公开(公告)号：US12209954B2

公开(公告)日：2025-01-28

申请号：US17633170

申请日：2020-08-06

Applicant: Life Technologies Corporation

Inventor： Shaohong Wang

IPC: G01N21/33 ,  G01N21/64 ,  G01N27/447

Abstract: An optical detection system for a capillary electrophoresis instrument is disclosed. The optical detection system comprises an ultraviolet (UV) source and an absorption measurement optical path. The optical path comprises a first plurality of optical elements comprising a first optical fiber array and other elements. The first plurality of optical elements are arranged to obtain a plurality of respective UV beamlets from a UV beam emitted by the UV source and to direct, at least partially using the first optical fiber array, the respective UV beamlets through respective capillaries of a plurality of capillaries and to an absorption detector positioned to detect respective signals for use in obtaining respective UV absorption measurements corresponding to the respective capillaries.

公开(公告)号：US11982620B2

公开(公告)日：2024-05-14

申请号：US17441258

申请日：2020-03-17

Applicant: Life Technologies Corporation

Inventor： Shaohong Wang

IPC: G01N21/64 ,  G01N21/17 ,  G01N21/33

CPC classification number: G01N21/645 ,  G01N21/33 ,  G01N2021/174 ,  G01N2021/6463

Abstract: An optical detection system for a capillary electrophoresis instrument is disclosed. The system includes an ultraviolet (UV) source and an absorption measurement optical path. In an embodiment, the optical path comprises a first plurality of optical elements arranged to obtain a plurality of respective UV beamlets from a UV beam emitted by the UV source and to direct the respective UV beamlets transversely through respective capillaries of a plurality of capillaries and to an absorption detector positioned to detect respective signals for use in obtaining respective UV absorption measurements corresponding to the respective capillaries.

公开(公告)号：US11860122B2

公开(公告)日：2024-01-02

申请号：US18098060

申请日：2023-01-17

Applicant: Life Technologies Corporation

Inventor： Shaohong Wang

IPC: G01J3/44 ,  G01N27/447 ,  G01J3/02 ,  G01J3/18

CPC classification number: G01N27/44721 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0289 ,  G01J3/0294 ,  G01J3/18 ,  G01J3/4406 ,  G01N27/44791

Abstract: A system for separating biological molecules includes a plurality of capillaries, a capillary mount, a plurality of optical fibers, a fiber mount, an optical detector, and a motion stage. The plurality of capillaries are configured to separate biological molecules in a sample. Each capillary comprising a detection portion configured to pass electromagnetic radiation into the capillary. The plurality of capillaries are coupled to the capillary mount such that the detection portions are fixedly located relative to one another. Each optical fiber includes a receiving end to receive emissions. The optical fibers are coupled to the fiber mount such that the receiving ends of the optical fibers are fixedly located relative to one another. The optical detector is configured to produce an alignment signal. The motion stage is configured to align the receiving ends of the optical fibers to the detection portions based on values of the alignment signal.

公开(公告)号：US20230333054A1

公开(公告)日：2023-10-19

申请号：US18098060

申请日：2023-01-17

Applicant: Life Technologies Corporation

Inventor： Shaohong Wang

IPC: G01N27/447 ,  G01J3/02 ,  G01J3/18 ,  G01J3/44

CPC classification number: G01N27/44721 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0289 ,  G01J3/0294 ,  G01J3/18 ,  G01J3/4406 ,  G01N27/44791

Abstract: A system for separating biological molecules includes a plurality of capillaries, a capillary mount, a plurality of optical fibers, a fiber mount, an optical detector, and a motion stage. The plurality of capillaries are configured to separate biological molecules in a sample. Each capillary comprising a detection portion configured to pass electromagnetic radiation into the capillary. The plurality of capillaries are coupled to the capillary mount such that the detection portions are fixedly located relative to one another. Each optical fiber includes a receiving end to receive emissions. The optical fibers are coupled to the fiber mount such that the receiving ends of the optical fibers are fixedly located relative to one another. The optical detector is configured to produce an alignment signal. The motion stage is configured to align the receiving ends of the optical fibers to the detection portions based on values of the alignment signal.

公开(公告)号：US20220155225A1

公开(公告)日：2022-05-19

申请号：US17441258

申请日：2020-03-17

Applicant: Life Technologies Corporation

Inventor： Shaohong Wang

IPC: G01N21/64 ,  G01N21/33

Abstract: An optical detection system for a capillary electrophoresis instrument is disclosed. The system includes an ultraviolet (UV) source and an absorption measurement optical path. In an embodiment, the optical path comprises a first plurality of optical elements arranged to obtain a plurality of respective UV beamlets from a UV beam emitted by the UV source and to direct the respective UV beamlets transversely through respective capillaries of a plurality of capillaries and to an absorption detector positioned to detect respective signals for use in obtaining respective UV absorption measurements corresponding to the respective capillaries.

公开(公告)号：US11604162B2

公开(公告)日：2023-03-14

申请号：US16488328

申请日：2018-02-23

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Shaohong Wang

IPC: G01J3/02 ,  G01N27/447 ,  G01J3/18 ,  G01J3/44

Abstract: A system for separating biological molecules includes a plurality of capillaries (101), a capillary mount (102), a plurality of optical fibers (145a, 145b), a fiber mount (603), an optical detector (138), and a motion stage (606). The plurality of capillaries (101) are configured to separate biological molecules in a sample. Each capillary (101) comprising a detection portion (121) configured to pass electromagnetic radiation into the capillary (101). The plurality of capillaries (101) are coupled to the capillary mount (102) such that the detection portions (121) are fixedly located relative to one another. Each optical fiber (145) includes a receiving end to receive emissions. The optical fibers (145) are coupled to the fiber mount (603) such that the receiving ends of the optical fibers are fixedly located relative to one another. The optical detector (138) is configured to produce an alignment signal. The motion stage (606) is configured to align the receiving ends of the optical fibers (145) to the detection portions (121) based on values of the alignment signal.