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公开(公告)号：US5973188A
公开(公告)日：1999-10-26
申请号：US963413
申请日：1997-11-03
申请人： Leo Alig , Paul Hadvary , Marianne Hurzeler Muller , Marcel Muller , Beat Steiner , Thomas Weller
发明人： Leo Alig , Paul Hadvary , Marianne Hurzeler Muller , Marcel Muller , Beat Steiner , Thomas Weller
IPC分类号： C07D401/12 , A61K31/00 , A61K31/19 , A61K31/22 , A61K31/24 , A61K31/27 , A61K31/34 , A61K31/341 , A61K31/395 , A61K31/4418 , A61K31/445 , A61K31/47 , A61K31/472 , A61P7/00 , A61P7/02 , A61P19/00 , C07C237/32 , C07C251/24 , C07C251/48 , C07C257/18 , C07C259/18 , C07C271/06 , C07C271/62 , C07C271/64 , C07C323/42 , C07C323/50 , C07C333/04 , C07D207/12 , C07D211/00 , C07D211/20 , C07D211/34 , C07D211/46 , C07D211/58 , C07D211/94 , C07D213/78 , C07D213/81 , C07D213/82 , C07D217/02 , C07D267/14 , C07D271/06 , C07D271/07 , C07D307/68 , C07D309/12 , C07D413/02 , C07D413/06 , C07D413/10 , C07D413/12 , C07F9/24 , C07C229/28 , C07C229/02
CPC分类号： C07D213/82 , C07C237/32 , C07C257/18 , C07C259/18 , C07C271/64 , C07C323/42 , C07C333/04 , C07D207/12 , C07D211/46 , C07D217/02 , C07D271/07 , C07D309/12 , C07D401/12 , C07D413/12 , C07F9/2491 , C07C2101/02 , C07C2101/14 , Y02P20/55
摘要： Acetic acid derivatives of the formula ##STR1## wherein L, M, T and Q have the significance given in the description, can be used for the treatment or prophylaxis of illnesses which are caused by the binding of adhesive proteins to blood platelets and by blood platelet aggregation and cell--cell adhesion, and are manufactured by cleaving protecting groups in the corresponding protected compounds or by converting the cyano group into the amidino group in corresponding nitrites.
摘要翻译： 下式的乙酸衍生物其中L，M，T和Q具有描述中给出的含义，可用于治疗或预防由粘合蛋白与血小板结合和血小板聚集引起的疾病， 细胞粘附，通过在相应的受保护化合物中裂解保护基团或通过将氰基转变成相应的亚硝酸盐中的脒基来制备。
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公开(公告)号：US5726185A
公开(公告)日：1998-03-10
申请号：US347736
申请日：1994-12-01
申请人： Leo Alig , Paul Hadvary , Marianne Hurzeler Muller , Marcel Muller , Beat Steiner , Thomas Weller
发明人： Leo Alig , Paul Hadvary , Marianne Hurzeler Muller , Marcel Muller , Beat Steiner , Thomas Weller
IPC分类号： C07D401/12 , A61K31/00 , A61K31/19 , A61K31/22 , A61K31/24 , A61K31/27 , A61K31/34 , A61K31/341 , A61K31/395 , A61K31/4418 , A61K31/445 , A61K31/47 , A61K31/472 , A61P7/00 , A61P7/02 , A61P19/00 , C07C237/32 , C07C251/24 , C07C251/48 , C07C257/18 , C07C259/18 , C07C271/06 , C07C271/62 , C07C271/64 , C07C323/42 , C07C323/50 , C07C333/04 , C07D207/12 , C07D211/00 , C07D211/20 , C07D211/34 , C07D211/46 , C07D211/58 , C07D211/94 , C07D213/78 , C07D213/81 , C07D213/82 , C07D217/02 , C07D267/14 , C07D271/06 , C07D271/07 , C07D307/68 , C07D309/12 , C07D413/02 , C07D413/06 , C07D413/10 , C07D413/12 , C07F9/24 , A61K31/43 , C07D211/08 , C07D211/92
CPC分类号： C07D213/82 , C07C237/32 , C07C257/18 , C07C259/18 , C07C271/64 , C07C323/42 , C07C333/04 , C07D207/12 , C07D211/46 , C07D217/02 , C07D271/07 , C07D309/12 , C07D401/12 , C07D413/12 , C07F9/2491 , C07C2101/02 , C07C2101/14 , Y02P20/55
摘要： Acetic acid derivatives of the formula ##STR1## wherein L, M, T and Q have the significance given in the description, can be used for the treatment or prophylaxis of illnesses which are caused by the binding of adhesive proteins to blood platelets and by blood platelet aggregation and cell-cell adhesion, and are manufactured by cleaving protecting groups in the corresponding protected compounds or by converting the cyano group into the amidino group in corresponding nitriles.
摘要翻译： 其中L，M，T和Q具有在说明书中给出的含义的式“IMAGE”I的乙酸衍生物可用于治疗或预防由粘合蛋白与血小板结合引起的疾病， 血小板聚集和细胞粘附，并通过裂解相应的保护化合物中的保护基团或通过将氰基转化为相应的腈中的脒基来制备。
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公开(公告)号：US5670515A
公开(公告)日：1997-09-23
申请号：US452616
申请日：1995-05-25
申请人： Leo Alig , Paul Hadvary , Marianne Hurzeler , Marcel Muller , Beat Steiner , Thomas Weller
发明人： Leo Alig , Paul Hadvary , Marianne Hurzeler , Marcel Muller , Beat Steiner , Thomas Weller
IPC分类号： A61K31/155 , A61K20060101 , A61K31/165 , A61K31/195 , A61K31/198 , A61K31/445 , A61K31/451 , A61P7/02 , A61P7/04 , C07C227/00 , C07C229/00 , C07C229/10 , C07C233/76 , C07C237/22 , C07C257/18 , C07C279/18 , C07D20060101 , C07D207/08 , C07D207/12 , C07D207/16 , C07D211/22 , C07D211/40 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/48 , C07D211/52 , C07D401/06 , C07D401/12 , C07D451/06 , C07D453/06 , A61K31/44 , C07D451/10 , C07D451/12
CPC分类号： C07D451/06 , C07C257/18 , C07D207/08 , C07D207/12 , C07D207/16 , C07D211/46 , C07D211/48 , C07D211/52 , C07D401/06 , C07D401/12 , C07C2101/12 , Y02P20/55
摘要： N-Acyl-.alpha.-aminocarboxylic acid derivatives of the formula ##STR1## wherein L, R' to R'" and Q have the definitions given in the specification, are for the treatment or prophylaxis of illnesses which are caused by the binding of adhesive proteins to blood platelets, by blood platelet aggregation and cell-cell adhesion. They are manufactured by cleaving off protecting groups in corresponding protected compounds or by converting the cyano group into the amidino group in corresponding nitriles.
摘要翻译： 其中L，R'至R“'和Q具有本说明书中给出的定义的式”IMAGE“I的N-酰基-α-氨基羧酸衍生物用于治疗或预防由结合引起的疾病 通过血小板聚集和细胞粘附，将胶粘蛋白与血小板结合。 它们通过在相应的受保护化合物中裂解保护基团或通过将氰基转化成相应的腈中的脒基来制备。
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公开(公告)号：US5378712A
公开(公告)日：1995-01-03
申请号：US854135
申请日：1992-03-19
申请人： Leo Alig , Paul Hadvary , Marianne Hurzeler , Marcel Muller , Beat Steiner , Thomas Weller
发明人： Leo Alig , Paul Hadvary , Marianne Hurzeler , Marcel Muller , Beat Steiner , Thomas Weller
IPC分类号： A61K31/155 , A61K20060101 , A61K31/165 , A61K31/195 , A61K31/198 , A61K31/445 , A61K31/451 , A61P7/02 , A61P7/04 , C07C227/00 , C07C229/00 , C07C229/10 , C07C233/76 , C07C237/22 , C07C257/18 , C07C279/18 , C07D20060101 , C07D207/08 , C07D207/12 , C07D207/16 , C07D211/22 , C07D211/40 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/48 , C07D211/52 , C07D401/06 , C07D401/12 , C07D451/06 , C07D453/06 , C07D211/56 , C07D211/62 , C07D211/92
CPC分类号： C07D451/06 , C07C257/18 , C07D207/08 , C07D207/12 , C07D207/16 , C07D211/46 , C07D211/48 , C07D211/52 , C07D401/06 , C07D401/12 , C07C2101/12 , Y02P20/55
摘要： N-Acyl-.alpha.-aminocarboxylic acid derivatives of the formula ##STR1## wherein L, R' to R"' and Q have the significance given in the description, can be used for the treatment or control of illnesses which are caused by the binding of adhesive proteins to blood platelets and by blood platelet aggregation and cell-cell adhesion.
摘要翻译： 其中L，R'至R“'和Q具有在说明书中给出的含义的式”IMAGE“I的N-酰基-α-氨基羧酸衍生物可用于治疗或控制由 粘附蛋白与血小板的结合以及血小板聚集和细胞粘附。
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公开(公告)号：US5658928A
公开(公告)日：1997-08-19
申请号：US310016
申请日：1994-09-21
申请人： Leo Alig , Paul Hadvary , Marianne Hurzeler , Marcel Muller , Beat Steiner , Thomas Weller
发明人： Leo Alig , Paul Hadvary , Marianne Hurzeler , Marcel Muller , Beat Steiner , Thomas Weller
IPC分类号： A61K31/155 , A61K20060101 , A61K31/165 , A61K31/195 , A61K31/198 , A61K31/445 , A61K31/451 , A61P7/02 , A61P7/04 , C07C227/00 , C07C229/00 , C07C229/10 , C07C233/76 , C07C237/22 , C07C257/18 , C07C279/18 , C07D20060101 , C07D207/08 , C07D207/12 , C07D207/16 , C07D211/22 , C07D211/40 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/48 , C07D211/52 , C07D401/06 , C07D401/12 , C07D451/06 , C07D453/06 , C07D211/56 , C07D211/62 , C07D211/92
CPC分类号： C07D451/06 , C07C257/18 , C07D207/08 , C07D207/12 , C07D207/16 , C07D211/46 , C07D211/48 , C07D211/52 , C07D401/06 , C07D401/12 , C07C2101/12 , Y02P20/55
摘要： N-Acyl-.alpha.-aminocarboxylic acid derivatives of the formula ##STR1## wherein L, R' to R'" and Q have the significance given in the description, can be used for the treatment or prophylaxis of illnesses which are caused by the binding of adhesive proteins to blood platelets and by blood platelet aggregation and cell-cell adhesion.
摘要翻译： 其中L，R'至R“'和Q具有在说明书中给出的含义的式”IMAGE“I的N-酰基-α-氨基羧酸衍生物可用于治疗或预防由 粘附蛋白与血小板的结合以及血小板聚集和细胞粘附。
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公开(公告)号：US5747522A
公开(公告)日：1998-05-05
申请号：US452614
申请日：1995-05-25
申请人： Leo Alig , Paul Hadvary , Marianne Hurzeler , Marcel Muller , Beat Steiner , Thomas Weller
发明人： Leo Alig , Paul Hadvary , Marianne Hurzeler , Marcel Muller , Beat Steiner , Thomas Weller
IPC分类号： A61K31/155 , A61K20060101 , A61K31/165 , A61K31/195 , A61K31/198 , A61K31/445 , A61K31/451 , A61P7/02 , A61P7/04 , C07C227/00 , C07C229/00 , C07C229/10 , C07C233/76 , C07C237/22 , C07C257/18 , C07C279/18 , C07D20060101 , C07D207/08 , C07D207/12 , C07D207/16 , C07D211/22 , C07D211/40 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/48 , C07D211/52 , C07D401/06 , C07D401/12 , C07D451/06 , C07D453/06 , A61K31/40 , A61K31/395
CPC分类号： C07D451/06 , C07C257/18 , C07D207/08 , C07D207/12 , C07D207/16 , C07D211/46 , C07D211/48 , C07D211/52 , C07D401/06 , C07D401/12 , C07C2101/12 , Y02P20/55
摘要： N-Acyl-.alpha.-aminocarboxylic acid derivatives of the formula ##STR1## wherein L, R' to R"' and Q have the significance given in the description, can be used for the treatment or prophylaxis of illnesses which are caused by the binding of adhesive proteins to blood platelets and by blood platelet aggregation and cell-cell adhesion. They are manufactured by cleaving off protecting groups in corresponding protected compounds or by converting the cyano group into the amidino group in corresponding nitriles.
摘要翻译： 其中L，R'至R“'和Q具有在说明书中给出的含义的式”IMAGE“I的N-酰基-α-氨基羧酸衍生物可用于治疗或预防由 粘附蛋白与血小板的结合以及血小板聚集和细胞粘附。 它们通过在相应的受保护化合物中裂解保护基团或通过将氰基转化成相应的腈中的脒基来制备。
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公开(公告)号：US5545658A
公开(公告)日：1996-08-13
申请号：US452615
申请日：1995-05-25
申请人： Leo Alig , Paul Hadvary , Marianne H urzeler , Marcel M uller , Beat Steiner , Thomas Weller
发明人： Leo Alig , Paul Hadvary , Marianne H urzeler , Marcel M uller , Beat Steiner , Thomas Weller
IPC分类号： C07C257/18 , C07D207/08 , C07D207/12 , C07D207/16 , C07D211/46 , C07D211/48 , C07D211/52 , C07D401/06 , C07D401/12 , C07D451/06 , A61K31/40
CPC分类号： C07D451/06 , C07C257/18 , C07D207/08 , C07D207/12 , C07D207/16 , C07D211/46 , C07D211/48 , C07D211/52 , C07D401/06 , C07D401/12 , C07C2101/12
摘要： N-Acyl-.alpha.-aminocarboxylic acid derivatives of the formula ##STR1## wherein L, R' to R'" and Q have the significance given in the description, can be used for the treatment or prophylaxis of illnesses which are caused by the binding of adhesive proteins to blood platelets and by blood platelet aggregation and cell-cell adhesion.
摘要翻译： 其中L，R'至R“'和Q具有在说明书中给出的含义的式”IMAGE“I的N-酰基-α-氨基羧酸衍生物可用于治疗或预防由 粘附蛋白与血小板的结合以及血小板聚集和细胞粘附。
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公开(公告)号：US20050136030A1
公开(公告)日：2005-06-23
申请号：US11062086
申请日：2005-02-18
申请人： Pierre Barbier , Paul Hadvary , Hans Lengsfeld
发明人： Pierre Barbier , Paul Hadvary , Hans Lengsfeld
IPC分类号： A61K45/00 , A61K31/16 , A61K31/21 , A61K31/337 , A61K31/365 , A61K31/56 , A61K31/70 , A61K31/715 , A61K31/717 , A61K31/718 , A61K31/721 , A61K31/724 , A61K31/785 , A61K45/06 , A61P1/16 , A61P3/04 , A61P3/06
CPC分类号： A61K31/721 , A61K31/365 , A61K31/70 , A61K31/715 , A61K31/716 , A61K31/717 , A61K31/785 , A61K45/06 , A61K2300/00
摘要： A pharmaceutical combination or composition containing a lipase inhibitor, preferably orlistat, and a bile acid sequestrant is useful for treating obesity.
摘要翻译： 含有脂肪酶抑制剂，优选奥利司他和胆汁酸螯合剂的药物组合或组合物可用于治疗肥胖症。
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公开(公告)号：US5763436A
公开(公告)日：1998-06-09
申请号：US715038
申请日：1996-09-17
申请人： Jean Ackermann , David Banner , Klaus Gubernator , Paul Hadvary , Kurt Hilpert , Klaus Muller , Ludvik Labler , Gerard Schmid , Thomas B. Tschopp , Hans Peter Wessel , Beat Wirz
发明人： Jean Ackermann , David Banner , Klaus Gubernator , Paul Hadvary , Kurt Hilpert , Klaus Muller , Ludvik Labler , Gerard Schmid , Thomas B. Tschopp , Hans Peter Wessel , Beat Wirz
IPC分类号： A61K31/445 , A61K31/4427 , A61K31/4433 , A61K31/47 , A61K31/535 , A61K31/5375 , A61K31/55 , A61P7/02 , A61P35/00 , C07D20060101 , C07D211/20 , C07D211/22 , C07D211/26 , C07D211/60 , C07D265/30 , C07D265/32 , C07D401/12 , C07D401/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D267/10
CPC分类号： C07D265/30 , C07D211/22 , C07D211/26 , C07D211/60 , C07D265/32 , C07D401/12 , C07D401/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , Y10S514/822
摘要： Compounds of the formula ##STR1## wherein L, M, R, T and X are set forth in the description, as well as hydrates or solvates thereof, which inhibit thrombin-induced platelet aggregation and clotting of fibrinogen in plasma, are described. The compounds of formula I are prepared by amidination or, depending on whether L is NH or O, by amide formation or esterification.
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公开(公告)号：US08012494B2
公开(公告)日：2011-09-06
申请号：US10794123
申请日：2004-03-05
申请人： Passchier Christiaan de Smidt , Paul Hadvary , Hans Lengsfeld , Thomas Rades , Hans Steffen , Joseph Tardio
发明人： Passchier Christiaan de Smidt , Paul Hadvary , Hans Lengsfeld , Thomas Rades , Hans Steffen , Joseph Tardio
IPC分类号： A61K9/00 , A61K31/70 , A61K31/335
CPC分类号： A61K9/1075 , A61K9/0007 , A61K9/485 , A61K9/4858 , A61K31/365
摘要： A pharmaceutical composition comprises at least one inhibitor of lipases, preferably an inhibitor of gastrointestinal and pancreatic lipases, such as orlistat, at least one surfactant, and at least one dispersant.
摘要翻译： 药物组合物包含至少一种脂肪酶抑制剂，优选胃肠和胰脂肪酶抑制剂，例如奥利司他，至少一种表面活性剂和至少一种分散剂。
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