventricular response to the atrial tissue stimulus pulse.
摘要翻译： 通过感应心房和心室去极化来区分心脏事件的装置和方法，其后具有相关联的不良期。 响应于感测到的心室去极化，检测到快速心室率。 响应于检测快速心室率，至少一个刺激脉冲被输送到心室的相关不应期内但在受刺激的心房组织的相关不应期内之外的心房组织。 确定对心房组织刺激脉冲的心室反应，并且基于对心房组织刺激脉冲的心室响应来区分心脏事件。
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公开(公告)号：US20120109237A1
公开(公告)日：2012-05-03
申请号：US12913354
申请日：2010-10-27
申请人： Yong-Fu Xiao , John L. Sommer , Scott J. Brabec , Lepeng Zeng , Jon F. Urban
发明人： Yong-Fu Xiao , John L. Sommer , Scott J. Brabec , Lepeng Zeng , Jon F. Urban
CPC分类号： A61N1/3622 , A61N1/36564 , A61N1/368
摘要： Various techniques for delivering atrial pacing and supraventricular stimulation to achieve a desired ventricular rate and/or cardiac output are described. One example method described includes delivering a pacing signal configured to cause an atrial depolarization to a heart of a patient, wherein the atrial depolarization results in an associated refractory period during the cardiac cycle, and delivering a signal to a supraventricular portion of the heart of the patient subsequent to the atrial refractory period and during a ventricular refractory period of the cardiac cycle.
摘要翻译： 描述用于递送心房起搏和室上性刺激以实现期望的心室率和/或心输出量的各种技术。 所描述的一个示例性方法包括递送起搏信号，所述起搏信号被配置成对患者的心脏进行心房去极化，其中所述心房去极化在心脏周期期间导致相关联的不应期，并将信号传递到心脏的心脏的室上部分 患者在心房不良期后和心动周期心室不应期。
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7.发明申请Medical Devices Incorporating Carbon Nanotube Material and Methods of Fabricating Same 审中-公开纳入碳纳米管材料的医疗器械及其制造方法公开(公告)号：US20100324643A1
公开(公告)日：2010-12-23
申请号：US12873389
申请日：2010-09-01
IPC分类号： A61N1/05
CPC分类号： A61N1/0556 , A61N1/056 , A61N1/0565
摘要： The present invention relates generally to medical devices; in particular and without limitation, to unique electrodes and/or electrical lead assemblies for stimulating cardiac tissue, muscle tissue, neurological tissue, brain tissue and/or organ tissue; to electrophysiology mapping and ablation catheters for monitoring and selectively altering physiologic conduction pathways; and, wherein said electrodes, lead assemblies and catheters optionally include fluid irrigation conduit(s) for providing therapeutic and/or performance enhancing materials to adjacent biological tissue, and wherein each said device is coupled to or incorporates nanotube structures or materials therein. The present invention also provides methods for fabricating, deploying, and operating such medical devices.
摘要翻译： 本发明一般涉及医疗器械; 特别是但不限于用于刺激心脏组织，肌肉组织，神经组织，脑组织和/或器官组织的独特电极和/或电引线组件; 用于电生理测绘和消融导管，用于监测和选择性地改变生理传导途径; 并且其中所述电极，引线组件和导管可选地包括用于向相邻生物组织提供治疗和/或增强性能的材料的流体冲洗导管，并且其中每个所述装置在其中耦合或纳入其中的纳米管结构或材料。 本发明还提供了制造，部署和操作这种医疗装置的方法。
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公开(公告)号：US07225035B2
公开(公告)日：2007-05-29
申请号：US10876003
申请日：2004-06-24
申请人： Scott J. Brabec , Douglas S. Hine
发明人： Scott J. Brabec , Douglas S. Hine
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N2001/0585
摘要： A pacing lead includes a first pacing cathode coupled to a first conductor, a second pacing cathode coupled to a second conductor, and a flexible anode coupled to a third conductor. The flexible anode has a length less than approximately 10 millimeters and is spaced apart from and proximal to the first pacing cathode and spaced apart from and distal to the second pacing cathode. The spacing between the anode and the first pacing cathode is approximately equal to the spacing between the anode and the second pacing cathode.
摘要翻译： 起搏引线包括耦合到第一导体的第一起搏阴极，耦合到第二导体的第二起搏阴极和耦合到第三导体的柔性阳极。 柔性阳极具有小于约10毫米的长度，并且与第一起搏阴极间隔开并靠近第一起搏阴极并与第二起搏阴极间隔开并远离第二起搏阴极。 阳极和第一起搏阴极之间的间隔大致等于阳极和第二起搏阴极之间的间隔。
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9.发明授权公开(公告)号：US06363287B1
公开(公告)日：2002-03-26
申请号：US09428191
申请日：1999-10-27
IPC分类号： A61N105
CPC分类号： A61N1/0568
摘要： A medical electrical lead having an elongated insulative sheath carrying an elongated electrical conductor therein and having a drug-dispensing electrode assembly coupled to a distal end of the elongated conductor. The electrode assembly takes the form of a conductive electrode member having a distal electrode portion exposed exterior to the elongated sheath and a shank portion extending proximally from the distal portion and coupled to the elongated conductor. A drug release device is mounted around the shank proximal to the distal portion of the electrode member and the electrode member is provided with at least one bore extending from a surface of the release device to a surface of the distal portion of the electrode member.
摘要翻译： 一种医用电引线，其具有细长的绝缘护套，其中带有细长的电导体，并且具有联接到细长导体的远端的药物分配电极组件。 电极组件采取导电电极构件的形式，其具有暴露在细长护套外部的远端电极部分和从远侧部分向近侧延伸并联接到细长导体的柄部分。 药物释放装置安装在靠近电极构件的远端部分的柄周围，并且电极构件设置有从释放装置的表面延伸到电极构件的远端部分的表面的至少一个孔。
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10.发明授权Using focal myocardial stimulation to distinguish supraventricular tachycardia from ventricular tachycardia 有权使用局灶性心肌刺激来区分室上性心动过速与室性心动过速公开(公告)号：US09144685B2
公开(公告)日：2015-09-29
申请号：US13357646
申请日：2012-01-25
申请人： Yong-Fu Xiao , Jeffrey M. Gillberg , Paul J. DeGroot , Eduardo N. Warman , Scott J. Brabec , John L. Sommer , Jon F. Urban , Lepeng Zeng
发明人： Yong-Fu Xiao , Jeffrey M. Gillberg , Paul J. DeGroot , Eduardo N. Warman , Scott J. Brabec , John L. Sommer , Jon F. Urban , Lepeng Zeng
CPC分类号： A61N1/365 , A61N1/3622 , A61N1/36585
摘要： An apparatus and method to discriminate cardiac events by sensing atrial and ventricular depolarizations having associated refractory periods thereafter. A fast ventricular rate is detected in response to the sensed ventricular depolarizations. Responsive to detecting the fast ventricular rate, at least one stimulus pulse is delivered to atrial tissue within the associated refractory period of the ventricle but outside of an associated refractory period of the stimulated atrial tissue. A ventricular response to the atrial tissue stimulus pulse is determined, and the cardiac event is discriminated based on the ventricular response to the atrial tissue stimulus pulse.
摘要翻译： 通过感应心房和心室去极化来区分心脏事件的装置和方法，其后具有相关联的不良期。 响应于感测到的心室去极化，检测到快速心室率。 响应于检测快速心室率，至少一个刺激脉冲被输送到心室的相关不应期内但在受刺激的心房组织的相关不应期内之外的心房组织。 确定对心房组织刺激脉冲的心室反应，并且基于对心房组织刺激脉冲的心室响应来区分心脏事件。
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