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公开(公告)号:US20090081707A1
公开(公告)日:2009-03-26
申请号:US12157753
申请日:2008-06-13
申请人: Leonard G. Presta , David L. Shelton , Roman Urfer
发明人: Leonard G. Presta , David L. Shelton , Roman Urfer
IPC分类号: G01N33/53
CPC分类号: C07K14/71 , A61K38/00 , C07K19/00 , C07K2319/00 , C07K2319/30
摘要: The invention concerns human trkB and trkC receptors and their functional derivatives. The invention further concerns immunoadhesins comprising trk receptor sequences fused to immunoglobulin sequences.
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公开(公告)号:US6025166A
公开(公告)日:2000-02-15
申请号:US444622
申请日:1995-05-19
申请人: Leonard G. Presta , David L. Shelton , Roman Urfer
发明人: Leonard G. Presta , David L. Shelton , Roman Urfer
IPC分类号: G01N33/53 , A61K38/00 , A61K38/55 , A61K39/395 , A61P1/00 , A61P9/08 , A61P9/10 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/18 , A61P25/28 , A61P29/00 , A61P35/00 , C07H21/04 , C07K14/705 , C07K14/71 , C07K16/28 , C07K19/00 , C12N15/02 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , C12P21/04 , C07H21/02
CPC分类号: C07K14/71 , C07K19/00 , A61K38/00 , C07K2319/00 , C07K2319/30
摘要: The invention concerns human trkB and trkC receptors and their functional derivatives. The invention further concerns imnunoadhesins comprising trk receptor sequences fused to immunoglobulin sequences.
摘要翻译: 本发明涉及人trkB和trkC受体及其功能衍生物。 本发明还涉及包含与免疫球蛋白序列融合的trk受体序列的抑制素。
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公开(公告)号:US6027927A
公开(公告)日:2000-02-22
申请号:US942562
申请日:1997-10-01
申请人: Leonard G. Presta , David L. Shelton , Roman Urfer
发明人: Leonard G. Presta , David L. Shelton , Roman Urfer
IPC分类号: G01N33/53 , A61K38/00 , A61K38/55 , A61K39/395 , A61P1/00 , A61P9/08 , A61P9/10 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/18 , A61P25/28 , A61P29/00 , A61P35/00 , C07H21/04 , C07K14/705 , C07K14/71 , C07K16/28 , C07K19/00 , C12N15/02 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68
CPC分类号: C07K14/71 , C07K19/00 , A61K38/00 , C07K2319/00 , C07K2319/30
摘要: The invention concerns human trkB and trkC receptors and their functional derivatives. The invention further concerns immunoadhesins comprising trk receptor sequences fused to immunoglobin sequences.
摘要翻译: 本发明涉及人trkB和trkC受体及其功能衍生物。 本发明还涉及包含与免疫球蛋白序列融合的trk受体序列的免疫粘附素。
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公开(公告)号:US5910574A
公开(公告)日:1999-06-08
申请号:US457880
申请日:1995-05-31
申请人: Leonard G. Presta , David L. Shelton , Roman Urfer
发明人: Leonard G. Presta , David L. Shelton , Roman Urfer
IPC分类号: G01N33/53 , A61K38/00 , A61K38/55 , A61K39/395 , A61P1/00 , A61P9/08 , A61P9/10 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/18 , A61P25/28 , A61P29/00 , A61P35/00 , C07H21/04 , C07K14/705 , C07K14/71 , C07K16/28 , C07K19/00 , C12N15/02 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68
CPC分类号: C07K14/71 , C07K19/00 , A61K38/00 , C07K2319/00 , C07K2319/30
摘要: The invention concerns human trkB and trkC receptors and their functional derivatives. The invention further concerns immunoadhesins comprising trk receptor sequences fused to immunoglobulin sequences.
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公开(公告)号:US5877016A
公开(公告)日:1999-03-02
申请号:US286846
申请日:1994-08-05
申请人: Leonard G. Presta , David L. Shelton , Roman Urfer
发明人: Leonard G. Presta , David L. Shelton , Roman Urfer
IPC分类号: G01N33/53 , A61K38/00 , A61K38/55 , A61K39/395 , A61P1/00 , A61P9/08 , A61P9/10 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/18 , A61P25/28 , A61P29/00 , A61P35/00 , C07H21/04 , C07K14/705 , C07K14/71 , C07K16/28 , C07K19/00 , C12N15/02 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , C12N5/00 , C07K16/00
CPC分类号: C07K14/71 , C07K19/00 , A61K38/00 , C07K2319/00 , C07K2319/30
摘要: The invention concerns human trkB and trkC receptors and their functional derivatives. The invention further concerns inmunoadhesins comprising trk receptor sequences fused to immunoglobulin sequences.
摘要翻译: 本发明涉及人trkB和trkC受体及其功能衍生物。 本发明进一步涉及包含与免疫球蛋白序列融合的trk受体序列的麻醉剂。
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公开(公告)号:US5844092A
公开(公告)日:1998-12-01
申请号:US359705
申请日:1994-12-20
申请人: Leonard G. Presta , David L. Shelton , Roman Urfer
发明人: Leonard G. Presta , David L. Shelton , Roman Urfer
IPC分类号: G01N33/53 , A61K38/00 , A61K38/55 , A61K39/395 , A61P1/00 , A61P9/08 , A61P9/10 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/18 , A61P25/28 , A61P29/00 , A61P35/00 , C07H21/04 , C07K14/705 , C07K14/71 , C07K16/28 , C07K19/00 , C12N15/02 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68
CPC分类号: C07K19/00 , C07K14/71 , A61K38/00 , C07K2319/00 , C07K2319/30
摘要: The invention concerns human trkB and trkC receptors and their functional derivatives. The invention further concerns immunoadhesins comprising trk receptor sequences fused to immunoglobulin sequences.
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公开(公告)号:US08101571B2
公开(公告)日:2012-01-24
申请号:US12254458
申请日:2008-10-20
申请人: Leonard G. Presta , Roman Urfer , John W. Winslow
发明人: Leonard G. Presta , Roman Urfer , John W. Winslow
IPC分类号: A61K38/18
摘要: NGF variants which have trkC-binding activity and trkC-signal inducing activity are provided. The variants optionally have trkA or trkB binding and signal induction activity. The NGF variants of the present invention are useful in the treatment of neuronal disorders. Nucleic acids and expression vectors encoding the NGF variant neurotrophins are also provided.
摘要翻译: 提供具有trkC结合活性和trkC信号诱导活性的NGF变体。 变体任选具有trkA或trkB结合和信号诱导活性。 本发明的NGF变体可用于治疗神经元疾病。 还提供了编码NGF变体神经营养蛋白的核酸和表达载体。
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公开(公告)号:US07452863B1
公开(公告)日:2008-11-18
申请号:US09066619
申请日:1998-04-24
申请人: Leonard G. Presta , Roman Urfer , John W. Winslow
发明人: Leonard G. Presta , Roman Urfer , John W. Winslow
摘要: NGF variants which have trkC-binding activity and trkC-signal inducing activity are provided. The variants optionally have trkA or trkB binding and signal induction activity. The NGF variants of the present invention are useful in the treatment of neuronal disorders. Nucleic acids and expression vectors encoding the NGF variant neurotrophins are also provided.
摘要翻译: 提供具有trkC结合活性和trkC信号诱导活性的NGF变体。 变体任选具有trkA或trkB结合和信号诱导活性。 本发明的NGF变体可用于治疗神经元疾病。 还提供了编码NGF变体神经营养蛋白的核酸和表达载体。
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公开(公告)号:US20090137471A1
公开(公告)日:2009-05-28
申请号:US12254458
申请日:2008-10-20
申请人: Leonard G. Presta , Roman Urfer , John W. Winslow
发明人: Leonard G. Presta , Roman Urfer , John W. Winslow
IPC分类号: A61K38/18 , C07K14/48 , C12N15/12 , A61P25/00 , C12N1/15 , C12N5/10 , C12N1/19 , C12N1/21 , C12N15/63 , C12P21/00
摘要: NGF variants which have trkC-binding activity and trkC-signal inducing activity are provided. The variants optionally have trkA or trkB binding and signal induction activity. The NGF variants of the present invention are useful in the treatment of neuronal disorders. Nucleic acids and expression vectors encoding the NGF variant neurotrophins are also provided.
摘要翻译: 提供具有trkC结合活性和trkC信号诱导活性的NGF变体。 变体任选具有trkA或trkB结合和信号诱导活性。 本发明的NGF变体可用于治疗神经元疾病。 还提供了编码NGF变体神经营养蛋白的核酸和表达载体。
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公开(公告)号:US06333310B1
公开(公告)日:2001-12-25
申请号:US08845541
申请日:1997-04-25
申请人: Leonard G. Presta , Roman Urfer , John W. Winslow
发明人: Leonard G. Presta , Roman Urfer , John W. Winslow
IPC分类号: A61K3818
CPC分类号: A61K38/185 , C07K14/475 , C07K14/48 , C12N15/11
摘要: NGF variants which have trkC-binding activity and trkC-signal inducing activity are provided. The variants optionally have trkA or trkB binding and signal induction activity. The NGF variants of the present invention are useful in the treatment of neuronal disorders. Nucleic acids and expression vectors encoding the NGF variant neurotrophins are also provided.
摘要翻译: 提供具有trkC结合活性和trkC信号诱导活性的NGF变体。 变体任选具有trkA或trkB结合和信号诱导活性。 本发明的NGF变体可用于治疗神经元疾病。 还提供了编码NGF变体神经营养蛋白的核酸和表达载体。
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