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公开(公告)号：US5973188A
公开(公告)日：1999-10-26
申请号：US963413
申请日：1997-11-03
申请人： Leo Alig , Paul Hadvary , Marianne Hurzeler Muller , Marcel Muller , Beat Steiner , Thomas Weller
发明人： Leo Alig , Paul Hadvary , Marianne Hurzeler Muller , Marcel Muller , Beat Steiner , Thomas Weller
IPC分类号： C07D401/12 , A61K31/00 , A61K31/19 , A61K31/22 , A61K31/24 , A61K31/27 , A61K31/34 , A61K31/341 , A61K31/395 , A61K31/4418 , A61K31/445 , A61K31/47 , A61K31/472 , A61P7/00 , A61P7/02 , A61P19/00 , C07C237/32 , C07C251/24 , C07C251/48 , C07C257/18 , C07C259/18 , C07C271/06 , C07C271/62 , C07C271/64 , C07C323/42 , C07C323/50 , C07C333/04 , C07D207/12 , C07D211/00 , C07D211/20 , C07D211/34 , C07D211/46 , C07D211/58 , C07D211/94 , C07D213/78 , C07D213/81 , C07D213/82 , C07D217/02 , C07D267/14 , C07D271/06 , C07D271/07 , C07D307/68 , C07D309/12 , C07D413/02 , C07D413/06 , C07D413/10 , C07D413/12 , C07F9/24 , C07C229/28 , C07C229/02
CPC分类号： C07D213/82 , C07C237/32 , C07C257/18 , C07C259/18 , C07C271/64 , C07C323/42 , C07C333/04 , C07D207/12 , C07D211/46 , C07D217/02 , C07D271/07 , C07D309/12 , C07D401/12 , C07D413/12 , C07F9/2491 , C07C2101/02 , C07C2101/14 , Y02P20/55
摘要： Acetic acid derivatives of the formula ##STR1## wherein L, M, T and Q have the significance given in the description, can be used for the treatment or prophylaxis of illnesses which are caused by the binding of adhesive proteins to blood platelets and by blood platelet aggregation and cell--cell adhesion, and are manufactured by cleaving protecting groups in the corresponding protected compounds or by converting the cyano group into the amidino group in corresponding nitrites.
摘要翻译： 下式的乙酸衍生物其中L，M，T和Q具有描述中给出的含义，可用于治疗或预防由粘合蛋白与血小板结合和血小板聚集引起的疾病， 细胞粘附，通过在相应的受保护化合物中裂解保护基团或通过将氰基转变成相应的亚硝酸盐中的脒基来制备。
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公开(公告)号：US5658928A
公开(公告)日：1997-08-19
申请号：US310016
申请日：1994-09-21
申请人： Leo Alig , Paul Hadvary , Marianne Hurzeler , Marcel Muller , Beat Steiner , Thomas Weller
发明人： Leo Alig , Paul Hadvary , Marianne Hurzeler , Marcel Muller , Beat Steiner , Thomas Weller
IPC分类号： A61K31/155 , A61K20060101 , A61K31/165 , A61K31/195 , A61K31/198 , A61K31/445 , A61K31/451 , A61P7/02 , A61P7/04 , C07C227/00 , C07C229/00 , C07C229/10 , C07C233/76 , C07C237/22 , C07C257/18 , C07C279/18 , C07D20060101 , C07D207/08 , C07D207/12 , C07D207/16 , C07D211/22 , C07D211/40 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/48 , C07D211/52 , C07D401/06 , C07D401/12 , C07D451/06 , C07D453/06 , C07D211/56 , C07D211/62 , C07D211/92
CPC分类号： C07D451/06 , C07C257/18 , C07D207/08 , C07D207/12 , C07D207/16 , C07D211/46 , C07D211/48 , C07D211/52 , C07D401/06 , C07D401/12 , C07C2101/12 , Y02P20/55
摘要： N-Acyl-.alpha.-aminocarboxylic acid derivatives of the formula ##STR1## wherein L, R' to R'" and Q have the significance given in the description, can be used for the treatment or prophylaxis of illnesses which are caused by the binding of adhesive proteins to blood platelets and by blood platelet aggregation and cell-cell adhesion.
摘要翻译： 其中L，R'至R“'和Q具有在说明书中给出的含义的式”IMAGE“I的N-酰基-α-氨基羧酸衍生物可用于治疗或预防由 粘附蛋白与血小板的结合以及血小板聚集和细胞粘附。
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公开(公告)号：US5747522A
公开(公告)日：1998-05-05
申请号：US452614
申请日：1995-05-25
申请人： Leo Alig , Paul Hadvary , Marianne Hurzeler , Marcel Muller , Beat Steiner , Thomas Weller
发明人： Leo Alig , Paul Hadvary , Marianne Hurzeler , Marcel Muller , Beat Steiner , Thomas Weller
IPC分类号： A61K31/155 , A61K20060101 , A61K31/165 , A61K31/195 , A61K31/198 , A61K31/445 , A61K31/451 , A61P7/02 , A61P7/04 , C07C227/00 , C07C229/00 , C07C229/10 , C07C233/76 , C07C237/22 , C07C257/18 , C07C279/18 , C07D20060101 , C07D207/08 , C07D207/12 , C07D207/16 , C07D211/22 , C07D211/40 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/48 , C07D211/52 , C07D401/06 , C07D401/12 , C07D451/06 , C07D453/06 , A61K31/40 , A61K31/395
CPC分类号： C07D451/06 , C07C257/18 , C07D207/08 , C07D207/12 , C07D207/16 , C07D211/46 , C07D211/48 , C07D211/52 , C07D401/06 , C07D401/12 , C07C2101/12 , Y02P20/55
摘要： N-Acyl-.alpha.-aminocarboxylic acid derivatives of the formula ##STR1## wherein L, R' to R"' and Q have the significance given in the description, can be used for the treatment or prophylaxis of illnesses which are caused by the binding of adhesive proteins to blood platelets and by blood platelet aggregation and cell-cell adhesion. They are manufactured by cleaving off protecting groups in corresponding protected compounds or by converting the cyano group into the amidino group in corresponding nitriles.
摘要翻译： 其中L，R'至R“'和Q具有在说明书中给出的含义的式”IMAGE“I的N-酰基-α-氨基羧酸衍生物可用于治疗或预防由 粘附蛋白与血小板的结合以及血小板聚集和细胞粘附。 它们通过在相应的受保护化合物中裂解保护基团或通过将氰基转化成相应的腈中的脒基来制备。
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公开(公告)号：US5670515A
公开(公告)日：1997-09-23
申请号：US452616
申请日：1995-05-25
申请人： Leo Alig , Paul Hadvary , Marianne Hurzeler , Marcel Muller , Beat Steiner , Thomas Weller
发明人： Leo Alig , Paul Hadvary , Marianne Hurzeler , Marcel Muller , Beat Steiner , Thomas Weller
IPC分类号： A61K31/155 , A61K20060101 , A61K31/165 , A61K31/195 , A61K31/198 , A61K31/445 , A61K31/451 , A61P7/02 , A61P7/04 , C07C227/00 , C07C229/00 , C07C229/10 , C07C233/76 , C07C237/22 , C07C257/18 , C07C279/18 , C07D20060101 , C07D207/08 , C07D207/12 , C07D207/16 , C07D211/22 , C07D211/40 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/48 , C07D211/52 , C07D401/06 , C07D401/12 , C07D451/06 , C07D453/06 , A61K31/44 , C07D451/10 , C07D451/12
CPC分类号： C07D451/06 , C07C257/18 , C07D207/08 , C07D207/12 , C07D207/16 , C07D211/46 , C07D211/48 , C07D211/52 , C07D401/06 , C07D401/12 , C07C2101/12 , Y02P20/55
摘要： N-Acyl-.alpha.-aminocarboxylic acid derivatives of the formula ##STR1## wherein L, R' to R'" and Q have the definitions given in the specification, are for the treatment or prophylaxis of illnesses which are caused by the binding of adhesive proteins to blood platelets, by blood platelet aggregation and cell-cell adhesion. They are manufactured by cleaving off protecting groups in corresponding protected compounds or by converting the cyano group into the amidino group in corresponding nitriles.
摘要翻译： 其中L，R'至R“'和Q具有本说明书中给出的定义的式”IMAGE“I的N-酰基-α-氨基羧酸衍生物用于治疗或预防由结合引起的疾病 通过血小板聚集和细胞粘附，将胶粘蛋白与血小板结合。 它们通过在相应的受保护化合物中裂解保护基团或通过将氰基转化成相应的腈中的脒基来制备。
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公开(公告)号：US5378712A
公开(公告)日：1995-01-03
申请号：US854135
申请日：1992-03-19
申请人： Leo Alig , Paul Hadvary , Marianne Hurzeler , Marcel Muller , Beat Steiner , Thomas Weller
发明人： Leo Alig , Paul Hadvary , Marianne Hurzeler , Marcel Muller , Beat Steiner , Thomas Weller
IPC分类号： A61K31/155 , A61K20060101 , A61K31/165 , A61K31/195 , A61K31/198 , A61K31/445 , A61K31/451 , A61P7/02 , A61P7/04 , C07C227/00 , C07C229/00 , C07C229/10 , C07C233/76 , C07C237/22 , C07C257/18 , C07C279/18 , C07D20060101 , C07D207/08 , C07D207/12 , C07D207/16 , C07D211/22 , C07D211/40 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/48 , C07D211/52 , C07D401/06 , C07D401/12 , C07D451/06 , C07D453/06 , C07D211/56 , C07D211/62 , C07D211/92
CPC分类号： C07D451/06 , C07C257/18 , C07D207/08 , C07D207/12 , C07D207/16 , C07D211/46 , C07D211/48 , C07D211/52 , C07D401/06 , C07D401/12 , C07C2101/12 , Y02P20/55
摘要： N-Acyl-.alpha.-aminocarboxylic acid derivatives of the formula ##STR1## wherein L, R' to R"' and Q have the significance given in the description, can be used for the treatment or control of illnesses which are caused by the binding of adhesive proteins to blood platelets and by blood platelet aggregation and cell-cell adhesion.
摘要翻译： 其中L，R'至R“'和Q具有在说明书中给出的含义的式”IMAGE“I的N-酰基-α-氨基羧酸衍生物可用于治疗或控制由 粘附蛋白与血小板的结合以及血小板聚集和细胞粘附。
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公开(公告)号：US5726185A
公开(公告)日：1998-03-10
申请号：US347736
申请日：1994-12-01
申请人： Leo Alig , Paul Hadvary , Marianne Hurzeler Muller , Marcel Muller , Beat Steiner , Thomas Weller
发明人： Leo Alig , Paul Hadvary , Marianne Hurzeler Muller , Marcel Muller , Beat Steiner , Thomas Weller
IPC分类号： C07D401/12 , A61K31/00 , A61K31/19 , A61K31/22 , A61K31/24 , A61K31/27 , A61K31/34 , A61K31/341 , A61K31/395 , A61K31/4418 , A61K31/445 , A61K31/47 , A61K31/472 , A61P7/00 , A61P7/02 , A61P19/00 , C07C237/32 , C07C251/24 , C07C251/48 , C07C257/18 , C07C259/18 , C07C271/06 , C07C271/62 , C07C271/64 , C07C323/42 , C07C323/50 , C07C333/04 , C07D207/12 , C07D211/00 , C07D211/20 , C07D211/34 , C07D211/46 , C07D211/58 , C07D211/94 , C07D213/78 , C07D213/81 , C07D213/82 , C07D217/02 , C07D267/14 , C07D271/06 , C07D271/07 , C07D307/68 , C07D309/12 , C07D413/02 , C07D413/06 , C07D413/10 , C07D413/12 , C07F9/24 , A61K31/43 , C07D211/08 , C07D211/92
CPC分类号： C07D213/82 , C07C237/32 , C07C257/18 , C07C259/18 , C07C271/64 , C07C323/42 , C07C333/04 , C07D207/12 , C07D211/46 , C07D217/02 , C07D271/07 , C07D309/12 , C07D401/12 , C07D413/12 , C07F9/2491 , C07C2101/02 , C07C2101/14 , Y02P20/55
摘要： Acetic acid derivatives of the formula ##STR1## wherein L, M, T and Q have the significance given in the description, can be used for the treatment or prophylaxis of illnesses which are caused by the binding of adhesive proteins to blood platelets and by blood platelet aggregation and cell-cell adhesion, and are manufactured by cleaving protecting groups in the corresponding protected compounds or by converting the cyano group into the amidino group in corresponding nitriles.
摘要翻译： 其中L，M，T和Q具有在说明书中给出的含义的式“IMAGE”I的乙酸衍生物可用于治疗或预防由粘合蛋白与血小板结合引起的疾病， 血小板聚集和细胞粘附，并通过裂解相应的保护化合物中的保护基团或通过将氰基转化为相应的腈中的脒基来制备。
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公开(公告)号：US5545658A
公开(公告)日：1996-08-13
申请号：US452615
申请日：1995-05-25
申请人： Leo Alig , Paul Hadvary , Marianne H urzeler , Marcel M uller , Beat Steiner , Thomas Weller
发明人： Leo Alig , Paul Hadvary , Marianne H urzeler , Marcel M uller , Beat Steiner , Thomas Weller
IPC分类号： C07C257/18 , C07D207/08 , C07D207/12 , C07D207/16 , C07D211/46 , C07D211/48 , C07D211/52 , C07D401/06 , C07D401/12 , C07D451/06 , A61K31/40
CPC分类号： C07D451/06 , C07C257/18 , C07D207/08 , C07D207/12 , C07D207/16 , C07D211/46 , C07D211/48 , C07D211/52 , C07D401/06 , C07D401/12 , C07C2101/12
摘要： N-Acyl-.alpha.-aminocarboxylic acid derivatives of the formula ##STR1## wherein L, R' to R'" and Q have the significance given in the description, can be used for the treatment or prophylaxis of illnesses which are caused by the binding of adhesive proteins to blood platelets and by blood platelet aggregation and cell-cell adhesion.
摘要翻译： 其中L，R'至R“'和Q具有在说明书中给出的含义的式”IMAGE“I的N-酰基-α-氨基羧酸衍生物可用于治疗或预防由 粘附蛋白与血小板的结合以及血小板聚集和细胞粘附。
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公开(公告)号：US20130303514A1
公开(公告)日：2013-11-14
申请号：US13980764
申请日：2012-01-18
申请人： Martin Bolli , Cyrille Lescop , Boris Mathys , Keith Morrison , Claus Mueller , Oliver Nayler , Beat Steiner
发明人： Martin Bolli , Cyrille Lescop , Boris Mathys , Keith Morrison , Claus Mueller , Oliver Nayler , Beat Steiner
IPC分类号： C07D413/14 , C07D413/04
CPC分类号： C07D413/14 , C07D413/04
摘要： The invention relates to pyridine derivatives of Formula (I) wherein A, R1, R2, R3, and R4 are as described in the description, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.
摘要翻译： 本发明涉及式（I）的吡啶衍生物，其中A，R 1，R 2，R 3和R 4如说明书中所述，其制备及其作为药物活性化合物的用途。 所述化合物特别充当免疫调节剂。
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公开(公告)号：USRE44359E1
公开(公告)日：2013-07-09
申请号：US13471899
申请日：2012-05-15
申请人： Yvo Graus , Jacques Himber , Miranda Jansen-Molenaar , Dorothee Kling , Erhard Kopetzki , Paul Parren , Frank Rebers , Beat Steiner , Anne Stern , Pamela Braemer , Kay-Gunnar Stubenrauch , Jan van de Winkel , Martine van Vugt
发明人： Yvo Graus , Jacques Himber , Miranda Jansen-Molenaar , Dorothee Kling , Erhard Kopetzki , Paul Parren , Frank Rebers , Beat Steiner , Anne Stern , Pamela Braemer , Kay-Gunnar Stubenrauch , Jan van de Winkel , Martine van Vugt
CPC分类号： C07K16/2854 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y10S435/81
摘要： This invention relates to anti-P-selectin antibodies and, in particular, to anti-P-selectin antibodies and variants thereof that contain an Fc part derived from human origin and do not bind complement factor C1q. These antibodies have new and inventive properties causing a benefit for a patient suffering from critical limb ischemia or peripheral arterial occlusive disease (CLI/PAOD).
摘要翻译： 本发明涉及抗P-选凝素抗体，特别涉及含有源自人源的Fc部分并且不结合补体因子C1q的抗P-选择蛋白抗体及其变体。 这些抗体具有新的和本发明的性质，为患有严重肢体缺血或外周动脉闭塞性疾病（CLI / PAOD）的患者带来益处。
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公开(公告)号：US08410151B2
公开(公告)日：2013-04-02
申请号：US12920574
申请日：2009-03-03
申请人： Martin Bolli , Cyrille Lescop , Boris Mathys , Claus Mueller , Oliver Nayler , Beat Steiner
发明人： Martin Bolli , Cyrille Lescop , Boris Mathys , Claus Mueller , Oliver Nayler , Beat Steiner
IPC分类号： A61K31/4245 , C07D271/06
CPC分类号： C07D271/06
摘要： The invention relates to novel aminomethyl benzene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.
摘要翻译： 本发明涉及新型氨基甲基苯衍生物，其制备及其作为药物活性化合物的用途。 所述化合物特别充当免疫调节剂。
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