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1.发明授权Bicyclic androgen and progesterone receptor modulator compounds and methods 有权双环雄激素和孕激素受体调节剂的化合物和方法公开(公告)号：US07696246B2
公开(公告)日：2010-04-13
申请号：US11165769
申请日：2005-06-23
IPC分类号： A61K31/352 , C07D311/18
CPC分类号： C07D215/227 , C07D209/34 , C07D209/96 , C07D215/36 , C07D215/38 , C07D239/80 , C07D265/18 , C07D265/36 , C07D277/68 , C07D311/14 , C07D311/20 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04 , C07D417/04
摘要： The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR and PR. More particularly, the invention relates to nonsteroidal compounds and compositions that are high affinity, high specificity agonists, partial agonists (i.e., partial activators and/or tissue-specific activators) and antagonists for AR and PR. Also provided are methods of making such compounds and pharmaceutical compositions, as well as critical intermediates used in their synthesis.
摘要翻译： 本发明涉及用于调节由AR和PR介导的过程的化合物，药物组合物和方法。 更具体地，本发明涉及非甾类化合物和组合物，其是高亲和力，高特异性激动剂，部分激动剂（即部分激活剂和/或组织特异性激活剂）和AR和PR的拮抗剂。 还提供制备这些化合物和药物组合物的方法，以及用于其合成的关键中间体。
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2.发明授权Bicyclic androgen and progesterone receptor modulator compounds and methods 有权双环雄激素和孕激素受体调节剂的化合物和方法公开(公告)号：US06566372B1
公开(公告)日：2003-05-20
申请号：US09649466
申请日：2000-08-24
申请人： Lin Zhi , Christopher Tegley , Barbara Pio , Cornelis Arjan Van Oeveren , Mehrnouch Motamedi , Esther Martinborough , Sarah West
发明人： Lin Zhi , Christopher Tegley , Barbara Pio , Cornelis Arjan Van Oeveren , Mehrnouch Motamedi , Esther Martinborough , Sarah West
IPC分类号： A61K3147
CPC分类号： C07D215/227 , C07D209/34 , C07D209/96 , C07D215/36 , C07D215/38 , C07D239/80 , C07D265/18 , C07D265/36 , C07D277/68 , C07D311/14 , C07D311/20 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04 , C07D417/04
摘要： The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR and PR. More particularly, the invention relates to nonsteroidal compounds and compositions that are high affinity, high specificity agonists, partial agonists (i.e., partial activators and/or tissue-specific activators) and antagonists for AR and PR. Also provided are methods of making such compounds and pharmaceutical compositions, as well as critical intermediates used in their synthesis.
摘要翻译： 本发明涉及用于调节由AR和PR介导的过程的化合物，药物组合物和方法。 更具体地，本发明涉及非甾类化合物和组合物，其是高亲和力，高特异性激动剂，部分激动剂（即部分激活剂和/或组织特异性激活剂）和AR和PR的拮抗剂。 还提供制备这些化合物和药物组合物的方法，以及用于其合成的关键中间体。
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3.发明申请6-Cycloamino-2-quinolinone derivatives as androgen receptor modulator compounds 有权6-环氨基-2-喹啉酮衍生物作为雄激素受体调节剂化合物公开(公告)号：US20070066650A1
公开(公告)日：2007-03-22
申请号：US10566569
申请日：2004-08-23
申请人： Lin Zhi , Esther Martinborough , Yixing Shen , Thomas Lau , Min Wu , Yun Long
发明人： Lin Zhi , Esther Martinborough , Yixing Shen , Thomas Lau , Min Wu , Yun Long
IPC分类号： A61K31/4709 , C07D401/02
CPC分类号： C07D401/04
摘要： The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR. Also provided are methods of making such compounds and pharmaceutical compositions.
摘要翻译： 本发明涉及用于调节由AR介导的过程的化合物，药物组合物和方法。 还提供了制备这些化合物和药物组合物的方法。
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4.发明申请Bicyclic androgen and progesterone receptor modulator compounds and methods 审中-公开双环雄激素和孕激素受体调节剂的化合物和方法公开(公告)号：US20110112084A9
公开(公告)日：2011-05-12
申请号：US12590805
申请日：2009-11-13
申请人： Lin Zhi , Christopher Tegley , Barbara Pio , Corneils Arjan Van Oeveren , Mehrnouch Motamedi , Esther Martinborough , Robert Higuchi , Lawrence G. Hamann
发明人： Lin Zhi , Christopher Tegley , Barbara Pio , Corneils Arjan Van Oeveren , Mehrnouch Motamedi , Esther Martinborough , Robert Higuchi , Lawrence G. Hamann
IPC分类号： A61K31/47 , C07D311/04 , C07D265/14 , C07D215/00 , A61K31/536 , A61K31/352 , A61P35/00 , A61P15/00
CPC分类号： C07D215/227 , C07D209/34 , C07D209/96 , C07D215/36 , C07D215/38 , C07D239/80 , C07D265/18 , C07D265/36 , C07D277/68 , C07D311/14 , C07D311/20 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04 , C07D417/04
摘要： The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR and PR. More particularly, the invention relates to nonsteroidal compounds and compositions that are high affinity, high specificity agonists, partial agonists (i.e., partial activators and/or tissue-specific activators) and antagonists for AR and PR. Also provided are methods of making such compounds and pharmaceutical compositions, as well as critical intermediates used in their synthesis.
摘要翻译： 本发明涉及用于调节由AR和PR介导的过程的化合物，药物组合物和方法。 更具体地，本发明涉及非甾类化合物和组合物，其是高亲和力，高特异性激动剂，部分激动剂（即部分激活剂和/或组织特异性激活剂）和AR和PR的拮抗剂。 还提供制备这些化合物和药物组合物的方法，以及用于其合成的关键中间体。
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公开(公告)号：US20100069379A1
公开(公告)日：2010-03-18
申请号：US12590805
申请日：2009-11-13
申请人： Lin Zhi , Christopher Tegley , Barbara Pio , Corneils Arjan Van Oeveren , Mehrnouch Motamedi , Esther Martinborough , Robert Higuchi , Lawrence G. Hamann
发明人： Lin Zhi , Christopher Tegley , Barbara Pio , Corneils Arjan Van Oeveren , Mehrnouch Motamedi , Esther Martinborough , Robert Higuchi , Lawrence G. Hamann
IPC分类号： A61K31/47 , C07D311/04 , C07D265/14 , C07D215/00 , A61K31/536 , A61K31/352 , A61P35/00 , A61P15/00
CPC分类号： C07D215/227 , C07D209/34 , C07D209/96 , C07D215/36 , C07D215/38 , C07D239/80 , C07D265/18 , C07D265/36 , C07D277/68 , C07D311/14 , C07D311/20 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04 , C07D417/04
摘要： The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR and PR. More particularly, the invention relates to nonsteroidal compounds and compositions that are high affinity, high specificity agonists, partial agonists (i.e., partial activators and/or tissue-specific activators) and antagonists for AR and PR. Also provided are methods of making such compounds and pharmaceutical compositions, as well as critical intermediates used in their synthesis.
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6.发明申请Bicyclic androgen and progesterone receptor modulator compounds and methods 有权双环雄激素和孕激素受体调节剂的化合物和方法公开(公告)号：US20050288350A1
公开(公告)日：2005-12-29
申请号：US11165769
申请日：2005-06-23
IPC分类号： A61K31/37 , A61K31/4025 , A61K31/404 , A61K31/407 , A61K31/416 , A61K31/4178 , A61K31/428 , A61K31/47 , A61K31/4704 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/517 , A61K31/536 , A61K31/5377 , A61K31/538 , A61K31/55 , A61P5/26 , A61P5/28 , A61P5/34 , A61P5/36 , A61P7/04 , A61P7/06 , A61P13/08 , A61P15/00 , A61P15/04 , A61P15/08 , A61P15/10 , A61P15/16 , A61P15/18 , A61P17/10 , A61P17/14 , A61P35/00 , A61P43/00 , C07D209/34 , C07D209/96 , C07D215/22 , C07D215/227 , C07D215/36 , C07D215/38 , C07D215/48 , C07D239/80 , C07D265/18 , C07D265/36 , C07D277/68 , C07D311/14 , C07D311/20 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04 , C07D417/04 , C07D45/02 , C07D49/02
CPC分类号： C07D215/227 , C07D209/34 , C07D209/96 , C07D215/36 , C07D215/38 , C07D239/80 , C07D265/18 , C07D265/36 , C07D277/68 , C07D311/14 , C07D311/20 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04 , C07D417/04
摘要： The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR and PR. More particularly, the invention relates to nonsteroidal compounds and compositions that are high affinity, high specificity agonists, partial agonists (i.e., partial activators and/or tissue-specific activators) and antagonists for AR and PR. Also provided are methods of making such compounds and pharmaceutical compositions, as well as critical intermediates used in their synthesis.
摘要翻译： 本发明涉及用于调节由AR和PR介导的过程的化合物，药物组合物和方法。 更具体地，本发明涉及非甾类化合物和组合物，其是高亲和力，高特异性激动剂，部分激动剂（即部分激活剂和/或组织特异性激活剂）和AR和PR的拮抗剂。 还提供制备这些化合物和药物组合物的方法，以及用于其合成的关键中间体。
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7.发明授权6-cycloamino-2-quinolinone derivatives as androgen receptor modulator compounds 有权6-环氨基-2-喹啉酮衍生物作为雄激素受体调节剂化合物公开(公告)号：US07816372B2
公开(公告)日：2010-10-19
申请号：US10566569
申请日：2004-08-23
申请人： Lin Zhi , Esther Martinborough , Yixing Shen , Thomas Lot Stevens Lau , Min Wu , Yun Oliver Long
发明人： Lin Zhi , Esther Martinborough , Yixing Shen , Thomas Lot Stevens Lau , Min Wu , Yun Oliver Long
IPC分类号： C07D215/38 , A61K31/02
CPC分类号： C07D401/04
摘要： The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR. Also provided are methods of making such compounds and pharmaceutical compositions.
摘要翻译： 本发明涉及用于调节由AR介导的过程的化合物，药物组合物和方法。 还提供了制备这些化合物和药物组合物的方法。
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8.发明申请6-Cycloamino-2-quinolinone derivatives as androgen receptor modulator compounds 有权6-环氨基-2-喹啉酮衍生物作为雄激素受体调节剂化合物公开(公告)号：US20080227810A9
公开(公告)日：2008-09-18
申请号：US10566569
申请日：2004-08-23
申请人： Lin Zhi , Esther Martinborough , Yixing Shen , Thomas Lau , Min Wu , Yun Long
发明人： Lin Zhi , Esther Martinborough , Yixing Shen , Thomas Lau , Min Wu , Yun Long
IPC分类号： A61K31/4709 , C07D401/02
CPC分类号： C07D401/04
摘要： The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR. Also provided are methods of making such compounds and pharmaceutical compositions.
摘要翻译： 本发明涉及用于调节由AR介导的过程的化合物，药物组合物和方法。 还提供了制备这些化合物和药物组合物的方法。
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公开(公告)号：US08501982B2
公开(公告)日：2013-08-06
申请号：US13157264
申请日：2011-06-09
申请人： Marcus F. Boehm , Esther Martinborough , Manisha Moorjani , Liming Huang , Junko Tamiya , Mark T. Griffith , Thomas Fowler , Andrew Novak , Michael Knaggs , Premji Meghani
发明人： Marcus F. Boehm , Esther Martinborough , Manisha Moorjani , Liming Huang , Junko Tamiya , Mark T. Griffith , Thomas Fowler , Andrew Novak , Michael Knaggs , Premji Meghani
IPC分类号： C07C69/76 , A61K31/235
CPC分类号： A61K38/02 , A61K31/24 , A61K31/34 , A61K31/343 , A61K31/381 , A61K31/42 , A61K31/428 , A61K31/455 , A61K31/498 , A61K31/5375 , A61K45/06 , C07C233/87 , C07C235/52 , C07C235/84 , C07C237/36 , C07C237/42 , C07C255/57 , C07C275/42 , C07C317/44 , C07D207/44 , C07D211/62 , C07D213/56 , C07D213/82 , C07D215/48 , C07D231/14 , C07D233/90 , C07D241/44 , C07D257/06 , C07D261/18 , C07D261/20 , C07D263/48 , C07D265/30 , C07D277/62 , C07D277/82 , C07D285/14 , C07D295/15 , C07D295/155 , C07D307/66 , C07D307/68 , C07D307/85 , C07D309/08 , C07D317/60 , C07D333/38 , C07D333/70 , C07D471/04
摘要： Compounds that bind the glucagon-like peptide 1 receptor (GLP-1) receptor are provided including compounds which are modulators of the GLP-1 receptors and compounds which are capable of inducing a stabilizing effect on the receptor for use in structural analyses of the GLP-1 receptor. Methods of synthesis, methods of therapeutic and/or prophylactic use, and methods of use in stabilizing GLP-1 receptor in vitro for crystallization of the GLP-1 receptor of such compounds are provided.
摘要翻译： 提供了结合胰高血糖素样肽1受体（GLP-1）受体的化合物，包括作为GLP-1受体的调节剂的化合物和能够诱导对受体的稳定作用的化合物，用于GLP的结构分析 -1受体。 提供了合成方法，治疗和/或预防用途的方法，以及用于稳定GLP-1受体体外用于结合这些化合物的GLP-1受体的方法。
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公开(公告)号：US08202861B2
公开(公告)日：2012-06-19
申请号：US10914988
申请日：2004-08-09
IPC分类号： A61K31/5415 , A61K31/5377 , A61K31/522 , A61K31/513 , A61K31/517
CPC分类号： C07D417/14 , C04B35/632 , C07C311/46 , C07C311/51 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D209/80 , C07D209/92 , C07D213/76 , C07D231/38 , C07D231/42 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/47 , C07D239/52 , C07D239/545 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D277/52 , C07D277/82 , C07D285/125 , C07D285/135 , C07D295/26 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D513/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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